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MX340370B - Derivados de acido 3-heteroaroilamino-propionico sustituidos y su uso como sustancias farmaceuticas. - Google Patents

Derivados de acido 3-heteroaroilamino-propionico sustituidos y su uso como sustancias farmaceuticas.

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Publication number
MX340370B
MX340370B MX2014010972A MX2014010972A MX340370B MX 340370 B MX340370 B MX 340370B MX 2014010972 A MX2014010972 A MX 2014010972A MX 2014010972 A MX2014010972 A MX 2014010972A MX 340370 B MX340370 B MX 340370B
Authority
MX
Mexico
Prior art keywords
heteroaroylamino
pharmaceuticals
substituted
diseases
propionic acid
Prior art date
Application number
MX2014010972A
Other languages
English (en)
Inventor
Ruf Sven
Sadowski Thorsten
Buning Christian
Wirth Klaus
Herman Schreuder
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44041622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX340370(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX340370B publication Critical patent/MX340370B/es

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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Abstract

La presente invención se refiere a compuestos de fórmula I, (ver fórmula) en la que A, D, E, L, G, R10, R30, R40, R50 y R60 tienen los significados indicados en las reivindicaciones, que son compuestos farmacéuticos activos valiosos. Son inhibidores de la proteasa catepsina A, y son útiles, por ejemplo, para el tratamiento de enfermedades tales como aterosclerosis, insuficiencia cardiaca, enfermedades renales, enfermedades hepáticas o enfermedades inflamatorias. La invención se refiere además a procedimientos para preparar los compuestos de fórmula I, a su uso y a composiciones farmacéuticas que los comprenden.
MX2014010972A 2011-01-26 2012-01-26 Derivados de acido 3-heteroaroilamino-propionico sustituidos y su uso como sustancias farmaceuticas. MX340370B (es)

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RU2013139349A (ru) 2015-03-10
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AR085013A1 (es) 2013-08-07
US8669370B2 (en) 2014-03-11
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US20140194445A1 (en) 2014-07-10
IL249826A0 (en) 2017-02-28
HRP20161545T1 (hr) 2016-12-30
MX2013007608A (es) 2013-09-06
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MX347157B (es) 2017-04-18
UY33874A (es) 2012-08-31
US20140135328A1 (en) 2014-05-15
CL2013002129A1 (es) 2013-12-20
WO2012101197A1 (en) 2012-08-02
JP5957467B2 (ja) 2016-07-27
CA2822120A1 (en) 2012-08-02
SI2667870T1 (sl) 2016-12-30
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RU2632897C2 (ru) 2017-10-11
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