MX344925B - Composiciones de insulina y cromo para el tratamiento y prevención de diabetes, hipoglucemia y alteraciones relacionadas. - Google Patents
Composiciones de insulina y cromo para el tratamiento y prevención de diabetes, hipoglucemia y alteraciones relacionadas.Info
- Publication number
- MX344925B MX344925B MX2013009948A MX2013009948A MX344925B MX 344925 B MX344925 B MX 344925B MX 2013009948 A MX2013009948 A MX 2013009948A MX 2013009948 A MX2013009948 A MX 2013009948A MX 344925 B MX344925 B MX 344925B
- Authority
- MX
- Mexico
- Prior art keywords
- chromium
- insulin
- hypoglycemia
- prevention
- treatment
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 7
- 229940125396 insulin Drugs 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 title abstract 3
- 208000013016 Hypoglycemia Diseases 0.000 title abstract 3
- 102000004877 Insulin Human genes 0.000 title abstract 3
- 108090001061 Insulin Proteins 0.000 title abstract 3
- 229910052804 chromium Inorganic materials 0.000 title abstract 3
- 239000011651 chromium Substances 0.000 title abstract 3
- 230000002218 hypoglycaemic effect Effects 0.000 title abstract 3
- 230000002265 prevention Effects 0.000 title abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a una composición que comprende cromo e insulina y/o un complejo de cromo-insulina, su método de preparación y su uso en la prevención y tratamiento de hipoglucemia y condiciones relacionadas con hipoglucemia. Esta composición puede ser administrada de numerosas maneras, incluyendo parental, intranasal y oralmente. La composición estabiliza los niveles de glucosa en el suero y tiene efecto sinergista en comparación con cromo e insulina administrados separadamente.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161448134P | 2011-03-01 | 2011-03-01 | |
| PCT/US2012/027342 WO2012119007A1 (en) | 2011-03-01 | 2012-03-01 | Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013009948A MX2013009948A (es) | 2014-03-27 |
| MX344925B true MX344925B (es) | 2017-01-11 |
Family
ID=45841644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013009948A MX344925B (es) | 2011-03-01 | 2012-03-01 | Composiciones de insulina y cromo para el tratamiento y prevención de diabetes, hipoglucemia y alteraciones relacionadas. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8933022B2 (es) |
| EP (2) | EP2680861B1 (es) |
| JP (1) | JP6152346B2 (es) |
| KR (1) | KR101836957B1 (es) |
| CN (2) | CN105749253A (es) |
| AU (1) | AU2012223282B2 (es) |
| CA (1) | CA2828572C (es) |
| ES (1) | ES2927800T3 (es) |
| IL (1) | IL228209B (es) |
| MX (1) | MX344925B (es) |
| WO (1) | WO2012119007A1 (es) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1969004T3 (da) | 2005-12-28 | 2011-11-28 | Novo Nordisk As | Insulinsammensætninger og metode til at lave en sammensætning |
| CA3013149C (en) | 2007-03-13 | 2021-12-07 | Jds Therapeutics, Llc | Methods and compositions for the sustained release of chromium |
| US8417311B2 (en) | 2008-09-12 | 2013-04-09 | Optiscan Biomedical Corporation | Fluid component analysis system and method for glucose monitoring and control |
| WO2009002867A2 (en) | 2007-06-26 | 2008-12-31 | Nutrition 21, Inc. | Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement |
| US7959598B2 (en) | 2008-08-20 | 2011-06-14 | Asante Solutions, Inc. | Infusion pump systems and methods |
| US20110313680A1 (en) * | 2010-06-22 | 2011-12-22 | Doyle Iii Francis J | Health Monitoring System |
| BR112013010345A2 (pt) | 2010-10-27 | 2017-07-25 | Novo Nordisk As | tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção |
| EP2663969B1 (en) | 2011-01-14 | 2020-04-15 | Federal Law Enforcement Development Services, Inc. | Method of providing lumens and tracking of lumen consumption |
| MX344925B (es) | 2011-03-01 | 2017-01-11 | N21 Acquisition Holding Llc | Composiciones de insulina y cromo para el tratamiento y prevención de diabetes, hipoglucemia y alteraciones relacionadas. |
| JP6755175B2 (ja) * | 2013-03-20 | 2020-09-16 | ノヴォ ノルディスク アー/エス | インスリン投薬レジメン |
| WO2014177623A1 (en) | 2013-04-30 | 2014-11-06 | Novo Nordisk A/S | Novel administration regime |
| US9561324B2 (en) | 2013-07-19 | 2017-02-07 | Bigfoot Biomedical, Inc. | Infusion pump system and method |
| GB2523989B (en) | 2014-01-30 | 2020-07-29 | Insulet Netherlands B V | Therapeutic product delivery system and method of pairing |
| CN107405446B (zh) | 2015-02-18 | 2020-09-29 | 英赛罗公司 | 流体输送和输注装置及其使用方法 |
| US10275573B2 (en) | 2016-01-13 | 2019-04-30 | Bigfoot Biomedical, Inc. | User interface for diabetes management system |
| CN108495665B (zh) | 2016-01-14 | 2021-04-09 | 比格福特生物医药公司 | 调整胰岛素输送速率 |
| HK1256995A1 (zh) | 2016-01-14 | 2019-10-11 | Bigfoot Biomedical, Inc. | 药物输送设备、系统和方法中的阻塞解决方案 |
| MX2018009748A (es) | 2016-02-11 | 2019-02-07 | Nutrition 21 Llc | Composiciones que contienen cromo para mejorar la salud y el estado físico. |
| US12383166B2 (en) | 2016-05-23 | 2025-08-12 | Insulet Corporation | Insulin delivery system and methods with risk-based set points |
| WO2018052981A1 (en) * | 2016-09-13 | 2018-03-22 | Stc.Unm | Compositions and methods for treating nicotine withdrawal |
| US10765807B2 (en) | 2016-09-23 | 2020-09-08 | Insulet Corporation | Fluid delivery device with sensor |
| EP3500161A4 (en) | 2016-12-12 | 2020-01-08 | Bigfoot Biomedical, Inc. | ALARMS AND WARNINGS FOR MEDICINE DELIVERY DEVICES AND RELATED SYSTEMS AND METHODS |
| US10758675B2 (en) | 2017-01-13 | 2020-09-01 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| EP3568859B1 (en) | 2017-01-13 | 2025-12-10 | Insulet Corporation | Insulin delivery methods, systems and devices |
| US10881792B2 (en) | 2017-01-13 | 2021-01-05 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| WO2018132723A1 (en) | 2017-01-13 | 2018-07-19 | Mazlish Bryan | Insulin delivery methods, systems and devices |
| US10500334B2 (en) | 2017-01-13 | 2019-12-10 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| USD928199S1 (en) | 2018-04-02 | 2021-08-17 | Bigfoot Biomedical, Inc. | Medication delivery device with icons |
| CN112236826B (zh) | 2018-05-04 | 2024-08-13 | 英赛罗公司 | 基于控制算法的药物输送系统的安全约束 |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| US11628251B2 (en) | 2018-09-28 | 2023-04-18 | Insulet Corporation | Activity mode for artificial pancreas system |
| EP3864668A1 (en) | 2018-10-11 | 2021-08-18 | Insulet Corporation | Event detection for drug delivery system |
| USD920343S1 (en) | 2019-01-09 | 2021-05-25 | Bigfoot Biomedical, Inc. | Display screen or portion thereof with graphical user interface associated with insulin delivery |
| EP3996679B1 (en) | 2019-07-12 | 2023-09-06 | Novo Nordisk A/S | High concentration insulin formulation |
| US11801344B2 (en) | 2019-09-13 | 2023-10-31 | Insulet Corporation | Blood glucose rate of change modulation of meal and correction insulin bolus quantity |
| US11935637B2 (en) | 2019-09-27 | 2024-03-19 | Insulet Corporation | Onboarding and total daily insulin adaptivity |
| WO2021113647A1 (en) | 2019-12-06 | 2021-06-10 | Insulet Corporation | Techniques and devices providing adaptivity and personalization in diabetes treatment |
| IL294021A (en) | 2019-12-16 | 2022-08-01 | Nutrition 21 Llc | Methods of production of arginine-silicate complexes |
| US11833329B2 (en) | 2019-12-20 | 2023-12-05 | Insulet Corporation | Techniques for improved automatic drug delivery performance using delivery tendencies from past delivery history and use patterns |
| US12036389B2 (en) | 2020-01-06 | 2024-07-16 | Insulet Corporation | Prediction of meal and/or exercise events based on persistent residuals |
| US12370307B2 (en) | 2020-02-03 | 2025-07-29 | Insulet Corporation | Use of fuzzy logic in predicting user behavior affecting blood glucose concentration in a closed loop control system of an automated insulin delivery device |
| US11551802B2 (en) | 2020-02-11 | 2023-01-10 | Insulet Corporation | Early meal detection and calorie intake detection |
| US11547800B2 (en) | 2020-02-12 | 2023-01-10 | Insulet Corporation | User parameter dependent cost function for personalized reduction of hypoglycemia and/or hyperglycemia in a closed loop artificial pancreas system |
| US11986630B2 (en) | 2020-02-12 | 2024-05-21 | Insulet Corporation | Dual hormone delivery system for reducing impending hypoglycemia and/or hyperglycemia risk |
| US11324889B2 (en) | 2020-02-14 | 2022-05-10 | Insulet Corporation | Compensation for missing readings from a glucose monitor in an automated insulin delivery system |
| US12495994B2 (en) | 2020-02-20 | 2025-12-16 | Insulet Corporation | Meal bolus subcategories in model based insulin therapy |
| US11607493B2 (en) | 2020-04-06 | 2023-03-21 | Insulet Corporation | Initial total daily insulin setting for user onboarding |
| WO2022020197A1 (en) | 2020-07-22 | 2022-01-27 | Insulet Corporation | Open-loop insulin delivery basal parameters based on insulin delivery records |
| US11684716B2 (en) | 2020-07-31 | 2023-06-27 | Insulet Corporation | Techniques to reduce risk of occlusions in drug delivery systems |
| EP4221785B1 (en) | 2020-09-30 | 2025-12-24 | Insulet Corporation | Drug delivery device with integrated optical-based glucose monitor |
| US12115351B2 (en) | 2020-09-30 | 2024-10-15 | Insulet Corporation | Secure wireless communications between a glucose monitor and other devices |
| US11160925B1 (en) | 2021-01-29 | 2021-11-02 | Insulet Corporation | Automatic drug delivery system for delivery of a GLP-1 therapeutic |
| WO2022192482A1 (en) | 2021-03-10 | 2022-09-15 | Insulet Corporation | A medicament delivery device with an adjustable and piecewise analyte level cost component to address persistent positive analyte level excursions |
| US11904140B2 (en) | 2021-03-10 | 2024-02-20 | Insulet Corporation | Adaptable asymmetric medicament cost component in a control system for medicament delivery |
| US12496398B2 (en) | 2021-05-28 | 2025-12-16 | Insulet Corporation | Threshold based automatic glucose control response |
| US12406760B2 (en) | 2021-06-07 | 2025-09-02 | Insulet Corporation | Exercise safety prediction based on physiological conditions |
| US12514980B2 (en) | 2021-06-30 | 2026-01-06 | Insulet Corporation | Adjustment of medicament delivery by a medicament delivery device based on menstrual cycle phase |
| US12521486B2 (en) | 2021-07-16 | 2026-01-13 | Insulet Corporation | Method for modification of insulin delivery during pregnancy in automatic insulin delivery systems |
| WO2023049900A1 (en) | 2021-09-27 | 2023-03-30 | Insulet Corporation | Techniques enabling adaptation of parameters in aid systems by user input |
| US11439754B1 (en) | 2021-12-01 | 2022-09-13 | Insulet Corporation | Optimizing embedded formulations for drug delivery |
| CN119053681A (zh) | 2022-04-27 | 2024-11-29 | 雅富顿化学公司 | 用于润滑油组合物的高硫化添加剂 |
| CA3275991A1 (en) | 2023-01-06 | 2024-07-11 | Insulet Corporation | Automatic or manual administration of meal boluses with subsequent automatic relaxation of safety constraints |
| WO2025090369A1 (en) | 2023-10-25 | 2025-05-01 | Afton Chemical Corporation | Additives with high sulfurization for lubricating oil compositions |
Family Cites Families (110)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK135268A (es) | 1973-02-09 | |||
| US4164573A (en) | 1975-06-13 | 1979-08-14 | Galinsky Alvin M | Composition and method for making a suppository for introducing a hypoglycemic agent into a mammal |
| EP0016496B1 (en) * | 1979-03-19 | 1983-10-19 | THE PROCTER & GAMBLE COMPANY | Chromium acetylacetonate as a dietary supplement and pharmaceutical agent |
| US4421685A (en) | 1980-03-27 | 1983-12-20 | Eli Lilly And Company | Process for producing an insulin |
| US4315927A (en) | 1980-08-08 | 1982-02-16 | The United States Of America As Represented By The Secretary Of Agriculture | Dietary supplementation with essential metal picolinates |
| USRE33988E (en) | 1980-08-08 | 1992-07-07 | The United States of America as repesented by the Secretary of Agriculture | Dietary supplementation with essential metal picolinates |
| FI78616C (fi) | 1982-02-05 | 1989-09-11 | Novo Industri As | Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt. |
| US4424057A (en) | 1982-04-01 | 1984-01-03 | House Hugh A | Wet-dry syringe |
| US5194615A (en) | 1983-07-08 | 1993-03-16 | The William Seroy Group | Synthetic GTF chromium nicotinate material and its preparation |
| US4954492A (en) | 1983-07-08 | 1990-09-04 | The William Seroy Group | Synthetic GTF chromium material for decreasing blood lipid levels and process therefor |
| US5731303A (en) | 1985-12-04 | 1998-03-24 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery compositions |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| DK179286D0 (da) | 1986-04-18 | 1986-04-18 | Nordisk Gentofte | Insulinpraeparat |
| US5175156A (en) | 1987-11-30 | 1992-12-29 | Nutrition 21 | Chromic picolinate treatment |
| US5087623A (en) | 1988-05-31 | 1992-02-11 | Nitrition 21 | Chromic picolinate treatment |
| US5085996A (en) | 1988-07-29 | 1992-02-04 | Evans Gary W | Microorganism growth acceleration medium containing an effective amount of picolinic acid or metal picolinate to promote growth of the microorganism |
| US5057320A (en) | 1988-08-01 | 1991-10-15 | Nutrition 21 | Means and method for increasing skin respiration |
| US6140304A (en) | 1988-09-28 | 2000-10-31 | Eicotech Corporation | Method of and nutritional and pharmaceutical compositions for reduction of hyperinsulinemia |
| US5087624A (en) | 1989-03-21 | 1992-02-11 | Nutrition 21 | Chromic picolinate treatment |
| DE69124223T2 (de) | 1990-02-05 | 1997-04-30 | Lifescience Corp | Vitamine und mineralien enthaltende nahrungszusätze |
| US6099856A (en) | 1992-06-15 | 2000-08-08 | Emisphere Technologies, Inc. | Active agent transport systems |
| US5629020A (en) | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
| IL99699A (en) | 1990-10-10 | 2002-04-21 | Autoimmune Inc | Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes |
| US5164384A (en) | 1991-06-19 | 1992-11-17 | Metagenics, Inc. | Anabolic mineral formula |
| US5336672A (en) | 1992-07-21 | 1994-08-09 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Increasing egg production in poultry |
| SE9203753D0 (sv) | 1992-12-11 | 1992-12-11 | Kabi Pharmacia Ab | Expression system for producing apolipoprotein ai-m |
| US5643957A (en) | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| CA2160693C (en) | 1993-04-22 | 2010-03-16 | Sam J. Milstein | Oral drug delivery compositions and methods |
| US5534488A (en) | 1993-08-13 | 1996-07-09 | Eli Lilly And Company | Insulin formulation |
| US5474978A (en) | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
| US5496827A (en) | 1994-07-15 | 1996-03-05 | Patrick; Jay | Compositions for the transdermal delivery of nutrients |
| US5989539A (en) | 1995-03-31 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| CN1151836C (zh) | 1995-03-31 | 2004-06-02 | 艾米斯菲尔技术有限公司 | 用作传送活性剂的化合物和组合物 |
| US5866536A (en) | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5965121A (en) | 1995-03-31 | 1999-10-12 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6001347A (en) | 1995-03-31 | 1999-12-14 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5650386A (en) | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
| US6090958A (en) | 1995-03-31 | 2000-07-18 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5582839A (en) | 1995-04-18 | 1996-12-10 | Nutrition 21 | Magnesium taurate and other mineral taurates |
| US6099869A (en) | 1995-04-18 | 2000-08-08 | Nutrition 21 | Calcium taurate and antihypertensive drug for hypertension |
| US5776498A (en) | 1995-11-06 | 1998-07-07 | Nutrition 21 | Magnesium taurate as an adjuvant to rapid thrombolytic therapy |
| US6329361B1 (en) | 1995-05-12 | 2001-12-11 | Nutrition 21 | High-dose chromic picolinate treatment of type II diabetes |
| US5597585A (en) | 1995-12-26 | 1997-01-28 | Williams; Andrew H. | Vitamin/mineral composition |
| US5635535A (en) | 1996-04-05 | 1997-06-03 | Wagstaff; Robert K. | Method for increasing blood glucose levels |
| US5804688A (en) | 1997-02-07 | 1998-09-08 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5990166A (en) | 1997-02-07 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6051561A (en) | 1997-02-07 | 2000-04-18 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
| US5876710A (en) | 1997-02-07 | 1999-03-02 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
| US5773647A (en) | 1997-02-07 | 1998-06-30 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5776888A (en) | 1997-02-07 | 1998-07-07 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5939381A (en) | 1997-02-07 | 1999-08-17 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6060513A (en) | 1997-02-07 | 2000-05-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5879681A (en) | 1997-02-07 | 1999-03-09 | Emisphere Technolgies Inc. | Compounds and compositions for delivering active agents |
| US6358504B1 (en) | 1997-02-07 | 2002-03-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5707970A (en) | 1997-02-12 | 1998-01-13 | Nutrition 21 | Arginine silicate complex and use thereof |
| US6291495B1 (en) * | 1997-02-24 | 2001-09-18 | Robert B. Rieveley | Method and composition for the treatment of diabetes |
| US5863944A (en) | 1997-04-30 | 1999-01-26 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| DE19722618A1 (de) | 1997-05-30 | 1998-12-03 | Philips Patentverwaltung | Hochtemperaturkondensator |
| ES2251097T3 (es) | 1997-08-08 | 2006-04-16 | Nutrition 21 | Tratamiento con cromo/biotina de la diabetes tipo ii. |
| US5914326A (en) | 1997-08-08 | 1999-06-22 | Ambi Inc. | Method for promoting weight and fat loss |
| US5789401A (en) | 1997-08-08 | 1998-08-04 | Nutrition 21 | High-dose chromium/biotin treatment of type II diabetes |
| US6004925A (en) | 1997-09-29 | 1999-12-21 | J. L. Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
| US6037323A (en) | 1997-09-29 | 2000-03-14 | Jean-Louis Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
| US6048846A (en) | 1998-02-26 | 2000-04-11 | Cochran; Timothy M. | Compositions used in human treatment |
| US6245027B1 (en) | 1998-04-10 | 2001-06-12 | Noam Alperin | Method of measuring intracranial pressure |
| US5948772A (en) | 1998-08-28 | 1999-09-07 | Ambi Inc. | Chromium picolinate compositions and uses thereof |
| CN1205994C (zh) | 1998-07-27 | 2005-06-15 | 艾米斯菲尔技术有限公司 | 经肺运送活性剂 |
| NZ509410A (en) | 1998-08-07 | 2003-08-29 | Emisphere Tech Inc | Compounds and compositions for delivering active agents |
| US5980905A (en) | 1998-08-28 | 1999-11-09 | Ambi Inc. | Chromium polynicotinate compositions and uses thereof |
| CA2344246A1 (en) | 1998-09-17 | 2000-03-23 | Akesis Pharmaceuticals, Inc. | Combinations of chromium or vanadium with antidiabetics for glucose metabolism disorders |
| US6376549B1 (en) * | 1998-09-17 | 2002-04-23 | Akesis Pharmaceuticals, Inc. | Metforimin-containing compositions for the treatment of diabetes |
| ATE311373T1 (de) | 1999-02-11 | 2005-12-15 | Emisphere Tech Inc | Oxadiazolverbindungen und -zusammensetzungen zur abgabe von wirkstoffen |
| CA2364849A1 (en) | 1999-02-26 | 2000-08-31 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| JP4588221B2 (ja) | 1999-04-05 | 2010-11-24 | エミスフェアー・テクノロジーズ・インク | 活性剤を送達するための二ナトリウム塩、一水和物、およびエタノール溶媒和物 |
| US6261606B1 (en) * | 1999-09-14 | 2001-07-17 | Natural Compounds, Ltd. | Naturally extracted and synthetic hypoglycemic or hypolipidemic compositions |
| JP2001104702A (ja) | 1999-10-01 | 2001-04-17 | Air Liquide Japan Ltd | ガスの集合回収装置および集合回収方法 |
| DE19948361A1 (de) | 1999-10-07 | 2001-04-12 | Bsh Bosch Siemens Hausgeraete | Kältegerät |
| US6689383B1 (en) | 1999-10-08 | 2004-02-10 | The United States Of America As Represented By The Secretary Of Agriculture | Chromium-histidine complexes as nutrient supplements |
| IL149337A0 (en) | 1999-11-05 | 2002-11-10 | Emisphere Tech Inc | Phenoxy carboxylic acid compounds and compositions for delivering active agents |
| WO2001034114A1 (en) | 1999-11-12 | 2001-05-17 | Emisphere Technologies, Inc. | Liquid heparin formulation |
| DE19959351A1 (de) | 1999-12-09 | 2001-06-13 | Bilstein Spezialfab Wilhelm | Schneidvorrichtung mit Eigenantrieb für eine Einrichtung zum Längsteilen von durchlaufenden Materialbahnen |
| AU2274201A (en) | 1999-12-16 | 2001-06-25 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| WO2001051454A1 (en) | 2000-01-13 | 2001-07-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| CN100482637C (zh) | 2000-06-29 | 2009-04-29 | 艾米斯菲尔技术有限公司 | 用于投递活性剂的化合物和组合物 |
| US6365176B1 (en) | 2000-08-08 | 2002-04-02 | Functional Foods, Inc. | Nutritional supplement for patients with type 2 diabetes mellitus for lipodystrophy |
| ATE429416T1 (de) | 2000-09-06 | 2009-05-15 | Emisphere Tech Inc | Cyanophenoxy-carbonsäuren und zusammensetzungen für die freisetzung aktiver substanzen |
| WO2002019969A2 (en) | 2000-09-06 | 2002-03-14 | Emisphere Technologies Inc. | (5-(2-hydroxy-4-chlorobenzoyl) aminovaleric acid and salts thereof and compositions containing the same for delivering active agents |
| US6809115B2 (en) | 2000-09-21 | 2004-10-26 | Nutrition 21, Inc. | Methods and compositions for the treatment of diabetes, the reduction of body fat, improvement of insulin sensitivity, reduction of hyperglycemia, and reduction of hypercholesterolemia with chromium complexes, conjugated fatty acids, and/or conjugated fatty alcohols |
| US20020086065A1 (en) | 2000-10-31 | 2002-07-04 | Katz David P. | Methods and compositions for the benefit of those suffering from polycystic ovary syndrome with chromium complexes |
| US20020098247A1 (en) | 2000-11-02 | 2002-07-25 | Komorowski James R. | Methods and compositions for the improvement of insulin sensitivity, reduction of hyperglycemia, and reduction of hypercholesterolemia with chromium complexes and alpha lipoic acid |
| JP2004521127A (ja) | 2001-02-27 | 2004-07-15 | ニュートリション 21、インコーポレイテッド | 異常脂血症及び食事誘発性食後高血糖症のクロム/ビオチン療法 |
| NZ527157A (en) | 2001-03-01 | 2005-04-29 | Emisphere Tech Inc | Compositions for delivering bisphosphonates |
| CA2438849A1 (en) | 2001-03-01 | 2002-09-12 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| WO2003043569A2 (en) | 2001-11-16 | 2003-05-30 | Nutrition 21, Inc. | Trans-10, cis-12 conjugated linoleic acid isomer for the treatment of diseases |
| US20030198666A1 (en) | 2002-01-07 | 2003-10-23 | Richat Abbas | Oral insulin therapy |
| AU2003226313A1 (en) | 2002-04-23 | 2003-11-10 | Nutrition 21, Inc. | Chromium compositions and methods for using the same for inhibiting drug-induced insulin resistance |
| US7063865B2 (en) | 2002-05-10 | 2006-06-20 | Jeremy Park Jones | Composition and method for substantially reducing the deleterious effects of alcohol on the body |
| US20040005368A1 (en) | 2002-07-01 | 2004-01-08 | Morris Mann | Novel approach to weight loss comprising a modified protein composition that regulates blood sugar in conjunction with compositions that increase oxygen uptake and suppress appetite |
| US7291591B2 (en) | 2003-04-11 | 2007-11-06 | All Natural Fmg, Inc. | Alcohol-free transdermal insulin composition |
| OA13177A (en) | 2003-06-04 | 2006-12-13 | Willem Jacob Serfontein | Nutritional compositions and use thereof. |
| US20050069593A1 (en) | 2003-09-29 | 2005-03-31 | Life Time Fitness, Inc. | Nutritional supplement containing 7-Keto-DHEA and conjugated linoleic acid |
| AU2004296784B2 (en) | 2003-12-08 | 2010-12-02 | Cpex Pharmaceuticals, Inc. | Pharmaceutical compositions and methods for insulin treatment |
| US20060024383A1 (en) | 2004-07-27 | 2006-02-02 | Roger Berlin | Compositions containing policosanol and chromium and/or chromium salts and their pharmaceutical uses |
| CN101102789B (zh) * | 2004-12-03 | 2012-05-30 | 罗得岛医院 | 阿尔茨海默病的诊断和治疗 |
| WO2008094939A1 (en) | 2007-01-31 | 2008-08-07 | Nutrition 21, Inc. | Use of chromium histidinate for treatment of cardiometabolic disorders |
| CA3013149C (en) | 2007-03-13 | 2021-12-07 | Jds Therapeutics, Llc | Methods and compositions for the sustained release of chromium |
| WO2009002867A2 (en) | 2007-06-26 | 2008-12-31 | Nutrition 21, Inc. | Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement |
| US20100262434A1 (en) | 2007-12-13 | 2010-10-14 | Shaya Steven A | Method and apparatus to calculate diabetic sensitivity factors affecting blood glucose |
| US9028879B2 (en) | 2009-07-01 | 2015-05-12 | Jds Therapeutics, Llc | Chromium complexes as enhancers of brain glucose transporters |
| MX344925B (es) | 2011-03-01 | 2017-01-11 | N21 Acquisition Holding Llc | Composiciones de insulina y cromo para el tratamiento y prevención de diabetes, hipoglucemia y alteraciones relacionadas. |
-
2012
- 2012-03-01 MX MX2013009948A patent/MX344925B/es active IP Right Grant
- 2012-03-01 EP EP12709222.9A patent/EP2680861B1/en active Active
- 2012-03-01 CN CN201610172098.8A patent/CN105749253A/zh active Pending
- 2012-03-01 ES ES12709222T patent/ES2927800T3/es active Active
- 2012-03-01 CA CA2828572A patent/CA2828572C/en active Active
- 2012-03-01 WO PCT/US2012/027342 patent/WO2012119007A1/en not_active Ceased
- 2012-03-01 EP EP22160569.4A patent/EP4070801A1/en not_active Withdrawn
- 2012-03-01 AU AU2012223282A patent/AU2012223282B2/en not_active Ceased
- 2012-03-01 CN CN201280020399.9A patent/CN103702672B/zh not_active Expired - Fee Related
- 2012-03-01 US US13/409,960 patent/US8933022B2/en active Active
- 2012-03-01 KR KR1020137025794A patent/KR101836957B1/ko not_active Expired - Fee Related
- 2012-03-01 JP JP2013556874A patent/JP6152346B2/ja not_active Expired - Fee Related
-
2013
- 2013-08-29 IL IL228209A patent/IL228209B/en active IP Right Grant
-
2014
- 2014-12-08 US US14/563,783 patent/US20150094258A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR101836957B1 (ko) | 2018-03-09 |
| US8933022B2 (en) | 2015-01-13 |
| WO2012119007A1 (en) | 2012-09-07 |
| CN103702672B (zh) | 2016-04-27 |
| JP6152346B2 (ja) | 2017-06-21 |
| CA2828572C (en) | 2021-02-23 |
| CN105749253A (zh) | 2016-07-13 |
| US20120225134A1 (en) | 2012-09-06 |
| CA2828572A1 (en) | 2012-09-07 |
| CN103702672A (zh) | 2014-04-02 |
| ES2927800T3 (es) | 2022-11-11 |
| JP2014506932A (ja) | 2014-03-20 |
| KR20140023298A (ko) | 2014-02-26 |
| US20150094258A1 (en) | 2015-04-02 |
| AU2012223282B2 (en) | 2017-02-02 |
| EP4070801A1 (en) | 2022-10-12 |
| AU2012223282A1 (en) | 2013-09-19 |
| EP2680861A1 (en) | 2014-01-08 |
| EP2680861B1 (en) | 2022-05-04 |
| IL228209B (en) | 2020-05-31 |
| MX2013009948A (es) | 2014-03-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX344925B (es) | Composiciones de insulina y cromo para el tratamiento y prevención de diabetes, hipoglucemia y alteraciones relacionadas. | |
| HK1211231A1 (en) | Exendin-4 derivatives | |
| PH12014500075A1 (en) | Pharmaceutical composition, methods for treating and uses thereof | |
| WO2013186240A3 (en) | Exendin-4 peptide analogues | |
| PH12015500688A1 (en) | Exendin-4 derivatives as dual glp1/glucagon agonists | |
| PH12013500808A1 (en) | Pharmaceutical combinations for the treatment of metabolic disorders | |
| MY176863A (en) | Ibat inhibitors for treatment of metabolic disorders and related conditions | |
| PL3517539T3 (pl) | Podstawiona dimeryczna pochodna chinazoliny, sposób jej wytwarzania i jej zastosowanie w kompozycjach farmaceutycznych do leczenia cukrzycy typu I i II | |
| MX356728B (es) | Combinación farmacéutica para usar en el tratamiento de pacientes que padecen diabetes de tipo 2. | |
| MY153062A (en) | Methods of treating gastrointestinal disorders independent of the intake of food | |
| PL2691109T3 (pl) | Zapobieganie hipoglikemii u pacjentów z cukrzycą typu 2 | |
| MX349254B (es) | Compuestos para el tratamiento del sindrome metabolico. | |
| WO2014071168A3 (en) | Administering inhibitors of tgfbeta signaling to improve muscle function in cancer patients | |
| WO2015003122A3 (en) | Regulation of glucose metabolism using anti-cgrp antibodies | |
| MX337139B (es) | Composicion de miel con l-alanil-l-glutamina. | |
| WO2014018763A3 (en) | Method of treating type i diabetes using apolipoprotein aiv | |
| WO2014014819A3 (en) | Methods of treating glucose metabolism disorders | |
| WO2013090319A3 (en) | Treatment of type i and type ii diabetes | |
| WO2012004416A3 (en) | Treatment of a disease associated with retinal degenerative disorder | |
| MX375398B (es) | Composición para la administración oral de magnesio en asociacion con una composicion para tratar la diabetes tipo 2 o las complicaciones de la misma. | |
| EA201490712A1 (ru) | Синергетическая травяная композиция для профилактики и лечения диабетической ретинопатии и катаракты | |
| HK1187552A (en) | Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders | |
| TN2013000187A1 (en) | Pharmaceutical composition, methods for treating and uses thereof | |
| HK1197726A (en) | Methods for increasing insulin sensitivity and treating diabetes | |
| HK1193342A (en) | Pharmaceutical combination for use in the treatment of diabetes type 2 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |