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MX2023011065A - Derivados de heteroarilos biciclicos como inhibidores de ectonucleotido pirofosfatasa fosfodiesterasa 1. - Google Patents

Derivados de heteroarilos biciclicos como inhibidores de ectonucleotido pirofosfatasa fosfodiesterasa 1.

Info

Publication number
MX2023011065A
MX2023011065A MX2023011065A MX2023011065A MX2023011065A MX 2023011065 A MX2023011065 A MX 2023011065A MX 2023011065 A MX2023011065 A MX 2023011065A MX 2023011065 A MX2023011065 A MX 2023011065A MX 2023011065 A MX2023011065 A MX 2023011065A
Authority
MX
Mexico
Prior art keywords
bicyclic heteroaryl
inhibitors
ectonucleotide pyrophosphatase
compounds
heteroaryl derivatives
Prior art date
Application number
MX2023011065A
Other languages
English (en)
Inventor
Klaus Klumpp
Ronald Hawley
Original Assignee
Riboscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riboscience Llc filed Critical Riboscience Llc
Publication of MX2023011065A publication Critical patent/MX2023011065A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/027—Organoboranes and organoborohydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
    • C07F9/65038—Five-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente divulgación proporciona ciertos compuestos heteroarílicos bicíclicos que inhiben la actividad enzimática de la ectonucleótido pirofosfatasa/fosfodiesterasa 1 (ENPP1) y que son, por consiguiente, útiles para el tratamiento de enfermedades y afecciones moduladas al menos en parte por ENPP1. En algunas realizaciones, los compuestos heteroarílicos bicíclicos incluyen los de Fórmula (I): (ver Fórmula) (I) En la presente también se proporcionan composiciones farmacéuticas que contienen tales compuestos y procesos para preparar tales compuestos.
MX2023011065A 2019-04-12 2021-10-07 Derivados de heteroarilos biciclicos como inhibidores de ectonucleotido pirofosfatasa fosfodiesterasa 1. MX2023011065A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962833455P 2019-04-12 2019-04-12
US201962881111P 2019-07-31 2019-07-31

Publications (1)

Publication Number Publication Date
MX2023011065A true MX2023011065A (es) 2023-09-28

Family

ID=70465561

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2021012305A MX2021012305A (es) 2019-04-12 2020-04-10 Derivados de heteroarilos biciclicos como inhibidores de ectonucleotido pirofosfatasa fosfodiesterasa 1.
MX2023011065A MX2023011065A (es) 2019-04-12 2021-10-07 Derivados de heteroarilos biciclicos como inhibidores de ectonucleotido pirofosfatasa fosfodiesterasa 1.

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MX2021012305A MX2021012305A (es) 2019-04-12 2020-04-10 Derivados de heteroarilos biciclicos como inhibidores de ectonucleotido pirofosfatasa fosfodiesterasa 1.

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US (2) US12029744B2 (es)
EP (2) EP3952995B1 (es)
JP (2) JP7598875B2 (es)
KR (1) KR20210151873A (es)
CN (1) CN114040915A (es)
AU (1) AU2020272034A1 (es)
BR (1) BR112021020241A2 (es)
CA (1) CA3136443A1 (es)
DK (1) DK3952995T3 (es)
ES (1) ES2960987T3 (es)
FI (1) FI3952995T3 (es)
HR (1) HRP20231413T1 (es)
HU (1) HUE064377T2 (es)
IL (1) IL286966A (es)
LT (1) LT3952995T (es)
MX (2) MX2021012305A (es)
PL (1) PL3952995T3 (es)
PT (1) PT3952995T (es)
RS (1) RS64792B1 (es)
SG (1) SG11202110888QA (es)
SI (1) SI3952995T1 (es)
SM (1) SMT202300373T1 (es)
TW (1) TW202103708A (es)
WO (1) WO2020210649A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021368622A1 (en) * 2020-10-30 2023-06-08 1Cbio, Inc. Ectonucleotide pyrophosphatase-phosphodiesterase-1 (enpp1) inhibitors and uses thereof
EP4286374A4 (en) * 2021-01-29 2024-11-20 Txinno Bioscience Inc. NOVEL BENZOTRIAZOLE DERIVATIVE WITH INHIBITING ACTIVITY AGAINST ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE AND USE THEREOF
WO2022197734A1 (en) * 2021-03-16 2022-09-22 Riboscience Llc Bicyclic heteroaryl boronate derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors
CN116444544A (zh) * 2022-01-10 2023-07-18 中国科学院上海药物研究所 苯并咪唑类化合物及其医药用途
AU2023376005A1 (en) * 2022-11-09 2025-03-13 Boehringer Ingelheim International Gmbh Cyclic benzimidazole derivatives as cgas inhibitors
WO2024149239A1 (zh) * 2023-01-10 2024-07-18 上海翊维康医药有限责任公司 杂芳环化合物及其制备方法和用途

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107288A (en) 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
US5240938A (en) 1991-02-13 1993-08-31 Merck & Co., Inc. Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring
GB9020931D0 (en) 1990-09-26 1990-11-07 Wellcome Found Heterocyclic compounds
IE914573A1 (en) 1991-01-17 1992-07-29 Ici Plc Boron compounds
IE914572A1 (en) 1991-01-17 1992-07-29 Zeneca Ltd Chemical process
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
DK40192D0 (da) 1992-03-26 1992-03-26 Neurosearch As Imidazolforbindelser, deres fremstilling og anvendelse
US5468757A (en) 1994-01-31 1995-11-21 Eli Lilly And Company 6-azaindole thromboxane synthase inhibitors
WO2001044257A1 (en) 1999-12-17 2001-06-21 Ariad Pharmaceuticals, Inc. Proton pump inhibitors
MXPA03008560A (es) 2001-03-22 2004-06-30 Abbot Gmbh & Co Kg Pirazolopirimidinas como agentes terapeuticos.
US20030114467A1 (en) 2001-06-21 2003-06-19 Shakespeare William C. Novel pyrazolo- and pyrrolo-pyrimidines and uses thereof
JP2005089334A (ja) 2003-09-12 2005-04-07 Sumitomo Pharmaceut Co Ltd ８−ヒドロキシアデニン化合物
WO2007134169A2 (en) 2006-05-10 2007-11-22 Nuada, Llc Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof
US20090264384A1 (en) 2004-11-01 2009-10-22 Nuada, Inc. Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof
DE102004060699A1 (de) 2004-12-16 2006-06-22 Ratiopharm Gmbh Verfahren zur Herstellung von Candesartan
WO2006067215A2 (en) 2004-12-22 2006-06-29 Algry Química, S. L. Intermediate compounds for the preparation of angiotensin ii receptor antagonists
ITMI20050801A1 (it) 2005-05-03 2006-11-04 Dipharma Spa Procedimento per la preparazione di telmisartan
WO2006125592A2 (en) 2005-05-24 2006-11-30 Lek Pharmaceuticals D.D. Process for the preparation of 2-alkyl-1-((2'-substituted-biphenyl-4-yl)methyl)-imidazole, dihydroimidazole or benzimidazole derivatives
WO2007021937A2 (en) 2005-08-11 2007-02-22 Ariad Pharmaceuticals, Inc. Unsaturated heterocyclic derivatives
CN100427488C (zh) * 2005-10-21 2008-10-22 上海东升新材料有限公司 腺嘌呤类衍生物及其合成方法
WO2007081755A2 (en) 2006-01-09 2007-07-19 Metabasis Therapeutics, Inc. Indole-benzimidazole and indazole inhibitors of tyrosine phosphatases
WO2008005555A1 (en) 2006-07-07 2008-01-10 Gilead Sciences, Inc. Modulators of toll-like receptor 7
JP2009242240A (ja) 2006-08-04 2009-10-22 Mebiopharm Co Ltd 含ホウ素キナゾリン誘導体
JO3598B1 (ar) * 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
TWI406850B (zh) 2007-06-05 2013-09-01 Theravance Inc 雙效苯并咪唑抗高血壓劑
ES2385773T3 (es) 2007-12-11 2012-07-31 Theravance, Inc. Derivados de benzoimidazol, de doble acción, y su utilización como agentes antihipertensivos
MX2010009765A (es) * 2008-03-06 2013-07-12 Anacor Pharmaceuticals Inc Moleculas pequeñas que contienen boro como agentes anti-inflamatorios.
KR101612971B1 (ko) 2008-05-14 2016-04-15 아스테라스 세이야쿠 가부시키가이샤 아미드 화합물
US20100016609A1 (en) 2008-07-15 2010-01-21 Wyeth Methods for the preparation of azole compounds
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
WO2011053247A1 (en) 2009-10-29 2011-05-05 Agency For Science, Technology And Research Method for the detection of an analyte by surface enhanced raman spectroscopy (sers)
EP2558461B1 (en) 2010-04-14 2015-12-02 Bristol-Myers Squibb Company Novel glucokinase activators and methods of using same
WO2011127933A1 (en) * 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
CA2825599C (en) 2011-02-01 2021-07-13 The Board Of Trustees Of The University Of Illinois 4-methyl-n-hydroxybenzamide compounds as histone deacetylase (hdac) inhibitors
WO2012158785A1 (en) * 2011-05-17 2012-11-22 Principia Biopharma Inc. Azaindole derivatives as tyrosine kinase inhibitors
LT2776439T (lt) 2011-11-09 2018-10-10 Janssen Sciences Ireland Uc Purino dariniai, skirti virusinų infekcijų gydymui
IN2014MN01875A (es) 2012-03-07 2015-07-03 Cancer Res Inst Royal
EP3137470B1 (en) 2014-05-01 2021-04-07 Novartis AG Compounds and compositions as toll-like receptor 7 agonists
WO2016036887A1 (en) 2014-09-02 2016-03-10 The Regents Of The University Of California Fluorescence assay for intestinal permeability
CA2963772A1 (en) 2014-10-08 2016-04-14 Thomas Helledays Stiftelse For Medicinsk Forskning Heterocyclic compounds as dctpp1 modulators
WO2016200840A1 (en) 2015-06-08 2016-12-15 Cleave Biosciences, Inc. Mono and bicyclic ring boronic acid, ester and salt compounds as inhibitors of p97 complex
GEP20207105B (en) * 2015-07-31 2020-05-11 Pfizer 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2yl carbamate derivatives as magl inhibitors
EP3478672B1 (en) 2016-06-29 2024-04-10 Université de Montréal Biarylmethyl heterocycles
BR112019012618A2 (pt) * 2016-12-22 2019-11-26 Mavupharma Inc inibidores de fosfodiesterase e métodos de tratamento microbiano
US20200085782A1 (en) 2016-12-22 2020-03-19 Mavupharma, Inc. Compositions and methods of enhancing or augmenting type i ifn production
US10487084B2 (en) 2017-08-16 2019-11-26 Bristol-Myers Squibb Company Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor
JP2020532526A (ja) 2017-08-31 2020-11-12 アッヴィ・インコーポレイテッド エクトヌクレオチドピロホスファターゼ−ホスホジエステラーゼ１（ｅｎｐｐ−１）阻害剤及びその使用
AU2018330188C1 (en) 2017-09-08 2024-02-29 The Board Of Trustees Of The Leland Stanford Junior University ENPP1 inhibitors and their use for the treatment of cancer
CN109206446B (zh) * 2017-11-14 2021-08-03 深圳市塔吉瑞生物医药有限公司 一种取代的含硼的化合物及包含该化合物的药物组合物
CN108409767B (zh) 2018-04-13 2020-07-10 上海泰坦科技股份有限公司 一种杂环联苯硼酸的制备方法
EP3902787A4 (en) 2018-12-28 2022-12-28 Riboscience LLC Quinazoline derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors
MX2021009269A (es) 2019-02-01 2021-08-24 Univ Leland Stanford Junior Inhibidores de enpp1 y metodos para modular una respuesta inmunitaria.
WO2020191501A1 (en) 2019-03-27 2020-10-01 Algernon Pharmaceuticals Inc. Methods and uses of bemithyl and derivatives for treating lung disease, fatty liver disease, and kidney disorders
BR112022004809A2 (pt) 2019-09-16 2022-06-21 Aten Porus Lifesciences Pvt Ltd Compostos 2-amino-s6-tiopurina substituídos como inibidores da proteína enpp1
AU2020353005A1 (en) 2019-09-23 2022-04-14 Nanjing Zhengxiang Pharmaceuticals Co., Ltd. Phosphodiesterase inhibitors and use
EP4081528A4 (en) 2019-12-23 2024-03-13 Sanford Burnham Prebys Medical Discovery Institute ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF
JP2023514550A (ja) 2020-02-04 2023-04-06 スティングレイ・セラピューティクス・インコーポレイテッド エクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ１（ｅｎｐｐ１）の阻害剤およびその使用方法
WO2021203772A1 (en) 2020-04-09 2021-10-14 Betta Pharmaceuticals Co., Ltd Ectonucleotide pyrophosphatase-phosphodiesterase 1 inhibitors,compositions and uses thereof

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LT3952995T (lt) 2023-11-10
SI3952995T1 (sl) 2023-12-29
CN114040915A (zh) 2022-02-11
EP4249070A2 (en) 2023-09-27
MX2021012305A (es) 2021-11-12
JP7598875B2 (ja) 2024-12-12
BR112021020241A2 (pt) 2021-12-07
FI3952995T3 (fi) 2023-10-26
US20220362266A1 (en) 2022-11-17
KR20210151873A (ko) 2021-12-14
AU2020272034A1 (en) 2021-10-28
CA3136443A1 (en) 2020-10-15
ES2960987T3 (es) 2024-03-07
SMT202300373T1 (it) 2023-11-13
EP3952995B1 (en) 2023-09-20
EP3952995A1 (en) 2022-02-16
EP4249070A3 (en) 2024-04-17
US12029744B2 (en) 2024-07-09
WO2020210649A1 (en) 2020-10-15
US20250041319A1 (en) 2025-02-06
JP2022526432A (ja) 2022-05-24
JP2025027105A (ja) 2025-02-26
PT3952995T (pt) 2023-10-25
HUE064377T2 (hu) 2024-03-28
TW202103708A (zh) 2021-02-01
HRP20231413T1 (hr) 2024-02-16
IL286966A (en) 2021-12-01
RS64792B1 (sr) 2023-11-30
PL3952995T3 (pl) 2024-03-11
SG11202110888QA (en) 2021-10-28
DK3952995T3 (da) 2023-10-30

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