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MX2023000344A - Metodo para la produccion fermentativa de acido guanidinoacetico. - Google Patents

Metodo para la produccion fermentativa de acido guanidinoacetico.

Info

Publication number
MX2023000344A
MX2023000344A MX2023000344A MX2023000344A MX2023000344A MX 2023000344 A MX2023000344 A MX 2023000344A MX 2023000344 A MX2023000344 A MX 2023000344A MX 2023000344 A MX2023000344 A MX 2023000344A MX 2023000344 A MX2023000344 A MX 2023000344A
Authority
MX
Mexico
Prior art keywords
fermentative production
guanidinoacetic acid
gaa
relates
present
Prior art date
Application number
MX2023000344A
Other languages
English (en)
Inventor
Frank Schneider
Frank Jankowitsch
Original Assignee
Evonik Operations Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Operations Gmbh filed Critical Evonik Operations Gmbh
Publication of MX2023000344A publication Critical patent/MX2023000344A/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/01—Methyltransferases (2.1.1)
    • C12Y201/01002—Guanidinoacetate N-methyltransferase (2.1.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/04—Amidinotransferases (2.1.4)
    • C12Y201/04001—Glycine amidinotransferase (2.1.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/03—Acyl groups converted into alkyl on transfer (2.3.3)
    • C12Y203/03009—Malate synthase (2.3.3.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01002—Alanine transaminase (2.6.1.2), i.e. alanine-aminotransferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01004—Glycine transaminase (2.6.1.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01044—Alanine--glyoxylate transaminase (2.6.1.44)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un microorganismo transformado que es capaz de producir ácido guanidinoacético (GAA) y a un método para la producción fermentativa de GAA usando dicho microorganismo. La presente invención también se refiere a un método para la producción fermentativa de creatina.
MX2023000344A 2020-07-09 2021-06-28 Metodo para la produccion fermentativa de acido guanidinoacetico. MX2023000344A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20184966 2020-07-09
PCT/EP2021/067647 WO2022008276A1 (en) 2020-07-09 2021-06-28 Method for the fermentative production of guanidinoacetic acid

Publications (1)

Publication Number Publication Date
MX2023000344A true MX2023000344A (es) 2023-02-13

Family

ID=71575016

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023000344A MX2023000344A (es) 2020-07-09 2021-06-28 Metodo para la produccion fermentativa de acido guanidinoacetico.

Country Status (14)

Country Link
US (1) US11999982B2 (es)
EP (1) EP4179099A1 (es)
JP (1) JP2023532782A (es)
KR (1) KR20230035564A (es)
CN (1) CN116096908A (es)
AR (1) AR122886A1 (es)
AU (1) AU2021303704A1 (es)
BR (1) BR112023000183A2 (es)
IL (1) IL299713A (es)
MX (1) MX2023000344A (es)
PH (1) PH12023550035A1 (es)
TW (1) TW202217005A (es)
WO (1) WO2022008276A1 (es)
ZA (1) ZA202301312B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023532784A (ja) 2020-07-09 2023-07-31 エボニック オペレーションズ ゲーエムベーハー グアニジノ酢酸の発酵産生方法
MX2023000344A (es) 2020-07-09 2023-02-13 Evonik Operations Gmbh Metodo para la produccion fermentativa de acido guanidinoacetico.
WO2023232583A1 (en) 2022-06-03 2023-12-07 Evonik Operations Gmbh Improved biotechnological method for producing guanidino acetic acid (gaa) by using nadh-dependent dehydrogenases
CN119317721A (zh) 2022-06-03 2025-01-14 赢创运营有限公司 生产胍基乙酸(gaa)的方法
WO2024094483A1 (en) * 2022-11-03 2024-05-10 Evonik Operations Gmbh Improved biotechnological process to produce guanidinoacetic acid (gaa) by targeted introduction or by increasing the activity of a transmembrane transport protein belonging to the amino acid-polyamine-organocation superfamily
WO2024094481A1 (en) 2022-11-03 2024-05-10 Evonik Operations Gmbh Improved biotechnological process to produce guanidinoacetic acid (gaa) by targeted introduction or by increasing the activity of a transmembrane exporter protein
WO2024160791A1 (en) * 2023-02-01 2024-08-08 Evonik Operations Gmbh Method for the fermentative production of guanidinoacetic acid using a microorganism comprising a heterologous l-threonine 3-dehydrogenase gene (tdh) and a glycine c-acetyltransferase gene (kbl)
WO2024160790A1 (en) 2023-02-01 2024-08-08 Evonik Operations Gmbh Method for the fermentative production of guanidinoacetic acid using a microorganism comprising a heterologous l-threonine aldolase gene
KR20250025214A (ko) 2023-08-14 2025-02-21 한국수력원자력 주식회사 당뇨병의 발생을 예측하는 방법
KR20250025215A (ko) 2023-08-14 2025-02-21 한국수력원자력 주식회사 당뇨병의 예방을 위한 방안의 제공 방법

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US3849250A (en) 1971-02-26 1974-11-19 Kyowa Hakko Kogyo Kk Process for producing l-arginine by fermentation
US7160705B2 (en) 2000-04-28 2007-01-09 Ajinomoto Co., Inc. Arginine repressor deficient strain of coryneform bacterium and method for producing L-arginine
CA2493096C (en) * 2002-08-09 2011-07-19 Ajinomoto Co., Inc. A method of increasing the ggt activity of plants, and plants with increased ggt activity and a method of producing such plants
DE502005002355D1 (de) 2004-06-09 2008-02-07 Evonik Degussa Gmbh Guanidinoessigsäure als futtermittelzusatz
KR101835935B1 (ko) * 2014-10-13 2018-03-12 씨제이제일제당 (주) L-아르기닌을 생산하는 코리네박테리움 속 미생물 및 이를 이용한 l-아르기닌의 제조 방법
CN106065411B (zh) * 2016-08-10 2021-12-07 洛阳华荣生物技术有限公司 发酵法生产肌酸
CN109952380B (zh) * 2016-10-26 2023-07-14 味之素株式会社 用于生产目标物质的方法
KR102766204B1 (ko) * 2017-12-19 2025-02-10 란자테크, 인크. 에틸렌 글리콜의 생물학적 생성을 위한 미생물 및 방법
CN110904018B (zh) * 2018-09-14 2022-09-09 中国科学院天津工业生物技术研究所 5-氨基乙酰丙酸生产菌株及其构建方法和应用
JP7594536B2 (ja) 2019-02-15 2024-12-04 ブラスケム エス．エー． 逆グリオキシル酸短絡を通じたグリコール酸およびグリシンの生成のための微生物および方法
CN111748506B (zh) 2019-03-29 2022-07-05 中国科学院微生物研究所 产胍基乙酸的工程菌及其构建方法与应用
MX2023000344A (es) 2020-07-09 2023-02-13 Evonik Operations Gmbh Metodo para la produccion fermentativa de acido guanidinoacetico.
JP2023532784A (ja) 2020-07-09 2023-07-31 エボニック オペレーションズ ゲーエムベーハー グアニジノ酢酸の発酵産生方法
KR20240012383A (ko) 2021-05-21 2024-01-29 에보닉 오퍼레이션스 게엠베하 아미노산 엑스포터의 불활성화에 의해 구아니디노 아세트산 (gaa) 제조를 위한 개선된 생명공학 방법

Also Published As

Publication number Publication date
JP2023532782A (ja) 2023-07-31
AR122886A1 (es) 2022-10-12
US11999982B2 (en) 2024-06-04
IL299713A (en) 2023-03-01
ZA202301312B (en) 2023-10-25
TW202217005A (zh) 2022-05-01
AU2021303704A1 (en) 2023-03-09
WO2022008276A1 (en) 2022-01-13
EP4179099A1 (en) 2023-05-17
BR112023000183A2 (pt) 2023-01-31
US20230265471A1 (en) 2023-08-24
CN116096908A (zh) 2023-05-09
PH12023550035A1 (en) 2024-03-11
KR20230035564A (ko) 2023-03-14

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