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MX2022015437A - Uso de inhibidores de la telomerasa para el tratamiento de trastornos mieloproliferativos y neoplasias mieloproliferativas. - Google Patents

Uso de inhibidores de la telomerasa para el tratamiento de trastornos mieloproliferativos y neoplasias mieloproliferativas.

Info

Publication number
MX2022015437A
MX2022015437A MX2022015437A MX2022015437A MX2022015437A MX 2022015437 A MX2022015437 A MX 2022015437A MX 2022015437 A MX2022015437 A MX 2022015437A MX 2022015437 A MX2022015437 A MX 2022015437A MX 2022015437 A MX2022015437 A MX 2022015437A
Authority
MX
Mexico
Prior art keywords
myeloproliferative
telomerase inhibitors
treatment
myeloproliferative disorders
disorders
Prior art date
Application number
MX2022015437A
Other languages
English (en)
Inventor
Monic J Stuart
Stephen Kelsey
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/841,711 external-priority patent/US9375485B2/en
Application filed by Geron Corp filed Critical Geron Corp
Publication of MX2022015437A publication Critical patent/MX2022015437A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

En la presente se proporcionan métodos para reducir la proliferación de células progenitoras neoplásicas y aliviar los síntomas asociados en individuos diagnosticados con MPN o MDS o que se cree que tienen trastornos mieloproliferativos, tal como la trombocitopenia esencial (ET). En la presente también se proporcionan métodos para usar inhibidores de la telomerasa para mantener los conteos de plaquetas en la sangre en intervalos relativamente normales en la sangre de individuos diagnosticados o que se sospecha que tienen trastornos mieloproliferativos, tales como ET.
MX2022015437A 2012-12-07 2015-06-05 Uso de inhibidores de la telomerasa para el tratamiento de trastornos mieloproliferativos y neoplasias mieloproliferativas. MX2022015437A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261734941P 2012-12-07 2012-12-07
US201361799069P 2013-03-15 2013-03-15
US13/841,711 US9375485B2 (en) 2012-12-07 2013-03-15 Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
US201361900347P 2013-11-05 2013-11-05

Publications (1)

Publication Number Publication Date
MX2022015437A true MX2022015437A (es) 2023-01-11

Family

ID=50883867

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2015007169A MX372753B (es) 2012-12-07 2013-11-15 Uso de inhibidores de la telomerasa para el tratamiento de trastornos mieloproliferativos y neoplasias mieloproliferativas.
MX2022015437A MX2022015437A (es) 2012-12-07 2015-06-05 Uso de inhibidores de la telomerasa para el tratamiento de trastornos mieloproliferativos y neoplasias mieloproliferativas.
MX2020003276A MX2020003276A (es) 2012-12-07 2015-06-05 Uso de inhibidores de la telomerasa para el tratamiento de trastornos mieloproliferativos y neoplasias mieloproliferativas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015007169A MX372753B (es) 2012-12-07 2013-11-15 Uso de inhibidores de la telomerasa para el tratamiento de trastornos mieloproliferativos y neoplasias mieloproliferativas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2020003276A MX2020003276A (es) 2012-12-07 2015-06-05 Uso de inhibidores de la telomerasa para el tratamiento de trastornos mieloproliferativos y neoplasias mieloproliferativas.

Country Status (36)

Country Link
EP (3) EP2928477B1 (es)
JP (5) JP6433911B2 (es)
KR (3) KR102294819B1 (es)
CN (2) CN104936602B (es)
AP (1) AP2015008504A0 (es)
AU (4) AU2013356533B2 (es)
BR (1) BR112015013260A2 (es)
CA (2) CA3188494A1 (es)
CL (2) CL2015001530A1 (es)
CY (2) CY1122169T1 (es)
DK (3) DK3646876T3 (es)
EA (1) EA032973B1 (es)
ES (3) ES2982897T3 (es)
FI (2) FI3646876T3 (es)
FR (1) FR25C1016I1 (es)
HK (1) HK1210940A1 (es)
HR (3) HRP20191784T1 (es)
HU (4) HUE045098T2 (es)
IL (3) IL317233A (es)
LT (3) LT3456333T (es)
MA (2) MA38193B1 (es)
ME (1) ME03538B (es)
MX (3) MX372753B (es)
MY (1) MY180634A (es)
NZ (1) NZ708920A (es)
PH (2) PH12019501008A1 (es)
PL (3) PL3456333T3 (es)
PT (3) PT3646876T (es)
RS (2) RS59363B1 (es)
SG (3) SG10201802926XA (es)
SI (3) SI2928477T1 (es)
SM (2) SMT201900567T1 (es)
TN (1) TN2015000249A1 (es)
UA (3) UA117116C2 (es)
WO (1) WO2014088785A1 (es)
ZA (3) ZA201504124B (es)

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DK1778711T3 (en) 2004-07-02 2017-10-02 Geron Corp SYNTHESIS OF PROTECTED 3'-AMINONUCLEOSIDE MONOMERS
SG10201912203XA (en) 2013-08-07 2020-02-27 Incyte Corp Sustained release dosage forms for a jak1 inhibitor
EP3539547A1 (en) * 2013-11-06 2019-09-18 Mayo Foundation for Medical Education and Research Methods and materials for treating hematological malignancies
AU2016250576C1 (en) 2015-04-23 2021-05-06 Geron Corporation Methods of polynucleotide preparation using multivalent cation salt compositions
EP3318276A1 (en) 2016-11-04 2018-05-09 Janssen Biotech, Inc. Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers
EP3658156A1 (en) * 2017-07-28 2020-06-03 Geron Corporation Methods of treating myelodysplastic syndrome
IL308399B1 (en) 2018-04-30 2025-04-01 Kartos Therapeutics Inc Methods of treating cancer
JP2021525795A (ja) * 2018-05-25 2021-09-27 カルトス セラピューティクス，インコーポレイテッド 骨髄増殖性腫瘍を治療する方法
MA53348A (fr) * 2018-07-31 2022-05-04 Geron Corp Méthodes d'identification de patients susceptibles de bénéficier d'un traitement à l'aide d'un inhibiteur de télomérase
JP7650798B2 (ja) 2018-11-29 2025-03-25 ジェロン・コーポレーション 骨髄異形成症候群を治療する方法
MX2022005354A (es) * 2019-11-04 2022-10-21 Geron Corp Uso de un inhibidor de la cinasa janus y un inhibidor de la telomerasa para el tratamiento de neoplasias mieloproliferativas.
JP2021157248A (ja) * 2020-03-25 2021-10-07 パイオニア株式会社 状況出力装置
US20240108734A1 (en) * 2021-01-22 2024-04-04 The Regents Of The University Of California Methods for treating and ameliorating cancer
WO2024259369A1 (en) * 2023-06-14 2024-12-19 Rarecells Inc. Compositions targeting giant cells in blood disorders

Family Cites Families (25)

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US5489508A (en) 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5583016A (en) 1994-07-07 1996-12-10 Geron Corporation Mammalian telomerase
US5958680A (en) 1994-07-07 1999-09-28 Geron Corporation Mammalian telomerase
US5863936A (en) 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
US5760062A (en) 1995-04-18 1998-06-02 Geron Corporation Telomerase inhibitors
US5656638A (en) 1995-04-18 1997-08-12 Geron Corporation Telomerase inhibitors
US5770613A (en) 1995-09-29 1998-06-23 Geron Corporation Telomerase inhibitors
US5767278A (en) 1995-10-06 1998-06-16 Geron Corporation Telomerase inhibitors
US6444650B1 (en) 1996-10-01 2002-09-03 Geron Corporation Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
JP2001507229A (ja) 1996-12-20 2001-06-05 ジェロン コーポレイション テロメラーゼのｒｎａ成分を検出および阻害するための方法
US6331399B1 (en) 2000-05-16 2001-12-18 Isis Pharmaceuticals, Inc. Antisense inhibition of tert expression
AU2004209428A1 (en) * 2003-01-31 2004-08-19 Jessie L.-S. Au Methods and compositions for using suramin, pentosan polysulfate, telomerase antisense, and telomerase inhibitors
CN1244592C (zh) * 2003-07-11 2006-03-08 暨南大学 抑制白血病细胞端粒酶活性的反义核酸及其应用
SI1667522T1 (en) 2003-09-09 2018-04-30 Geron Corporation Modified oligonucleotides for the inhibition of telomerase
US20050282893A1 (en) * 2004-01-30 2005-12-22 Au Jessie L Methods and compositions for using suramin, pentosan, polysulfate, telomerase antisense and telomerase inhibitors
DK1778711T3 (en) 2004-07-02 2017-10-02 Geron Corp SYNTHESIS OF PROTECTED 3'-AMINONUCLEOSIDE MONOMERS
FR2877013A1 (fr) 2004-10-27 2006-04-28 Assist Publ Hopitaux De Paris Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez
US20060166221A1 (en) 2005-01-21 2006-07-27 Bahou Wadie F Methods of diagnosing essential thrombocythemia
WO2006113426A2 (en) * 2005-04-15 2006-10-26 Geron Corporation Cancer treatment by combined inhibition of telomerase and tubulin activities
US7998938B2 (en) 2005-04-15 2011-08-16 Geron Corporation Cancer treatment by combined inhibition of proteasome and telomerase activities
US20070224598A1 (en) 2006-03-15 2007-09-27 The Methodist Hospital Research Institute System and method for detection of mutations in JAK2 polynucleotides
US20080021013A1 (en) 2006-07-21 2008-01-24 Cephalon, Inc. JAK inhibitors for treatment of myeloproliferative disorders
ES2986404T3 (es) 2006-10-30 2024-11-11 Geron Corp Inhibidor de telomerasa y gemcitabina combinados para el tratamiento del cáncer
CN101220044B (zh) * 2008-01-21 2010-06-02 中国药科大学 端粒酶抑制剂及其制备方法和用途

Also Published As

Publication number Publication date
NZ708920A (en) 2020-08-28
PH12015501282B1 (en) 2015-08-24
PT3456333T (pt) 2020-06-01
PT3646876T (pt) 2024-05-15
EP2928477A4 (en) 2016-09-21
CY1122169T1 (el) 2020-11-25
ZA202212327B (en) 2025-03-26
UA126015C2 (uk) 2022-08-03
AU2013356533B2 (en) 2018-09-27
EP3646876B1 (en) 2024-02-14
IL280144A (en) 2021-03-01
SMT201900567T1 (it) 2019-11-13
HRP20240624T1 (hr) 2024-08-02
DK3456333T3 (da) 2020-05-18
IL280144B1 (en) 2025-01-01
CA3188494A1 (en) 2014-06-12
LT3646876T (lt) 2024-05-10
LT2928477T (lt) 2019-10-10
FIC20250019I1 (fi) 2025-05-07
JP2016504307A (ja) 2016-02-12
EP2928477B1 (en) 2019-07-24
MX372753B (es) 2020-06-26
HRP20200993T1 (hr) 2020-11-27
HUE045098T2 (hu) 2019-12-30
CY1123206T1 (el) 2021-10-29
JP2022179684A (ja) 2022-12-02
MX2015007169A (es) 2016-03-31
MA45504B1 (fr) 2021-10-29
JP2020041001A (ja) 2020-03-19
SI3456333T1 (sl) 2020-10-30
WO2014088785A8 (en) 2015-07-16
IL239266B (en) 2019-11-28
AU2013356533A1 (en) 2014-06-12
CA2892907C (en) 2023-03-21
SG10201802926XA (en) 2018-05-30
CN104936602A (zh) 2015-09-23
TN2015000249A1 (en) 2016-10-03
BR112015013260A2 (pt) 2018-02-06
WO2014088785A1 (en) 2014-06-12
JP7288098B2 (ja) 2023-06-06
KR102294819B1 (ko) 2021-09-01
KR102662590B1 (ko) 2024-05-03
RS59363B1 (sr) 2019-11-29
AU2018282364A1 (en) 2019-05-23
IL317233A (en) 2025-01-01
HK1210940A1 (en) 2016-05-13
AU2024203138A1 (en) 2024-07-25
SG11201504383TA (en) 2015-07-30
SG10202103341SA (en) 2021-05-28
ME03538B (me) 2020-07-20
MX2020003276A (es) 2020-07-20
AU2020267142A1 (en) 2020-12-03
HRP20191784T1 (hr) 2019-12-27
PT2928477T (pt) 2019-10-25
ES2982897T3 (es) 2024-10-18
UA128370C2 (uk) 2024-06-26
PH12019501008A1 (en) 2022-11-14
KR20210107906A (ko) 2021-09-01
ZA201504124B (en) 2017-05-31
RS60401B1 (sr) 2020-07-31
CL2015001530A1 (es) 2016-03-28
KR20230028590A (ko) 2023-02-28
EA032973B1 (ru) 2019-08-30
FR25C1016I1 (fr) 2025-06-20
PL2928477T3 (pl) 2020-03-31
SMT202000328T1 (it) 2020-07-08
EA201590878A1 (ru) 2016-04-29
EP3646876A1 (en) 2020-05-06
AU2020267142B2 (en) 2024-05-16
PL3646876T3 (pl) 2024-07-22
ES2789176T3 (es) 2020-10-26
JP6998191B2 (ja) 2022-02-04
MA38193A1 (fr) 2017-12-29
EP3456333A1 (en) 2019-03-20
MA45504A1 (fr) 2020-05-29
IL239266A0 (en) 2015-07-30
EP3456333B8 (en) 2020-05-13
MY180634A (en) 2020-12-03
SI2928477T1 (sl) 2019-11-29
KR20150091130A (ko) 2015-08-07
HUS2500019I1 (hu) 2025-05-28
AU2020267142C1 (en) 2024-08-08
HUE066402T2 (hu) 2024-07-28
PH12015501282A1 (en) 2015-08-24
HK1212226A1 (en) 2016-06-10
DK3646876T3 (da) 2024-05-06
JP2022050537A (ja) 2022-03-30
IL280144B2 (en) 2025-05-01
HUE049858T2 (hu) 2020-11-30
SI3646876T1 (sl) 2024-07-31
FI3646876T3 (fi) 2024-05-14
PL3456333T3 (pl) 2020-09-21
EP2928477A1 (en) 2015-10-14
EP3456333B1 (en) 2020-04-01
LT3456333T (lt) 2020-06-25
JP6433911B2 (ja) 2018-12-05
NZ748134A (en) 2020-10-30
CA2892907A1 (en) 2014-06-12
ES2744790T3 (es) 2020-02-26
UA117116C2 (uk) 2018-06-25
CN104936602B (zh) 2020-07-17
JP2018035196A (ja) 2018-03-08
ZA202108991B (en) 2023-05-31
AP2015008504A0 (en) 2015-06-30
CL2017002156A1 (es) 2018-05-04
CN111617252A (zh) 2020-09-04
DK2928477T3 (da) 2019-10-07
MA38193B1 (fr) 2018-12-31

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