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MX2022003016A - Metodo de produccion con iones de cobre controlados. - Google Patents

Metodo de produccion con iones de cobre controlados.

Info

Publication number
MX2022003016A
MX2022003016A MX2022003016A MX2022003016A MX2022003016A MX 2022003016 A MX2022003016 A MX 2022003016A MX 2022003016 A MX2022003016 A MX 2022003016A MX 2022003016 A MX2022003016 A MX 2022003016A MX 2022003016 A MX2022003016 A MX 2022003016A
Authority
MX
Mexico
Prior art keywords
medium
production method
copper ion
controlled production
cells
Prior art date
Application number
MX2022003016A
Other languages
English (en)
Inventor
Seiko Yamamoto
Hiroyuki Doi
Isamu Terashima
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of MX2022003016A publication Critical patent/MX2022003016A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/80—Undefined extracts from animals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención proporciona un método de cultivo celular que comprende añadir un medio para siembra que contiene células a un medio inicial y comenzar a cultivar la célula en el medio inicial, en donde el medio inicial tiene un aditivo de medio de cultivo obtenido de organismos añadido al mismo y la cantidad de las especies amidadas C-terminal en la proteína producida es controlada por el contenido de cobre del medio inicial al inicio del cultivo de células.
MX2022003016A 2015-03-26 2017-09-25 Metodo de produccion con iones de cobre controlados. MX2022003016A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2015063662 2015-03-26

Publications (1)

Publication Number Publication Date
MX2022003016A true MX2022003016A (es) 2022-04-07

Family

ID=56977504

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017012223A MX390879B (es) 2015-03-26 2016-03-25 Metodo de produccion con iones de cobre controlados.
MX2022003016A MX2022003016A (es) 2015-03-26 2017-09-25 Metodo de produccion con iones de cobre controlados.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2017012223A MX390879B (es) 2015-03-26 2016-03-25 Metodo de produccion con iones de cobre controlados.

Country Status (13)

Country Link
US (2) US11046772B2 (es)
EP (2) EP4219694A1 (es)
JP (1) JP6752776B2 (es)
CN (1) CN107406832A (es)
AR (1) AR104050A1 (es)
AU (2) AU2016237086B2 (es)
BR (1) BR112017020401B1 (es)
CA (1) CA2980695A1 (es)
IL (1) IL254668B (es)
MX (2) MX390879B (es)
SG (1) SG11201707873TA (es)
TW (1) TWI716392B (es)
WO (1) WO2016153041A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
CA2773522C (en) 2009-10-26 2023-04-18 Chugai Seiyaku Kabushiki Kaisha Method for the production of a glycosylated immunoglobulin
US8580264B2 (en) 2010-11-08 2013-11-12 Genentech, Inc. Subcutaneously administered anti-IL-6 receptor antibody
AR104050A1 (es) * 2015-03-26 2017-06-21 Chugai Pharmaceutical Co Ltd Proceso de producción con iones de cobre controlados
TWI859234B (zh) * 2019-05-15 2024-10-21 日商積水化學工業股份有限公司 細胞培養用支架材料及細胞培養用容器

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100249937B1 (ko) 1991-04-25 2000-04-01 나가야마 오사무 인간 인터루킨-6 수용체에 대한 재구성 인간 항체
JP3630453B2 (ja) 1994-09-30 2005-03-16 中外製薬株式会社 Ｉｌ−６レセプター抗体を有効成分とする未熟型骨髄腫細胞治療剤
JP3822137B2 (ja) 2002-05-20 2006-09-13 中外製薬株式会社 動物細胞培養用培地の添加剤およびそれを用いたタンパク質の製造方法
WO2005090405A1 (ja) 2004-03-24 2005-09-29 Chugai Seiyaku Kabushiki Kaisha インターロイキン－６受容体に対するヒト型化抗体のサブタイプ
US9714410B2 (en) * 2005-01-05 2017-07-25 Chugai Seiyaku Kabushiki Kaisha Cell culture method and utilization of the same
PT2115126E (pt) * 2007-03-02 2015-08-24 Wyeth Llc Utilização de cobre e glutamato na cultura de células para a produção de polipeptídeos
TW200902708A (en) * 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
CA2773522C (en) * 2009-10-26 2023-04-18 Chugai Seiyaku Kabushiki Kaisha Method for the production of a glycosylated immunoglobulin
CA2804275A1 (en) 2010-07-08 2012-01-12 Baxter International Inc. Method of producing recombinant adamts13 in cell culture
JP6176849B2 (ja) * 2011-07-19 2017-08-09 中外製薬株式会社 アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤
CN105246510A (zh) * 2013-03-15 2016-01-13 豪夫迈·罗氏有限公司 细胞培养培养基和抗体生产方法
KR102118240B1 (ko) * 2013-08-20 2020-06-03 레크 파마슈티칼스 디.디. 폴리펩티드의 α-아미드화 및/또는 C-말단 아미노산 분열의 제어를 위한 세포 배양 매질 및 방법
KR20160138477A (ko) * 2014-03-23 2016-12-05 어드밴텍 바이오사이언스 파마큐티카 엘티디에이 구리를 이용한 재조합 단백질의 발현 증가 방법
AR104050A1 (es) * 2015-03-26 2017-06-21 Chugai Pharmaceutical Co Ltd Proceso de producción con iones de cobre controlados

Also Published As

Publication number Publication date
MX390879B (es) 2025-03-21
EP3276001A1 (en) 2018-01-31
TW201708532A (zh) 2017-03-01
CN107406832A (zh) 2017-11-28
AR104050A1 (es) 2017-06-21
CA2980695A1 (en) 2016-09-29
US11046772B2 (en) 2021-06-29
JPWO2016153041A1 (ja) 2018-01-18
US20210269536A1 (en) 2021-09-02
AU2022204600B2 (en) 2024-10-17
BR112017020401A2 (pt) 2018-06-05
EP3276001A4 (en) 2018-09-12
US20180051090A1 (en) 2018-02-22
AU2022204600A1 (en) 2022-07-21
WO2016153041A1 (ja) 2016-09-29
AU2016237086A1 (en) 2017-10-19
AU2016237086B2 (en) 2022-04-14
IL254668B (en) 2021-01-31
BR112017020401B1 (pt) 2021-04-06
EP4219694A1 (en) 2023-08-02
MX2017012223A (es) 2018-01-30
JP6752776B2 (ja) 2020-09-09
IL254668A0 (en) 2017-11-30
EP3276001C0 (en) 2025-05-07
TWI716392B (zh) 2021-01-21
EP3276001B1 (en) 2025-05-07
SG11201707873TA (en) 2017-10-30

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