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MX2022001812A - Variantes del receptor estimulante de macrofagos 1 (mst1r) y sus usos. - Google Patents

Variantes del receptor estimulante de macrofagos 1 (mst1r) y sus usos.

Info

Publication number
MX2022001812A
MX2022001812A MX2022001812A MX2022001812A MX2022001812A MX 2022001812 A MX2022001812 A MX 2022001812A MX 2022001812 A MX2022001812 A MX 2022001812A MX 2022001812 A MX2022001812 A MX 2022001812A MX 2022001812 A MX2022001812 A MX 2022001812A
Authority
MX
Mexico
Prior art keywords
mst1r
variants
macrophage stimulating
stimulating receptor
receptor
Prior art date
Application number
MX2022001812A
Other languages
English (en)
Inventor
Aris Baras
Julie Horowitz
Manuel Allen Revez Ferreira
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2022001812A publication Critical patent/MX2022001812A/es

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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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Abstract

En la presente se proporcionan métodos para tratar pacientes que tienen enfermedad inflamatoria intestinal (IBD) o colangitis esclerosante primaria (PSC).
MX2022001812A 2019-08-12 2020-08-11 Variantes del receptor estimulante de macrofagos 1 (mst1r) y sus usos. MX2022001812A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962885402P 2019-08-12 2019-08-12
PCT/US2020/045784 WO2021030358A1 (en) 2019-08-12 2020-08-11 Macrophage stimulating 1 receptor (mst1r) variants and uses thereof

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MX2022001812A true MX2022001812A (es) 2022-03-11

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MX2022001812A MX2022001812A (es) 2019-08-12 2020-08-11 Variantes del receptor estimulante de macrofagos 1 (mst1r) y sus usos.

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US (2) US11752197B2 (es)
EP (1) EP4013494A1 (es)
JP (2) JP2022544393A (es)
CN (2) CN120866510A (es)
AU (1) AU2020329191B2 (es)
CA (1) CA3148611A1 (es)
MX (1) MX2022001812A (es)
WO (1) WO2021030358A1 (es)

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AU2023398983A1 (en) * 2022-12-15 2025-07-03 Empirico Inc. Treatment of mst1 related diseases and disorders

Family Cites Families (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2362670A1 (en) * 1999-03-12 2000-09-14 Georgetown University Matriptase, a serine protease and its applications
US7195759B2 (en) * 2001-06-06 2007-03-27 The University Of Manitoba Therapeutic uses of glandular kallikrein
US7919084B2 (en) * 2002-06-17 2011-04-05 St. Vincent's Hospital Sydney Limited Methods of diagnosis, prognosis and treatment of cardiovascular disease
EP2305813A3 (en) 2002-11-14 2012-03-28 Dharmacon, Inc. Fuctional and hyperfunctional sirna
US20070037186A1 (en) 2005-05-20 2007-02-15 Yuqiu Jiang Thyroid fine needle aspiration molecular assay
WO2007079096A2 (en) * 2005-12-29 2007-07-12 Dyax Corp. Protease inhibition
EP1921149A1 (en) 2006-11-13 2008-05-14 AEterna Zentaris GmbH Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof
RU2473555C2 (ru) 2006-12-19 2013-01-27 ДжинГоу, Инк. Новые способы функционального анализа большого количества экспериментальных данных и групп генов, идентифицированных из указанных данных
WO2008095050A1 (en) 2007-01-30 2008-08-07 Pharmacyclics, Inc. Methods for determining cancer resistance to histone deacetylase inhibitors
CA2712697A1 (en) 2008-01-22 2009-07-30 Biogen Idec Ma Inc. Ron antibodies and uses thereof
WO2009098246A1 (en) 2008-02-05 2009-08-13 Æterna Zentaris Gmbh Recombinant bacteria with e. coli hemolysin secretion system and increased expression and/or secretion of hlya, process of manufacturing and uses thereof
KR20100011620A (ko) * 2008-07-25 2010-02-03 국립암센터 커큐민을 포함하는 트란스글루타미나제 억제용 조성물
WO2010036629A2 (en) 2008-09-26 2010-04-01 National Health Research Institutes Fused multicyclic compounds as protein kinase inhibitors
TWI480050B (zh) 2009-02-10 2015-04-11 Daiichi Sankyo Co Ltd 抗-mst1r抗體及其用途
GB2480980A (en) 2009-03-02 2011-12-07 Trackfive Diagnostics Inc Methods for predicting cancer response to EGFR inhibitors
CA2754392A1 (en) 2009-03-11 2010-09-16 Nestec S.A. Tissue-specific aging biomarkers
US20120171672A1 (en) * 2009-04-14 2012-07-05 Prometheus Laboratories Inc. Inflammatory bowel disease prognostics
NZ595471A (en) * 2009-04-14 2014-01-31 Nestec Sa Inflammatory bowel disease prognostics
WO2012122302A2 (en) 2011-03-07 2012-09-13 Oregon Health & Science University Methods, apparatuses, and systems for detecting and quantifying phosphoproteins
WO2011078778A1 (en) 2009-12-22 2011-06-30 Biovator Technologies Ab Method for assessing the sensitisation capability of a compound
US20130129723A1 (en) 2009-12-29 2013-05-23 Emergent Product Development Seattle, Llc Heterodimer Binding Proteins and Uses Thereof
HUE029257T2 (en) 2009-12-29 2017-02-28 Aptevo Res And Dev Llc Heterodimer binding proteins and their use
KR101378919B1 (ko) 2010-01-28 2014-04-14 포항공과대학교 산학협력단 혈액으로부터 직접 폐암 진단 및 폐암의 서브타입 진단이 가능한 마커를 선별하는 시스템 생물학적 방법 및 이로부터 선별된 혈액으로부터 직접 폐암 진단 및 폐암 서브타입 진단이 가능한 마커
PH12013500974A1 (en) * 2010-11-17 2013-07-08 Chugai Pharmaceutical Co Ltd Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii
CN102093421B (zh) 2011-01-28 2014-07-02 北京康辰药业有限公司 一种含磷取代基的喹啉类化合物及其制备方法、以及含有该化合物的药物组合物及其应用
US20130064901A1 (en) 2011-04-18 2013-03-14 Agency For Science, Technology And Research Gene expression profiling for classifying and treating gastric cancer
CN102228666B (zh) * 2011-06-29 2013-07-17 烟台新时代健康产业有限公司 来自松花粉与姜黄的组合物及其制备方法和在制备治疗炎症性肠病的药物中的应用
US8790651B2 (en) * 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
CN102408411B (zh) 2011-09-19 2014-10-22 北京康辰药业股份有限公司 一种含喹啉基的羟肟酸类化合物及其制备方法、以及含有该化合物的药物组合物及其应用
EP2749642A4 (en) 2011-11-30 2015-03-04 Nat Cancer Ct INDUCED MALIGNE STEM CELLS
US8725426B2 (en) 2012-01-31 2014-05-13 Genomic Health, Inc. Gene expression profile algorithm and test for determining prognosis of prostate cancer
US9429565B2 (en) 2012-05-08 2016-08-30 Cellecta, Inc. Clonal analysis of functional genomic assays and compositions for practicing same
WO2013174432A1 (en) 2012-05-24 2013-11-28 Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis
JP5993093B2 (ja) 2012-10-12 2016-09-14 メドイミューン・リミテッドMedImmune Limited ピロロベンゾジアゼピン類およびその複合体
DK2906248T3 (en) 2012-10-12 2019-03-04 Medimmune Ltd Pyrrolobenzodiazepines and their conjugates
CN104955485B (zh) 2012-10-12 2018-01-30 Adc疗法责任有限公司 吡咯并苯并二氮杂卓‑抗her2抗体结合物
KR101995621B1 (ko) 2012-10-12 2019-07-03 에이디씨 테라퓨틱스 에스에이 피롤로벤조디아제핀-항-cd22 항체 컨주게이트
WO2014057114A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-anti-psma antibody conjugates
WO2014057118A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sarl Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
US9931414B2 (en) 2012-10-12 2018-04-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
EP2906296B1 (en) 2012-10-12 2018-03-21 ADC Therapeutics SA Pyrrolobenzodiazepine-antibody conjugates
JP6270859B2 (ja) 2012-10-12 2018-01-31 エイディーシー・セラピューティクス・エス・アー・エール・エルAdc Therapeutics Sarl ピロロベンゾジアゼピン−抗体結合体
US10695433B2 (en) 2012-10-12 2020-06-30 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
WO2014071218A2 (en) 2012-11-02 2014-05-08 University Of Utah Research Foundation Biomarkers for breast cancer and methods of using same
CN104812913B (zh) 2012-11-07 2019-03-15 私募蛋白质体公司 慢性阻塞性肺疾病(copd)生物标记及其用途
HK1212998A1 (zh) * 2012-11-30 2016-06-24 F. Hoffmann-La Roche Ag Ron组合物及其使用方法
AU2014230735B2 (en) 2013-03-13 2018-03-15 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
CA2914500C (en) 2013-06-06 2021-04-20 Merck Patent Gmbh A quinoline inhibitor of the macrophage stimulating 1 receptor mst1 r
WO2015050875A1 (en) 2013-10-01 2015-04-09 The Regents Of The University Of California Endometriosis classifier
US10010624B2 (en) 2013-10-11 2018-07-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
EP3054985B1 (en) 2013-10-11 2018-12-26 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
US9956299B2 (en) 2013-10-11 2018-05-01 Medimmune Limited Pyrrolobenzodiazepine—antibody conjugates
WO2015052533A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
EP3066215B1 (en) 2013-11-06 2019-04-24 The United States of America, represented by the Secretary, Department of Health and Human Services Method for subtyping lymphoma types by means of expression profiling
ITMI20132065A1 (it) * 2013-12-11 2015-06-12 Farmatron Ltd Sistemi terapeutici a rilascio modificato per la somministrazione orale di curcumina nel trattamento delle malattie intestinali
WO2015085351A1 (en) * 2013-12-12 2015-06-18 Newsouth Innovations Pty Limited Pharmaconutrient composition
WO2015120382A1 (en) 2014-02-07 2015-08-13 The Johns Hopkins University Predicting response to epigenetic drug therapy
US20150259751A1 (en) 2014-03-17 2015-09-17 Washington University Molecular signature for aggressive squamous cell carcinomas of the head and neck
US9433629B2 (en) 2014-05-23 2016-09-06 Juan Paz Garcia Formulation for regeneration of bone, cartilage, teeth, and periodontium and treatment of tumors and cysts
AU2015264043B2 (en) 2014-05-23 2020-08-13 Regen Therapies, Inc. Formulation for regeneration of bone, cartilage, teeth, and periodontium and treatment of tumors and cysts
US9669074B2 (en) 2014-05-23 2017-06-06 Juan Paz Garcia Formulation for regeneration of bone, cartilage, teeth, and periodontium and treatment of tumors and cysts
US9089580B1 (en) 2015-02-04 2015-07-28 Juan Paz Garcia Formulation for regeneration of bone, cartilage, teeth, and periodontium and treatment of tumors and cysts
US11124836B2 (en) 2014-06-16 2021-09-21 Worldwide Innovative Network Method for selecting personalized tri-therapy for cancer treatment
CN106687141A (zh) 2014-09-10 2017-05-17 麦迪穆有限责任公司 吡咯并苯并二氮杂卓及其缀合物
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
US20170298443A1 (en) 2014-09-25 2017-10-19 Moffitt Genetics Corporation Prognostic tumor biomarkers
EP3029149B1 (en) 2014-12-03 2020-02-12 Fundació Centre de Regulació Genòmica Method of the identification of targets for alternative splicing
JP6815318B2 (ja) 2014-12-23 2021-01-20 ダナ−ファーバー キャンサー インスティテュート,インコーポレイテッド 二官能性分子によって標的化タンパク質分解を誘導する方法
US9694084B2 (en) 2014-12-23 2017-07-04 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
WO2016141169A1 (en) 2015-03-03 2016-09-09 Caris Mpi, Inc. Molecular profiling for cancer
GB201506389D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
PE20180670A1 (es) 2015-05-20 2018-04-19 Broad Inst Inc Neoantigenos compartidos
WO2017007612A1 (en) 2015-07-07 2017-01-12 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
FR3039832A1 (fr) 2015-08-04 2017-02-10 Univ Francois Rabelais De Tours Igg1 et leur utilisation therapeutique
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
EP3452101A2 (en) 2016-05-04 2019-03-13 CureVac AG Rna encoding a therapeutic protein
EP3455218A4 (en) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION
ES2921257T3 (es) 2016-06-20 2022-08-22 Daegu Gyeongbuk Medical Innovation Found Nuevo derivado de imidazopiridina, procedimiento para prepararlo y composición farmacéutica que contiene el mismo como ingrediente activo para prevenir o tratar el cáncer
US20180064821A1 (en) * 2016-09-02 2018-03-08 South Dakota Board Of Regents Site specific curcumin-polymer molecular complexes and methods of treating colon diseases and inflammation
WO2018053142A2 (en) 2016-09-14 2018-03-22 President And Fellows Of Harvard College Methods and compositions for modulating erythropoiesis
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201619490D0 (en) 2016-11-17 2017-01-04 Medimmune Ltd Pyrrolobenzodiazepine conjugates
JP2020533269A (ja) 2016-12-14 2020-11-19 デベロップメント センター フォー バイオテクノロジー 抗体−薬物複合体およびその使用
AU2017258901A1 (en) 2016-12-30 2018-07-19 Allarity Therapeutics Europe ApS Methods for predicting drug responsiveness in cancer patients
CA3058175A1 (en) 2017-03-31 2018-10-04 Bristol-Myers Squibb Company Methods of treating tumor
SI3612537T1 (sl) 2017-04-18 2022-10-28 Medimmune Limited Konjugati pirolobenzodiazepina
CA3065919A1 (en) 2017-06-07 2018-12-13 Silverback Therapeutics, Inc. Antibody construct conjugates
US11041208B2 (en) 2017-06-08 2021-06-22 The Cleveland Clinic Foundation Urine biomarkers for detecting graft rejection
US20180356402A1 (en) 2017-06-08 2018-12-13 The Cleveland Clinic Foundation Urine biomarkers for detecting graft rejection
EP3654993A4 (en) 2017-07-17 2021-08-25 The Broad Institute, Inc. HUMAN COLON CELL ATLAS IN GOOD HEALTH WITH HEMORRHAGIC RECTO-COLITIS
EP3688187A4 (en) 2017-09-25 2021-09-29 Skyhawk Therapeutics, Inc. PROCEDURES AND COMPOSITIONS FOR SCREENING AND IDENTIFYING SPICE MODULATORS
US11660315B2 (en) 2017-09-28 2023-05-30 Immpact-Bio Ltd. Universal platform for preparing an inhibitory chimeric antigen receptor (iCAR)
WO2019140380A1 (en) 2018-01-12 2019-07-18 Kymera Therapeutics, Inc. Protein degraders and uses thereof
AU2019200325A1 (en) 2018-01-31 2019-08-15 Liplasome Pharma Aps Methods for treating cancer and predicting drug responsiveness in cancer patients
US10883992B2 (en) 2018-02-22 2021-01-05 Regents Of The University Of Minnesota Universal kinase substrates and methods of use thereof
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
WO2019232485A1 (en) 2018-05-31 2019-12-05 Nvigen, Inc. Accurate blood test to predict cancer incidence, recurrence, guide and monitor treatment intervention
EP3795571B1 (en) 2018-07-02 2024-05-08 Shenzhen TargetRx, Inc. Alkynyl(hetero)aromatic compound for inhibiting protein kinase activity
WO2020018019A1 (en) 2018-07-16 2020-01-23 Agency For Science, Technology And Research Method for isolating a cardiomyocyte population
JP7162931B2 (ja) 2018-07-17 2022-10-31 深▲チェン▼市塔吉瑞生物医薬有限公司 キナーゼ活性を阻害するためのアルキニル(ヘテロ)芳香族化合物
WO2020036437A1 (ko) 2018-08-16 2020-02-20 재단법인 대구경북첨단의료산업진흥재단 치환된 헤테로아릴 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 단백질 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물
EP3856236B1 (en) 2018-09-28 2023-05-17 ImmPACT-Bio Ltd. Methods for identifying activating antigen receptor (acar)/inhibitory chimeric antigen receptor (icar) pairs for use in cancer therapies

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