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MX2022001230A - Esteviol glicosidos de alta pureza. - Google Patents

Esteviol glicosidos de alta pureza.

Info

Publication number
MX2022001230A
MX2022001230A MX2022001230A MX2022001230A MX2022001230A MX 2022001230 A MX2022001230 A MX 2022001230A MX 2022001230 A MX2022001230 A MX 2022001230A MX 2022001230 A MX2022001230 A MX 2022001230A MX 2022001230 A MX2022001230 A MX 2022001230A
Authority
MX
Mexico
Prior art keywords
steviol glycosides
reb
methods
highly purified
rebaudiosides
Prior art date
Application number
MX2022001230A
Other languages
English (en)
Inventor
Indra Prakash
Cyrille Jarrin
Cynthia Bunders
Aurelien Badie
Daniel Auriol
Halle Robert Ter
Avetik Markosyan
Original Assignee
Purecircle Sdn Bhd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2015/045906 external-priority patent/WO2016028899A1/en
Application filed by Purecircle Sdn Bhd filed Critical Purecircle Sdn Bhd
Publication of MX2022001230A publication Critical patent/MX2022001230A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/36—Terpene glycosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01021—Beta-glucosidase (3.2.1.21)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Seasonings (AREA)

Abstract

Se describen métodos para preparar esteviol glicósidos altamente purificados, particularmente Rebaudiósidos A, D y M. Los métodos incluyen la utilización de microorganismos recombinantes para convertir varias composiciones de partida a esteviol glicósidos objetivo. Además, se describen esteviol glicósidos novedosos Reb D2, Reb M2 y Reb I, así como métodos para preparar los mismos. Los rebaudiósidos altamente purificados son útiles como edulcorante no calórico en composiciones comestibles y masticables tales como cualquiera de bebidas, confituras, productos de panadería, galletitas y gomas de mascar.
MX2022001230A 2014-09-19 2017-03-17 Esteviol glicosidos de alta pureza. MX2022001230A (es)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201462052544P 2014-09-19 2014-09-19
US201462061359P 2014-10-08 2014-10-08
US201462062288P 2014-10-10 2014-10-10
US201462064630P 2014-10-16 2014-10-16
US201462082446P 2014-11-20 2014-11-20
US201462097387P 2014-12-29 2014-12-29
US201562118132P 2015-02-19 2015-02-19
US201562185964P 2015-06-29 2015-06-29
PCT/US2015/045906 WO2016028899A1 (en) 2014-08-19 2015-08-19 Methods for preparing rebaudioside i and uses

Publications (1)

Publication Number Publication Date
MX2022001230A true MX2022001230A (es) 2022-03-02

Family

ID=55533681

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017003666A MX389746B (es) 2014-09-19 2015-08-21 Esteviol glicosidos de alta pureza.
MX2022001230A MX2022001230A (es) 2014-09-19 2017-03-17 Esteviol glicosidos de alta pureza.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2017003666A MX389746B (es) 2014-09-19 2015-08-21 Esteviol glicosidos de alta pureza.

Country Status (6)

Country Link
US (1) US11653679B2 (es)
EP (2) EP4166010A1 (es)
CN (2) CN113549664A (es)
BR (1) BR112017005656A2 (es)
MX (2) MX389746B (es)
WO (1) WO2016043926A1 (es)

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US9752174B2 (en) * 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
US10264811B2 (en) 2014-05-19 2019-04-23 Epc Natural Products Co., Ltd. Stevia sweetener with improved solubility
JP6855376B2 (ja) 2014-12-17 2021-04-07 カーギル インコーポレイテッド 経口摂取又は経口使用のためのステビオールグリコシド化合物、組成物、及びステビオールグリコシド溶解度を増強するための方法
EP3277829B1 (en) 2015-04-03 2020-07-08 DSM IP Assets B.V. Steviol glycosides
US10815514B2 (en) 2016-05-16 2020-10-27 Evolva Sa Production of steviol glycosides in recombinant hosts
JP2019517801A (ja) 2016-06-15 2019-06-27 コデクシス， インコーポレイテッド 操作されたβ−グルコシダーゼおよびグルコシル化方法
AU2017285444B2 (en) * 2016-06-17 2021-07-29 Cargill, Incorporated Steviol glycoside compositions for oral ingestion or use
ES2964976T3 (es) 2016-10-14 2024-04-10 Conagen Inc Producción biosintética de glucósidos de esteviol y procesos para el mismo
US11542536B2 (en) 2016-12-14 2023-01-03 The Coca-Cola Company Preparing novel steviol glycosides by bioconversion
BR112019015992A2 (pt) 2017-02-03 2020-05-26 Codexis, Inc. Glicosiltransferase engenheirada, polinucleotídeo engenheirado, vetor, célula hospedeira, métodos para produzir pelo menos uma glicosiltransferase engenheirada, para produzir pelo menos uma variante de sacarose sintase engenheirada, para produzir rebaudiosídeo m, rebaudiosídeo a e/ou rebaudiosídeo i e rebaudiosídeo d e para glicosilação de um substrato, composição, sacarose sintase engenheirada, rebaudiosídeo m, rebaudiosídeo a, rebaudiosídeo i, e, rebaudiosídeo d.
WO2018164747A1 (en) * 2017-03-06 2018-09-13 Conagen Inc. Biosynthetic production of steviol glycoside rebaudioside d4 from rebaudioside e
EP3624599A4 (en) * 2017-05-15 2020-11-18 PureCircle USA Inc. HIGHLY PURE STEVIOL GLYCOSIDE
BR112019027992B1 (pt) * 2017-06-30 2024-02-27 Conagen Inc Método para alterar a glicosilação de um glicosídeo de esteviol
GB201805578D0 (en) * 2018-04-04 2018-05-16 Optibiotix Health Ltd Prebiotic compositions and methods of production thereof
GB201805576D0 (en) 2018-04-04 2018-05-16 Optibiotix Ltd Sweeteners and methods of production thereof
CN115997912B (zh) * 2018-05-08 2025-05-13 伊比西(北京)植物药物技术有限公司 具有改善风味剖面的甜菊醇糖甙组合物
JP7498708B2 (ja) 2018-11-09 2024-06-12 ギンゴー バイオワークス， インコーポレイテッド モグロシドの生合成
WO2020237226A1 (en) * 2019-05-23 2020-11-26 Arzeda Corp. Compositions and methods for producing steviol glycosides
CA3144658A1 (en) 2019-06-25 2020-12-30 Manus Bio, Inc. Uridine diphosphate-dependent glycosyltransferase enzyme
EP4454481A3 (en) * 2019-08-23 2025-01-01 Suntory Holdings Limited Method for producing aqueous composition containing rebaudioside d, sweetening composition containing rebaudioside d, and beverage containing sweetening composition
CN110592043B (zh) * 2019-11-01 2022-10-18 广西师范大学 一种udp-葡萄糖基转移酶突变体及其应用
CN110872586B (zh) * 2019-11-11 2024-01-30 天津大学 固定化葡萄糖基转移酶及制备方法及催化生产莱鲍迪苷d的方法
CN114703159B (zh) * 2022-03-15 2023-05-26 林影 一种葡糖基转移酶突变体及其应用
CN115975972B (zh) * 2022-12-20 2023-07-25 杭州力文所生物科技有限公司 一种糖基转移酶突变体及其编码基因

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116102603A (zh) * 2008-10-03 2023-05-12 守田化学工业株式会社 新的甜菊醇糖苷
CA3176307A1 (en) 2010-06-02 2011-12-08 Evolva Nutrition, Inc. Recombinant production of steviol glycosides
EP2742142B2 (en) * 2011-08-08 2020-03-25 Evolva SA Recombinant production of steviol glycosides
CN103159808B (zh) * 2011-12-09 2017-03-29 上海泓博智源医药股份有限公司 一种制备天然甜味剂的工艺方法
CA3152828A1 (en) 2011-12-19 2013-06-27 The Coca-Cola Company Methods for purifying steviol glycosides and uses of the same
CN104203005A (zh) 2012-01-23 2014-12-10 帝斯曼知识产权资产管理有限公司 二萜的生产
US9752174B2 (en) * 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
EP2852296B1 (en) * 2012-05-22 2021-12-15 PureCircle SDN BHD Process for producing a high-purity steviol glycoside
CN110551646B (zh) * 2013-02-06 2024-04-26 埃沃尔瓦公司 用于提高莱鲍迪苷d和莱鲍迪苷m之产生的方法
US9717267B2 (en) 2013-03-14 2017-08-01 The Coca-Cola Company Beverages containing rare sugars
US10683323B2 (en) 2013-03-15 2020-06-16 The Coca-Cola Company Mogrosides, compositions and their purification
CN108329365B (zh) * 2013-03-15 2022-04-05 可口可乐公司 甜菊醇糖苷、其组合物以及其纯化
US9522929B2 (en) 2014-05-05 2016-12-20 Conagen Inc. Non-caloric sweetener
AU2017285444B2 (en) * 2016-06-17 2021-07-29 Cargill, Incorporated Steviol glycoside compositions for oral ingestion or use
MY194280A (en) * 2016-08-12 2022-11-25 Amyris Inc Udp-dependent glycosyltransferase for high efficiency production of rebaudiosides
WO2018164747A1 (en) 2017-03-06 2018-09-13 Conagen Inc. Biosynthetic production of steviol glycoside rebaudioside d4 from rebaudioside e
BR112019027992B1 (pt) 2017-06-30 2024-02-27 Conagen Inc Método para alterar a glicosilação de um glicosídeo de esteviol

Also Published As

Publication number Publication date
US20170303565A1 (en) 2017-10-26
MX2017003666A (es) 2018-02-01
CN107105734A (zh) 2017-08-29
WO2016043926A1 (en) 2016-03-24
CN113549664A (zh) 2021-10-26
EP3193636A1 (en) 2017-07-26
BR112017005656A2 (pt) 2018-07-31
US11653679B2 (en) 2023-05-23
EP3193636B1 (en) 2022-07-06
MX389746B (es) 2025-03-20
EP4166010A1 (en) 2023-04-19
EP3193636A4 (en) 2018-06-20

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