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MX2021013225A - Composiciones y metodos para el tratamiento del cancer utilizando una terapia de celulas t modificadas de cd8. - Google Patents

Composiciones y metodos para el tratamiento del cancer utilizando una terapia de celulas t modificadas de cd8.

Info

Publication number
MX2021013225A
MX2021013225A MX2021013225A MX2021013225A MX2021013225A MX 2021013225 A MX2021013225 A MX 2021013225A MX 2021013225 A MX2021013225 A MX 2021013225A MX 2021013225 A MX2021013225 A MX 2021013225A MX 2021013225 A MX2021013225 A MX 2021013225A
Authority
MX
Mexico
Prior art keywords
cancer
compositions
treatment
methods
cell therapy
Prior art date
Application number
MX2021013225A
Other languages
English (en)
Inventor
Alex Franzusoff
Barbara Sennino
Stefanie Mandl-Cashman
Kyle Jacoby
Michael M Dubreuil
John Gagnon
Original Assignee
Pact Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pact Pharma Inc filed Critical Pact Pharma Inc
Publication of MX2021013225A publication Critical patent/MX2021013225A/es

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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • A61K40/4201—Neoantigens
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Abstract

Composiciones que comprenden y métodos para el tratamiento de cáncer utilizando una terapia celular basada en neoTCR con un constructo de expresión de CD8.
MX2021013225A 2019-05-01 2020-04-30 Composiciones y metodos para el tratamiento del cancer utilizando una terapia de celulas t modificadas de cd8. MX2021013225A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962841753P 2019-05-01 2019-05-01
US201962841748P 2019-05-01 2019-05-01
PCT/US2020/030818 WO2020223537A1 (en) 2019-05-01 2020-04-30 Compositions and methods for the treatment of cancer using a cdb engineered t cell therapy

Publications (1)

Publication Number Publication Date
MX2021013225A true MX2021013225A (es) 2022-01-06

Family

ID=73029470

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2021013225A MX2021013225A (es) 2019-05-01 2020-04-30 Composiciones y metodos para el tratamiento del cancer utilizando una terapia de celulas t modificadas de cd8.
MX2021013218A MX2021013218A (es) 2019-05-01 2020-04-30 Composiciones y metodos para el tratamiento del cancer usando una terapia con celulas t modificadas con tet2.

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MX2021013218A MX2021013218A (es) 2019-05-01 2020-04-30 Composiciones y metodos para el tratamiento del cancer usando una terapia con celulas t modificadas con tet2.

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Country Link
US (3) US20210085720A1 (es)
EP (2) EP3953379A4 (es)
JP (2) JP2022531231A (es)
KR (2) KR20220005050A (es)
CN (1) CN113748127B (es)
AU (2) AU2020266579A1 (es)
CA (2) CA3136740A1 (es)
IL (2) IL287643A (es)
MX (2) MX2021013225A (es)
SG (2) SG11202111865UA (es)
WO (3) WO2020223537A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3114788A1 (en) * 2018-09-28 2020-04-02 Memorial Sloan-Kettering Cancer Center Immunoresponsive cells expressing dominant negative fas and uses thereof
BR112022003891A2 (pt) * 2019-09-06 2022-05-31 Crispr Therapeutics Ag Células t geneticamente manipuladas possuindo persistência melhorada em cultura
CN115461087A (zh) * 2020-04-24 2022-12-09 派克特制药公司 确定细胞中基因编辑效率的方法
WO2022109277A1 (en) * 2020-11-20 2022-05-27 Pact Pharma, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER USING A TGFβRII ENGINEERED T CELL THERAPY
EP4259651A2 (en) * 2020-12-14 2023-10-18 Fred Hutchinson Cancer Center Compositions and methods for cellular immunotherapy
WO2022140361A1 (en) * 2020-12-22 2022-06-30 Ludwig Institute For Cancer Research Ltd Genetically engineered lymphocytes for adoptive cell therapy
WO2022177970A1 (en) * 2021-02-18 2022-08-25 University Of Florida Research Foundation, Incorporated Enhancing metabolic fitness of t cells to treat cancer
WO2022182890A1 (en) 2021-02-25 2022-09-01 Lyell Immunopharma, Inc. Codon-optimized nucleotide sequences encoding an ap-1 transcription factor
WO2022182891A1 (en) 2021-02-25 2022-09-01 Lyell Immunopharma, Inc. Ror1 targeting chimeric antigen receptor
JP2024523014A (ja) * 2021-06-11 2024-06-25 パクト ファーマ インコーポレイテッド 細胞製剤を査定する方法
EP4423145A1 (en) 2021-10-28 2024-09-04 Lyell Immunopharma, Inc. Methods for culturing cells expressing ror1-binding protein
EP4423121A1 (en) 2021-10-28 2024-09-04 Lyell Immunopharma, Inc. Methods for culturing cells expressing c-jun
CN114373511B (zh) * 2022-03-15 2022-08-30 南方医科大学南方医院 基于5hmC分子标志物检测的肠癌模型及肠癌模型构建方法
WO2023212507A1 (en) * 2022-04-26 2023-11-02 Fred Hutchinson Cancer Center Compositions and methods for cellular immunotherapy
WO2024026490A1 (en) 2022-07-28 2024-02-01 Sqz Biotechnologies Company Polynucleotides encoding linked antigens and uses thereof
WO2024064637A2 (en) * 2022-09-19 2024-03-28 Emendobio Inc. Biallelic knockout of faslg
WO2024064606A2 (en) * 2022-09-19 2024-03-28 Emendobio Inc. Biallelic knockout of ctla4
WO2024064607A2 (en) * 2022-09-19 2024-03-28 Emendobio Inc. Biallelic knockout of tet2
WO2024064952A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells overexpressing c-jun
WO2024064958A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
WO2024077174A1 (en) 2022-10-05 2024-04-11 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
CN116179495A (zh) * 2022-11-28 2023-05-30 上海恩凯细胞技术有限公司 转基因免疫细胞及其应用
WO2025010272A1 (en) 2023-07-03 2025-01-09 Neoimmunetech, Inc. Heterodimeric fc molecules and uses thereof
WO2025027088A1 (en) * 2023-07-31 2025-02-06 T-Knife Gmbh An enhanced chimeric human cd8 co-receptor, a nucleic acid encoding the enhanced chimeric human cd8 co-receptor, corresponding vectors, isolated t-cells transduced with the nucleic acid or corresponding vectors and kits for preparing them, as well as corresponding pharmaceutical compositions and methods for treating a patient having a disease
WO2025045752A1 (en) * 2023-08-25 2025-03-06 T-Knife Gmbh Chimeric human cd 95 switch receptor, t-cell expressing said receptor together with an engineered t-cell receptor, respective vectors, kits, pharmaceutical compositions and methods for treating a patient having a disease

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US20020127594A1 (en) * 2000-06-22 2002-09-12 Gearing David P. Don-1 gene and polypeptides and uses therefor
US6355412B1 (en) * 1999-07-09 2002-03-12 The European Molecular Biology Laboratory Methods and compositions for directed cloning and subcloning using homologous recombination
US7485291B2 (en) * 2003-06-03 2009-02-03 Cell Genesys, Inc. Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
WO2008042814A2 (en) * 2006-09-29 2008-04-10 California Institute Of Technology Mart-1 t cell receptors
WO2013033626A2 (en) * 2011-08-31 2013-03-07 Trustees Of Dartmouth College Nkp30 receptor targeted therapeutics
US10316289B2 (en) * 2012-09-06 2019-06-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of producing T memory stem cell populations
HUE051523T2 (hu) * 2013-11-21 2021-03-01 Ucl Business Ltd Sejt
AU2015342867B2 (en) 2014-11-06 2020-03-26 University Of Maryland, Baltimore CD8alpha and T cell receptor variants and methods of using same in modulating immune cell responses
KR102699643B1 (ko) 2015-04-06 2024-08-28 리제너론 파아마슈티컬스, 인크. 비인간 동물에서의 인간화 t 세포 매개 면역반응
MA44907A (fr) 2015-09-11 2018-07-18 Agenus Inc Cellules hôtes génétiquement modifiées et leurs procédés d'utilisation
MX2018003353A (es) * 2015-09-17 2018-09-17 Novartis Ag Terapias con celulas cart con una eficacia mejorada.
EA201891212A1 (ru) * 2015-12-18 2019-01-31 Сангамо Терапьютикс, Инк. Адресная дезорганизация клеточного рецептора гкгс
WO2017176769A1 (en) * 2016-04-04 2017-10-12 Indi Molecular, Inc. Cd8-specific capture agents, compositions, and methods of using and making
MX2019003176A (es) * 2016-09-23 2019-07-04 Hutchinson Fred Cancer Res Receptores de linfocitos t (tcr) especificos del antigeno menor de histocompatibilidad (h) ah-1 y sus usos.
KR20190100200A (ko) * 2016-11-22 2019-08-28 알로플렉스 바이오테라퓨틱스 동종이형 종양 세포 백신
CA3055983A1 (en) * 2017-03-15 2018-09-20 Fred Hutchinson Cancer Research Center High affinity mage-a1-specific tcrs and uses thereof
BR112019018124A2 (pt) * 2017-03-22 2020-04-07 Intellia Therapeutics Inc composições e métodos para imunooncologia
KR20190127892A (ko) 2017-03-22 2019-11-13 노파르티스 아게 바이오마커 및 효능이 증진된 car t 세포 요법
US11512287B2 (en) * 2017-06-16 2022-11-29 Sangamo Therapeutics, Inc. Targeted disruption of T cell and/or HLA receptors
WO2019004831A1 (en) * 2017-06-30 2019-01-03 Academisch Ziekenhuis Leiden (H.O.D.N. Leids Universitair Medisch Centrum) TREATMENT OF HEMATOLOGICAL MALIGNANCIES
EP3679145A2 (en) * 2017-09-08 2020-07-15 Poseida Therapeutics, Inc. Compositions and methods for chimeric ligand receptor (clr)-mediated conditional gene expression
CN111918659B (zh) * 2017-10-30 2024-01-30 派克特制药公司 原代细胞基因编辑
WO2019136335A1 (en) * 2018-01-05 2019-07-11 Gencyte Therapeutics, Inc. Precision molecular adaptor system for car-t immunotherapy
CA3095741A1 (en) 2018-04-02 2019-10-10 Pact Pharma, Inc. Peptide-mhc compacts
WO2020049496A1 (en) * 2018-09-05 2020-03-12 Glaxosmithkline Intellectual Property Development Limited T cell modification
GB201819540D0 (en) * 2018-11-30 2019-01-16 Adaptimmune Ltd T cell modification
KR20210126073A (ko) 2019-02-12 2021-10-19 팩트 파마, 인크. 항원 특이적 t 세포의 식별을 위한 조성물 및 방법
PE20220164A1 (es) * 2019-05-27 2022-01-28 Immatics Us Inc Vectores viricos y uso de los mismos en terapias celulares adoptivas

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