EA201691866A1 - Проникающие в опухоль лимфоциты для адоптивной клеточной терапии - Google Patents
Проникающие в опухоль лимфоциты для адоптивной клеточной терапииInfo
- Publication number
- EA201691866A1 EA201691866A1 EA201691866A EA201691866A EA201691866A1 EA 201691866 A1 EA201691866 A1 EA 201691866A1 EA 201691866 A EA201691866 A EA 201691866A EA 201691866 A EA201691866 A EA 201691866A EA 201691866 A1 EA201691866 A1 EA 201691866A1
- Authority
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- Eurasian Patent Office
- Prior art keywords
- cell therapy
- lymphocytes
- permitting
- tumor
- methods
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 210000004698 lymphocyte Anatomy 0.000 title abstract 4
- 230000003044 adaptive effect Effects 0.000 title 1
- 238000002659 cell therapy Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- 238000011467 adoptive cell therapy Methods 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000000149 penetrating effect Effects 0.000 abstract 1
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4271—Melanoma antigens
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- A—HUMAN NECESSITIES
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- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/57—Skin; melanoma
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/05—Adjuvants
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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Abstract
В заявке описываются композиции и способы наращивания проникающих в опухоль лимфоцитов ex vivo с целью их применения при адоптивной клеточной терапии (АКТ). Также описываются композиции и способы идентификации агента для наращивания проникающих в опухоль лимфоцитов ex vivo с целью их применения при АКТ. Также в изобретении предлагаются способы лечения рака с применением проникающих в опухоль лимфоцитов, нарощенных с помощью описанных в настоящем документе способов.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461955970P | 2014-03-20 | 2014-03-20 | |
US201461973002P | 2014-03-31 | 2014-03-31 | |
PCT/US2015/021759 WO2015143328A1 (en) | 2014-03-20 | 2015-03-20 | Tumor-infiltrating lymphocytes for adoptive cell therapy |
Publications (2)
Publication Number | Publication Date |
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EA201691866A1 true EA201691866A1 (ru) | 2017-01-30 |
EA036386B1 EA036386B1 (ru) | 2020-11-03 |
Family
ID=54145388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201691866A EA036386B1 (ru) | 2014-03-20 | 2015-03-20 | Проникающие в опухоль лимфоциты для адоптивной клеточной терапии |
Country Status (11)
Country | Link |
---|---|
US (3) | US20170081635A1 (ru) |
EP (2) | EP3698850A1 (ru) |
JP (4) | JP2017511375A (ru) |
KR (3) | KR20160146713A (ru) |
CN (2) | CN112080467A (ru) |
AU (3) | AU2015231041B2 (ru) |
CA (1) | CA2943389C (ru) |
EA (1) | EA036386B1 (ru) |
ES (1) | ES2776407T3 (ru) |
MX (2) | MX374472B (ru) |
WO (1) | WO2015143328A1 (ru) |
Families Citing this family (32)
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AU2015231041B2 (en) | 2014-03-20 | 2020-07-16 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Tumor-infiltrating lymphocytes for adoptive cell therapy |
ES2980788T3 (es) | 2014-04-10 | 2024-10-03 | H Lee Moffitt Cancer Ct & Res | Expansión mejorada de linfocitos infiltrantes de tumores para terapia celular adoptiva |
WO2017023801A1 (en) | 2015-07-31 | 2017-02-09 | Regents Of The University Of Minnesota | Intracellular genomic transplant and methods of therapy |
EP3228701A1 (en) * | 2016-04-05 | 2017-10-11 | Fundación Centro Nacional de Investigaciones Oncológicas Carlos III | Method for preparing lymphocytes capable of infiltrating a solid tumor, lymphocytes obtainable by said method and uses thereof |
MX2019000149A (es) | 2016-07-07 | 2019-09-23 | Iovance Biotherapeutics Inc | Proteinas de union a ligando 1 de muerte programada 1 (pd-l1) y metodos de uso de las mismas. |
EP3529359B1 (en) | 2016-10-18 | 2023-12-13 | Regents of the University of Minnesota | Tumor infiltrating lymphocytes for use in therapy |
MX2019004707A (es) | 2016-10-26 | 2019-08-12 | Iovance Biotherapeutics Inc | Reestimulacion de linfocitos infiltrantes de tumor crioconservados. |
TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
MA46916A (fr) | 2016-11-17 | 2019-09-25 | Iovance Biotherapeutics Inc | Resttumorinfiltrierende lymphozyten und verfahren zur herstellung und verwendung davon |
WO2018129336A1 (en) | 2017-01-06 | 2018-07-12 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
JP2020509018A (ja) * | 2017-03-01 | 2020-03-26 | ネクター セラピューティクス | 養子細胞移植療法と併せてインターロイキン−2受容体α,β−選択的作動薬を用いる免疫療法的治療方法 |
JOP20190224A1 (ar) * | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
US11254913B1 (en) | 2017-03-29 | 2022-02-22 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
KR20200010468A (ko) | 2017-05-24 | 2020-01-30 | 노파르티스 아게 | 항체-사이토카인 생착된 단백질 및 암 치료에 있어서의 사용 방법 |
WO2018226714A1 (en) * | 2017-06-05 | 2018-12-13 | Iovance Biotherapeutics, Inc. | Methods of using tumor infiltrating lymphocytes in double-refractory melanoma |
JP2020530307A (ja) | 2017-06-30 | 2020-10-22 | インティマ・バイオサイエンス,インコーポレーテッド | 遺伝子治療のためのアデノ随伴ウイルスベクター |
US11713446B2 (en) | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
CN111836887A (zh) | 2018-01-08 | 2020-10-27 | 艾欧凡斯生物治疗公司 | 产生富含肿瘤抗原特异性t细胞的til产品的方法 |
GB201801067D0 (en) * | 2018-01-23 | 2018-03-07 | Price Nicola Kaye | Biomarkers predictive of tumour infiltrating lymphocyte therapy and uses thereof |
JP7558563B2 (ja) | 2018-03-15 | 2024-10-01 | ケーエスキュー セラピューティクス, インコーポレイテッド | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
KR20210005138A (ko) | 2018-04-27 | 2021-01-13 | 이오반스 바이오테라퓨틱스, 인크. | 종양 침윤 림프구의 확장 및 유전자 편집을 위한 폐쇄 방법 및 면역요법에서의 그의 용도 |
CN108486120B (zh) * | 2018-04-28 | 2019-12-06 | 新乡医学院 | 一种新型CpG ODN序列及其在抗黑色素瘤上的应用 |
US20220090018A1 (en) | 2018-11-05 | 2022-03-24 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and used of the same in immunotherapy |
GB201911066D0 (en) | 2019-08-02 | 2019-09-18 | Achilles Therapeutics Ltd | T cell therapy |
BR112022021020A2 (pt) | 2020-04-22 | 2023-02-14 | Iovance Biotherapeutics Inc | Método de fabricação de um produto de terapia celular, métodos de tratamento do paciente com o produto de terapia celular de expansão e fabricado, e, método de fabricação de um produto de terapia celular |
JP2023524435A (ja) | 2020-04-28 | 2023-06-12 | アキレス セラピューティクス ユーケー リミテッド | T細胞療法 |
CA3196553A1 (en) * | 2020-10-27 | 2022-05-05 | Amer BEG | Oncolytic virus boosts t cell response for effective til therapy |
EP4320435A1 (en) | 2021-04-09 | 2024-02-14 | Achilles Therapeutics UK Limited | Batch release assay for pharmaceutical products relating to t cell therapies |
GB202109886D0 (en) | 2021-07-08 | 2021-08-25 | Achilles Therapeutics Uk Ltd | Assay |
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US20230270784A1 (en) * | 2021-12-07 | 2023-08-31 | Memgen, Inc. | Oncolytic virus boosts t cell response for effective til therapy |
EP4507704A1 (en) | 2022-04-15 | 2025-02-19 | Iovance Biotherapeutics, Inc. | Til expansion processes using specific cytokine combinations and/or akti treatment |
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US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
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WO2012127464A2 (en) * | 2011-03-23 | 2012-09-27 | Gavish-Galilee Bio Applications Ltd | Constitutively activated t cells for use in adoptive cell therapy |
WO2013192628A1 (en) | 2012-06-22 | 2013-12-27 | University Of South Florida | Peptoid-peptide hybrids and their use |
CN103243072B (zh) * | 2013-05-09 | 2016-03-02 | 杭州中赢生物医疗科技有限公司 | CD8α-白介素21片段-CD137复合物扩增激活淋巴细胞的方法 |
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CN103520198B (zh) * | 2013-09-24 | 2016-01-20 | 彭光勇 | 一种制备用于阻止肿瘤细胞诱导t细胞老化并逆转其免疫抑制能力的药物的方法及其在抗肿瘤免疫治疗中的用途 |
AU2015231041B2 (en) | 2014-03-20 | 2020-07-16 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Tumor-infiltrating lymphocytes for adoptive cell therapy |
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- 2015-03-20 MX MX2016012176A patent/MX374472B/es active IP Right Grant
- 2015-03-20 CA CA2943389A patent/CA2943389C/en active Active
- 2015-03-20 EP EP19220121.8A patent/EP3698850A1/en active Pending
- 2015-03-20 KR KR1020167029042A patent/KR20160146713A/ko not_active Ceased
- 2015-03-20 US US15/126,436 patent/US20170081635A1/en not_active Abandoned
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- 2015-03-20 CN CN202010876959.7A patent/CN112080467A/zh active Pending
- 2015-03-20 EA EA201691866A patent/EA036386B1/ru unknown
- 2015-03-20 KR KR1020237018885A patent/KR20230085225A/ko not_active Ceased
- 2015-03-20 WO PCT/US2015/021759 patent/WO2015143328A1/en active Application Filing
- 2015-03-20 CN CN201580022690.3A patent/CN106659913A/zh active Pending
- 2015-03-20 ES ES15765854T patent/ES2776407T3/es active Active
- 2015-03-20 KR KR1020247039885A patent/KR20250004905A/ko active Pending
- 2015-03-20 EP EP15765854.3A patent/EP3119477B1/en active Active
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- 2016-09-20 MX MX2020005634A patent/MX2020005634A/es unknown
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- 2020-07-15 JP JP2020121328A patent/JP2020182477A/ja active Pending
- 2020-10-15 AU AU2020256412A patent/AU2020256412A1/en not_active Abandoned
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- 2022-05-24 US US17/752,481 patent/US12291724B2/en active Active
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