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MX2021009087A - Anticuerpos y receptores quimericos de antigenos especificos para receptor 1 huerfano tipo receptor tirosina-cinasa (ror1). - Google Patents

Anticuerpos y receptores quimericos de antigenos especificos para receptor 1 huerfano tipo receptor tirosina-cinasa (ror1).

Info

Publication number
MX2021009087A
MX2021009087A MX2021009087A MX2021009087A MX2021009087A MX 2021009087 A MX2021009087 A MX 2021009087A MX 2021009087 A MX2021009087 A MX 2021009087A MX 2021009087 A MX2021009087 A MX 2021009087A MX 2021009087 A MX2021009087 A MX 2021009087A
Authority
MX
Mexico
Prior art keywords
ror1
antibodies
tyrosine kinase
receptors
chimeric antigen
Prior art date
Application number
MX2021009087A
Other languages
English (en)
Inventor
Stephen Jacob Goldfless
Collin Hauskins
Brian Belmont
Catherine Sierra
Rupesh Amin
Aye Chen
Yue Jiang
Andreia Costa
Jenna Bailey
Samriti Bedi
Eric Jeffery
Yeonjoo Oh
Madeline Williams
Original Assignee
Juno Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Juno Therapeutics Inc filed Critical Juno Therapeutics Inc
Publication of MX2021009087A publication Critical patent/MX2021009087A/es

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C07K16/2857—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, orphan receptor
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    • C12N15/09—Recombinant DNA-technology
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Abstract

Se proporcionan moléculas que se unen al receptor 1 huérfano de tipo receptor tirosina-cinasa (ROR1), en particular, a anticuerpos humanos específicos para ROR1, que incluyen fragmentos de anticuerpo. La presente descripción se refiere además a receptores recombinantes, que incluyen receptores de antígenos quiméricos (CARs) que contienen estos anticuerpos o fragmentos, y polinucleótidos que codifican para los anticuerpos, fragmentos de unión a antígeno o receptores específicos para ROR1. La descripción se refiere además a células genéticamente modificadas, que contienen estas proteínas y receptores de unión a ROR1, y a métodos y usos relacionados de los mismos en terapia celular adoptiva.
MX2021009087A 2019-01-29 2020-01-28 Anticuerpos y receptores quimericos de antigenos especificos para receptor 1 huerfano tipo receptor tirosina-cinasa (ror1). MX2021009087A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962798456P 2019-01-29 2019-01-29
PCT/US2020/015489 WO2020160050A1 (en) 2019-01-29 2020-01-28 Antibodies and chimeric antigen receptors specific for receptor tyrosine kinase like orphan receptor 1 (ror1)

Publications (1)

Publication Number Publication Date
MX2021009087A true MX2021009087A (es) 2021-09-08

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MX2021009087A MX2021009087A (es) 2019-01-29 2020-01-28 Anticuerpos y receptores quimericos de antigenos especificos para receptor 1 huerfano tipo receptor tirosina-cinasa (ror1).

Country Status (19)

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US (2) US12268741B2 (es)
EP (1) EP3917570A1 (es)
JP (1) JP7678753B2 (es)
KR (1) KR20210122272A (es)
CN (1) CN113365660A (es)
AR (1) AR119683A1 (es)
AU (1) AU2020215576A1 (es)
BR (1) BR112021014833A2 (es)
CA (1) CA3123303A1 (es)
CL (1) CL2021001986A1 (es)
CO (1) CO2021011327A2 (es)
EA (1) EA202192103A1 (es)
IL (1) IL285182A (es)
MA (1) MA54863A (es)
MX (1) MX2021009087A (es)
PE (1) PE20212198A1 (es)
SG (1) SG11202107976SA (es)
TW (1) TW202043280A (es)
WO (1) WO2020160050A1 (es)

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