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MX2021004647A - Formas cristalinas de moduladores de los canales de potasio. - Google Patents

Formas cristalinas de moduladores de los canales de potasio.

Info

Publication number
MX2021004647A
MX2021004647A MX2021004647A MX2021004647A MX2021004647A MX 2021004647 A MX2021004647 A MX 2021004647A MX 2021004647 A MX2021004647 A MX 2021004647A MX 2021004647 A MX2021004647 A MX 2021004647A MX 2021004647 A MX2021004647 A MX 2021004647A
Authority
MX
Mexico
Prior art keywords
crystalline forms
potassium channel
channel modulators
crystalline
amorphous forms
Prior art date
Application number
MX2021004647A
Other languages
English (en)
Inventor
Jun Xu
Gregg F Keaney
Wenfeng Xue
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2021004647A publication Critical patent/MX2021004647A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se proporcionan en la presente descripción formas cristalinas y amorfas de un compuesto que tiene Fórmula estructural 1: (ver Fórmula) También se proporcionan composiciones farmacéuticas que comprenden las formas cristalina y amorfa, métodos para su fabricación y usos de las mismas para tratar una variedad de enfermedades, trastornos o afecciones asociadas con los canales de potasio.
MX2021004647A 2018-10-22 2019-10-21 Formas cristalinas de moduladores de los canales de potasio. MX2021004647A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862748632P 2018-10-22 2018-10-22
PCT/US2019/057203 WO2020086456A1 (en) 2018-10-22 2019-10-21 Crystalline forms of potassium channel modulators

Publications (1)

Publication Number Publication Date
MX2021004647A true MX2021004647A (es) 2021-08-16

Family

ID=68503217

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2021004647A MX2021004647A (es) 2018-10-22 2019-10-21 Formas cristalinas de moduladores de los canales de potasio.
MX2024003904A MX2024003904A (es) 2018-10-22 2021-04-22 Formas cristalinas de moduladores de los canales de potasio.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2024003904A MX2024003904A (es) 2018-10-22 2021-04-22 Formas cristalinas de moduladores de los canales de potasio.

Country Status (12)

Country Link
US (1) US11993586B2 (es)
EP (1) EP3870291A1 (es)
JP (1) JP2022508945A (es)
KR (1) KR20210080446A (es)
CN (1) CN113226466A (es)
AU (1) AU2019366312B2 (es)
BR (1) BR112021007552A2 (es)
CA (1) CA3116339A1 (es)
IL (1) IL282348A (es)
MA (1) MA53978A (es)
MX (2) MX2021004647A (es)
WO (1) WO2020086456A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113226466A (zh) 2018-10-22 2021-08-06 科登特治疗公司 钾通道调节剂的结晶形式

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