MX2020008103A - Metodos y composiciones para polarizacion de macrofagos. - Google Patents
Metodos y composiciones para polarizacion de macrofagos.Info
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- MX2020008103A MX2020008103A MX2020008103A MX2020008103A MX2020008103A MX 2020008103 A MX2020008103 A MX 2020008103A MX 2020008103 A MX2020008103 A MX 2020008103A MX 2020008103 A MX2020008103 A MX 2020008103A MX 2020008103 A MX2020008103 A MX 2020008103A
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Abstract
En la presente se describen composiciones y métodos que comprenden vesículas extracelulares que comprenden ácido nucleico que se dirige a genes, lo que conduce a la polarización de macrófagos de macrófagos asociados a tumores. En ciertas modalidades, en la presente se describen métodos y composiciones para aumentar la polarización de macrófagos para el tratamiento del cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862629563P | 2018-02-12 | 2018-02-12 | |
PCT/US2019/017731 WO2019157535A1 (en) | 2018-02-12 | 2019-02-12 | Methods and compositions for macrophage polarization |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020008103A true MX2020008103A (es) | 2020-09-25 |
Family
ID=65729420
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020008103A MX2020008103A (es) | 2018-02-12 | 2019-02-12 | Metodos y composiciones para polarizacion de macrofagos. |
Country Status (17)
Country | Link |
---|---|
US (2) | US11512315B2 (es) |
EP (1) | EP3752615A1 (es) |
JP (2) | JP2021512608A (es) |
KR (1) | KR20200120624A (es) |
CN (2) | CN119614501A (es) |
AU (1) | AU2019218991A1 (es) |
BR (1) | BR112020016228A2 (es) |
CA (1) | CA3088009A1 (es) |
CL (1) | CL2020002053A1 (es) |
CO (1) | CO2020009694A2 (es) |
EA (1) | EA202091486A1 (es) |
IL (1) | IL276409A (es) |
MX (1) | MX2020008103A (es) |
PH (1) | PH12020551195A1 (es) |
SG (1) | SG11202006021SA (es) |
TW (1) | TW202003846A (es) |
WO (1) | WO2019157535A1 (es) |
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CN119614501A (zh) | 2018-02-12 | 2025-03-14 | 隆萨销售股份公司 | 用于巨噬细胞极化的方法和组合物 |
US12312584B2 (en) | 2018-10-02 | 2025-05-27 | Exosome Therapeutics, Inc. | cGMP exosome loaded therapeutics for treating sickle cell disease |
WO2020106772A1 (en) * | 2018-11-19 | 2020-05-28 | Exosome Therapeutics, Inc. | Exosome loaded therapeutics for the treatment of non-alcoholic steatohepatitis, diabetes mellitus type 1 and type 2, atherosclerotic cardiovascular disease, and alpha 1 antitrypsin deficiency |
AU2020327360A1 (en) * | 2019-08-14 | 2022-02-17 | Lonza Sales Ag | Extracellular vesicle linked to molecules and uses thereof |
CA3147366A1 (en) * | 2019-08-14 | 2021-02-18 | Adam T. BOUTIN | Extracellular vesicles with stat3-antisense oligonucleotides |
US20230018254A1 (en) * | 2019-08-14 | 2023-01-19 | Codiak Biosciences, Inc. | Extracellular vesicles with antisense oligonucleotides targeting kras |
CN114729356A (zh) * | 2019-08-14 | 2022-07-08 | 科迪亚克生物科学公司 | 靶向stat6的细胞外囊泡-aso构建体 |
BR112022002690A2 (pt) * | 2019-08-14 | 2022-08-23 | Codiak Biosciences Inc | Construtos de vesícula-aso extracelular tendo como alvo cebp/beta |
US20240099973A1 (en) * | 2019-09-25 | 2024-03-28 | Lonza Sales Ag | Extracellular vesicle compositions |
CN115297850A (zh) * | 2019-12-05 | 2022-11-04 | 得克萨斯州大学系统董事会 | 用于肝纤维化和其他与纤维化相关的疾病的基于外排体的治疗 |
US20230190815A1 (en) | 2020-05-11 | 2023-06-22 | Strm.Bio Incorporated | Compositions and methods related to megakaryocyte-derived extracellular vesicles |
WO2021237100A1 (en) * | 2020-05-21 | 2021-11-25 | Codiak Biosciences, Inc. | Methods of targeting extracellular vesicles to lung |
CN111748523B (zh) * | 2020-07-17 | 2022-11-22 | 南通大学 | 一种免疫调节小胞外囊泡的制备方法及其用途 |
WO2022076596A1 (en) * | 2020-10-06 | 2022-04-14 | Codiak Biosciences, Inc. | Extracellular vesicle-aso constructs targeting stat6 |
CN113262305B (zh) * | 2021-05-27 | 2022-03-25 | 浙江大学 | Coro1a基因作为靶点在制备抗肿瘤药物中的应用 |
CN117897386A (zh) | 2021-07-02 | 2024-04-16 | 斯帕克生物制药有限公司 | 苯并吡喃衍生物及其用途 |
CN113521252B (zh) * | 2021-07-29 | 2022-12-20 | 南开大学 | Tnfsf15蛋白作为巨噬细胞免疫增强剂的用途及其活化方法 |
WO2023069628A2 (en) * | 2021-10-21 | 2023-04-27 | Nanothera Biosciences, Inc. | Compositions and methods for silencing kras |
CN114058621B (zh) * | 2021-12-03 | 2023-06-16 | 温州医科大学 | 一种lncRNA基因修饰细胞分泌的外泌体及应用 |
CN114209814B (zh) * | 2021-12-15 | 2024-02-23 | 南开大学 | Tnfsf15蛋白在促进骨髓干细胞分化为巨噬细胞并扩增中的用途 |
CN114561347A (zh) * | 2022-02-25 | 2022-05-31 | 和携科技有限公司 | 一种脂肪间充质干细胞的培养基和培养方法 |
CN115137708B (zh) * | 2022-06-24 | 2023-05-16 | 重庆医科大学 | 装载yap1核酸序列的肝纤维化靶向纳米颗粒及其制备方法和应用 |
EP4554984A1 (en) * | 2022-07-13 | 2025-05-21 | Navidea Biopharmaceuticals, Inc. | Mannosylated amine dextran drug delivery vehicles with degradable disulfide/carbonate linkers targeting payloads to cd206 expressing cells |
CN115261410A (zh) * | 2022-07-20 | 2022-11-01 | 中山大学 | 一种基因编辑工程化m1型巨噬细胞外泌体的制备方法及其应用 |
WO2024044788A2 (en) * | 2022-08-26 | 2024-02-29 | Georgia State University Research Foundation, Inc. | Treating chronic inflammation and cancer by macrophage polarization |
CN115814108B (zh) * | 2022-12-27 | 2025-04-25 | 华中科技大学 | 一种用于个性化肿瘤治疗的工程化巨噬细胞载药微颗粒制剂及其制备方法 |
CN116370647B (zh) * | 2023-04-11 | 2025-07-11 | 吉林大学 | 一种用于胰腺癌免疫治疗的工程化外泌体及制备方法 |
CN119215144A (zh) * | 2023-09-08 | 2024-12-31 | 首都医科大学附属北京朝阳医院 | Lrg1在制备促进巨噬细胞向m1型分化的药物中的应用和巨噬细胞激活剂 |
KR102635831B1 (ko) * | 2023-11-01 | 2024-02-13 | 강원대학교 산학협력단 | Cxcl11에 의한 m2 대식세포의 재분극 유도를 통한 폐섬유화증 치료 용도 |
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IL272786B2 (en) | 2017-08-25 | 2025-03-01 | Codiak Biosciences Inc | Preparation of therapeutic exosomes using membrane proteins |
CN119614501A (zh) | 2018-02-12 | 2025-03-14 | 隆萨销售股份公司 | 用于巨噬细胞极化的方法和组合物 |
AU2020327360A1 (en) * | 2019-08-14 | 2022-02-17 | Lonza Sales Ag | Extracellular vesicle linked to molecules and uses thereof |
US20210322405A1 (en) * | 2020-04-15 | 2021-10-21 | Washington University | Compositions and methods for treating cancer |
US20250163150A1 (en) * | 2022-03-04 | 2025-05-22 | I-Mab Biopharma Us Limited | Combination therapies comprising a kras inhibitor for the treatment of cancer |
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2019
- 2019-02-12 CN CN202411511570.7A patent/CN119614501A/zh active Pending
- 2019-02-12 US US16/969,511 patent/US11512315B2/en active Active
- 2019-02-12 WO PCT/US2019/017731 patent/WO2019157535A1/en active Application Filing
- 2019-02-12 CN CN201980011011.0A patent/CN111918967B/zh active Active
- 2019-02-12 EA EA202091486A patent/EA202091486A1/ru unknown
- 2019-02-12 KR KR1020207022341A patent/KR20200120624A/ko not_active Ceased
- 2019-02-12 AU AU2019218991A patent/AU2019218991A1/en active Pending
- 2019-02-12 SG SG11202006021SA patent/SG11202006021SA/en unknown
- 2019-02-12 TW TW108104676A patent/TW202003846A/zh unknown
- 2019-02-12 CA CA3088009A patent/CA3088009A1/en active Pending
- 2019-02-12 JP JP2020542161A patent/JP2021512608A/ja not_active Ceased
- 2019-02-12 BR BR112020016228-0A patent/BR112020016228A2/pt unknown
- 2019-02-12 MX MX2020008103A patent/MX2020008103A/es unknown
- 2019-02-12 EP EP19710511.7A patent/EP3752615A1/en active Pending
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2020
- 2020-07-30 IL IL276409A patent/IL276409A/en unknown
- 2020-08-05 CO CONC2020/0009694A patent/CO2020009694A2/es unknown
- 2020-08-06 PH PH12020551195A patent/PH12020551195A1/en unknown
- 2020-08-07 CL CL2020002053A patent/CL2020002053A1/es unknown
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2022
- 2022-11-04 US US18/052,785 patent/US20230365971A1/en active Pending
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2024
- 2024-09-09 JP JP2024154757A patent/JP2024166292A/ja active Pending
Also Published As
Publication number | Publication date |
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CA3088009A1 (en) | 2019-08-15 |
TW202003846A (zh) | 2020-01-16 |
CL2020002053A1 (es) | 2020-12-18 |
CO2020009694A2 (es) | 2020-10-30 |
PH12020551195A1 (en) | 2021-08-16 |
CN111918967B (zh) | 2024-11-19 |
JP2024166292A (ja) | 2024-11-28 |
US20200407725A1 (en) | 2020-12-31 |
AU2019218991A1 (en) | 2020-07-09 |
IL276409A (en) | 2020-09-30 |
CN119614501A (zh) | 2025-03-14 |
BR112020016228A2 (pt) | 2020-12-08 |
KR20200120624A (ko) | 2020-10-21 |
US20230365971A1 (en) | 2023-11-16 |
JP2021512608A (ja) | 2021-05-20 |
EA202091486A1 (ru) | 2021-02-08 |
CN111918967A (zh) | 2020-11-10 |
EP3752615A1 (en) | 2020-12-23 |
WO2019157535A1 (en) | 2019-08-15 |
SG11202006021SA (en) | 2020-08-28 |
US11512315B2 (en) | 2022-11-29 |
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