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MX2020008103A - Metodos y composiciones para polarizacion de macrofagos. - Google Patents

Metodos y composiciones para polarizacion de macrofagos.

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Publication number
MX2020008103A
MX2020008103A MX2020008103A MX2020008103A MX2020008103A MX 2020008103 A MX2020008103 A MX 2020008103A MX 2020008103 A MX2020008103 A MX 2020008103A MX 2020008103 A MX2020008103 A MX 2020008103A MX 2020008103 A MX2020008103 A MX 2020008103A
Authority
MX
Mexico
Prior art keywords
compositions
methods
macrophage polarization
polarization
macrophage
Prior art date
Application number
MX2020008103A
Other languages
English (en)
Inventor
Sriram Sathyanarayanan
Douglas E Williams
Dalia Burzyn
Adam Thomas Boutin
Sushrut Kamerkar
Original Assignee
Codiak Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Codiak Biosciences Inc filed Critical Codiak Biosciences Inc
Publication of MX2020008103A publication Critical patent/MX2020008103A/es

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Abstract

En la presente se describen composiciones y métodos que comprenden vesículas extracelulares que comprenden ácido nucleico que se dirige a genes, lo que conduce a la polarización de macrófagos de macrófagos asociados a tumores. En ciertas modalidades, en la presente se describen métodos y composiciones para aumentar la polarización de macrófagos para el tratamiento del cáncer.
MX2020008103A 2018-02-12 2019-02-12 Metodos y composiciones para polarizacion de macrofagos. MX2020008103A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862629563P 2018-02-12 2018-02-12
PCT/US2019/017731 WO2019157535A1 (en) 2018-02-12 2019-02-12 Methods and compositions for macrophage polarization

Publications (1)

Publication Number Publication Date
MX2020008103A true MX2020008103A (es) 2020-09-25

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MX2020008103A MX2020008103A (es) 2018-02-12 2019-02-12 Metodos y composiciones para polarizacion de macrofagos.

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US (2) US11512315B2 (es)
EP (1) EP3752615A1 (es)
JP (2) JP2021512608A (es)
KR (1) KR20200120624A (es)
CN (2) CN119614501A (es)
AU (1) AU2019218991A1 (es)
BR (1) BR112020016228A2 (es)
CA (1) CA3088009A1 (es)
CL (1) CL2020002053A1 (es)
CO (1) CO2020009694A2 (es)
EA (1) EA202091486A1 (es)
IL (1) IL276409A (es)
MX (1) MX2020008103A (es)
PH (1) PH12020551195A1 (es)
SG (1) SG11202006021SA (es)
TW (1) TW202003846A (es)
WO (1) WO2019157535A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119614501A (zh) 2018-02-12 2025-03-14 隆萨销售股份公司 用于巨噬细胞极化的方法和组合物
US12312584B2 (en) 2018-10-02 2025-05-27 Exosome Therapeutics, Inc. cGMP exosome loaded therapeutics for treating sickle cell disease
WO2020106772A1 (en) * 2018-11-19 2020-05-28 Exosome Therapeutics, Inc. Exosome loaded therapeutics for the treatment of non-alcoholic steatohepatitis, diabetes mellitus type 1 and type 2, atherosclerotic cardiovascular disease, and alpha 1 antitrypsin deficiency
AU2020327360A1 (en) * 2019-08-14 2022-02-17 Lonza Sales Ag Extracellular vesicle linked to molecules and uses thereof
CA3147366A1 (en) * 2019-08-14 2021-02-18 Adam T. BOUTIN Extracellular vesicles with stat3-antisense oligonucleotides
US20230018254A1 (en) * 2019-08-14 2023-01-19 Codiak Biosciences, Inc. Extracellular vesicles with antisense oligonucleotides targeting kras
CN114729356A (zh) * 2019-08-14 2022-07-08 科迪亚克生物科学公司 靶向stat6的细胞外囊泡-aso构建体
BR112022002690A2 (pt) * 2019-08-14 2022-08-23 Codiak Biosciences Inc Construtos de vesícula-aso extracelular tendo como alvo cebp/beta
US20240099973A1 (en) * 2019-09-25 2024-03-28 Lonza Sales Ag Extracellular vesicle compositions
CN115297850A (zh) * 2019-12-05 2022-11-04 得克萨斯州大学系统董事会 用于肝纤维化和其他与纤维化相关的疾病的基于外排体的治疗
US20230190815A1 (en) 2020-05-11 2023-06-22 Strm.Bio Incorporated Compositions and methods related to megakaryocyte-derived extracellular vesicles
WO2021237100A1 (en) * 2020-05-21 2021-11-25 Codiak Biosciences, Inc. Methods of targeting extracellular vesicles to lung
CN111748523B (zh) * 2020-07-17 2022-11-22 南通大学 一种免疫调节小胞外囊泡的制备方法及其用途
WO2022076596A1 (en) * 2020-10-06 2022-04-14 Codiak Biosciences, Inc. Extracellular vesicle-aso constructs targeting stat6
CN113262305B (zh) * 2021-05-27 2022-03-25 浙江大学 Coro1a基因作为靶点在制备抗肿瘤药物中的应用
CN117897386A (zh) 2021-07-02 2024-04-16 斯帕克生物制药有限公司 苯并吡喃衍生物及其用途
CN113521252B (zh) * 2021-07-29 2022-12-20 南开大学 Tnfsf15蛋白作为巨噬细胞免疫增强剂的用途及其活化方法
WO2023069628A2 (en) * 2021-10-21 2023-04-27 Nanothera Biosciences, Inc. Compositions and methods for silencing kras
CN114058621B (zh) * 2021-12-03 2023-06-16 温州医科大学 一种lncRNA基因修饰细胞分泌的外泌体及应用
CN114209814B (zh) * 2021-12-15 2024-02-23 南开大学 Tnfsf15蛋白在促进骨髓干细胞分化为巨噬细胞并扩增中的用途
CN114561347A (zh) * 2022-02-25 2022-05-31 和携科技有限公司 一种脂肪间充质干细胞的培养基和培养方法
CN115137708B (zh) * 2022-06-24 2023-05-16 重庆医科大学 装载yap1核酸序列的肝纤维化靶向纳米颗粒及其制备方法和应用
EP4554984A1 (en) * 2022-07-13 2025-05-21 Navidea Biopharmaceuticals, Inc. Mannosylated amine dextran drug delivery vehicles with degradable disulfide/carbonate linkers targeting payloads to cd206 expressing cells
CN115261410A (zh) * 2022-07-20 2022-11-01 中山大学 一种基因编辑工程化m1型巨噬细胞外泌体的制备方法及其应用
WO2024044788A2 (en) * 2022-08-26 2024-02-29 Georgia State University Research Foundation, Inc. Treating chronic inflammation and cancer by macrophage polarization
CN115814108B (zh) * 2022-12-27 2025-04-25 华中科技大学 一种用于个性化肿瘤治疗的工程化巨噬细胞载药微颗粒制剂及其制备方法
CN116370647B (zh) * 2023-04-11 2025-07-11 吉林大学 一种用于胰腺癌免疫治疗的工程化外泌体及制备方法
CN119215144A (zh) * 2023-09-08 2024-12-31 首都医科大学附属北京朝阳医院 Lrg1在制备促进巨噬细胞向m1型分化的药物中的应用和巨噬细胞激活剂
KR102635831B1 (ko) * 2023-11-01 2024-02-13 강원대학교 산학협력단 Cxcl11에 의한 m2 대식세포의 재분극 유도를 통한 폐섬유화증 치료 용도

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6860201A (en) * 2000-06-19 2002-01-02 Halliburton Energy Serv Inc Apparatus and methods for applying time lapse vsp to monitor a reservoir
US20040115634A1 (en) * 2002-12-11 2004-06-17 Isis Pharmaceuticals, Inc. Modulation of stat 6 expression
DE102006050655A1 (de) * 2006-10-24 2008-04-30 Halmon Beheer B.V. Pharmazeutische Zusammensetzung zur Behandlung allergischer Erkrankungen
CN103555722B (zh) * 2009-04-03 2016-08-31 戴瑟纳制药公司 利用不对称双链rna特异性抑制kras的方法和组合物
WO2010115202A2 (en) * 2009-04-03 2010-10-07 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of kras by blunt ended double-stranded rna
JP2014507160A (ja) * 2011-02-22 2014-03-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス エス.アー.エール.エル. 循環バイオマーカー
EP2922861A4 (en) 2012-11-26 2016-09-14 Caris Life Sciences Switzerland Holdings Gmbh BIOMARKER COMPOSITIONS AND METHODS
EP3057662A4 (en) * 2013-10-17 2017-03-29 Children's Hospital Los Angeles Antibody dependent exosome therapy
AU2015335029B2 (en) * 2014-10-24 2021-09-23 Astrazeneca Ab Combination
CA2988585A1 (en) * 2015-06-10 2016-12-15 Raghu Kalluri Use of exosomes for the treatment of disease
GB201516801D0 (en) * 2015-09-22 2015-11-04 Immunovia Ab Method, array and use thereof
WO2017053722A1 (en) 2015-09-24 2017-03-30 Ionis Pharmaceuticals, Inc. Modulators of kras expression
KR20180122433A (ko) 2016-03-15 2018-11-12 코디악 바이오사이언시즈, 인크. 치료용 막 소포
WO2018039119A1 (en) 2016-08-22 2018-03-01 Codiak Biosciences, Inc. Methods of suppressing delivery of exosomes to liver and spleen
IL272786B2 (en) 2017-08-25 2025-03-01 Codiak Biosciences Inc Preparation of therapeutic exosomes using membrane proteins
CN119614501A (zh) 2018-02-12 2025-03-14 隆萨销售股份公司 用于巨噬细胞极化的方法和组合物
AU2020327360A1 (en) * 2019-08-14 2022-02-17 Lonza Sales Ag Extracellular vesicle linked to molecules and uses thereof
US20210322405A1 (en) * 2020-04-15 2021-10-21 Washington University Compositions and methods for treating cancer
US20250163150A1 (en) * 2022-03-04 2025-05-22 I-Mab Biopharma Us Limited Combination therapies comprising a kras inhibitor for the treatment of cancer

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CA3088009A1 (en) 2019-08-15
TW202003846A (zh) 2020-01-16
CL2020002053A1 (es) 2020-12-18
CO2020009694A2 (es) 2020-10-30
PH12020551195A1 (en) 2021-08-16
CN111918967B (zh) 2024-11-19
JP2024166292A (ja) 2024-11-28
US20200407725A1 (en) 2020-12-31
AU2019218991A1 (en) 2020-07-09
IL276409A (en) 2020-09-30
CN119614501A (zh) 2025-03-14
BR112020016228A2 (pt) 2020-12-08
KR20200120624A (ko) 2020-10-21
US20230365971A1 (en) 2023-11-16
JP2021512608A (ja) 2021-05-20
EA202091486A1 (ru) 2021-02-08
CN111918967A (zh) 2020-11-10
EP3752615A1 (en) 2020-12-23
WO2019157535A1 (en) 2019-08-15
SG11202006021SA (en) 2020-08-28
US11512315B2 (en) 2022-11-29

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