MX2020004516A - Metodos y composiciones para la dosificacion de celulas t con receptor de antigeno quimerico alogenicas. - Google Patents
Metodos y composiciones para la dosificacion de celulas t con receptor de antigeno quimerico alogenicas.Info
- Publication number
- MX2020004516A MX2020004516A MX2020004516A MX2020004516A MX2020004516A MX 2020004516 A MX2020004516 A MX 2020004516A MX 2020004516 A MX2020004516 A MX 2020004516A MX 2020004516 A MX2020004516 A MX 2020004516A MX 2020004516 A MX2020004516 A MX 2020004516A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- compositions
- cells
- antigen receptor
- chimeric antigen
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 108091007741 Chimeric antigen receptor T cells Proteins 0.000 title 1
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
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- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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Abstract
La presente descripción se refiere a dosificaciones para el tratamiento de pacientes humanos susceptibles o diagnosticados con una enfermedad, tal como cáncer. Se proporcionan métodos para administrar células T con receptor de antígeno quimérico (CAR). También se proporcionan composiciones y artículos de fabricación para usar en los métodos.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762579426P | 2017-10-31 | 2017-10-31 | |
| US201862716898P | 2018-08-09 | 2018-08-09 | |
| US201862750215P | 2018-10-24 | 2018-10-24 | |
| PCT/US2018/058288 WO2019089650A1 (en) | 2017-10-31 | 2018-10-30 | Methods and compositions for dosing of allogeneic chimeric antigen receptor t cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020004516A true MX2020004516A (es) | 2020-10-20 |
Family
ID=64332391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020004516A MX2020004516A (es) | 2017-10-31 | 2018-10-30 | Metodos y composiciones para la dosificacion de celulas t con receptor de antigeno quimerico alogenicas. |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US20190125799A1 (es) |
| EP (2) | EP4477270A3 (es) |
| JP (3) | JP7451410B2 (es) |
| KR (1) | KR20200094147A (es) |
| CN (2) | CN111886015B (es) |
| AU (2) | AU2018360566C1 (es) |
| BR (1) | BR112020008428A2 (es) |
| CA (1) | CA3079747A1 (es) |
| CO (1) | CO2020006443A2 (es) |
| DK (1) | DK3703710T3 (es) |
| ES (1) | ES2989180T3 (es) |
| FI (1) | FI3703710T3 (es) |
| IL (2) | IL318639A (es) |
| MX (1) | MX2020004516A (es) |
| MY (1) | MY204419A (es) |
| PE (1) | PE20211266A1 (es) |
| PH (1) | PH12020550598A1 (es) |
| SG (1) | SG11202003849VA (es) |
| TW (1) | TWI899047B (es) |
| WO (1) | WO2019089650A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3703710T3 (da) * | 2017-10-31 | 2024-10-14 | Allogene Therapeutics Inc | Fremgangsmåder og sammensætninger til dosering af allogene kimær antigenreceptor-t-celler til behandling af refraktært og/eller recidiveret storcellet b-cellelymfom eller refraktært og/eller recidiveret follikulært lymfom |
| AU2020267057A1 (en) | 2019-04-30 | 2021-11-18 | Crispr Therapeutics Ag | Allogeneic cell therapy of B cell malignancies using genetically engineered T cells targeting CD19 |
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| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| DE69127627T2 (de) | 1990-08-29 | 1998-02-19 | Genpharm Int | Produktion und Nützung nicht-menschliche transgentiere zur Produktion heterologe Antikörper |
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| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
| GB201206559D0 (en) | 2012-04-13 | 2012-05-30 | Ucl Business Plc | Polypeptide |
| PL2855667T3 (pl) | 2012-05-25 | 2024-03-25 | Cellectis | Sposoby uzyskiwania metodami inżynierii allogenicznych i opornych na immunosupresję limfocytów t do immunoterapii |
| UY35468A (es) * | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| EP4364809A3 (en) * | 2013-05-13 | 2024-07-24 | Cellectis | Cd19 specific chimeric antigen receptor and uses thereof |
| US20170002060A1 (en) * | 2014-01-08 | 2017-01-05 | Moderna Therapeutics, Inc. | Polynucleotides for the in vivo production of antibodies |
| SG10201811816RA (en) * | 2014-02-14 | 2019-02-27 | Univ Texas | Chimeric antigen receptors and methods of making |
| US20170209492A1 (en) * | 2014-07-31 | 2017-07-27 | Novartis Ag | Subset-optimized chimeric antigen receptor-containing t-cells |
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| JP7197979B2 (ja) * | 2015-05-28 | 2022-12-28 | カイト ファーマ インコーポレイテッド | T細胞療法のために患者をコンディショニングする方法 |
| CN106117366A (zh) * | 2016-06-24 | 2016-11-16 | 安徽未名细胞治疗有限公司 | 一种cd19特异性嵌合抗原受体及其编码基因、应用 |
| CN106544365B (zh) * | 2016-10-25 | 2019-11-22 | 山东兴瑞生物科技有限公司 | 一种人抗cd19嵌合抗原受体修饰的cik的制备方法及应用 |
| CN106520806B (zh) * | 2016-11-03 | 2018-06-19 | 宜明细胞生物科技有限公司 | 一种重组car基因及其载体、car-t细胞和应用 |
| CN106520837A (zh) * | 2016-11-30 | 2017-03-22 | 河南省华隆生物技术有限公司 | 一种重组载体及其应用 |
| CN107287164A (zh) * | 2017-07-07 | 2017-10-24 | 青岛协和华美医学诊断技术有限公司 | 靶向cd19的嵌合抗原受体t细胞、制备方法及应用 |
| DK3703710T3 (da) | 2017-10-31 | 2024-10-14 | Allogene Therapeutics Inc | Fremgangsmåder og sammensætninger til dosering af allogene kimær antigenreceptor-t-celler til behandling af refraktært og/eller recidiveret storcellet b-cellelymfom eller refraktært og/eller recidiveret follikulært lymfom |
| US11896617B2 (en) * | 2019-04-26 | 2024-02-13 | Allogene Therapeutics, Inc. | Polynucleotides encoding rituximab-resistant chimeric antigen receptors |
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