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MX2017017117A - Moleculas multiespecificas de union a antigenos y usos de estas. - Google Patents

Moleculas multiespecificas de union a antigenos y usos de estas.

Info

Publication number
MX2017017117A
MX2017017117A MX2017017117A MX2017017117A MX2017017117A MX 2017017117 A MX2017017117 A MX 2017017117A MX 2017017117 A MX2017017117 A MX 2017017117A MX 2017017117 A MX2017017117 A MX 2017017117A MX 2017017117 A MX2017017117 A MX 2017017117A
Authority
MX
Mexico
Prior art keywords
binding
antigen
target molecule
internalization
molecule
Prior art date
Application number
MX2017017117A
Other languages
English (en)
Inventor
Thurston Gavin
Papadopoulos Nicholas
Delfino Frank
Andreev Julian
Thambi Nithya
Martin Joel
CYGNAR Katherine
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2017017117A publication Critical patent/MX2017017117A/es

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Abstract

La presente invención proporciona moléculas multiespecíficas de unión a antígenos y usos de estas. Las moléculas multiespecíficas de unión a antígenos comprenden un primer dominio de unión a un antígeno que se une específicamente a una molécula objetivo, y un segundo dominio de unión a un antígeno que se une específicamente a una proteína efectora con internalización. Las moléculas multiespecíficas de unión a antígenos de la presente invención puede, en algunas modalidades, ser anticuerpos biespecíficos que son capaces de unirse tanto a una molécula objetivo como a una proteína efectora con internalización. En ciertas modalidades de la invención, la unión simultánea de la molécula objetivo y la proteína efectora con internalización por la molécula multiespecífica de unión a antígenos de la presente invención da como resultado la atenuación de la actividad de la molécula objetivo en mayor medida que la unión de la molécula objetivo sola. En otras modalidades de la invención, la molécula objetivo es un antígeno asociado a un tumor, y la unión simultánea del antígeno asociado al tumor y la proteína efectora con internalización por la molécula multiespecífica de unión a antígenos de la presente invención provoca o facilita la destrucción dirigida de las células tumorales.
MX2017017117A 2015-07-06 2016-07-06 Moleculas multiespecificas de union a antigenos y usos de estas. MX2017017117A (es)

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