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EA201491686A1 - Мультиспецифические антигенсвязывающие молекулы и их применения - Google Patents

Мультиспецифические антигенсвязывающие молекулы и их применения

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Publication number
EA201491686A1
EA201491686A1 EA201491686A EA201491686A EA201491686A1 EA 201491686 A1 EA201491686 A1 EA 201491686A1 EA 201491686 A EA201491686 A EA 201491686A EA 201491686 A EA201491686 A EA 201491686A EA 201491686 A1 EA201491686 A1 EA 201491686A1
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EA
Eurasian Patent Office
Prior art keywords
binding
antigen
target molecule
multispecific antigen
binding molecules
Prior art date
Application number
EA201491686A
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English (en)
Other versions
EA036225B1 (ru
Inventor
Николас Дж. Пападопулос
Эндрю Дж. МЕРФИ
Арис Н. Экономидис
Кэтрин Диана Сиджнэр
Original Assignee
Ридженерон Фармасьютикалз, Инк.
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Application filed by Ридженерон Фармасьютикалз, Инк. filed Critical Ридженерон Фармасьютикалз, Инк.
Publication of EA201491686A1 publication Critical patent/EA201491686A1/ru
Publication of EA036225B1 publication Critical patent/EA036225B1/ru

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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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Abstract

Данное изобретение предоставляет мультиспецифические антигенсвязывающие молекулы и их применения. Мультиспецифические антигенсвязывающие молекулы содержат первый антигенсвязывающий домен, который специфично связывает молекулу-мишень, и второй антигенсвязывающий домен, который специфично связывает интернализующийся эффекторный белок. Мультиспецифические антигенсвязывающие молекулы по данному изобретению могут в некоторых вариантах осуществления являться биспецифическим антителами, которые способны к связыванию, как молекулы-мишени, так и интернализующегося эффекторного белка. В некоторых вариантах осуществления изобретения одновременное связывание молекулы-мишени и интернализующегося эффекторного белка мультиспецифической антигенсвязывающей молекулой по данному изобретению приводит к аттенуации активности молекулы-мишени в большей степени, чем связывание молекулы-мишени отдельно. В других вариантах осуществления изобретения молекула-мишень является ассоциированным с опухолью антигеном, и одновременное связывание ассоциированного с опухолью антигена и интернализующегося эффекторного белка мультиспецифической антигенсвязывающей молекулой по данному изобретению вызывает или облегчает направленное умерщвление опухолевых клеток.
EA201491686A 2012-03-14 2013-03-13 Мультиспецифические антигенсвязывающие молекулы и их применения EA036225B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261610494P 2012-03-14 2012-03-14
US201261721831P 2012-11-02 2012-11-02
US201361751286P 2013-01-11 2013-01-11
PCT/US2013/030636 WO2013138400A1 (en) 2012-03-14 2013-03-13 Multispecific antigen-binding molecules and uses thereof

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EA201491686A1 true EA201491686A1 (ru) 2014-12-30
EA036225B1 EA036225B1 (ru) 2020-10-15

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US (2) US20130243775A1 (ru)
EP (2) EP3421488A3 (ru)
JP (4) JP6883944B2 (ru)
KR (3) KR102494534B1 (ru)
CN (2) CN104302664B (ru)
AU (2) AU2013232266A1 (ru)
BR (1) BR112014022692A8 (ru)
CA (1) CA2867265C (ru)
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MX (3) MX361875B (ru)
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NZ (1) NZ631565A (ru)
PL (1) PL2825553T3 (ru)
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