MX2017009713A - Sal de tosilato de n-[3-[(4ar,7as)-2-amino-6-(5-fluoropirimidin-2- il)-4,4a,5,7-tetrahidropirrolo[3,4-d] [1,3]tiazin-7a-il]-4-fluoro- fenil]-5-metoxi-pirazin-2-carboxamida. - Google Patents
Sal de tosilato de n-[3-[(4ar,7as)-2-amino-6-(5-fluoropirimidin-2- il)-4,4a,5,7-tetrahidropirrolo[3,4-d] [1,3]tiazin-7a-il]-4-fluoro- fenil]-5-metoxi-pirazin-2-carboxamida.Info
- Publication number
- MX2017009713A MX2017009713A MX2017009713A MX2017009713A MX2017009713A MX 2017009713 A MX2017009713 A MX 2017009713A MX 2017009713 A MX2017009713 A MX 2017009713A MX 2017009713 A MX2017009713 A MX 2017009713A MX 2017009713 A MX2017009713 A MX 2017009713A
- Authority
- MX
- Mexico
- Prior art keywords
- tetrahydropyrrolo
- fluoropyrimidin
- pyrazine
- carboxamide
- fluoro
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se refiere a una sal de tosilato de N-[3-[(4aR,7aS)-2-amino-6-(5-fluoropirimidin-2-il)-4,4a,5,7-tetra hidropirrolo[3,4-d][1,3]tiazin-7a-il]-4-fluoro-fenil]-5-metoxi-pi razina-2-carboxamida.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562109733P | 2015-01-30 | 2015-01-30 | |
| PCT/US2016/014423 WO2016122968A1 (en) | 2015-01-30 | 2016-01-22 | Tosylate salt of n-[3-[(4ar,7as)-2-amino-6-(5-fluoropyrimidin-2-yl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-4-fluoro-phenyl]-5-methoxy-pyrazine-2-carboxamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2017009713A true MX2017009713A (es) | 2017-11-17 |
Family
ID=55275232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017009713A MX2017009713A (es) | 2015-01-30 | 2016-01-22 | Sal de tosilato de n-[3-[(4ar,7as)-2-amino-6-(5-fluoropirimidin-2- il)-4,4a,5,7-tetrahidropirrolo[3,4-d] [1,3]tiazin-7a-il]-4-fluoro- fenil]-5-metoxi-pirazin-2-carboxamida. |
Country Status (41)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI574969B (zh) * | 2015-01-30 | 2017-03-21 | 美國禮來大藥廠 | 甲苯磺酸鹽 |
| WO2019094608A1 (en) | 2017-11-08 | 2019-05-16 | Denali Therapeutics Inc. | Anti-bace1 antibodies and methods of use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT401651B (de) * | 1994-06-14 | 1996-11-25 | Biochemie Gmbh | 7-(2-(2-aminothiazol-4-yl)-2-(z)- hydroximinoacetamido)-3-n,n- dimethylcarbamoyloxymethyl-3-cephem-4- |
| KR20100075679A (ko) * | 2007-12-07 | 2010-07-02 | 화이자 인코포레이티드 | 트랜스-ｎ-이소부틸-3-플루오로-3-[3-플루오로-4-(피롤리딘-1-일메틸)-페닐]-사이클로부탄카복스아미드의 토실레이트 염 |
| RS54311B1 (en) * | 2008-01-18 | 2016-02-29 | Eisai R&D Management Co. Ltd. | KONDEZOVANI AMINODIHYDROTIAZINE DERIVATIVE |
| TWI593692B (zh) * | 2013-03-12 | 2017-08-01 | 美國禮來大藥廠 | 四氫吡咯并噻嗪化合物 |
| TWI570127B (zh) * | 2014-09-15 | 2017-02-11 | 美國禮來大藥廠 | 結晶型N-[3-[(4aR,7aS)-2-胺基-6-(5-氟嘧啶-2-基)-4,4a,5,7-四氫吡咯并[3,4-d][1,3]噻嗪-7a-基]-4-氟-苯基]-5-甲氧基-吡嗪-2-甲醯胺、其用途及醫藥組合物 |
| TWI574969B (zh) * | 2015-01-30 | 2017-03-21 | 美國禮來大藥廠 | 甲苯磺酸鹽 |
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2016
- 2016-01-13 TW TW105100973A patent/TWI574969B/zh not_active IP Right Cessation
- 2016-01-13 AR ARP160100076A patent/AR103406A1/es unknown
- 2016-01-22 HU HUE16702654A patent/HUE048029T2/hu unknown
- 2016-01-22 WO PCT/US2016/014423 patent/WO2016122968A1/en active Application Filing
- 2016-01-22 LT LTEP16702654.1T patent/LT3250575T/lt unknown
- 2016-01-22 SI SI201630517T patent/SI3250575T1/sl unknown
- 2016-01-22 MA MA41420A patent/MA41420B1/fr unknown
- 2016-01-22 ME MEP-2019-347A patent/ME03581B/me unknown
- 2016-01-22 DK DK16702654.1T patent/DK3250575T3/da active
- 2016-01-22 HR HRP20192240TT patent/HRP20192240T1/hr unknown
- 2016-01-22 KR KR1020177020943A patent/KR101950129B1/ko not_active Expired - Fee Related
- 2016-01-22 NZ NZ732381A patent/NZ732381A/en not_active IP Right Cessation
- 2016-01-22 JP JP2017540253A patent/JP6723250B2/ja active Active
- 2016-01-22 PL PL16702654T patent/PL3250575T3/pl unknown
- 2016-01-22 PE PE2017001211A patent/PE20171333A1/es unknown
- 2016-01-22 EA EA201791229A patent/EA031330B1/ru not_active IP Right Cessation
- 2016-01-22 MD MDE20170309T patent/MD3250575T2/ro unknown
- 2016-01-22 MX MX2017009713A patent/MX2017009713A/es unknown
- 2016-01-22 CN CN201680005234.2A patent/CN107108657B/zh active Active
- 2016-01-22 TN TNP/2017/000332A patent/TN2017000332A1/en unknown
- 2016-01-22 PT PT167026541T patent/PT3250575T/pt unknown
- 2016-01-22 BR BR112017012149-2A patent/BR112017012149A2/pt not_active Application Discontinuation
- 2016-01-22 EP EP16702654.1A patent/EP3250575B1/en active Active
- 2016-01-22 CA CA2969475A patent/CA2969475C/en not_active Expired - Fee Related
- 2016-01-22 AU AU2016211827A patent/AU2016211827B2/en not_active Ceased
- 2016-01-22 RS RS20191663A patent/RS59730B1/sr unknown
- 2016-01-22 UA UAA201707108A patent/UA119581C2/uk unknown
- 2016-01-22 SG SG11201706038PA patent/SG11201706038PA/en unknown
- 2016-01-22 US US15/535,523 patent/US10080758B2/en active Active
- 2016-01-22 CR CR20170287A patent/CR20170287A/es unknown
- 2016-01-22 ES ES16702654T patent/ES2768782T3/es active Active
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2017
- 2017-06-07 IL IL252754A patent/IL252754A0/en unknown
- 2017-06-08 ZA ZA2017/03937A patent/ZA201703937B/en unknown
- 2017-07-03 DO DO2017000159A patent/DOP2017000159A/es unknown
- 2017-07-06 SV SV2017005478A patent/SV2017005478A/es unknown
- 2017-07-25 CL CL2017001899A patent/CL2017001899A1/es unknown
- 2017-07-27 GT GT201700166A patent/GT201700166A/es unknown
- 2017-07-28 EC ECIEPI201748768A patent/ECSP17048768A/es unknown
- 2017-07-28 PH PH12017501356A patent/PH12017501356A1/en unknown
- 2017-08-01 CO CONC2017/0007810A patent/CO2017007810A2/es unknown
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2019
- 2019-04-10 JP JP2019074951A patent/JP2019142902A/ja not_active Ceased
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2020
- 2020-01-15 CY CY20201100033T patent/CY1122548T1/el unknown
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