MX2017008569A - Derivados de glucagon con estabilidad mejorada. - Google Patents
Derivados de glucagon con estabilidad mejorada.Info
- Publication number
- MX2017008569A MX2017008569A MX2017008569A MX2017008569A MX2017008569A MX 2017008569 A MX2017008569 A MX 2017008569A MX 2017008569 A MX2017008569 A MX 2017008569A MX 2017008569 A MX2017008569 A MX 2017008569A MX 2017008569 A MX2017008569 A MX 2017008569A
- Authority
- MX
- Mexico
- Prior art keywords
- glucagon derivative
- obesity
- hypoglycemia
- present
- glucagon
- Prior art date
Links
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical class C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title abstract 4
- 208000013016 Hypoglycemia Diseases 0.000 abstract 3
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 3
- 208000008589 Obesity Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 235000020824 obesity Nutrition 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 108010063919 Glucagon Receptors Proteins 0.000 abstract 1
- 102100040890 Glucagon receptor Human genes 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000003579 anti-obesity Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000000704 physical effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a un nuevo péptido derivado del glucagón y a una composición para la prevención o el tratamiento de hipoglucemia, que contiene el nuevo péptido derivado del glucagón como principio activo. El derivado de glucagón de acuerdo con la presente invención tiene propiedades físicas mejoradas debido al cambio en el punto isoeléctrico (pl) mientras que es capaz de mantener una actividad en los receptores del glucagón y, por tanto, puede mejorar la conformidad del paciente cuando se usa como un agente hipoglucémico y también es adecuado para la administración en combinación con otros agentes antiobesidad. Por consiguiente, el derivado de glucagón de acuerdo con la presente invención se puede usar de manera eficaz para la prevención y el tratamiento de la hipoglucemia y la obesidad.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20140193800 | 2014-12-30 | ||
| PCT/KR2015/014422 WO2016108586A1 (ko) | 2014-12-30 | 2015-12-30 | 안정성이 증가된 글루카곤 유도체 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2017008569A true MX2017008569A (es) | 2017-10-20 |
Family
ID=56284642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017008569A MX2017008569A (es) | 2014-12-30 | 2015-12-30 | Derivados de glucagon con estabilidad mejorada. |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US11135271B2 (es) |
| EP (2) | EP3575314B1 (es) |
| JP (2) | JP6797122B2 (es) |
| KR (1) | KR102291020B1 (es) |
| CN (1) | CN107636009B (es) |
| AR (1) | AR103322A1 (es) |
| AU (1) | AU2015372818A1 (es) |
| CA (1) | CA2972748A1 (es) |
| CL (1) | CL2017001718A1 (es) |
| CO (1) | CO2017006308A2 (es) |
| CR (1) | CR20170293A (es) |
| DO (1) | DOP2017000156A (es) |
| EA (1) | EA035527B1 (es) |
| EC (1) | ECSP17040923A (es) |
| ES (1) | ES2976562T3 (es) |
| GT (1) | GT201700150A (es) |
| HK (1) | HK1248713A1 (es) |
| IL (2) | IL253206B (es) |
| MA (1) | MA40709B1 (es) |
| MX (1) | MX2017008569A (es) |
| MY (1) | MY185334A (es) |
| PE (2) | PE20230304A1 (es) |
| PH (1) | PH12017501222B1 (es) |
| SG (1) | SG11201705376SA (es) |
| TN (1) | TN2017000271A1 (es) |
| TW (1) | TW201639878A (es) |
| UA (1) | UA126960C2 (es) |
| WO (1) | WO2016108586A1 (es) |
| ZA (1) | ZA201705015B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20170293A (es) | 2014-12-30 | 2017-11-03 | Hanmi Pharm Ind Co Ltd | Derivados de glucagón con estabilidad mejorada |
| MA41887B1 (fr) | 2015-06-30 | 2020-05-29 | Hanmi Pharm Ind Co Ltd | Dérivé de glucagon et composition comprenant un conjugué à action prolongée de celui-ci |
| TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
| PL3398961T3 (pl) | 2015-12-31 | 2022-09-26 | Hanmi Pharm. Co., Ltd. | Potrójny aktywator aktywujący receptory glukagonu, glp-1 i gip |
| MY190855A (en) * | 2016-06-29 | 2022-05-12 | Hanmi Pharma Co Ltd | Glucagon derivative, conjugate thereof, composition comprising same and therapeutic use thereof |
| BR112019016077A2 (pt) | 2017-02-03 | 2020-03-31 | Hanmi Pharm. Co., Ltd. | Conjugado da fórmula 1, método para preparar o conjugado, preparação de atuação longa, preparação para prevenir ou tratar diabetes e método para tratar diabetes |
| SG11202005510SA (en) * | 2017-12-22 | 2020-07-29 | Hanmi Pharmaceutical Co Ltd | Therapeutic enzyme fusion protein having a novel structure and use thereof |
| WO2019147718A1 (en) * | 2018-01-23 | 2019-08-01 | Xeris Pharmaceuticals, Inc. | Treatment of post-bariatric hypoglycemia using mini-dose stable glucagon |
| AU2019405389A1 (en) * | 2018-12-21 | 2021-06-24 | Hanmi Pharm. Co., Ltd. | Pharmaceutical composition containing insulin and glucagon |
| CN109836486B (zh) * | 2019-01-30 | 2020-09-08 | 北京双因生物科技有限公司 | 成纤维生长因子21变体、其融合蛋白及其用途 |
| MX2022014669A (es) | 2020-05-22 | 2023-02-13 | Hanmi Pharm Ind Co Ltd | Formulacion liquida de conjugado de derivado de glucagon de accion prolongada. |
| BR112023000515A2 (pt) | 2020-07-15 | 2023-03-21 | Hanmi Pharm Ind Co Ltd | Composição farmacêutica e seu uso |
| US20240197834A1 (en) | 2021-04-09 | 2024-06-20 | Hanmi Pharm. Co., Ltd. | Pharmaceutical composition for preventing or treating chronic renal disease including glucagon derivative |
| KR20230095666A (ko) * | 2021-12-22 | 2023-06-29 | 한미약품 주식회사 | 간 표적 물질 및 이의 용도 |
| CN115536739B (zh) * | 2022-07-04 | 2023-04-14 | 北京惠之衡生物科技有限公司 | 一种glp-1受体和gcg受体共激动多肽衍生物的制备方法 |
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| KR102418477B1 (ko) * | 2014-12-30 | 2022-07-08 | 한미약품 주식회사 | 글루카곤 유도체 |
| MA41887B1 (fr) * | 2015-06-30 | 2020-05-29 | Hanmi Pharm Ind Co Ltd | Dérivé de glucagon et composition comprenant un conjugué à action prolongée de celui-ci |
| TW201718629A (zh) * | 2015-09-25 | 2017-06-01 | 韓美藥品股份有限公司 | 包含多個生理多肽及免疫球蛋白Ｆｃ區之蛋白質接合物 |
| PL3398961T3 (pl) | 2015-12-31 | 2022-09-26 | Hanmi Pharm. Co., Ltd. | Potrójny aktywator aktywujący receptory glukagonu, glp-1 i gip |
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2015
- 2015-12-30 CR CR20170293A patent/CR20170293A/es unknown
- 2015-12-30 UA UAA201707040A patent/UA126960C2/uk unknown
- 2015-12-30 MX MX2017008569A patent/MX2017008569A/es unknown
- 2015-12-30 US US15/540,729 patent/US11135271B2/en active Active
- 2015-12-30 AR ARP150104340A patent/AR103322A1/es unknown
- 2015-12-30 AU AU2015372818A patent/AU2015372818A1/en not_active Abandoned
- 2015-12-30 EP EP19172184.4A patent/EP3575314B1/en active Active
- 2015-12-30 TN TN2017000271A patent/TN2017000271A1/en unknown
- 2015-12-30 WO PCT/KR2015/014422 patent/WO2016108586A1/ko active Application Filing
- 2015-12-30 PE PE2022001996A patent/PE20230304A1/es unknown
- 2015-12-30 EP EP15875680.9A patent/EP3241841A4/en not_active Withdrawn
- 2015-12-30 ES ES19172184T patent/ES2976562T3/es active Active
- 2015-12-30 MY MYPI2017000967A patent/MY185334A/en unknown
- 2015-12-30 MA MA40709A patent/MA40709B1/fr unknown
- 2015-12-30 KR KR1020150189532A patent/KR102291020B1/ko active Active
- 2015-12-30 CN CN201580077186.3A patent/CN107636009B/zh active Active
- 2015-12-30 CA CA2972748A patent/CA2972748A1/en active Pending
- 2015-12-30 PE PE2017001168A patent/PE20171154A1/es unknown
- 2015-12-30 JP JP2017535417A patent/JP6797122B2/ja active Active
- 2015-12-30 TW TW104144427A patent/TW201639878A/zh unknown
- 2015-12-30 SG SG11201705376SA patent/SG11201705376SA/en unknown
- 2015-12-30 EA EA201791333A patent/EA035527B1/ru not_active IP Right Cessation
- 2015-12-30 PH PH1/2017/501222A patent/PH12017501222B1/en unknown
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2017
- 2017-06-27 CO CONC2017/0006308A patent/CO2017006308A2/es unknown
- 2017-06-27 IL IL253206A patent/IL253206B/en unknown
- 2017-06-28 GT GT201700150A patent/GT201700150A/es unknown
- 2017-06-28 CL CL2017001718A patent/CL2017001718A1/es unknown
- 2017-06-28 EC ECIEPI201740923A patent/ECSP17040923A/es unknown
- 2017-06-29 DO DO2017000156A patent/DOP2017000156A/es unknown
- 2017-07-24 ZA ZA2017/05015A patent/ZA201705015B/en unknown
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2018
- 2018-04-10 HK HK18104685.2A patent/HK1248713A1/zh unknown
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2020
- 2020-08-28 JP JP2020144259A patent/JP7079301B2/ja active Active
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2021
- 2021-03-09 IL IL281375A patent/IL281375B/en unknown
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