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MX2017001416A - Sales co-formadoras de (2s,3s)-7-fluoro-2-(4-fluorofenil)-3-(1-met il-1h-1,2,4-triazol-5-il)-4-oxo-1,2,3,4-tetrahidroquinolin-5-carb oxilato de metilo y sus metodos de preparacion. - Google Patents

Sales co-formadoras de (2s,3s)-7-fluoro-2-(4-fluorofenil)-3-(1-met il-1h-1,2,4-triazol-5-il)-4-oxo-1,2,3,4-tetrahidroquinolin-5-carb oxilato de metilo y sus metodos de preparacion.

Info

Publication number
MX2017001416A
MX2017001416A MX2017001416A MX2017001416A MX2017001416A MX 2017001416 A MX2017001416 A MX 2017001416A MX 2017001416 A MX2017001416 A MX 2017001416A MX 2017001416 A MX2017001416 A MX 2017001416A MX 2017001416 A MX2017001416 A MX 2017001416A
Authority
MX
Mexico
Prior art keywords
triazol
oxo
fluoro
tetrahydroquinolin
fluorofenil
Prior art date
Application number
MX2017001416A
Other languages
English (en)
Other versions
MX389260B (es
Inventor
Henderson Mark
Campbell Colm
Klaus HERZ Christian
BAUER Nico
Bonnaud Thierry
Lambert Olivier
JAGUSCH Carsten
Original Assignee
Medivation Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivation Technologies Inc filed Critical Medivation Technologies Inc
Publication of MX2017001416A publication Critical patent/MX2017001416A/es
Publication of MX389260B publication Critical patent/MX389260B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/19—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

En la presente se describen las sales coformadoras de (2S,3S)-7-fluoro-2-(4-fluorophenyl)-3-( 1-methyl-1H-1,2,4-triazol- 5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate de metilo opcionalmente como un solvato, y además como una opción, como un hidrato, que incluye las formas cristalinas, y los métodos de preparación del (2S,3S)-7-fluoro-2-(4-fluorofenil)-3-(1-metil-1H-1 ,2,4-triazol-5-il)-4-oxo-1,2,3,4-tetrahidroquinolin-5-carboxilato de metilo, opcionalmente como sales coformadoras.
MX2017001416A 2014-07-31 2015-07-30 Sales co-formadoras de (2s,3s)-7-fluoro-2-(4-fluorofenil)-3-(1-metil-1h-1,2,4-triazol-5-il)-4-oxo-1,2,3,4-tetrahidroquinolin-5-carboxilato de metilo y sus metodos de preparacion. MX389260B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462031521P 2014-07-31 2014-07-31
PCT/US2015/042867 WO2016019125A1 (en) 2014-07-31 2015-07-30 Coformer salts of (2s,3s)-methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1h-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate and methods of preparing them

Publications (2)

Publication Number Publication Date
MX2017001416A true MX2017001416A (es) 2017-05-19
MX389260B MX389260B (es) 2025-03-20

Family

ID=55218310

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017001416A MX389260B (es) 2014-07-31 2015-07-30 Sales co-formadoras de (2s,3s)-7-fluoro-2-(4-fluorofenil)-3-(1-metil-1h-1,2,4-triazol-5-il)-4-oxo-1,2,3,4-tetrahidroquinolin-5-carboxilato de metilo y sus metodos de preparacion.

Country Status (15)

Country Link
US (3) US20170217921A1 (es)
EP (1) EP3174855B1 (es)
JP (4) JP2017523243A (es)
KR (1) KR20170038850A (es)
CN (1) CN107155326B (es)
AU (1) AU2015296289B2 (es)
BR (1) BR112017001977A2 (es)
CA (1) CA2956714A1 (es)
EA (1) EA201790290A1 (es)
ES (1) ES2947501T3 (es)
IL (1) IL250365B (es)
MX (1) MX389260B (es)
SG (1) SG11201700734RA (es)
TW (1) TWI693214B (es)
WO (1) WO2016019125A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2767537T (lt) 2008-08-06 2017-08-10 Medivation Technologies, Inc. Poli(adp-ribozės)polimerazės (parp) dihidropiridoftalazinono inhibitoriai
JP5883397B2 (ja) 2010-02-03 2016-03-15 ビオマリン プハルマセウトイカル インコーポレイテッド Ｐｔｅｎ欠損に関連した疾患の治療におけるポリ（ａｄｐリボース）ポリメラーゼ（ｐａｒｐ）のジヒドロピリドフタラジノン阻害剤の使用
CN102834008B (zh) 2010-02-08 2014-04-23 生物马林药物股份有限公司 合成二氢吡啶并酞嗪酮衍生物的方法
AR083502A1 (es) 2010-10-21 2013-02-27 Biomarin Pharm Inc Sal tosilada de (8s,9r)-5-fluoro-8-(4-fluorofenil)-9-(1-metil-1h-1,2,4-triazol-5-il)-8,9-dihidro-2h-pirido[4,3,2-de]ftalazin-3(7h)-ona cristalina
US9708319B1 (en) * 2016-06-13 2017-07-18 Yong Xu Synthesis of PARP inhibitor talazoparib
KR20200071097A (ko) 2017-10-13 2020-06-18 메르크 파텐트 게엠베하 Parp 억제제 및 pd-1 축 결합 길항제의 조합
TW201938165A (zh) 2017-12-18 2019-10-01 美商輝瑞股份有限公司 治療癌症的方法及組合療法
US20210355223A1 (en) 2018-11-05 2021-11-18 Pfizer Inc. Combinations for Treating Cancer
JP2023517044A (ja) 2020-03-09 2023-04-21 ファイザー・インク 融合タンパク質およびその使用
JP2023548896A (ja) 2020-11-13 2023-11-21 ファイザー・インク タラゾパリブ軟質ゼラチンカプセル剤形
KR20230118597A (ko) 2020-12-07 2023-08-11 화이자 인코포레이티드 탈라조파립을 사용한 치료에 감수성인 종양을 확인하는방법 및 그의 치료 방법
BR112023018906A2 (pt) 2021-03-24 2023-10-10 Astellas Pharma Inc Combinação de talazoparib e um antiandrógeno para o tratamento de câncer de próstata metastático sensível à castração com mutação no gene ddr
WO2023131894A1 (en) 2022-01-08 2023-07-13 Pfizer Inc. Genomic loss of heterozygosity as a predictive biomarker for treatment with talazoparib and methods of treatment thereof
WO2024074959A1 (en) 2022-10-02 2024-04-11 Pfizer Inc. Combination of talazoparib and enzalutamide in the treatment of metastatic castration-resistant prostate cancer
TW202425976A (zh) 2022-12-17 2024-07-01 美商輝瑞大藥廠 用於治療轉移性去勢抵抗性前列腺癌之他拉唑帕尼及恩雜魯胺之組合

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JPS5852253A (ja) * 1981-09-21 1983-03-28 Tanabe Seiyaku Co Ltd Ρ−ヒドロキシフエニルグリシン・α−フエニルエタンスルホン酸塩及びその光学分割法
US4415504A (en) * 1981-09-21 1983-11-15 Tanabe Seiyaku Co., Ltd. p-Hydroxyphenylglycine.α-phenylethanesulfonate, process for production thereof and utilization thereof in resolution of p-hydroxyphenylglycine
JPS63192753A (ja) * 1987-02-05 1988-08-10 Otsuka Pharmaceut Co Ltd テトラヒドロキノリン誘導体の光学分割法
JPH08322591A (ja) * 1995-06-02 1996-12-10 Sumitomo Pharmaceut Co Ltd 光学分割により光学的に純粋な１，２，３，４−テトラヒドロキノリン−２−酢酸エステル類を得る方法
EP2178875A1 (en) * 2007-08-22 2010-04-28 4Sc Ag Indolopyridines as inhibitors of the kinesin spindle protein (eg5 )
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LT2767537T (lt) * 2008-08-06 2017-08-10 Medivation Technologies, Inc. Poli(adp-ribozės)polimerazės (parp) dihidropiridoftalazinono inhibitoriai
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AR083502A1 (es) * 2010-10-21 2013-02-27 Biomarin Pharm Inc Sal tosilada de (8s,9r)-5-fluoro-8-(4-fluorofenil)-9-(1-metil-1h-1,2,4-triazol-5-il)-8,9-dihidro-2h-pirido[4,3,2-de]ftalazin-3(7h)-ona cristalina
WO2013028495A1 (en) * 2011-08-19 2013-02-28 Biomarin Pharmaceutical Inc. Dihydropyridophthalazinone inhibitors of poly (adp-ribose) polymerase (parp) for the treatment of multiple myeloma

Also Published As

Publication number Publication date
US20190106401A1 (en) 2019-04-11
NZ728634A (en) 2021-09-24
WO2016019125A1 (en) 2016-02-04
ES2947501T3 (es) 2023-08-10
CN107155326B (zh) 2021-03-05
TW201617319A (zh) 2016-05-16
US20210094930A1 (en) 2021-04-01
SG11201700734RA (en) 2017-02-27
JP2022116288A (ja) 2022-08-09
TWI693214B (zh) 2020-05-11
IL250365A0 (en) 2017-03-30
AU2015296289A1 (en) 2017-03-02
EA201790290A1 (ru) 2017-07-31
MX389260B (es) 2025-03-20
JP2024123096A (ja) 2024-09-10
KR20170038850A (ko) 2017-04-07
CN107155326A (zh) 2017-09-12
AU2015296289B2 (en) 2020-02-27
EP3174855A1 (en) 2017-06-07
CA2956714A1 (en) 2016-02-04
US20170217921A1 (en) 2017-08-03
JP2017523243A (ja) 2017-08-17
IL250365B (en) 2021-02-28
JP2020125303A (ja) 2020-08-20
EP3174855A4 (en) 2018-03-21
EP3174855B1 (en) 2023-05-10
BR112017001977A2 (pt) 2017-11-21

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