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MX2016016923A - Produccion de xilitol a partir de glucosa mediante una cepa recombinante. - Google Patents

Produccion de xilitol a partir de glucosa mediante una cepa recombinante.

Info

Publication number
MX2016016923A
MX2016016923A MX2016016923A MX2016016923A MX2016016923A MX 2016016923 A MX2016016923 A MX 2016016923A MX 2016016923 A MX2016016923 A MX 2016016923A MX 2016016923 A MX2016016923 A MX 2016016923A MX 2016016923 A MX2016016923 A MX 2016016923A
Authority
MX
Mexico
Prior art keywords
xylitol
production
glucose
recombinant strain
xylulose
Prior art date
Application number
MX2016016923A
Other languages
English (en)
Other versions
MX374308B (es
Inventor
Schwab Markus
Defretin Sophie
Diefenbacher Melanie
Chang Yiming
HONDA MALCA Sumire
Gerard Tania
Heysen Arnaud
THOR Friederike
schaefer Astrid
Original Assignee
Roquette Freres
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roquette Freres filed Critical Roquette Freres
Publication of MX2016016923A publication Critical patent/MX2016016923A/es
Publication of MX374308B publication Critical patent/MX374308B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01009—D-Xylulose reductase (1.1.1.9), i.e. xylitol dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/0101—L-Xylulose reductase (1.1.1.10)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01011—D-Arabinitol 4-dehydrogenase (1.1.1.11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a un hospedador microbiano recombinante para la producción de xilitol, conteniendo el hospedador microbiano recombinante una secuencia de ácido nucleico que codifica una D-arabitol 4-oxidorreductasa específica de NAD+ (EC 1.1.1.11) que utiliza d-arabitol como sustrato y que produce D-xilulosa como producto, y una secuencia de ácido nucleico que codifica una xilitol deshidrogenasa específica de NADPH utilizando D-xilulosa como sustrato y produciendo xilitol como producto.
MX2016016923A 2014-06-18 2015-06-17 Producción de xilitol a partir de glucosa mediante una cepa recombinante. MX374308B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14305934.3A EP2957640B1 (en) 2014-06-18 2014-06-18 Production of xylitol from glucose by a recombinant strain
PCT/EP2015/063549 WO2015193350A1 (en) 2014-06-18 2015-06-17 Production of xylitol from glucose by a recombinant strain

Publications (2)

Publication Number Publication Date
MX2016016923A true MX2016016923A (es) 2017-04-27
MX374308B MX374308B (es) 2025-03-06

Family

ID=50981446

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016016923A MX374308B (es) 2014-06-18 2015-06-17 Producción de xilitol a partir de glucosa mediante una cepa recombinante.
MX2020002674A MX2020002674A (es) 2014-06-18 2016-12-16 Produccion de xilitol a partir de glucosa mediante una cepa recombinante.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2020002674A MX2020002674A (es) 2014-06-18 2016-12-16 Produccion de xilitol a partir de glucosa mediante una cepa recombinante.

Country Status (14)

Country Link
US (2) US10494614B2 (es)
EP (2) EP2957640B1 (es)
JP (1) JP6537534B2 (es)
KR (1) KR102496301B1 (es)
CN (1) CN106661540B (es)
CA (1) CA2952709C (es)
DK (2) DK2957640T3 (es)
ES (2) ES2673865T3 (es)
MX (2) MX374308B (es)
PL (2) PL2957640T3 (es)
RU (1) RU2693593C2 (es)
SG (1) SG11201610417XA (es)
TR (2) TR201808404T4 (es)
WO (1) WO2015193350A1 (es)

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* Cited by examiner, † Cited by third party
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US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US11419903B2 (en) 2015-11-30 2022-08-23 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US12279989B2 (en) 2011-02-04 2025-04-22 Seed Health, Inc. Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US11998479B2 (en) 2011-02-04 2024-06-04 Seed Health, Inc. Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure
US12257272B2 (en) 2015-12-24 2025-03-25 Seed Health, Inc. Method and system for reducing the likelihood of developing depression in an individual
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
US11213552B2 (en) 2015-11-30 2022-01-04 Joseph E. Kovarik Method for treating an individual suffering from a chronic infectious disease and cancer
US11529379B2 (en) 2013-12-20 2022-12-20 Seed Health, Inc. Method and system for reducing the likelihood of developing colorectal cancer in an individual human being
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
US12246043B2 (en) 2013-12-20 2025-03-11 Seed Health, Inc. Topical application to treat acne vulgaris
US12329783B2 (en) 2013-12-20 2025-06-17 Seed Health, Inc. Method and system to improve the health of a person's skin microbiome
US11998574B2 (en) 2013-12-20 2024-06-04 Seed Health, Inc. Method and system for modulating an individual's skin microbiome
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US12005085B2 (en) 2013-12-20 2024-06-11 Seed Health, Inc. Probiotic method and composition for maintaining a healthy vaginal microbiome
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US11026982B2 (en) 2015-11-30 2021-06-08 Joseph E. Kovarik Method for reducing the likelihood of developing bladder or colorectal cancer in an individual human being
US11642382B2 (en) 2013-12-20 2023-05-09 Seed Health, Inc. Method for treating an individual suffering from bladder cancer
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US11672835B2 (en) 2013-12-20 2023-06-13 Seed Health, Inc. Method for treating individuals having cancer and who are receiving cancer immunotherapy
PL2957640T3 (pl) * 2014-06-18 2018-09-28 Roquette Frères Wytwarzanie ksylitolu z glukozy za pomocą rekombinowanego szczepu
CN108977432B (zh) * 2018-07-27 2021-04-06 浙江工业大学 重组大肠杆菌固定化细胞及在利用木糖母液生产木糖醇中的应用
EP4077646A1 (en) * 2019-12-18 2022-10-26 Evolva SA Host cells and their use for producing ribitol and further monosaccharides
CN113025516A (zh) 2020-12-28 2021-06-25 浙江华康药业股份有限公司 一种利用木糖二次母液发酵制备木糖醇的方法
CN113151367A (zh) * 2021-05-10 2021-07-23 湖北工业大学 一种自我保护的鲁氏结合酵母从头合成木糖醇的发酵方法

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US4008285A (en) 1974-04-22 1977-02-15 Melaja Asko J Process for making xylitol
BR9007009A (pt) 1989-01-17 1991-11-12 Xyrofin Oy Processo para producao de xilitol a partir de solucao de xilose aquosa
FR2652589B1 (fr) * 1989-10-04 1995-02-17 Roquette Freres Procede de fabrication de xylitol et de produits riches en xylitol.
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JP4453869B2 (ja) * 2004-06-25 2010-04-21 信和化工株式会社 変異型キシリトールデヒドロゲナーゼ酵素、これを産生する微生物、該酵素または微生物を用いたキシリトールをキシルロースに変換する方法
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PL2957640T3 (pl) * 2014-06-18 2018-09-28 Roquette Frères Wytwarzanie ksylitolu z glukozy za pomocą rekombinowanego szczepu

Also Published As

Publication number Publication date
EP2957640A1 (en) 2015-12-23
MX374308B (es) 2025-03-06
ES2673865T3 (es) 2018-06-26
EP3158074A1 (en) 2017-04-26
PL2957640T3 (pl) 2018-09-28
KR102496301B1 (ko) 2023-02-07
US20170130209A1 (en) 2017-05-11
TR201808404T4 (tr) 2018-07-23
WO2015193350A1 (en) 2015-12-23
EP3158074B1 (en) 2019-04-24
ES2733650T3 (es) 2019-12-02
EP2957640B1 (en) 2018-03-14
US10494614B2 (en) 2019-12-03
BR112016029704A2 (pt) 2017-10-24
KR20170020362A (ko) 2017-02-22
RU2017101446A3 (es) 2018-10-26
US20200032224A1 (en) 2020-01-30
JP6537534B2 (ja) 2019-07-03
CA2952709A1 (en) 2015-12-23
DK3158074T3 (da) 2019-07-22
CA2952709C (en) 2022-11-08
CN106661540B (zh) 2021-02-09
SG11201610417XA (en) 2017-01-27
DK2957640T3 (en) 2018-06-25
JP2017518066A (ja) 2017-07-06
US10829742B2 (en) 2020-11-10
RU2017101446A (ru) 2018-07-18
CN106661540A (zh) 2017-05-10
TR201909794T4 (tr) 2019-07-22
RU2693593C2 (ru) 2019-07-03
PL3158074T3 (pl) 2019-10-31
MX2020002674A (es) 2020-07-22

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