MX2016013955A - Drimenol-sintasas y metodo de produccion de drimenol. - Google Patents
Drimenol-sintasas y metodo de produccion de drimenol.Info
- Publication number
- MX2016013955A MX2016013955A MX2016013955A MX2016013955A MX2016013955A MX 2016013955 A MX2016013955 A MX 2016013955A MX 2016013955 A MX2016013955 A MX 2016013955A MX 2016013955 A MX2016013955 A MX 2016013955A MX 2016013955 A MX2016013955 A MX 2016013955A
- Authority
- MX
- Mexico
- Prior art keywords
- drimenol
- polypeptides
- producing
- synthases
- useful
- Prior art date
Links
- HMWSKUKBAWWOJL-KCQAQPDRSA-N drimenol Chemical compound CC1(C)CCC[C@]2(C)[C@@H](CO)C(C)=CC[C@H]21 HMWSKUKBAWWOJL-KCQAQPDRSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- HMWSKUKBAWWOJL-UHFFFAOYSA-N Drimenol Natural products CC1(C)CCCC2(C)C(CO)C(C)=CCC21 HMWSKUKBAWWOJL-UHFFFAOYSA-N 0.000 title abstract 3
- HMWSKUKBAWWOJL-YDHLFZDLSA-N drimentol Natural products OC[C@H]1C(C)=CC[C@H]2C(C)(C)CCC[C@@]12C HMWSKUKBAWWOJL-YDHLFZDLSA-N 0.000 title abstract 3
- 101000924190 Aspergillus calidoustus Drimenol cyclase drtB Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- VWFJDQUYCIWHTN-YFVJMOTDSA-N 2-trans,6-trans-farnesyl diphosphate Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CO[P@](O)(=O)OP(O)(O)=O VWFJDQUYCIWHTN-YFVJMOTDSA-N 0.000 abstract 1
- VWFJDQUYCIWHTN-FBXUGWQNSA-N Farnesyl diphosphate Natural products CC(C)=CCC\C(C)=C/CC\C(C)=C/COP(O)(=O)OP(O)(O)=O VWFJDQUYCIWHTN-FBXUGWQNSA-N 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/07—Diphosphoric monoester hydrolases (3.1.7)
- C12Y301/07007—Drimenol cyclase (3.1.7.7)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La presente invención se refiere a un método para producir drimenol y/o derivados de drimenol, al poner en contacto al menos un polipéptido con el difosfato de farnesilo. El método puede ser realizado in vitro o in vivo. La presente invención también proporciona las secuencias de aminoácidos de los polipéptidos útiles en el método de la invención, y el ácido nucleico que codifica los polipéptidos de la invención. El método proporciona además las células y organismos hospederos genéticamente modificados para expresar los polipéptidos de la invención, y útiles para producir drimenol y/o derivados de drimenol.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2014076890 | 2014-05-06 | ||
| PCT/EP2015/059988 WO2015169871A2 (en) | 2014-05-06 | 2015-05-06 | Drimenol synthases ii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016013955A true MX2016013955A (es) | 2017-04-10 |
Family
ID=53483771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016013955A MX2016013955A (es) | 2014-05-06 | 2015-05-06 | Drimenol-sintasas y metodo de produccion de drimenol. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10385363B2 (es) |
| EP (1) | EP3140410B1 (es) |
| JP (1) | JP6622220B2 (es) |
| CN (1) | CN106460014B (es) |
| BR (1) | BR112016025905B1 (es) |
| CA (1) | CA2946813A1 (es) |
| ES (1) | ES2759724T3 (es) |
| MX (1) | MX2016013955A (es) |
| WO (1) | WO2015169871A2 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018009245A2 (pt) * | 2015-11-05 | 2018-11-06 | Firmenich & Cie | drimenol sintases iii |
| ES2949068T3 (es) * | 2017-05-03 | 2023-09-25 | Firmenich & Cie | Sesquiterpeno sintasas para la producción de drimenol y mezclas de los mismos |
| WO2019229064A2 (en) * | 2018-05-29 | 2019-12-05 | Firmenich Sa | Method for producing albicanol compounds |
| JP7619936B2 (ja) * | 2018-10-15 | 2025-01-22 | フイルメニツヒ ソシエテ アノニム | ドリマニルアセテート化合物を生成する方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD3273G2 (ro) * | 2006-07-14 | 2007-10-31 | Институт Химии Академии Наук Молдовы | Procedeu de obţinere a acetatului drimenolului din 11-monoacetatul driman-8a,11-diolului |
| US9303252B2 (en) | 2010-10-29 | 2016-04-05 | Evolva, Inc. | Modified valencene synthase polypeptides, encoding nucleic acid molecules and uses thereof |
| EP2768952A2 (en) | 2011-10-19 | 2014-08-27 | Keygene N.V. | Methods for producing cinnamolide and/or drimendiol |
| WO2013064411A1 (en) | 2011-11-01 | 2013-05-10 | Firmenich Sa | Cytochrome p450 and use thereof for the enzymatic oxidation of terpenes |
| CN106459949A (zh) * | 2014-05-06 | 2017-02-22 | 弗门尼舍有限公司 | 补身醇合酶及生产补身醇的方法 |
-
2015
- 2015-05-06 MX MX2016013955A patent/MX2016013955A/es unknown
- 2015-05-06 BR BR112016025905-0A patent/BR112016025905B1/pt active IP Right Grant
- 2015-05-06 US US15/330,814 patent/US10385363B2/en active Active
- 2015-05-06 WO PCT/EP2015/059988 patent/WO2015169871A2/en active Application Filing
- 2015-05-06 JP JP2016566715A patent/JP6622220B2/ja not_active Expired - Fee Related
- 2015-05-06 CN CN201580023219.6A patent/CN106460014B/zh active Active
- 2015-05-06 CA CA2946813A patent/CA2946813A1/en not_active Abandoned
- 2015-05-06 ES ES15730972T patent/ES2759724T3/es active Active
- 2015-05-06 EP EP15730972.5A patent/EP3140410B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112016025905B1 (pt) | 2024-01-09 |
| EP3140410A2 (en) | 2017-03-15 |
| EP3140410B1 (en) | 2019-09-11 |
| US20180251797A1 (en) | 2018-09-06 |
| JP2017517251A (ja) | 2017-06-29 |
| CN106460014B (zh) | 2020-10-02 |
| BR112016025905A2 (pt) | 2017-12-12 |
| US10385363B2 (en) | 2019-08-20 |
| CA2946813A1 (en) | 2015-11-12 |
| ES2759724T3 (es) | 2020-05-12 |
| WO2015169871A2 (en) | 2015-11-12 |
| WO2015169871A3 (en) | 2016-01-14 |
| JP6622220B2 (ja) | 2019-12-18 |
| CN106460014A (zh) | 2017-02-22 |
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