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MX2016012485A - Proceso para preparar 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3h -imidazo[4,5-b]piridin-2-il)piridin-2-amina. - Google Patents

Proceso para preparar 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3h -imidazo[4,5-b]piridin-2-il)piridin-2-amina.

Info

Publication number
MX2016012485A
MX2016012485A MX2016012485A MX2016012485A MX2016012485A MX 2016012485 A MX2016012485 A MX 2016012485A MX 2016012485 A MX2016012485 A MX 2016012485A MX 2016012485 A MX2016012485 A MX 2016012485A MX 2016012485 A MX2016012485 A MX 2016012485A
Authority
MX
Mexico
Prior art keywords
pyridin
phenyl
aminocyclobutyl
imidazo
amine
Prior art date
Application number
MX2016012485A
Other languages
English (en)
Other versions
MX367267B (es
Inventor
P Reed David
Mao Jianmin
Xie Chen Jian-
Bates Craig
Original Assignee
Arqule Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule Inc filed Critical Arqule Inc
Publication of MX2016012485A publication Critical patent/MX2016012485A/es
Publication of MX367267B publication Critical patent/MX367267B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se dirige a procesos para la síntesis de 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3H-imidazo[4,5-b]piridi n-2-il)piridin-2-amina (ver Fórmula).
MX2016012485A 2014-03-24 2015-03-24 Proceso para preparar 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3h -imidazo[4,5-b]piridin-2-il)piridin-2-amina. MX367267B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461969546P 2014-03-24 2014-03-24
PCT/US2015/022177 WO2015148464A1 (en) 2014-03-24 2015-03-24 Process of preparing 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3h-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine

Publications (2)

Publication Number Publication Date
MX2016012485A true MX2016012485A (es) 2016-12-16
MX367267B MX367267B (es) 2019-08-12

Family

ID=54141455

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016012485A MX367267B (es) 2014-03-24 2015-03-24 Proceso para preparar 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3h -imidazo[4,5-b]piridin-2-il)piridin-2-amina.

Country Status (16)

Country Link
US (2) US9464083B2 (es)
EP (1) EP3122748B1 (es)
JP (1) JP6578298B2 (es)
KR (1) KR20160135234A (es)
CN (1) CN106459036B (es)
AU (1) AU2015236273B2 (es)
BR (1) BR112016021910A2 (es)
CA (1) CA2938923A1 (es)
DK (1) DK3122748T3 (es)
ES (1) ES2692243T3 (es)
IL (2) IL247480A (es)
MX (1) MX367267B (es)
RU (1) RU2677478C2 (es)
TW (1) TWI662033B (es)
WO (1) WO2015148464A1 (es)
ZA (1) ZA201605598B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018013430A2 (en) 2016-07-12 2018-01-18 Arisan Therapeutics Inc. Heterocyclic compounds for the treatment of arenavirus infection
US11103493B2 (en) 2017-08-02 2021-08-31 Merck Sharp & Dohme Corp. Substituted pyridinyl compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors
EP3661909B1 (en) * 2017-08-02 2023-08-16 Merck Sharp & Dohme LLC Novel substituted phenyl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
EP4486390A1 (en) * 2022-03-02 2025-01-08 Terremoto Biosciences, Inc Covalent modifiers of akt1 and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9801526D0 (sv) * 1998-04-29 1998-04-29 Astra Ab New compounds
KR100830859B1 (ko) * 2000-04-27 2008-05-21 아스텔라스세이야쿠 가부시키가이샤 이미다조피리딘 유도체 및 이를 함유하는 의약 조성물
US6403588B1 (en) * 2000-04-27 2002-06-11 Yamanouchi Pharmaceutical Co., Ltd. Imidazopyridine derivatives
US7442709B2 (en) * 2003-08-21 2008-10-28 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine c-Kit inhibitors
EP1658289B1 (en) * 2003-08-21 2009-03-18 OSI Pharmaceuticals, Inc. 3-substituted imidazopyridine-derivatives as c-kit inhibitors
DE602007004092D1 (de) 2006-03-22 2010-02-11 Vertex Pharma C-met-proteinkinasehemmer zur behandlung proliferativer erkrankungen
DK2519522T3 (en) * 2009-12-30 2014-12-08 Arqule Inc SUBSTITUTED IDAZOPYRIDINYL AMINOPYRIDINE COMPOUNDS
JP5959330B2 (ja) * 2011-06-17 2016-08-02 田辺三菱製薬株式会社 新規抗血小板薬
AU2012272937B2 (en) * 2011-06-24 2016-09-29 Arqule, Inc Substituted imidazopyridinyl-aminopyridine compounds
US8815854B2 (en) 2011-06-24 2014-08-26 Arqule, Inc. Substituted imidazopyridinyl compounds
WO2013078254A1 (en) * 2011-11-22 2013-05-30 Array Biopharma Inc. Bicyclic heteroaryl derivatives as kinase inhibitors

Also Published As

Publication number Publication date
JP2017516749A (ja) 2017-06-22
IL247480A (en) 2017-07-31
TWI662033B (zh) 2019-06-11
BR112016021910A2 (pt) 2017-08-15
AU2015236273B2 (en) 2019-03-28
EP3122748B1 (en) 2018-09-26
IL253239B (en) 2018-04-30
JP6578298B2 (ja) 2019-09-18
RU2016141426A3 (es) 2018-11-19
RU2677478C2 (ru) 2019-01-17
AU2015236273A1 (en) 2016-08-25
CN106459036A (zh) 2017-02-22
CN106459036B (zh) 2021-07-16
WO2015148464A1 (en) 2015-10-01
RU2016141426A (ru) 2018-04-25
US20160376270A1 (en) 2016-12-29
EP3122748A4 (en) 2017-09-27
EP3122748A1 (en) 2017-02-01
US9464083B2 (en) 2016-10-11
ES2692243T3 (es) 2018-11-30
IL253239A0 (en) 2017-08-31
CA2938923A1 (en) 2015-10-01
US9834556B2 (en) 2017-12-05
DK3122748T3 (en) 2018-11-05
MX367267B (es) 2019-08-12
ZA201605598B (en) 2018-12-19
KR20160135234A (ko) 2016-11-25
US20150266876A1 (en) 2015-09-24
TW201623301A (zh) 2016-07-01

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