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MX2014009219A - Compuestos de purinona como inhibidores de quinasas. - Google Patents

Compuestos de purinona como inhibidores de quinasas.

Info

Publication number
MX2014009219A
MX2014009219A MX2014009219A MX2014009219A MX2014009219A MX 2014009219 A MX2014009219 A MX 2014009219A MX 2014009219 A MX2014009219 A MX 2014009219A MX 2014009219 A MX2014009219 A MX 2014009219A MX 2014009219 A MX2014009219 A MX 2014009219A
Authority
MX
Mexico
Prior art keywords
btk
compounds
disclosed
conditions
inhibitors
Prior art date
Application number
MX2014009219A
Other languages
English (en)
Inventor
Shunqi Yan
Wei Chen
David J Loury
Longcheng Wang
Leah Lynn Frye
Original Assignee
Pharmacyclics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacyclics Inc filed Critical Pharmacyclics Inc
Publication of MX2014009219A publication Critical patent/MX2014009219A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
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  • Dermatology (AREA)
  • Endocrinology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
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  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
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Abstract

Se describen en el presente documento compuestos que forman enlaces covalentes con la tirosina quinasa de Bruton (Btk). También se describen inhibidores irreversibles de Btk. Además, también se describen inhibidores reversibles de Btk. También se describen composiciones farmacéuticas que incluyen los compuestos. Se describen métodos para utilizar los inhibidores de Bkt, solos junto con otros agentes terapéuticos, para el tratamiento de dolencias o enfermedades autoinmunes, enfermedades o dolencias heteroinmunes, cáncer, incluyendo linfoma, y enfermedades o dolencias inflamatorias.
MX2014009219A 2012-01-31 2013-01-30 Compuestos de purinona como inhibidores de quinasas. MX2014009219A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261593146P 2012-01-31 2012-01-31
US201261637765P 2012-04-24 2012-04-24
US13/460,524 US8501724B1 (en) 2012-01-31 2012-04-30 Purinone compounds as kinase inhibitors
PCT/US2013/023918 WO2013116382A1 (en) 2012-01-31 2013-01-30 Purinone compounds as kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2014009219A true MX2014009219A (es) 2015-02-05

Family

ID=48870746

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014009219A MX2014009219A (es) 2012-01-31 2013-01-30 Compuestos de purinona como inhibidores de quinasas.

Country Status (14)

Country Link
US (3) US8501724B1 (es)
EP (2) EP2809672A4 (es)
JP (3) JP6095075B2 (es)
KR (2) KR20180030730A (es)
CN (2) CN104640861B (es)
AU (3) AU2013215166B2 (es)
BR (1) BR112014018728A8 (es)
CA (2) CA2863140C (es)
HK (1) HK1203489A1 (es)
IL (1) IL261282A (es)
MX (1) MX2014009219A (es)
PH (1) PH12014501815A1 (es)
RU (2) RU2018118216A (es)
WO (1) WO2013116382A1 (es)

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