MX2012014301A - Inhibidores macrociclicos de serina proteasa de hepatitis c. - Google Patents
Inhibidores macrociclicos de serina proteasa de hepatitis c.Info
- Publication number
- MX2012014301A MX2012014301A MX2012014301A MX2012014301A MX2012014301A MX 2012014301 A MX2012014301 A MX 2012014301A MX 2012014301 A MX2012014301 A MX 2012014301A MX 2012014301 A MX2012014301 A MX 2012014301A MX 2012014301 A MX2012014301 A MX 2012014301A
- Authority
- MX
- Mexico
- Prior art keywords
- protease inhibitors
- serine protease
- present
- hepatitis
- macrocyclic hepatitis
- Prior art date
Links
- 208000006454 hepatitis Diseases 0.000 title 1
- 231100000283 hepatitis Toxicity 0.000 title 1
- 239000003001 serine protease inhibitor Substances 0.000 title 1
- 150000002678 macrocyclic compounds Chemical class 0.000 abstract 2
- 208000005176 Hepatitis C Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 208000010710 hepatitis C virus infection Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se refiere a nuevos compuestos macrocíclicos y a métodos para el tratamiento de una infección por el virus de la hepatitis C, en un sujeto que necesite tal tratamiento con dichos compuestos macrocíclicos. La presente invención además se refiere a composiciones farmacéuticas que comprenden los compuestos de la presente invención o sales, ésteres o profármacos farmacéuticamente aceptables de los mismos, en combinación con un vehículo o excipiente farmacéuticamente aceptable.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39710310P | 2010-06-07 | 2010-06-07 | |
| PCT/US2011/039397 WO2011156337A2 (en) | 2010-06-07 | 2011-06-07 | Macrocyclic hepatitis c serine protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012014301A true MX2012014301A (es) | 2013-04-29 |
Family
ID=45098613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012014301A MX2012014301A (es) | 2010-06-07 | 2011-06-07 | Inhibidores macrociclicos de serina proteasa de hepatitis c. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8748374B2 (es) |
| EP (1) | EP2576564A4 (es) |
| JP (1) | JP2013528217A (es) |
| CN (1) | CN103025736B (es) |
| CA (1) | CA2801584A1 (es) |
| MX (1) | MX2012014301A (es) |
| TW (1) | TW201211046A (es) |
| WO (1) | WO2011156337A2 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2576564A4 (en) | 2010-06-07 | 2014-01-22 | Abbvie Inc | MACROCYCLIC HEPATITIS C SERIN PROTEASE INHIBITORS |
| US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| UA119315C2 (uk) | 2012-07-03 | 2019-06-10 | Гіліад Фармассет Елелсі | Інгібітори вірусу гепатиту с |
| PT2909205T (pt) | 2012-10-19 | 2017-02-06 | Bristol Myers Squibb Co | Derivados de carbamato de hexadecahidrociclopropa(e)pirrolo(1,2- a)(1,4)diazaciclopentadecinilo substituídos com 9-metilo como inibidores da protease não estrutural 3 (ns3) para o tratamento de infeções por vírus da hepatite c |
| EP2914613B1 (en) | 2012-11-02 | 2017-11-22 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| US9643999B2 (en) * | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2914598B1 (en) | 2012-11-02 | 2017-10-18 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| US9409943B2 (en) | 2012-11-05 | 2016-08-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2014137869A1 (en) | 2013-03-07 | 2014-09-12 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| WO2014145095A1 (en) | 2013-03-15 | 2014-09-18 | Gilead Sciences, Inc. | Macrocyclic and bicyclic inhibitors of hepatitis c virus |
| CN104163851B (zh) * | 2013-05-20 | 2019-03-05 | 湘北威尔曼制药股份有限公司 | 氟代的α-羰基类HCV NS3/4A丝氨酸蛋白酶抑制剂 |
| PL3043803T3 (pl) | 2013-09-11 | 2022-11-07 | Emory University | Kompozycje nukleotydowe i nukleozydowe oraz ich zastosowanie |
| JP7129703B2 (ja) | 2016-04-28 | 2022-09-02 | エモリー ユニバーシティー | アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用 |
| WO2018236928A1 (en) * | 2017-06-20 | 2018-12-27 | University Of Massachusetts | NS3 / 4A PROTEASE INHIBITORS OF HEPATITIS C VIRUS |
| WO2019075259A1 (en) * | 2017-10-11 | 2019-04-18 | Cornell University | MACROCYCLIC COMPOUNDS AS PROTEASE INHIBITORS |
| CN110981820B (zh) * | 2019-12-25 | 2023-05-19 | 上海彩迩文生化科技有限公司 | 一种酸性条件下合成喹喔啉-2-酮的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0302957A2 (hu) * | 2000-04-19 | 2003-12-29 | Schering Corporation | Hepatitis C vírus alkil- és aril-alanin P2 csoportokat tartalmazó makrociklusos NS-3 szerin proteáz inhibitorai |
| CN1771050A (zh) * | 2003-02-07 | 2006-05-10 | 益安药业 | 丙型肝炎丝氨酸蛋白酶的大环抑制剂 |
| US7176208B2 (en) * | 2003-04-18 | 2007-02-13 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
| US7125845B2 (en) * | 2003-07-03 | 2006-10-24 | Enanta Pharmaceuticals, Inc. | Aza-peptide macrocyclic hepatitis C serine protease inhibitors |
| GB0612423D0 (en) | 2006-06-23 | 2006-08-02 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| TWI454264B (zh) | 2006-06-26 | 2014-10-01 | Enanta Pharm Inc | 喹啉基巨環ｃ型肝炎病毒絲胺酸蛋白酶抑制劑 |
| WO2009073719A1 (en) * | 2007-12-05 | 2009-06-11 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl derivatives |
| CN105001302A (zh) * | 2009-09-28 | 2015-10-28 | 英特穆恩公司 | C型肝炎病毒复制的环肽抑制剂 |
| TW201119667A (en) * | 2009-10-19 | 2011-06-16 | Enanta Pharm Inc | Bismacrocyclic compounds as hepatitis C virus inhibitors |
| EP2576564A4 (en) | 2010-06-07 | 2014-01-22 | Abbvie Inc | MACROCYCLIC HEPATITIS C SERIN PROTEASE INHIBITORS |
| CN103534256B (zh) | 2010-12-30 | 2016-08-10 | 益安药业 | 大环丙型肝炎丝氨酸蛋白酶抑制剂 |
-
2011
- 2011-06-07 EP EP11792997.6A patent/EP2576564A4/en not_active Withdrawn
- 2011-06-07 US US13/154,721 patent/US8748374B2/en active Active
- 2011-06-07 MX MX2012014301A patent/MX2012014301A/es active IP Right Grant
- 2011-06-07 CA CA2801584A patent/CA2801584A1/en not_active Abandoned
- 2011-06-07 JP JP2013514287A patent/JP2013528217A/ja active Pending
- 2011-06-07 CN CN201180038242.4A patent/CN103025736B/zh active Active
- 2011-06-07 TW TW100119863A patent/TW201211046A/zh unknown
- 2011-06-07 WO PCT/US2011/039397 patent/WO2011156337A2/en active Application Filing
-
2014
- 2014-06-09 US US14/299,095 patent/US9493506B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20140287992A1 (en) | 2014-09-25 |
| US8748374B2 (en) | 2014-06-10 |
| EP2576564A4 (en) | 2014-01-22 |
| EP2576564A2 (en) | 2013-04-10 |
| US9493506B2 (en) | 2016-11-15 |
| CN103025736B (zh) | 2016-07-06 |
| WO2011156337A2 (en) | 2011-12-15 |
| TW201211046A (en) | 2012-03-16 |
| CN103025736A (zh) | 2013-04-03 |
| US20120101031A1 (en) | 2012-04-26 |
| JP2013528217A (ja) | 2013-07-08 |
| CA2801584A1 (en) | 2011-12-15 |
| WO2011156337A3 (en) | 2012-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |