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MX2012006805A - Indolil-piperidinil bencilaminas como inhibidores de beta-triptasa. - Google Patents

Indolil-piperidinil bencilaminas como inhibidores de beta-triptasa.

Info

Publication number
MX2012006805A
MX2012006805A MX2012006805A MX2012006805A MX2012006805A MX 2012006805 A MX2012006805 A MX 2012006805A MX 2012006805 A MX2012006805 A MX 2012006805A MX 2012006805 A MX2012006805 A MX 2012006805A MX 2012006805 A MX2012006805 A MX 2012006805A
Authority
MX
Mexico
Prior art keywords
indolyl
beta
benzylamines
piperidinyl
tryptase inhibitors
Prior art date
Application number
MX2012006805A
Other languages
English (en)
Inventor
Yong Mi Choi-Sledeski
Patrick Wai-Kwok Shum
Thaddeus R Nieduzak
Guyan Liang
Gregory B Poli
Gregory T Stoklosa
Zhicheng Zhao
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX2012006805A publication Critical patent/MX2012006805A/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P11/02—Nasal agents, e.g. decongestants
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
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  • Hematology (AREA)
  • Biomedical Technology (AREA)
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  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)

Abstract

La presente invención describe y reivindica una serie de indolil-piperidinil bencilaminas sustituidas de fórmula (I), en donde R1, R2 y R3 son como se describen en este documento. Más específicamente, los compuestos de la presente invención son inhibidores de ß-triptasa y, por lo tanto, son útiles como agentes farmacéuticos. Además, la presente invención describe métodos de preparación de indolil-piperidinil bencilaminas sustituidas.
MX2012006805A 2009-12-23 2010-12-21 Indolil-piperidinil bencilaminas como inhibidores de beta-triptasa. MX2012006805A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28965009P 2009-12-23 2009-12-23
FR1057580 2010-09-21
PCT/US2010/061461 WO2011079102A1 (en) 2009-12-23 2010-12-21 Indolyl-piperidinyl benzylamines as beta-tryptase inhibitors

Publications (1)

Publication Number Publication Date
MX2012006805A true MX2012006805A (es) 2012-07-10

Family

ID=44246893

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012006805A MX2012006805A (es) 2009-12-23 2010-12-21 Indolil-piperidinil bencilaminas como inhibidores de beta-triptasa.

Country Status (14)

Country Link
US (1) US20120245161A1 (es)
EP (1) EP2516419A1 (es)
JP (1) JP2013515733A (es)
KR (1) KR20120097410A (es)
CN (1) CN102770425A (es)
AR (1) AR079662A1 (es)
AU (1) AU2010333779A1 (es)
CA (1) CA2784894A1 (es)
MX (1) MX2012006805A (es)
RU (1) RU2012131341A (es)
SG (1) SG181504A1 (es)
TW (1) TW201132633A (es)
UY (1) UY33155A (es)
WO (1) WO2011079102A1 (es)

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JP6037277B2 (ja) * 2012-12-19 2016-12-07 国立研究開発法人農業・食品産業技術総合研究機構 オーキシン生合成阻害剤
KR102227271B1 (ko) 2013-04-15 2021-03-12 에프엠씨 코포레이션 살진균성 아미드
US20170157135A1 (en) * 2013-11-25 2017-06-08 Novogen Limited Functionalised and substituted indoles as anti-cancer agents
WO2015157005A1 (en) 2014-04-10 2015-10-15 E I Du Pont De Nemours And Company Substituted tolyl fungicide mixtures
WO2018064465A1 (en) 2016-09-29 2018-04-05 The Regents Of The University Of California Compounds for increasing neural plasticity
CA3056886A1 (en) 2017-03-21 2018-09-27 Arbutus Biopharma Corporation Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same
EA202090485A1 (ru) 2017-08-14 2020-05-27 Эпизайм, Инк. Способы лечения рака путем ингибирования setd2
JP7627209B2 (ja) 2018-08-14 2025-02-05 エピザイム，インコーポレイティド 置換インドール及びその使用方法
TWI846654B (zh) 2018-11-06 2024-06-21 美商富曼西公司 經取代之甲苯基殺真菌劑
CN109438214B (zh) * 2018-11-13 2021-06-11 大连奇凯医药科技有限公司 高纯度5-溴-2,4-二氟苯甲酸的制备方法
AU2020229779B9 (en) 2019-02-27 2025-09-18 The Regents Of The University Of California Azepino-indoles and other heterocycles for treating brain disorders
JP7636796B2 (ja) * 2019-02-27 2025-02-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 脳障害を治療するためのｎ－置換インドール及び他の複素環化合物
UY39189A (es) 2020-05-06 2021-12-31 Fmc Corp Fungicidas de tolilo sustituido y sus mezclas
CN113372223B (zh) * 2021-05-20 2022-10-28 宁波职业技术学院 一种2-氟-3-溴-苄胺的制备方法
KR20240054334A (ko) * 2021-09-03 2024-04-25 선전 01 라이프 사이언스 앤 테크놀로지 컴파니 리미티드 인돌계 화합물 및 이의 제조 방법과 용도
MX2024007221A (es) 2021-12-15 2024-08-27 Delix Therapeutics Inc Psicoplastogenos sustituidos con fenoxi y benciloxi y sus usos.

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US6777433B2 (en) 1999-12-22 2004-08-17 Merck Frosst Canada & Co. Protein tyrosine phosphatase 1B (PTP-1B) inhibitors containing two ortho-substituted aromatic phosphonates
GB0012362D0 (en) * 2000-05-22 2000-07-12 Aventis Pharma Ltd Chemical compounds
AU2001257413B2 (en) * 2000-05-22 2007-01-18 Aventisub Llc Arylmethylamine derivatives for use as tryptase inhibitors
CA2542514A1 (en) 2003-10-23 2005-05-06 Pharmacia Corporation Pyrimidine compounds for the treatment of inflammation
DOP2005000039A (es) * 2004-03-26 2005-10-31 Aventis Pharma Inc Hidrocloruro de [4-(5-aminometil-2-fluoro-fenil)- piperidin-1-il]-(4-bomo-3-metil-5-propoxi-tiofen-2-il)-metanona como un inhibidor de la triptasa de mastocitos
HRP20151338T1 (hr) * 2008-08-22 2016-01-15 Sanofi [4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-[7-fluoro-1-(2-metoksi-etil)-4trifluorometoksi-1h-indol-3-il]metanon kao inhibitor triptaze mastocita
FR2955324A1 (fr) * 2010-01-15 2011-07-22 Sanofi Aventis [4-(5-aminomethyl-phenyl)-piperidin-1-yl]-1h-indol-3-yl]-methanones disubstituees
EP2516418B1 (en) * 2009-12-23 2014-05-14 Sanofi Prodrugs of [4[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(1h-pyrrolo-pyridin-yl)-methanones and synthesis thereof

Also Published As

Publication number Publication date
CN102770425A (zh) 2012-11-07
CA2784894A1 (en) 2011-06-30
RU2012131341A (ru) 2014-01-27
UY33155A (es) 2011-07-29
AU2010333779A1 (en) 2012-07-12
AR079662A1 (es) 2012-02-08
EP2516419A1 (en) 2012-10-31
JP2013515733A (ja) 2013-05-09
KR20120097410A (ko) 2012-09-03
WO2011079102A1 (en) 2011-06-30
SG181504A1 (en) 2012-07-30
TW201132633A (en) 2011-10-01
US20120245161A1 (en) 2012-09-27

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