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MX2010008690A - Farmacoforos duales - antagonistas muscarinicos de pde4. - Google Patents

Farmacoforos duales - antagonistas muscarinicos de pde4.

Info

Publication number
MX2010008690A
MX2010008690A MX2010008690A MX2010008690A MX2010008690A MX 2010008690 A MX2010008690 A MX 2010008690A MX 2010008690 A MX2010008690 A MX 2010008690A MX 2010008690 A MX2010008690 A MX 2010008690A MX 2010008690 A MX2010008690 A MX 2010008690A
Authority
MX
Mexico
Prior art keywords
pde4
dual
muscarinic
antagonistics
pharmacophores
Prior art date
Application number
MX2010008690A
Other languages
English (en)
Inventor
Zehong Wan
Hongxing Yan
James Francis Callahan
Guoliang Lin
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40935342&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2010008690(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MX2010008690A publication Critical patent/MX2010008690A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a nuevos compuestos de la fórmula (I) y a sus sales farmacéuticamente aceptables, (ver fórmula) a composiciones farmacéuticas y a su uso como cromóforos duales que tienen actividad inhibitoria contra receptores de PDE4 y receptores muscarinicos de acetilcolina (mAChRs), siendo así de utilidad para tratar enfermedades respiratorias.
MX2010008690A 2008-02-06 2009-02-05 Farmacoforos duales - antagonistas muscarinicos de pde4. MX2010008690A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2656308P 2008-02-06 2008-02-06
PCT/US2009/033128 WO2009100166A1 (en) 2008-02-06 2009-02-05 Dual pharmacophores-pde4-muscarinic antagonistics

Publications (1)

Publication Number Publication Date
MX2010008690A true MX2010008690A (es) 2010-08-30

Family

ID=40935342

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010008690A MX2010008690A (es) 2008-02-06 2009-02-05 Farmacoforos duales - antagonistas muscarinicos de pde4.

Country Status (19)

Country Link
US (1) US8084449B2 (es)
EP (1) EP2259681A4 (es)
JP (1) JP2011511082A (es)
KR (1) KR20100113155A (es)
CN (1) CN101990401A (es)
AR (1) AR070562A1 (es)
AU (1) AU2009212408A1 (es)
BR (1) BRPI0908008A2 (es)
CA (1) CA2714352A1 (es)
CL (1) CL2009000250A1 (es)
CR (1) CR11665A (es)
DO (1) DOP2010000235A (es)
EA (1) EA201070916A1 (es)
IL (1) IL207352A0 (es)
MX (1) MX2010008690A (es)
PE (1) PE20091552A1 (es)
TW (1) TW201000476A (es)
UY (1) UY31637A1 (es)
WO (1) WO2009100166A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012011784A (es) 2010-04-16 2013-03-21 Bayer Ip Gmbh Nuevos compuestos heterociclicos como pesticidas.
US8367829B2 (en) 2010-05-10 2013-02-05 Gilead Sciences, Inc. Bi-functional pyrazolopyridine compounds
EP2585451B1 (de) 2010-06-28 2017-03-01 Bayer Intellectual Property GmbH Heterocyclische verbindungen als schädlingsbekämpfungsmittel
US9763924B2 (en) * 2014-06-05 2017-09-19 Chiesi Farmaceutici S.P.A. Aminoester derivatives
WO2016077464A1 (en) 2014-11-11 2016-05-19 Johnson & Johnson Consumer Inc. Amino acid derivatives and their uses
US9321744B1 (en) 2015-06-26 2016-04-26 Industrial Technology Research Institute Method for preparing 2,5-furan dicarboxylic acid
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas

Family Cites Families (57)

* Cited by examiner, † Cited by third party
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US3856799A (en) * 1971-08-05 1974-12-24 Squibb & Sons Inc Intermediates for production of amino derivatives of pyrazolopyridine carboxylic acids and esters
US3833594A (en) * 1971-08-05 1974-09-03 Squibb & Sons Inc Amino derivatives of pyrazolopyridine carboxylic acids and esters
BE787249A (fr) * 1971-08-05 1973-02-05 Squibb & Sons Inc Derives amino d'acides pyrazolopyridine carboxyliques, leurs esters et les sels de ces composes, ainsi que leurs procedes de preparation
US3925388A (en) * 1971-08-05 1975-12-09 Squibb & Sons Inc 4-Piperazino-{8 3,4-b{9 pyridine-5-carboxylic acids and esters
CA1003419A (en) 1971-11-23 1977-01-11 Theodor Denzel Process for the production of pyrazolo (3,4-b) pyridines
US3840546A (en) * 1972-11-15 1974-10-08 Squibb & Sons Inc Amino derivatives of pyrazolopyridine carboxamides
US3979399A (en) * 1972-11-15 1976-09-07 E. R. Squibb & Sons, Inc. Amino derivatives of pyrazolopyridine carboxamides
US4364948A (en) 1981-09-28 1982-12-21 Ici Americas Inc. Pyrazolo[3,4-b]pyridine compounds
US6326379B1 (en) 1998-09-16 2001-12-04 Bristol-Myers Squibb Co. Fused pyridine inhibitors of cGMP phosphodiesterase
US6670364B2 (en) 2001-01-31 2003-12-30 Telik, Inc. Antagonists of MCP-1 function and methods of use thereof
US6677365B2 (en) 2001-04-03 2004-01-13 Telik, Inc. Antagonists of MCP-1 function and methods of use thereof
US6825184B2 (en) * 2001-10-18 2004-11-30 Boehringer Ingelheim Pharmaceuticals, Inc. 1,4-Disubstituted benzo-fused urea compounds
EP1499598A1 (en) 2002-04-18 2005-01-26 Ucb, S.A. Chemical compounds with dual activity, processes for their preparation and pharmaceutical compositions
PE20040892A1 (es) 2002-08-06 2004-11-19 Glaxo Group Ltd Antagonistas del receptor muscarinico m3 de acetilcolina
GB0230045D0 (en) 2002-12-23 2003-01-29 Glaxo Group Ltd Compounds
SI1539753T1 (sl) 2002-09-16 2009-12-31 Glaxo Group Ltd Spojine pirazolo(3,4-B)piridina in njihova uporaba kot inhibitorji fosfodiesteraze
US7232841B2 (en) 2003-04-07 2007-06-19 Glaxo Group Limited M3 muscarinic acetylcholine receptor antagonists
PE20050250A1 (es) 2003-07-17 2005-04-08 Glaxo Group Ltd Antagonistas de los receptores muscarinicos de la acetilcolina
PE20050711A1 (es) 2003-07-17 2005-09-10 Glaxo Group Ltd Compuestos 8-azoniabiciclo[3.2.1] octanos como antagonistas de los receptores muscarinicos de la acetilcolina
TW200523261A (en) 2003-07-17 2005-07-16 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
PE20050963A1 (es) 2003-10-14 2006-01-11 Glaxo Group Ltd Compuestos derivados de 8-azoniabiciclo [3.2.1]octanos como antagonistas de receptores de acetilcolina muscarinicos
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Also Published As

Publication number Publication date
CL2009000250A1 (es) 2009-09-11
IL207352A0 (en) 2010-12-30
KR20100113155A (ko) 2010-10-20
AR070562A1 (es) 2010-04-21
US8084449B2 (en) 2011-12-27
CA2714352A1 (en) 2009-08-13
WO2009100166A1 (en) 2009-08-13
PE20091552A1 (es) 2009-10-25
CN101990401A (zh) 2011-03-23
AU2009212408A1 (en) 2009-08-13
TW201000476A (en) 2010-01-01
EA201070916A1 (ru) 2011-02-28
DOP2010000235A (es) 2011-01-15
US20090203657A1 (en) 2009-08-13
UY31637A1 (es) 2009-08-03
BRPI0908008A2 (pt) 2015-08-18
CR11665A (es) 2011-01-11
EP2259681A4 (en) 2012-04-04
EP2259681A1 (en) 2010-12-15
JP2011511082A (ja) 2011-04-07

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal