MX2010005276A - Proceso de esterilizacion por filtracion en estado diluido para biopolimeros viscoelasticos. - Google Patents
Proceso de esterilizacion por filtracion en estado diluido para biopolimeros viscoelasticos.Info
- Publication number
- MX2010005276A MX2010005276A MX2010005276A MX2010005276A MX2010005276A MX 2010005276 A MX2010005276 A MX 2010005276A MX 2010005276 A MX2010005276 A MX 2010005276A MX 2010005276 A MX2010005276 A MX 2010005276A MX 2010005276 A MX2010005276 A MX 2010005276A
- Authority
- MX
- Mexico
- Prior art keywords
- biopolymers
- viscoelastic
- dilute
- sterilization process
- biopolymer
- Prior art date
Links
- 229920001222 biopolymer Polymers 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 230000001954 sterilising effect Effects 0.000 title abstract 3
- 238000004659 sterilization and disinfection Methods 0.000 title abstract 3
- 238000001914 filtration Methods 0.000 title 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 2
- 229920002674 hyaluronan Polymers 0.000 abstract 2
- 229960003160 hyaluronic acid Drugs 0.000 abstract 2
- 230000015556 catabolic process Effects 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000008174 sterile solution Substances 0.000 abstract 1
- 230000009469 supplementation Effects 0.000 abstract 1
- 238000000108 ultra-filtration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Sustainable Development (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Los productos manufacturados de ácido hialurónico se utilizan en numerosas aplicaciones quirúrgicas que incluyen la complementación viscoelástica para el tratamiento de la osteoartritis, sin embargo, las técnicas de esterilización tradicionales dan por resultado la descomposición de estos biopolímeros viscoelásticos de alto peso molecular y de esta manera son inadecuadas. Se dan a conocer procesos para obtener soluciones estériles, concentradas de biopolímeros de alto peso molecular tal como el ácido hialurónico. Los procesos incluyen la esterilización por filtración con una preparación diluida del biopolímero y la concentración del biopolímero esterilizado por filtración, diluido mediante la ultrafiltración hasta una concentración deseada.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07120568 | 2007-11-13 | ||
PCT/IB2008/003042 WO2009063291A1 (en) | 2007-11-13 | 2008-11-12 | Dilute filtration sterilization process for viscoelastic biopolymers |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2010005276A true MX2010005276A (es) | 2010-08-31 |
MX338879B MX338879B (es) | 2016-05-04 |
Family
ID=39060256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010005276A MX338879B (es) | 2007-11-13 | 2008-11-12 | Proceso de esterilizacion por filtracion en estado diluido para biopolimeros viscoelasticos. |
Country Status (14)
Country | Link |
---|---|
US (3) | US20110130473A1 (es) |
EP (1) | EP2209814B1 (es) |
JP (1) | JP2011503047A (es) |
KR (1) | KR20100094982A (es) |
CN (1) | CN101855248B (es) |
AU (1) | AU2008322629B2 (es) |
CA (1) | CA2705850C (es) |
ES (1) | ES2622834T3 (es) |
IL (1) | IL205402A (es) |
MX (1) | MX338879B (es) |
NZ (1) | NZ584919A (es) |
PL (1) | PL2209814T3 (es) |
RU (1) | RU2501811C2 (es) |
WO (1) | WO2009063291A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101855248B (zh) | 2007-11-13 | 2012-08-22 | 生物技术通用(以色列)有限公司 | 用于粘弹性生物聚合物的稀释过滤灭菌方法 |
ES2762864T3 (es) * | 2008-06-18 | 2020-05-26 | Oxford Biomedica Ltd | Purificación de virus |
US8283463B2 (en) * | 2010-02-09 | 2012-10-09 | Bausch & Lomb Incorporated | Sterile hyaluronic acid solutions |
JP2011195607A (ja) * | 2010-03-17 | 2011-10-06 | Denki Kagaku Kogyo Kk | ヒアルロン酸及び/又はその塩の精製法 |
JP2011195608A (ja) * | 2010-03-17 | 2011-10-06 | Denki Kagaku Kogyo Kk | ヒアルロン酸及び/又はその塩の精製法 |
JP2011195611A (ja) * | 2010-03-17 | 2011-10-06 | Denki Kagaku Kogyo Kk | ヒアルロン酸及び/又はその塩の精製法 |
JP2011195604A (ja) * | 2010-03-17 | 2011-10-06 | Denki Kagaku Kogyo Kk | ヒアルロン酸及び/又はその塩の含有液中の異物除去方法 |
CN102492051B (zh) * | 2011-12-13 | 2013-08-28 | 中南大学 | 玉竹的深加工及综合利用工艺 |
TWI424007B (zh) | 2011-12-22 | 2014-01-21 | Ind Tech Res Inst | 使膠體交聯的方法與藉由此方法形成之經交聯的膠體 |
KR20220028153A (ko) * | 2012-01-20 | 2022-03-08 | 임무노포토닉스 인코퍼레이티드 | 키토산 유래 조성물 |
CN102978257B (zh) * | 2012-12-20 | 2014-12-10 | 江苏久吾高科技股份有限公司 | 一种右旋糖酐的生产方法 |
US10519419B2 (en) * | 2014-01-23 | 2019-12-31 | Nissan Chemical Corporation | Method for producing culture medium composition |
CN104193850A (zh) * | 2014-08-16 | 2014-12-10 | 厦门世达膜科技有限公司 | 一种肝素钠粗品的生产方法 |
CN104804105B (zh) * | 2015-04-08 | 2018-04-27 | 成都郫县新星成明食品研究所 | 采用陶瓷膜过滤法制备卡拉胶的方法 |
MX383146B (es) | 2017-01-11 | 2025-03-13 | Ferring Bv | Composición farmacéutica de disgregación rápida. |
TWI837085B (zh) * | 2017-03-07 | 2024-04-01 | 日商持田製藥股份有限公司 | 海藻酸液劑 |
WO2020016820A1 (en) | 2018-07-18 | 2020-01-23 | Bio-Technology General (Israel) Ltd. | Process of, and arrangement for, sterile filtering a non-newtonian liquid and formulation of a liquid obtainable thereby |
CN110760015B (zh) * | 2019-11-19 | 2022-07-22 | 河北鑫合生物化工有限公司 | 改进的三赞胶的提取方法 |
WO2023219171A1 (ja) * | 2022-05-13 | 2023-11-16 | 合同会社Kortuc Japan | 高粘性溶液の滅菌化・無菌化法 |
WO2025088072A1 (en) | 2023-10-25 | 2025-05-01 | Ferring B.V. | Compositions comprising progesterone and uses thereof |
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US4141973A (en) * | 1975-10-17 | 1979-02-27 | Biotrics, Inc. | Ultrapure hyaluronic acid and the use thereof |
DE3244214A1 (de) * | 1982-11-30 | 1984-05-30 | B. Braun Melsungen Ag, 3508 Melsungen | Verfahren zur reinigung und fraktionierung von heparin |
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FR2569724B1 (fr) | 1984-09-04 | 1991-02-08 | Chisso Corp | Procede pour la preparation d'acide hyaluronique |
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US6660853B2 (en) * | 2000-12-15 | 2003-12-09 | Al Prescott | Method for purifying high molecular weight hyaluronic acid |
WO2004014399A1 (en) | 2002-08-07 | 2004-02-19 | Laboratoire Medidom S.A. | Process for preparing a sterile high molecular weight hyaluronic acid formulation |
RU2280041C1 (ru) * | 2005-04-21 | 2006-07-20 | Общество с ограниченной ответственностью Научно-производственное предприятие "Тульская индустрия ЛТД" | Способ получения водорастворимых солевых комплексов гиалуроновой кислоты (варианты) |
EP1976857A4 (en) * | 2006-01-13 | 2011-08-03 | Baxter Int | PROCESS FOR CLEANING POLYSACCHARIDES |
CN101855248B (zh) | 2007-11-13 | 2012-08-22 | 生物技术通用(以色列)有限公司 | 用于粘弹性生物聚合物的稀释过滤灭菌方法 |
-
2008
- 2008-11-12 CN CN2008801157224A patent/CN101855248B/zh active Active
- 2008-11-12 JP JP2010532673A patent/JP2011503047A/ja active Pending
- 2008-11-12 ES ES08849793.8T patent/ES2622834T3/es active Active
- 2008-11-12 EP EP08849793.8A patent/EP2209814B1/en active Active
- 2008-11-12 AU AU2008322629A patent/AU2008322629B2/en active Active
- 2008-11-12 US US12/742,861 patent/US20110130473A1/en not_active Abandoned
- 2008-11-12 MX MX2010005276A patent/MX338879B/es active IP Right Grant
- 2008-11-12 CA CA2705850A patent/CA2705850C/en active Active
- 2008-11-12 NZ NZ584919A patent/NZ584919A/en unknown
- 2008-11-12 RU RU2010118163/13A patent/RU2501811C2/ru active
- 2008-11-12 KR KR1020107012081A patent/KR20100094982A/ko not_active Ceased
- 2008-11-12 WO PCT/IB2008/003042 patent/WO2009063291A1/en active Application Filing
- 2008-11-12 PL PL08849793T patent/PL2209814T3/pl unknown
-
2010
- 2010-04-28 IL IL205402A patent/IL205402A/en active IP Right Grant
-
2013
- 2013-09-10 US US14/023,196 patent/US9896518B2/en active Active
-
2018
- 2018-01-22 US US15/876,645 patent/US20180142041A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IL205402A (en) | 2015-10-29 |
ES2622834T3 (es) | 2017-07-07 |
RU2010118163A (ru) | 2011-12-20 |
CA2705850A1 (en) | 2009-05-22 |
RU2501811C2 (ru) | 2013-12-20 |
KR20100094982A (ko) | 2010-08-27 |
EP2209814B1 (en) | 2017-01-25 |
MX338879B (es) | 2016-05-04 |
US20180142041A1 (en) | 2018-05-24 |
CA2705850C (en) | 2016-07-19 |
WO2009063291A1 (en) | 2009-05-22 |
PL2209814T3 (pl) | 2017-08-31 |
AU2008322629A1 (en) | 2009-05-22 |
JP2011503047A (ja) | 2011-01-27 |
US9896518B2 (en) | 2018-02-20 |
EP2209814A1 (en) | 2010-07-28 |
US20110130473A1 (en) | 2011-06-02 |
CN101855248B (zh) | 2012-08-22 |
WO2009063291A8 (en) | 2009-09-17 |
US20140018315A1 (en) | 2014-01-16 |
IL205402A0 (en) | 2010-12-30 |
NZ584919A (en) | 2012-05-25 |
CN101855248A (zh) | 2010-10-06 |
AU2008322629B2 (en) | 2013-05-16 |
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