IT1306643B1 - Processo per la preparazione dei composti autoreticolati dell'acidoialuronico e dei suoi derivati ottenibili mediante la tecnica - Google Patents

Processo per la preparazione dei composti autoreticolati dell'acidoialuronico e dei suoi derivati ottenibili mediante la tecnica

Info

Publication number: IT1306643B1
Authority: IT; Italy
Prior art keywords: technique; preparation; hyaluronic acid; self; cross
Prior art date: 1999-04-08

Application number

IT1999PD000070A

Other languages

English (en)

Inventor

Paolo Pallado

Marco Baggio

Carbonare Maurizio Dalle

Lanfranco Callegaro

Original Assignee

Fidia Advanced Biopolymers Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-08

Filing date

1999-04-08

Publication date

2001-10-02

1999-04-08 Priority to IT1999PD000070A priority Critical patent/IT1306643B1/it

1999-04-08 Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl

2000-03-30 Priority to DE60011062T priority patent/DE60011062D1/de

2000-03-30 Priority to PCT/EP2000/002814 priority patent/WO2000061640A1/en

2000-03-30 Priority to US09/958,147 priority patent/US6552184B1/en

2000-03-30 Priority to CA002369275A priority patent/CA2369275C/en

2000-03-30 Priority to EP00929332A priority patent/EP1165619B1/en

2000-03-30 Priority to AU47459/00A priority patent/AU769657B2/en

2000-03-30 Priority to JP2000611580A priority patent/JP2002542316A/ja

2000-03-30 Priority to AT00929332T priority patent/ATE267843T1/de

2000-10-08 Publication of ITPD990070A1 publication Critical patent/ITPD990070A1/it

2001-10-02 Application granted granted Critical

2001-10-02 Publication of IT1306643B1 publication Critical patent/IT1306643B1/it

Links

238000000034 method Methods 0.000 title abstract 3
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title abstract 2
229920002674 hyaluronan Polymers 0.000 title abstract 2
229960003160 hyaluronic acid Drugs 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
239000012296 anti-solvent Substances 0.000 abstract 1
239000012620 biological material Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
238000001356 surgical procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Polymers & Plastics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Materials Engineering (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Materials For Medical Uses (AREA)

IT1999PD000070A 1999-04-08 1999-04-08 Processo per la preparazione dei composti autoreticolati dell'acidoialuronico e dei suoi derivati ottenibili mediante la tecnica IT1306643B1 (it)

Priority Applications (9)

Application Number	Priority Date	Filing Date	Title
IT1999PD000070A IT1306643B1 (it)	1999-04-08	1999-04-08	Processo per la preparazione dei composti autoreticolati dell'acidoialuronico e dei suoi derivati ottenibili mediante la tecnica
PCT/EP2000/002814 WO2000061640A1 (en)	1999-04-08	2000-03-30	Process for the preparation of autocrosslinked compounds of hyaluronic acid and the derivatives thereof by the supercritical antisolvent technique
US09/958,147 US6552184B1 (en)	1999-04-08	2000-03-30	Process for the preparation of autocrosslinked compounds of hyaluronic acid and the derivatives thereof by the supercritical antisolvent technique
CA002369275A CA2369275C (en)	1999-04-08	2000-03-30	Process for the preparation of autocrosslinked compounds of hyaluronic acid and the derivatives thereof by the supercritical antisolvent technique
DE60011062T DE60011062D1 (de)	1999-04-08	2000-03-30	Verfahren zur herstellung von selbstvernetzten hyaluronsäuren und deren derivaten mittels superkritischer anti-lösungsmittel
EP00929332A EP1165619B1 (en)	1999-04-08	2000-03-30	Process for the preparation of autocrosslinked compounds of hyaluronic acid and the derivatives thereof by the supercritical antisolvent technique
AU47459/00A AU769657B2 (en)	1999-04-08	2000-03-30	Process for the preparation of autocrosslinked compounds of hyaluronic acid and the derivatives thereof by the supercritical antisolvent technique
JP2000611580A JP2002542316A (ja)	1999-04-08	2000-03-30	超臨界抗溶媒技術による、ヒアルロン酸及びその誘導体の、自己架橋した化合物の製造方法
AT00929332T ATE267843T1 (de)	1999-04-08	2000-03-30	Verfahren zur herstellung von selbstvernetzten hyaluronsäuren und deren derivaten mittels superkritischer anti-lösungsmittel

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT1999PD000070A IT1306643B1 (it)	1999-04-08	1999-04-08	Processo per la preparazione dei composti autoreticolati dell'acidoialuronico e dei suoi derivati ottenibili mediante la tecnica

Publications (2)

Publication Number	Publication Date
ITPD990070A1 ITPD990070A1 (it)	2000-10-08
IT1306643B1 true IT1306643B1 (it)	2001-10-02

Family

ID=11392546

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT1999PD000070A IT1306643B1 (it)	1999-04-08	1999-04-08	Processo per la preparazione dei composti autoreticolati dell'acidoialuronico e dei suoi derivati ottenibili mediante la tecnica

Country Status (9)

Country	Link
US (1)	US6552184B1 (it)
EP (1)	EP1165619B1 (it)
JP (1)	JP2002542316A (it)
AT (1)	ATE267843T1 (it)
AU (1)	AU769657B2 (it)
CA (1)	CA2369275C (it)
DE (1)	DE60011062D1 (it)
IT (1)	IT1306643B1 (it)
WO (1)	WO2000061640A1 (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE376824T1 (de)	1999-01-13	2007-11-15	Alchemia Oncology Pty Ltd	Verwendung von hyaluronan zur herstellung eines medikaments zur erhöhung der wirksamkeit von zytotoxischen arzneimitteln
US9066919B2 (en) *	2000-07-14	2015-06-30	Alchemia Oncology Pty Limited	Hyaluronan as a chemo-sensitizer in the treatment of cancer
AUPQ879500A0 (en) *	2000-07-14	2000-08-10	Meditech Research Limited	Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
EP1427447A4 (en) *	2001-08-27	2007-05-23	Alchemia Oncology Ltd	IMPROVED THERAPEUTIC PROTOCOLS
AU2006274509B2 (en)	2005-07-27	2012-01-19	Alchemia Oncology Pty Limited	Therapeutic protocols using hyaluronan
EP2772260A3 (en)	2005-09-07	2014-10-15	Alchemia Oncology Pty Limited	Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment
EP1942117A1 (en) *	2006-12-29	2008-07-09	Sigea S.R.L.	Derivatives of acid polysaccharides
PL2209814T3 (pl) *	2007-11-13	2017-08-31	Bio-Technology General (Israel) Ltd.	Proces sterylizacji przez filtrację z rozcieńczaniem dla lepkosprężystych biopolimerów
WO2020016820A1 (en)	2018-07-18	2020-01-23	Bio-Technology General (Israel) Ltd.	Process of, and arrangement for, sterile filtering a non-newtonian liquid and formulation of a liquid obtainable thereby

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1219587B (it) *	1988-05-13	1990-05-18	Fidia Farmaceutici	Polisaccaridi carbossiilici autoreticolati
ATE212545T1 (de) *	1995-03-28	2002-02-15	Fidia Advanced Biopolymers Srl	Nanosphären mit einem biokompatiblen polysaccharid
US5833891A (en) *	1996-10-09	1998-11-10	The University Of Kansas	Methods for a particle precipitation and coating using near-critical and supercritical antisolvents
WO1997031691A1 (en) *	1996-03-01	1997-09-04	The University Of Kansas	Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
IT1287698B1 (it) *	1996-08-29	1998-08-18	Fidia Advanced Biopolymers Srl	Fili da sutura essenzialmente costituiti da derivati esterei dello acido ialuronico

1999
- 1999-04-08 IT IT1999PD000070A patent/IT1306643B1/it active
2000
- 2000-03-30 DE DE60011062T patent/DE60011062D1/de not_active Expired - Lifetime
- 2000-03-30 EP EP00929332A patent/EP1165619B1/en not_active Expired - Lifetime
- 2000-03-30 AU AU47459/00A patent/AU769657B2/en not_active Ceased
- 2000-03-30 JP JP2000611580A patent/JP2002542316A/ja active Pending
- 2000-03-30 US US09/958,147 patent/US6552184B1/en not_active Expired - Fee Related
- 2000-03-30 WO PCT/EP2000/002814 patent/WO2000061640A1/en active IP Right Grant
- 2000-03-30 AT AT00929332T patent/ATE267843T1/de not_active IP Right Cessation
- 2000-03-30 CA CA002369275A patent/CA2369275C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1165619A1 (en)	2002-01-02
AU769657B2 (en)	2004-01-29
US6552184B1 (en)	2003-04-22
CA2369275A1 (en)	2000-10-19
EP1165619B1 (en)	2004-05-26
CA2369275C (en)	2009-02-03
ATE267843T1 (de)	2004-06-15
AU4745900A (en)	2000-11-14
WO2000061640A1 (en)	2000-10-19
DE60011062D1 (de)	2004-07-01
JP2002542316A (ja)	2002-12-10
ITPD990070A1 (it)	2000-10-08

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