MX2010001774A - Pirrolidin aril-eteres como antagonistas de receptores de nk3. - Google Patents
Pirrolidin aril-eteres como antagonistas de receptores de nk3.Info
- Publication number
- MX2010001774A MX2010001774A MX2010001774A MX2010001774A MX2010001774A MX 2010001774 A MX2010001774 A MX 2010001774A MX 2010001774 A MX2010001774 A MX 2010001774A MX 2010001774 A MX2010001774 A MX 2010001774A MX 2010001774 A MX2010001774 A MX 2010001774A
- Authority
- MX
- Mexico
- Prior art keywords
- sub
- lower alkyl
- hydrogen
- halogen
- membered heteroaryl
- Prior art date
Links
- 102000002003 Neurokinin-3 Receptors Human genes 0.000 title abstract 2
- 108010040716 Neurokinin-3 Receptors Proteins 0.000 title abstract 2
- -1 Pyrrolidine aryl-ether Chemical class 0.000 title abstract 2
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 2
- 125000000217 alkyl group Chemical group 0.000 abstract 12
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invención se refiere a un compuesto de fórmula general I en donde Ar es arilo o un heteroarilo de cinco o seis miembros; (ver fórmula) es un grupo mono- o bi-heterocíclico de seis a nueve miembros, en donde X puede ser un átomo de carbono, SO2 o además un heteroátomo seleccionado entre el grupo consistente por N y O; si X es un átomo de carbono, O, SO2 o N sin sustituir, entonces R1 es hidrógeno, hidroxi, ciano, -(CH2)q-OH,-(CH2)q-NRR´, -(CH2)q-CN, alquilo inferior, -S(O)2-alquilo inferior, -NR-S(O)2-alquilo inferior, -C(O)alquilo inferior, -NR-C(O)-alquilo interior, fenilo, o es un grupo heterocíclico seleccionado entre piperidinil-2-ona; si X es un átomo de N sustituido por R1, entonces R1 es hidrógeno, -(CH2)q-OH, -(CH2)q-NRR´, -(CH2)q-CN, alquilo inferior, -S(O)2-alquilo inferior, arilo o un heteroarilo de cinco o seis miembros o -C(O)-alquilo interior, con la condición de que q sea 2 ó 3. R/R´ son independientemente uno de otro hidrógeno o alquilo inferior; R2 es hidrógeno, halógeno, alquilo inferior, ciano, alcoxi interior sustituido por halógeno, alquilo inferior sustituido por halógeno o es un heteroarilo de cinco o seis miembros; R3 es hidrógeno o halógeno; R4 es hidrógeno o alquilo inferior; n es 1 ó 2; en caso de que n sea 2, R1 puede ser el mismo o diferente; o es 1 ó 2; en caso de que o sea 2, R2 puede ser el mismo o diferente; p es 1 ó 2; en caso de que p sea 2, R3 puede ser el mismo o diferente; q es 1, 2 ó 3; s es 0, 1, 2,3 ó 4; o a una sal farmacéuticamente activa de lo mismo. La invención incluye a todas las formas estereoisoméricas, incluidos los diastereoisómeros y enantiómeros individuales del compuesto de fórmula (1) así como a las mezclas racémicas y no racémicas de lo mismo. Se ha encontrado que los compuestos presentes tienen un gran potencial como antagonistas de receptores de NK-3 para el tratamiento de la depresión, dolor, psicosis, enfermedad de Parkinson, esquizofrenia, ansiedad y el trastorno de hiperactividad con déficit de atención (ADHD).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07114790 | 2007-08-22 | ||
| PCT/EP2008/060566 WO2009024502A1 (en) | 2007-08-22 | 2008-08-12 | Pyrrolidine aryl-ether as nk3 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010001774A true MX2010001774A (es) | 2010-03-10 |
Family
ID=39870345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010001774A MX2010001774A (es) | 2007-08-22 | 2008-08-12 | Pirrolidin aril-eteres como antagonistas de receptores de nk3. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7812021B2 (es) |
| EP (1) | EP2190815B1 (es) |
| JP (1) | JP2010536818A (es) |
| KR (1) | KR101194467B1 (es) |
| CN (1) | CN101861302A (es) |
| AR (1) | AR067991A1 (es) |
| AT (1) | ATE519738T1 (es) |
| AU (1) | AU2008290634B2 (es) |
| BR (1) | BRPI0815674A2 (es) |
| CA (1) | CA2697325A1 (es) |
| CL (1) | CL2008002450A1 (es) |
| ES (1) | ES2369955T3 (es) |
| MX (1) | MX2010001774A (es) |
| PE (1) | PE20090621A1 (es) |
| RU (1) | RU2010108687A (es) |
| TW (1) | TW200916462A (es) |
| WO (1) | WO2009024502A1 (es) |
| ZA (1) | ZA201001125B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8063075B2 (en) * | 2008-06-10 | 2011-11-22 | Hoffmann-La Roche Inc. | Pyrrolidine ether derivatives as NK3 receptor antagonists |
| JP2012505173A (ja) * | 2008-10-09 | 2012-03-01 | エフ．ホフマン−ラ ロシュ アーゲー | ピロリジンｎ−ベンジル誘導体 |
| KR101372743B1 (ko) | 2009-01-30 | 2014-03-14 | 에프. 호프만-라 로슈 아게 | Ｎｋ3 수용체 길항제로서 피페리딘 유도체 |
| US8318759B2 (en) * | 2009-02-18 | 2012-11-27 | Hoffmann-La Roche Inc. | Pyrrolidine derivatives as NK3 receptor antagonists |
| SA110310332B1 (ar) | 2009-05-01 | 2013-12-10 | Astrazeneca Ab | مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل ) |
| US8394834B2 (en) | 2009-08-25 | 2013-03-12 | Hoffman-La Roche Inc. | Pyrrolidines as NK3 receptor antagonists |
| US20110144081A1 (en) | 2009-12-15 | 2011-06-16 | Henner Knust | Pyrrolidine derivatives |
| US20110152233A1 (en) * | 2009-12-18 | 2011-06-23 | Henner Knust | Pyrrolidine compounds |
| AU2011275547B2 (en) | 2010-07-06 | 2015-10-29 | Astrazeneca Ab | Therapeutic agents 976 |
| US8507535B2 (en) * | 2010-07-07 | 2013-08-13 | Hoffmann-La Roche Inc. | Methyl-pyrrolidine ether derivatives |
| US8618303B2 (en) * | 2011-01-07 | 2013-12-31 | Hoffmann-La Roche Inc. | Pyrrolidine derivatives |
| UY34194A (es) | 2011-07-15 | 2013-02-28 | Astrazeneca Ab | ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad? |
| KR20190129867A (ko) * | 2017-02-17 | 2019-11-20 | 트레베나, 인코포레이티드. | 5-원 아자-헤테로고리 함유 델타-오피오이드 수용체 조절 화합물, 및 그의 사용 및 제조 방법 |
| BR112019016775A2 (pt) | 2017-02-17 | 2020-03-31 | Trevena, Inc. | Compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 7 membros, métodos de uso e produção dos mesmos |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN148482B (es) | 1977-06-03 | 1981-03-07 | Pfizer | |
| GB9321557D0 (en) | 1992-11-03 | 1993-12-08 | Zeneca Ltd | Carboxamide derivatives |
| EP0714891A1 (en) * | 1994-11-22 | 1996-06-05 | Eli Lilly And Company | Heterocyclic tachykinin receptor antagonists |
| EP0946548B1 (en) * | 1996-12-19 | 2002-03-06 | Aventis Pharmaceuticals Inc. | Novel heterocyclic substituted pyrrolidine amide derivatives |
| AU2004277932B2 (en) * | 2003-09-30 | 2009-07-16 | Merck & Co., Inc. | Phenyl pyrrolidine ether tachykinin receptor antagonists |
| US7138423B2 (en) * | 2004-07-20 | 2006-11-21 | Bristol-Myers Squibb Company | Arylpyrrolidine derivatives as NK-1 /SSRI antagonists |
| CN101061104A (zh) * | 2004-11-22 | 2007-10-24 | 默克公司 | 哌啶基哌啶速激肽受体拮抗剂 |
| WO2006073589A2 (en) * | 2004-11-22 | 2006-07-13 | Merck & Co., Inc. | Cycloalkyl keto piperidine tachykinin receptor antagonists |
| AU2008285718A1 (en) * | 2007-08-07 | 2009-02-12 | F. Hoffmann-La Roche Ag | Pyrrolidine aryl-ether as NK3 receptor antagonists |
-
2008
- 2008-08-12 KR KR1020107006058A patent/KR101194467B1/ko not_active Expired - Fee Related
- 2008-08-12 CN CN200880103704A patent/CN101861302A/zh active Pending
- 2008-08-12 AT AT08787130T patent/ATE519738T1/de active
- 2008-08-12 JP JP2010521396A patent/JP2010536818A/ja active Pending
- 2008-08-12 WO PCT/EP2008/060566 patent/WO2009024502A1/en active Application Filing
- 2008-08-12 EP EP08787130A patent/EP2190815B1/en not_active Not-in-force
- 2008-08-12 BR BRPI0815674-3A2A patent/BRPI0815674A2/pt not_active IP Right Cessation
- 2008-08-12 RU RU2010108687/04A patent/RU2010108687A/ru not_active Application Discontinuation
- 2008-08-12 AU AU2008290634A patent/AU2008290634B2/en not_active Expired - Fee Related
- 2008-08-12 MX MX2010001774A patent/MX2010001774A/es active IP Right Grant
- 2008-08-12 CA CA2697325A patent/CA2697325A1/en not_active Abandoned
- 2008-08-12 ES ES08787130T patent/ES2369955T3/es active Active
- 2008-08-20 CL CL2008002450A patent/CL2008002450A1/es unknown
- 2008-08-21 TW TW097131984A patent/TW200916462A/zh unknown
- 2008-08-21 AR ARP080103635A patent/AR067991A1/es unknown
- 2008-08-21 PE PE2008001420A patent/PE20090621A1/es not_active Application Discontinuation
- 2008-08-21 US US12/195,545 patent/US7812021B2/en not_active Expired - Fee Related
-
2010
- 2010-02-16 ZA ZA201001125A patent/ZA201001125B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2697325A1 (en) | 2009-02-26 |
| CL2008002450A1 (es) | 2009-07-31 |
| ATE519738T1 (de) | 2011-08-15 |
| AU2008290634A1 (en) | 2009-02-26 |
| AR067991A1 (es) | 2009-10-28 |
| BRPI0815674A2 (pt) | 2015-02-18 |
| PE20090621A1 (es) | 2009-05-16 |
| EP2190815B1 (en) | 2011-08-10 |
| TW200916462A (en) | 2009-04-16 |
| AU2008290634B2 (en) | 2012-12-06 |
| ZA201001125B (en) | 2010-10-27 |
| KR101194467B1 (ko) | 2012-10-24 |
| CN101861302A (zh) | 2010-10-13 |
| WO2009024502A1 (en) | 2009-02-26 |
| US7812021B2 (en) | 2010-10-12 |
| ES2369955T3 (es) | 2011-12-09 |
| US20090054644A1 (en) | 2009-02-26 |
| EP2190815A1 (en) | 2010-06-02 |
| RU2010108687A (ru) | 2011-09-27 |
| JP2010536818A (ja) | 2010-12-02 |
| KR20100043105A (ko) | 2010-04-27 |
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