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MX2009010060A - Compuestos moduladores del receptor de esfingosin-1-fosfato y uso de los mismos. - Google Patents

Compuestos moduladores del receptor de esfingosin-1-fosfato y uso de los mismos.

Info

Publication number
MX2009010060A
MX2009010060A MX2009010060A MX2009010060A MX2009010060A MX 2009010060 A MX2009010060 A MX 2009010060A MX 2009010060 A MX2009010060 A MX 2009010060A MX 2009010060 A MX2009010060 A MX 2009010060A MX 2009010060 A MX2009010060 A MX 2009010060A
Authority
MX
Mexico
Prior art keywords
compounds
hepatitis
disease
treating
receptor modulating
Prior art date
Application number
MX2009010060A
Other languages
English (en)
Inventor
Zhaoda Zhang
Xiang Y Yu
Victor J Cee
Roland Burli
Jian Lin
Srinivasa R Cheruku
Nili Schutz
Ashis Saha
Oren Becker
Jennifer Golden
Brian Alan Lanman
Susana Neira
Dilara Mccauley
Pini Orbach
Robert C Penland
Kimberley Gannon
Silvia Noiman
Mercedes Lobera
Anurag Sharadendu
Sharon Shacham
Original Assignee
Epix Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epix Pharm Inc filed Critical Epix Pharm Inc
Publication of MX2009010060A publication Critical patent/MX2009010060A/es

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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Urology & Nephrology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a compuestos de la fórmula general (I) que tienen actividad como agentes moduladores del receptor de S1P y al uso de estos compuestos para tratar enfermedades asociadas con actividad inadecuada del receptor de S1P. Los compuestos pueden usarse como inmunomoduladores, por ejemplo, para tratar o prevenir enfermedades tales como trastornos autoinmunes e inmunitarios relacionados incluyendo lupus eritematoso sistémico, enfermedades inflamatorias del intestino tales como enferedad de Crohn y colitis ulcerosa, diabetes tipo I, uveítis, psoriasis, maistenia grave, artritis reumatoide, nefrosis no glomerular, hepatitis, enfermedad de Behcet, glomerulonefritis, púrpura trombocitopénica crónica, anemia hemolítica, hepatitis y granuloma de Wegner; y para tratar otras afecciones.
MX2009010060A 2007-03-21 2007-03-21 Compuestos moduladores del receptor de esfingosin-1-fosfato y uso de los mismos. MX2009010060A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2007/007044 WO2007109334A2 (en) 2006-03-21 2007-03-21 Sip receptor modulating compounds and use thereof

Publications (1)

Publication Number Publication Date
MX2009010060A true MX2009010060A (es) 2010-01-20

Family

ID=41091586

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009010060A MX2009010060A (es) 2007-03-21 2007-03-21 Compuestos moduladores del receptor de esfingosin-1-fosfato y uso de los mismos.

Country Status (6)

Country Link
EP (2) EP2121648A2 (es)
JP (1) JP5191497B2 (es)
AU (1) AU2007227278B2 (es)
CA (1) CA2679980A1 (es)
MX (1) MX2009010060A (es)
WO (1) WO2007109334A2 (es)

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WO2007109334B1 (en) 2008-03-27
AU2007227278A1 (en) 2007-09-27
EP2364976B1 (en) 2014-10-08
WO2007109334A3 (en) 2008-01-10
EP2121648A2 (en) 2009-11-25
JP5191497B2 (ja) 2013-05-08
AU2007227278B2 (en) 2014-09-11

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