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MX2007014619A - Pirrolopiridinas de utilidad como inhibidores de proteina quinasa. - Google Patents

Pirrolopiridinas de utilidad como inhibidores de proteina quinasa.

Info

Publication number
MX2007014619A
MX2007014619A MX2007014619A MX2007014619A MX2007014619A MX 2007014619 A MX2007014619 A MX 2007014619A MX 2007014619 A MX2007014619 A MX 2007014619A MX 2007014619 A MX2007014619 A MX 2007014619A MX 2007014619 A MX2007014619 A MX 2007014619A
Authority
MX
Mexico
Prior art keywords
sup
inhibitors
protein kinase
useful
pyrrolopyridines
Prior art date
Application number
MX2007014619A
Other languages
English (en)
Inventor
Tiansheng Wang
Jian Wang
Gabriel Martinez-Botella
Francesco G Salituro
Mark W Ledeboer
Albert C Pierce
Guy W Bemis
Luc J Farmer
Marion W Wannamaker
Randy S Bethiel
Michael J Arnost
John H Come
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MX2007014619A publication Critical patent/MX2007014619A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)

Abstract

La presente invención se relaciona con compuestos de la fórmula (I) en donde Q, Z, R1, R2 y R3 son como se describe en la reivindicación 1 útiles como inhibidores de proteínas cinasas, en particular las cinasas de la familia JAK y la familia ROCK. La invención también proporciona las composiciones farmacéuticamente aceptables que comprenden los compuestos y métodos para utilizar las composiciones en el tratamiento de diversas enfermedades, condiciones, o trastornos.
MX2007014619A 2005-05-20 2006-05-22 Pirrolopiridinas de utilidad como inhibidores de proteina quinasa. MX2007014619A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68355405P 2005-05-20 2005-05-20
PCT/US2006/019711 WO2006127587A1 (en) 2005-05-20 2006-05-22 Pyrrolopyridines useful as inhibitors of protein kinase

Publications (1)

Publication Number Publication Date
MX2007014619A true MX2007014619A (es) 2009-02-13

Family

ID=36940144

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007014619A MX2007014619A (es) 2005-05-20 2006-05-22 Pirrolopiridinas de utilidad como inhibidores de proteina quinasa.

Country Status (16)

Country Link
US (1) US8921376B2 (es)
EP (3) EP1881983B1 (es)
JP (3) JP2008545660A (es)
KR (1) KR20080016659A (es)
CN (1) CN101228161B (es)
AT (1) ATE540948T1 (es)
AU (1) AU2006251623A1 (es)
CA (1) CA2609126A1 (es)
ES (1) ES2380795T3 (es)
IL (1) IL187438A0 (es)
MX (1) MX2007014619A (es)
NO (1) NO20076502L (es)
NZ (1) NZ564065A (es)
RU (2) RU2435769C2 (es)
WO (1) WO2006127587A1 (es)
ZA (1) ZA200710379B (es)

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ATE540948T1 (de) 2012-01-15
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IL187438A0 (en) 2008-02-09
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NO20076502L (no) 2008-02-19
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US20070135466A1 (en) 2007-06-14
US8921376B2 (en) 2014-12-30

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