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MX174433B - Proceso para preparar 3-arilcarbonil-1h-indol y producto obtenido - Google Patents

Proceso para preparar 3-arilcarbonil-1h-indol y producto obtenido

Info

Publication number
MX174433B
MX174433B MX024839A MX2483991A MX174433B MX 174433 B MX174433 B MX 174433B MX 024839 A MX024839 A MX 024839A MX 2483991 A MX2483991 A MX 2483991A MX 174433 B MX174433 B MX 174433B
Authority
MX
Mexico
Prior art keywords
indol
prepare
product obtained
aryl carbonyl
naphthyl
Prior art date
Application number
MX024839A
Other languages
English (en)
Other versions
MX24839A (es
Inventor
Susan Jean Ward
Malcolm Rice Bell
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of MX24839A publication Critical patent/MX24839A/es
Publication of MX174433B publication Critical patent/MX174433B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a un compuesto que tiene la fórmula: caracterizado porque R2 es hidrógeno o alquilo inferior; y R3 es alcoximetilfenilo inferior, bencilo, alcoxiestiril inferior, (1H-imidazol-1-il)naftil, 2-(1-naftil)etenil, 1-(1,2,3,4-tetra-hidronaftil), antrilo, fenantrilo o pirenilo; y sales de adición ácida del mismo.
MX024839A 1990-03-08 1991-03-08 Proceso para preparar 3-arilcarbonil-1h-indol y producto obtenido MX174433B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49020190A 1990-03-08 1990-03-08

Publications (2)

Publication Number Publication Date
MX24839A MX24839A (es) 1993-10-01
MX174433B true MX174433B (es) 1994-05-16

Family

ID=23947024

Family Applications (1)

Application Number Title Priority Date Filing Date
MX024839A MX174433B (es) 1990-03-08 1991-03-08 Proceso para preparar 3-arilcarbonil-1h-indol y producto obtenido

Country Status (21)

Country Link
EP (1) EP0445781B1 (es)
JP (1) JP3157179B2 (es)
KR (1) KR0183396B1 (es)
AT (1) ATE133663T1 (es)
AU (1) AU643757B2 (es)
CA (1) CA2036307C (es)
DE (1) DE69116705T2 (es)
DK (1) DK0445781T3 (es)
ES (1) ES2082872T3 (es)
FI (1) FI95369C (es)
GR (1) GR3019058T3 (es)
HU (1) HU215125B (es)
IE (1) IE72953B1 (es)
IL (1) IL97426A (es)
MX (1) MX174433B (es)
MY (1) MY106109A (es)
NO (1) NO179612C (es)
NZ (1) NZ237309A (es)
PH (1) PH27022A (es)
PT (1) PT96938B (es)
RU (1) RU2073670C1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5068234A (en) * 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
GB9204365D0 (en) * 1992-02-28 1992-04-08 Pfizer Ltd Indoles
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2713225B1 (fr) * 1993-12-02 1996-03-01 Sanofi Sa N-pipéridino-3-pyrazolecarboxamide substitué.
FR2713224B1 (fr) * 1993-12-02 1996-03-01 Sanofi Sa N-pipéridino-3-pyrazolecarboxamide substitué.
ES2099007B1 (es) * 1993-07-16 1997-12-01 Pfizer Res & Dev Derivados de indol.
FR2714057B1 (fr) * 1993-12-17 1996-03-08 Sanofi Elf Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant.
SK16332000A3 (sk) * 1998-05-01 2001-06-11 Eli Lilly And Company Ester ako inhibítor spla2
ATE247963T1 (de) * 1998-05-26 2003-09-15 Pfizer Prod Inc Medikament zur behandlung von glaukoma und ischämischer retinopathie
AU2042301A (en) * 1999-12-03 2001-06-12 Alcon Universal Limited 1-aminoalkyl-1H-indoles for treating glaucoma
US6545036B2 (en) * 2000-01-18 2003-04-08 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
CA2399791A1 (en) * 2000-02-11 2001-08-16 Bristol-Myers Squibb Company Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases
TWI231757B (en) * 2001-09-21 2005-05-01 Solvay Pharm Bv 1H-Imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity
AR038966A1 (es) * 2002-03-18 2005-02-02 Solvay Pharm Bv Derivados de tiazol que tienen actividad antagonista, agonista o agonista parcial de cb1
SE0203070D0 (en) 2002-10-16 2002-10-16 Astrazeneca Ab Novel compounds
TW200508197A (en) * 2003-03-31 2005-03-01 Ucb Sa Indolone-acetamide derivatives, processes for preparing them and their uses
RU2376302C2 (ru) * 2004-03-05 2009-12-20 Н.В.Органон Производные (индол-3-ил)гетероциклических соединений в качестве агонистов каннабиноидных рецепторов св1
JP5047940B2 (ja) * 2005-03-12 2012-10-10 ユニリーバー・ナームローゼ・ベンノートシヤープ アミノ−オキソ−インドール−イリデン化合物を含む頭髪および／または頭皮ケア組成物
FR2893615B1 (fr) * 2005-11-18 2008-03-07 Sanofi Aventis Sa Derives de 3-acylindole, leur preparation et leur application en therapeutique
RU2404185C1 (ru) * 2009-04-16 2010-11-20 Учреждение Российской академии наук Институт молекулярной генетики РАН (ИМГ РАН) РАВНОМЕРНО МЕЧЕННЫЙ ТРИТИЕМ (R)-(+)-[5-МЕТИЛ-3-(4-МОРФОЛИНИЛМЕТИЛ)-2,3-ДИГИДРО-[1,4]ОКСАЗИНО [2,3,4-hi]-6-ИНДОЛИЛ]-1-НАФТАЛИНИЛМЕТАНОН АЦЕТАТ
JP6025234B1 (ja) * 2016-03-10 2016-11-16 株式会社サンライフ 箸における箸置き形成方法及び箸置き機能を有する箸
CN107628981B (zh) * 2017-10-31 2019-07-30 威海市妇女儿童医院 一种肉桂酰基吲哚啉化合物及其制备青光眼药物的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1436771A (en) * 1973-02-16 1976-05-26 Labaz Indole derivatives and process for preparing the same
US4581354A (en) * 1984-08-06 1986-04-08 Sterling Drug Inc. 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use
US4634776A (en) * 1984-08-06 1987-01-06 Sterling Drug, Inc. 3-arylcarbonyl-and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles
US4634698A (en) * 1984-09-24 1987-01-06 Schering Corporation Antiglaucoma agents
DE3821148A1 (de) * 1988-06-23 1989-12-28 Erwin Von Dr Angerer Aminoalkylindole, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate

Also Published As

Publication number Publication date
NO910868D0 (no) 1991-03-05
JPH04235164A (ja) 1992-08-24
RU2073670C1 (ru) 1997-02-20
GR3019058T3 (en) 1996-05-31
AU7266991A (en) 1991-09-12
PH27022A (en) 1993-02-01
DE69116705T2 (de) 1996-09-26
MX24839A (es) 1993-10-01
IL97426A (en) 1996-03-31
DE69116705D1 (de) 1996-03-14
FI95369B (fi) 1995-10-13
JP3157179B2 (ja) 2001-04-16
DK0445781T3 (da) 1996-02-19
AU643757B2 (en) 1993-11-25
EP0445781A1 (en) 1991-09-11
IE72953B1 (en) 1997-05-07
CA2036307A1 (en) 1991-09-09
KR910016745A (ko) 1991-11-05
ES2082872T3 (es) 1996-04-01
NZ237309A (en) 1993-02-25
FI95369C (fi) 1996-01-25
NO910868L (no) 1991-09-09
FI911131L (fi) 1991-09-09
HU215125B (hu) 1998-09-28
EP0445781B1 (en) 1996-01-31
NO179612B (no) 1996-08-05
IE910700A1 (en) 1991-09-11
FI911131A0 (fi) 1991-03-06
CA2036307C (en) 2002-07-09
MY106109A (en) 1995-03-31
KR0183396B1 (ko) 1999-05-01
ATE133663T1 (de) 1996-02-15
PT96938B (pt) 1998-07-31
IL97426A0 (en) 1992-06-21
NO179612C (no) 1996-11-13
HUT56492A (en) 1991-09-30
PT96938A (pt) 1991-10-31

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