MX168415B - Procedimiento para la preparacion de derivados de silibinina - Google Patents

Procedimiento para la preparacion de derivados de silibinina

Info

Publication number: MX168415B
Authority: MX; Mexico
Prior art keywords: independently; ethyl acetate; weight; ethanol; alkali metal
Prior art date: 1984-11-22

Application number

MX009022A

Other languages

English (en)

Spanish (es)

Inventor

Hartwig Soicke

Karlheinz Schmidt

Reinhard Braatz

Klaus Gorler

Gunter Halbach

Original Assignee

Madaus Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-11-22

Filing date

1985-11-22

Publication date

1993-05-24

1985-11-22 Application filed by Madaus Ag filed Critical Madaus Ag

1993-05-24 Publication of MX168415B publication Critical patent/MX168415B/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Silicon Compounds (AREA)

MX009022A 1984-11-22 1985-11-22 Procedimiento para la preparacion de derivados de silibinina MX168415B (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19843442639 DE3442639A1 (de)	1984-11-22	1984-11-22	Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten

Publications (1)

Publication Number	Publication Date
MX168415B true MX168415B (es)	1993-05-24

Family

ID=6250903

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MX009022A MX168415B (es)	1984-11-22	1985-11-22	Procedimiento para la preparacion de derivados de silibinina

Country Status (29)

Country	Link
JP (1)	JPS61143377A (sv)
KR (1)	KR870001020B1 (sv)
AR (1)	AR240931A1 (sv)
AT (1)	AT393268B (sv)
BE (1)	BE903693A (sv)
CA (1)	CA1337124C (sv)
CH (1)	CH659473A5 (sv)
CS (1)	CS273610B2 (sv)
DD (1)	DD259191A1 (sv)
DE (1)	DE3442639A1 (sv)
DK (1)	DK164865C (sv)
EG (1)	EG19424A (sv)
ES (1)	ES8609311A1 (sv)
FI (1)	FI84064C (sv)
FR (1)	FR2573427B1 (sv)
GB (1)	GB2167414B (sv)
HU (1)	HU195503B (sv)
IE (1)	IE58791B1 (sv)
IT (1)	IT1190426B (sv)
LU (1)	LU86163A1 (sv)
MX (1)	MX168415B (sv)
NL (1)	NL192387C (sv)
NO (1)	NO160205C (sv)
PL (1)	PL146890B1 (sv)
PT (1)	PT81532B (sv)
SE (1)	SE465676B (sv)
SU (1)	SU1436875A3 (sv)
YU (1)	YU43689B (sv)
ZA (1)	ZA858951B (sv)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8716918D0 (en) *	1987-07-17	1987-08-26	Inverni Della Beffa Spa	Soluble derivatives of silybin
US5262439A (en) *	1992-04-30	1993-11-16	The Regents Of The University Of California	Soluble analogs of probucol
DK1856085T3 (en) *	2005-03-11	2015-10-05	Howard Florey Inst Pty Ltd	FLAVONOID COMPOUNDS AND APPLICATIONS THEREOF
RU2482844C2 (ru) *	2007-11-15	2013-05-27	Мадаус Гмбх	Силибининовый компонент для лечения гепатита
WO2009062737A1 (en) *	2007-11-15	2009-05-22	Madaus Gmbh	Silibinin component for the treatment of hepatitis
AU2010247716B2 (en) *	2009-05-14	2015-11-05	Madaus Gmbh	Amorphous silibinin for the treatment of viral hepatitis
US20150174213A1 (en)	2012-07-05	2015-06-25	Nutramax Laboratories, Inc.	Compositions comprising sulforaphane or a sulforaphane precursor and ursolic acid
CN103113359B (zh) *	2013-02-22	2016-01-06	西安安健药业有限公司	水飞蓟宾二偏琥珀酸酯及其药用盐
CN103193768B (zh) *	2013-02-22	2016-03-30	西安安健药业有限公司	治疗肝病的水飞蓟宾二偏琥珀酸酯异构体
CN103172622B (zh) *	2013-02-22	2015-11-04	西安安健药业有限公司	水飞蓟宾二偏琥珀酸酯的活性异构体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1963318A1 (de) *	1969-12-17	1971-06-24	Schwabe Willmar Gmbh & Co	Silybinhalbester der Bernsteinsaeure und der Phthalsaeure,ihre Salze mit pharmakologisch vertraglichen Basen,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten

1984
- 1984-11-22 DE DE19843442639 patent/DE3442639A1/de active Granted
1985
- 1985-11-11 IE IE280885A patent/IE58791B1/en not_active IP Right Cessation
- 1985-11-13 LU LU86163A patent/LU86163A1/de unknown
- 1985-11-14 YU YU1786/85A patent/YU43689B/xx unknown
- 1985-11-14 AR AR302267A patent/AR240931A1/es active
- 1985-11-15 GB GB08528226A patent/GB2167414B/en not_active Expired
- 1985-11-18 NL NL8503171A patent/NL192387C/nl not_active IP Right Cessation
- 1985-11-18 FI FI854535A patent/FI84064C/sv not_active IP Right Cessation
- 1985-11-19 CH CH4935/85A patent/CH659473A5/de not_active IP Right Cessation
- 1985-11-19 AT AT3371/85A patent/AT393268B/de not_active IP Right Cessation
- 1985-11-20 SE SE8505487A patent/SE465676B/sv not_active IP Right Cessation
- 1985-11-20 DD DD85283042A patent/DD259191A1/de not_active IP Right Cessation
- 1985-11-20 CS CS837885A patent/CS273610B2/cs unknown
- 1985-11-20 CA CA000495804A patent/CA1337124C/en not_active Expired - Fee Related
- 1985-11-21 SU SU853985401A patent/SU1436875A3/ru active
- 1985-11-21 ZA ZA858951A patent/ZA858951B/xx unknown
- 1985-11-21 EG EG74085A patent/EG19424A/xx active
- 1985-11-21 DK DK537785A patent/DK164865C/da not_active IP Right Cessation
- 1985-11-21 NO NO854655A patent/NO160205C/no not_active IP Right Cessation
- 1985-11-21 IT IT22932/85A patent/IT1190426B/it active
- 1985-11-21 PL PL1985256374A patent/PL146890B1/pl unknown
- 1985-11-21 ES ES549116A patent/ES8609311A1/es not_active Expired
- 1985-11-21 HU HU854448A patent/HU195503B/hu not_active IP Right Cessation
- 1985-11-21 PT PT81532A patent/PT81532B/pt not_active IP Right Cessation
- 1985-11-22 KR KR1019850008733A patent/KR870001020B1/ko not_active IP Right Cessation
- 1985-11-22 MX MX009022A patent/MX168415B/es unknown
- 1985-11-22 BE BE2/60850A patent/BE903693A/fr not_active IP Right Cessation
- 1985-11-22 FR FR858517321A patent/FR2573427B1/fr not_active Expired
- 1985-11-22 JP JP60261629A patent/JPS61143377A/ja active Granted

Also Published As

Publication number	Publication date
GB8528226D0 (en)	1985-12-18
JPS61143377A (ja)	1986-07-01
FI854535A0 (fi)	1985-11-18
FR2573427A1 (fr)	1986-05-23
ES549116A0 (es)	1986-09-01
HU195503B (en)	1988-05-30
BE903693A (fr)	1986-05-22
YU43689B (en)	1989-10-31
NO160205B (no)	1988-12-12
SE8505487D0 (sv)	1985-11-20
CA1337124C (en)	1995-09-26
DK164865C (da)	1993-01-18
CS837885A2 (en)	1990-08-14
FI84064C (sv)	1991-10-10
DE3442639C2 (sv)	1989-08-10
AR240931A1 (es)	1991-03-27
FR2573427B1 (fr)	1989-03-10
HUT40114A (en)	1986-11-28
YU178685A (en)	1988-02-29
DK164865B (da)	1992-08-31
FI84064B (fi)	1991-06-28
ES8609311A1 (es)	1986-09-01
AR240931A2 (es)	1991-03-27
LU86163A1 (de)	1986-03-24
GB2167414A (en)	1986-05-29
EG19424A (en)	1995-02-28
DE3442639A1 (de)	1986-05-22
DK537785D0 (da)	1985-11-21
JPH0432073B2 (sv)	1992-05-28
IT1190426B (it)	1988-02-16
SU1436875A3 (ru)	1988-11-07
NL8503171A (nl)	1986-06-16
KR860004056A (ko)	1986-06-16
ZA858951B (en)	1986-08-27
DK537785A (da)	1986-05-23
NL192387B (nl)	1997-03-03
PT81532A (de)	1985-12-01
CS273610B2 (en)	1991-03-12
CH659473A5 (de)	1987-01-30
SE8505487L (sv)	1986-05-23
AT393268B (de)	1991-09-25
KR870001020B1 (ko)	1987-05-23
PT81532B (pt)	1987-11-11
ATA337185A (de)	1991-02-15
IE58791B1 (en)	1993-11-17
NO854655L (no)	1986-05-23
IT8522932A0 (it)	1985-11-21
NL192387C (nl)	1997-07-04
PL146890B1 (en)	1989-03-31
SE465676B (sv)	1991-10-14
DD259191A1 (de)	1988-08-17
PL256374A1 (en)	1986-12-02
GB2167414B (en)	1989-01-11
FI854535A (fi)	1986-05-23
NO160205C (no)	1989-03-22
IE852808L (en)	1986-05-22

Publication	Publication Date	Title
MX168415B (es)	1993-05-24	Procedimiento para la preparacion de derivados de silibinina
Elvidge et al.	1950	461. Unsaturated lactones and related substances. Part IV. Lactonic products derived from muconic acid
US2656366A (en)	1953-10-20	Water-soluble esters of cortisone and related compounds
US3580936A (en)	1971-05-25	5beta-taurocholenic acids and 5beta-taurocholadienic acids
Walborsky et al.	1957	Reaction of Ezo-norbornylene Oxide with Hydrogen Bromide
Cristol et al.	1958	Bridged Polycyclic Compounds. VII. The Bromination of Quadricyclo [2, 2, 1, 02, 6, 03, 5] heptane-2, 3-dicarboxylic Acid1, 2
ES2035102T3 (es)	1993-04-16	Compuestos que contienen hierro biodisponible, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
US2379381A (en)	1945-06-26	Composition of matter
Behrman	1976	The bacterial oxidation of nicotinic acid: N-Formylmaleamic and N-formylfumaramic acids
Fujimoto et al.	1953	A Synthesis of Progesterone Labeled in Position 41
GB1203538A (en)	1970-08-26	Cubane derivatives
US2128199A (en)	1938-08-23	Antirachitically active product
ES410060A1 (es)	1976-01-01	Un procedimiento de desdoblamiento de dl-aletrolona.
JPS53108933A (en)	1978-09-22	Production of amidinoformic acid derivative
GB722594A (en)	1955-01-26	Improvements in the manufacture of cellulose esters
PH13267A (en)	1980-02-27	D*honoandrostant-117oc-carboxylic acid derivatives
Wu et al.	1953	Oleanolic acid from cranberries
NAKATA et al.	1975	Diterpenoids. XXXIV. Stereochemistry on the Rearranged Compound (Benzilic Acid Rearrangement) of Methyl 6, 7-Dioxo-5α, 10α-podocarpa-8, 11, 13-trien-15-oate
US2621181A (en)	1952-12-09	Steroid adducts
GB1421527A (en)	1976-01-21	Dicarboxylic acid
GB512583A (en)	1939-09-20	Improvements in preparation of salts of hexamethylenetetramine
GB513818A (en)	1939-10-23	Improvements in and relating to the manufacture of compounds of p-tolylmethylcarbinol
HU229607B1 (en)	2014-02-28	Anhydride stabilization
Bourne et al.	1958	251. Studies of trifluoroacetic acid. Part XIV. Reaction of acyl trifluoroacetates with 1: 6-di-O-benzoyl-2: 4–3: 5-di-O-methylene-D-glucitol
GB890749A (en)	1962-03-07	Esters of testosterone and 19-nortestosterone, and method for the production thereof