MEP40808A - NOVEL OCTAHYDRO-6,10-DIOXO-6H-PYRIDAZINO/1,2-a/ /1,2/DIAZEPIN-1-CARBOXYLIC ACID DERIVATIVES, PREPARATION METHOD AND USE FOR PREPARING THERAPEUTICALLY ACTIVE COMPOUNDS - Google Patents

NOVEL OCTAHYDRO-6,10-DIOXO-6H-PYRIDAZINO/1,2-a/ /1,2/DIAZEPIN-1-CARBOXYLIC ACID DERIVATIVES, PREPARATION METHOD AND USE FOR PREPARING THERAPEUTICALLY ACTIVE COMPOUNDS

Info

Publication number: MEP40808A
Authority: ME; Montenegro
Prior art keywords: pyridazino; diazepin; dioxo; preparation; carboxylic acid
Prior art date: 1998-04-27

Application number

MEP-408/08A

Other languages

Bosnian (bs)

English (en)

Inventor

Colette Colladant

Veronique Crocq

John Patrick Larkin

Patrick Roussel

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-27

Filing date

1999-04-26

Publication date

2011-02-10

1999-04-26 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2011-02-10 Publication of MEP40808A publication Critical patent/MEP40808A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)

MEP-408/08A 1998-04-27 1999-04-26 NOVEL OCTAHYDRO-6,10-DIOXO-6H-PYRIDAZINO/1,2-a/ /1,2/DIAZEPIN-1-CARBOXYLIC ACID DERIVATIVES, PREPARATION METHOD AND USE FOR PREPARING THERAPEUTICALLY ACTIVE COMPOUNDS MEP40808A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9805243A FR2777889B1 (fr)	1998-04-27	1998-04-27	Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs
PCT/FR1999/000981 WO1999055724A1 (fr)	1998-04-27	1999-04-26	NOUVEAUX DERIVES DE L'ACIDE OCTAHYDRO-6,10-DIOXO-6H-PYRIDAZINO[1,2-a] [1,2] DIAZEPINE-1-CARBOXYLIQUE, LEUR PROCEDE DE PREPARATION ET LEUR APPLICATION A LA PREPARATION DE COMPOSES THERAPEUTIQUEMENT ACTIFS

Publications (1)

Publication Number	Publication Date
MEP40808A true MEP40808A (en)	2011-02-10

Family

ID=9525705

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
MEP-2008-408A ME00300B (me)	1998-04-27	1999-04-26	NOVI DERIVATI OKT AHIDR0-6, 10-DIOKS0-6N-PIRIDAZINO/l,2-a/ /l,2/DIAZEPIN-1-KARBOKSILNE KISELINE, NJIHOV POSTUPAK DOBIJANJA I NJIHOVA PRIMENA ZA DOBIJANJE TERAPEUTSKI AKTIVNIH JEDINJENJA
MEP-408/08A MEP40808A (en)	1998-04-27	1999-04-26	NOVEL OCTAHYDRO-6,10-DIOXO-6H-PYRIDAZINO/1,2-a/ /1,2/DIAZEPIN-1-CARBOXYLIC ACID DERIVATIVES, PREPARATION METHOD AND USE FOR PREPARING THERAPEUTICALLY ACTIVE COMPOUNDS

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
MEP-2008-408A ME00300B (me)	1998-04-27	1999-04-26	NOVI DERIVATI OKT AHIDR0-6, 10-DIOKS0-6N-PIRIDAZINO/l,2-a/ /l,2/DIAZEPIN-1-KARBOKSILNE KISELINE, NJIHOV POSTUPAK DOBIJANJA I NJIHOVA PRIMENA ZA DOBIJANJE TERAPEUTSKI AKTIVNIH JEDINJENJA

Country Status (37)

Country	Link
US (3)	US6548664B1 (xx)
EP (1)	EP1073673B1 (xx)
JP (2)	JP4332298B2 (xx)
KR (1)	KR100561582B1 (xx)
CN (1)	CN1167711C (xx)
AP (1)	AP1518A (xx)
AR (1)	AR016466A1 (xx)
AU (1)	AU755286B2 (xx)
BG (1)	BG65282B1 (xx)
BR (1)	BR9910020A (xx)
CA (1)	CA2330492C (xx)
CU (1)	CU23155A3 (xx)
CY (1)	CY1107599T1 (xx)
DE (1)	DE69934790T2 (xx)
DK (1)	DK1073673T3 (xx)
EA (1)	EA003280B1 (xx)
EE (1)	EE04682B1 (xx)
ES (1)	ES2279617T3 (xx)
FR (1)	FR2777889B1 (xx)
GE (1)	GEP20033119B (xx)
HR (1)	HRP20000733B1 (xx)
HU (1)	HU230060B1 (xx)
ID (1)	ID26292A (xx)
IL (3)	IL139102A0 (xx)
ME (2)	ME00300B (xx)
NO (1)	NO328864B1 (xx)
NZ (1)	NZ507618A (xx)
PL (1)	PL203762B1 (xx)
PT (1)	PT1073673E (xx)
RS (1)	RS50423B (xx)
SI (1)	SI1073673T1 (xx)
SK (1)	SK288050B6 (xx)
TR (1)	TR200003142T2 (xx)
TW (1)	TWI249537B (xx)
UA (1)	UA71913C2 (xx)
WO (1)	WO1999055724A1 (xx)
ZA (1)	ZA200006081B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6201118B1 (en)	1998-08-19	2001-03-13	Vertex Pharmaceuticals Inc.	Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor
US6177565B1 (en)	1998-08-19	2001-01-23	Vertex Pharmaceuticals Inc.	Process for synthesizing piperazic acid
FR2853901B1 (fr) *	2003-04-16	2005-06-17	Isochem Sa	Procede de preparation de derives de l'acide hexahydropyridazine-3-carboxylique
WO2005028449A1 (en) *	2003-06-26	2005-03-31	Honeywell Specialty Chemicals Seelze Gmbh	Improved process for the manufacture of 1,2-disubstituted hexahydropyridazine-3-carboxylic acids and esters thereof
CN100404516C (zh) *	2004-02-13	2008-07-23	大连绿源药业有限责任公司	六氢哒嗪三羧酸酯的制备方法
WO2005122682A2 (en)	2004-06-18	2005-12-29	Ranbaxy Laboratories Limited	Process for the preparation of esters of piperazic acid
WO2012049646A1 (en)	2010-10-12	2012-04-19	Ranbaxy Laboratories Limited	Process for the preparation of an intermediate of cilazapril

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6204261B1 (en) *	1995-12-20	2001-03-20	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β Converting enzyme inhibitors
GB2128984B (en) *	1982-05-12	1985-05-22	Hoffmann La Roche	Diaza-bicyclic compounds
US5552397A (en) *	1992-05-18	1996-09-03	E. R. Squibb & Sons, Inc.	Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
DK0640086T3 (da) *	1992-05-15	1999-12-06	Merrell Pharma Inc	Mercaptoacetylamido-pyridazo[1,2-a][1,2]diazepin-derivateranvendelige som enkephalinase- og ACE-inhibitorer
US5552400A (en) *	1994-06-08	1996-09-03	Sterling Winthrop Inc.	Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors
US5756466A (en) *	1994-06-17	1998-05-26	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US6201118B1 (en) *	1998-08-19	2001-03-13	Vertex Pharmaceuticals Inc.	Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor
US6177565B1 (en) *	1998-08-19	2001-01-23	Vertex Pharmaceuticals Inc.	Process for synthesizing piperazic acid

1998
- 1998-04-27 FR FR9805243A patent/FR2777889B1/fr not_active Expired - Lifetime
1999
- 1999-04-07 TW TW088105540A patent/TWI249537B/zh not_active IP Right Cessation
- 1999-04-22 AR ARP990101859A patent/AR016466A1/es not_active Application Discontinuation
- 1999-04-26 ES ES99915834T patent/ES2279617T3/es not_active Expired - Lifetime
- 1999-04-26 NZ NZ507618A patent/NZ507618A/en not_active IP Right Cessation
- 1999-04-26 HU HU0102447A patent/HU230060B1/hu not_active IP Right Cessation
- 1999-04-26 AP APAP/P/2000/001973A patent/AP1518A/en active
- 1999-04-26 HR HR20000733A patent/HRP20000733B1/xx not_active IP Right Cessation
- 1999-04-26 DK DK99915834T patent/DK1073673T3/da active
- 1999-04-26 US US09/674,327 patent/US6548664B1/en not_active Expired - Lifetime
- 1999-04-26 PT PT99915834T patent/PT1073673E/pt unknown
- 1999-04-26 EA EA200001107A patent/EA003280B1/ru not_active IP Right Cessation
- 1999-04-26 WO PCT/FR1999/000981 patent/WO1999055724A1/fr active Application Filing
- 1999-04-26 RS YUP-658/00A patent/RS50423B/sr unknown
- 1999-04-26 AU AU34274/99A patent/AU755286B2/en not_active Ceased
- 1999-04-26 EP EP99915834A patent/EP1073673B1/fr not_active Expired - Lifetime
- 1999-04-26 IL IL13910299A patent/IL139102A0/xx active IP Right Grant
- 1999-04-26 SI SI9930952T patent/SI1073673T1/sl unknown
- 1999-04-26 KR KR1020007011895A patent/KR100561582B1/ko not_active Expired - Fee Related
- 1999-04-26 PL PL343720A patent/PL203762B1/pl unknown
- 1999-04-26 DE DE69934790T patent/DE69934790T2/de not_active Expired - Lifetime
- 1999-04-26 EE EEP200000619A patent/EE04682B1/xx unknown
- 1999-04-26 SK SK1600-2000A patent/SK288050B6/sk not_active IP Right Cessation
- 1999-04-26 JP JP2000545882A patent/JP4332298B2/ja not_active Expired - Fee Related
- 1999-04-26 ME MEP-2008-408A patent/ME00300B/me unknown
- 1999-04-26 BR BR9910020-7A patent/BR9910020A/pt not_active IP Right Cessation
- 1999-04-26 UA UA2000116680A patent/UA71913C2/uk unknown
- 1999-04-26 CA CA2330492A patent/CA2330492C/fr not_active Expired - Fee Related
- 1999-04-26 GE GEAP19995634A patent/GEP20033119B/en unknown
- 1999-04-26 TR TR2000/03142T patent/TR200003142T2/xx unknown
- 1999-04-26 ID IDW20002188A patent/ID26292A/id unknown
- 1999-04-26 CN CNB998076139A patent/CN1167711C/zh not_active Expired - Fee Related
- 1999-04-26 ME MEP-408/08A patent/MEP40808A/xx unknown
2000
- 2000-10-18 IL IL139102A patent/IL139102A/en not_active IP Right Cessation
- 2000-10-25 CU CU229A patent/CU23155A3/es unknown
- 2000-10-26 NO NO20005391A patent/NO328864B1/no not_active IP Right Cessation
- 2000-10-26 BG BG104891A patent/BG65282B1/bg unknown
- 2000-10-27 ZA ZA200006081A patent/ZA200006081B/xx unknown
2002
- 2002-03-20 US US10/102,591 patent/US6570012B2/en not_active Expired - Lifetime
- 2002-12-06 US US10/313,422 patent/US20030130269A1/en not_active Abandoned
2007
- 2007-03-22 CY CY20071100404T patent/CY1107599T1/el unknown
2008
- 2008-03-12 IL IL190120A patent/IL190120A/en not_active IP Right Cessation
2009
- 2009-04-10 JP JP2009096241A patent/JP5101558B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU755286B2 (en)	2002-12-05
DE69934790D1 (de)	2007-02-22
US20030130269A1 (en)	2003-07-10
HRP20000733A2 (en)	2001-02-28
WO1999055724A1 (fr)	1999-11-04
CY1107599T1 (el)	2013-03-13
DE69934790T2 (de)	2007-10-31
HRP20000733B1 (hr)	2009-06-30
JP2002513030A (ja)	2002-05-08
ES2279617T3 (es)	2007-08-16
AU3427499A (en)	1999-11-16
BG104891A (en)	2001-10-31
EE200000619A (et)	2002-06-17
FR2777889B1 (fr)	2004-07-09
ME00300B (me)	2011-05-10
HU230060B1 (hu)	2015-06-29
JP2009155343A (ja)	2009-07-16
TWI249537B (en)	2006-02-21
RS50423B (sr)	2009-12-31
GEP20033119B (en)	2003-11-25
PL343720A1 (en)	2001-09-10
NZ507618A (en)	2003-07-25
CU23155A3 (es)	2006-07-18
AP2000001973A0 (en)	2000-12-31
YU65800A (sh)	2003-01-31
ZA200006081B (en)	2001-10-29
ID26292A (id)	2000-12-14
KR20010043033A (ko)	2001-05-25
CA2330492A1 (fr)	1999-11-04
EE04682B1 (et)	2006-08-15
NO20005391D0 (no)	2000-10-26
CA2330492C (fr)	2012-03-13
HUP0102447A3 (en)	2003-05-28
BR9910020A (pt)	2001-01-09
EA003280B1 (ru)	2003-04-24
NO328864B1 (no)	2010-05-31
CN1167711C (zh)	2004-09-22
SK288050B6 (sk)	2013-03-01
UA71913C2 (uk)	2005-01-17
PL203762B1 (pl)	2009-11-30
IL190120A (en)	2011-10-31
US20020128473A1 (en)	2002-09-12
CN1306539A (zh)	2001-08-01
IL139102A0 (en)	2001-11-25
US6548664B1 (en)	2003-04-15
DK1073673T3 (da)	2007-05-07
KR100561582B1 (ko)	2006-03-20
EP1073673B1 (fr)	2007-01-10
HK1039131A1 (en)	2002-04-12
NO20005391L (no)	2000-12-19
SK16002000A3 (sk)	2001-09-11
US6570012B2 (en)	2003-05-27
AR016466A1 (es)	2001-07-04
EP1073673A1 (fr)	2001-02-07
AP1518A (en)	2005-12-12
EA200001107A1 (ru)	2001-04-23
BG65282B1 (bg)	2007-11-30
FR2777889A1 (fr)	1999-10-29
IL190120A0 (en)	2008-08-07
JP4332298B2 (ja)	2009-09-16
TR200003142T2 (tr)	2001-03-21
PT1073673E (pt)	2007-03-30
JP5101558B2 (ja)	2012-12-19
IL139102A (en)	2008-06-05
HUP0102447A2 (hu)	2001-11-28
SI1073673T1 (sl)	2007-04-30

Publication	Publication Date	Title
CA2304713A1 (en)	1999-04-22	Biphenyl-5-alkanoic acid derivatives and use thereof
ES8101586A1 (es)	1980-12-16	Un procedimiento para la preparacion de nuevos derivados de quinazolina.
IL85988A (en)	1992-08-18	1-phenyl-3-naphthalenyloxy-propanamines,process for their preparation and pharmaceutical compositions containing them
HUT43051A (en)	1987-09-28	Process for preparing pyridine-carboxylic acid derivatives and pharmaceutical compositions containing thereof as active ingredients
AU2736088A (en)	1989-06-29	Pharmaceutical compositions comprising benzylidene- and cinnamylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells, certain such novel compounds and their preparation
IL108259A0 (en)	1994-04-12	Piperazine derivates, their preparation and pharmaceutical compositions containing them
ES481729A1 (es)	1980-03-01	Procedimiento para la preparacion de derivados de 1,2-dihi- droquinolein-2-onas.
MXPA03000547A (es)	2004-04-05	Uso de derivados de amidas de acido valproico y de acido 2-valproenico, para el tratamiento de manias en trastornos bipolares.
AU557954B2 (en)	1987-01-15	Diethylaminoalkoxy-benzhydrol derivatives
MEP40808A (en)	2011-02-10	NOVEL OCTAHYDRO-6,10-DIOXO-6H-PYRIDAZINO/1,2-a/ /1,2/DIAZEPIN-1-CARBOXYLIC ACID DERIVATIVES, PREPARATION METHOD AND USE FOR PREPARING THERAPEUTICALLY ACTIVE COMPOUNDS
ES484718A1 (es)	1980-09-01	Un procedimiento para la preparacion de benzopiranos.
HUP0402033A2 (hu)	2005-02-28	2-Amino-4-piridil-metil-tiazolin-származékok alkalmazása az indukálható NO-szintetáz inhibitoraként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
AU558261B2 (en)	1987-01-22	Dialkylaminoalkyoxybenzylalcohol derivatives
HUP9903526A2 (hu)	2000-06-28	Pirimidinszármazékok és az ezeket tartalmazó gyógyszerkészítmények
ES8800140A1 (es)	1987-11-01	Un procedimiento para preparar un compuesto de n-fenil-trans-4-guanidincometilciclohexanocarboxamida.
MY141653A (en)	2010-05-31	Detergent composition having low skin irritability
IL115085A (en)	1999-06-20	Piperazine bicyclic carboxamide derivatives their preparation and pharmaceutical compositions containing them
ATE78032T1 (de)	1992-07-15	2-pyridylessigsaeurederivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
IL70552A (en)	1986-12-31	Aminoethoxybenzyl alcohol derivatives,their preparation and pharmaceutical compositions containing them
EP0035270A3 (en)	1981-10-14	Heterocyclic compounds, compositions thereof, their preparation and use
IL108225A (en)	1997-04-15	2-THIENYLIMIDAZO £2, 1-b\| BENZOTHIAZOLE-3-ACETIC ACID DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
GB1460266A (en)	1976-12-31	Pyridine-thioether-sulphoxides processes for their preparation and compositions containing them
ES8104224A1 (es)	1981-04-01	Un procedimiento para la preparacion de derivados de tetra- hidrobenzo c pirrol