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HUP0402033A2 - 2-Amino-4-piridil-metil-tiazolin-származékok alkalmazása az indukálható NO-szintetáz inhibitoraként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

2-Amino-4-piridil-metil-tiazolin-származékok alkalmazása az indukálható NO-szintetáz inhibitoraként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0402033A2
HUP0402033A2 HU0402033A HUP0402033A HUP0402033A2 HU P0402033 A2 HUP0402033 A2 HU P0402033A2 HU 0402033 A HU0402033 A HU 0402033A HU P0402033 A HUP0402033 A HU P0402033A HU P0402033 A2 HUP0402033 A2 HU P0402033A2
Authority
HU
Hungary
Prior art keywords
inducible
amino
preparation
inhibitors
pyridylmethyl
Prior art date
Application number
HU0402033A
Other languages
English (en)
Inventor
Eric Bacque
Antony Bigot
Jean-Christophe Carry
Serge Mignani
Baptiste Ronan
Michel Tabart
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0114508A external-priority patent/FR2832150B1/fr
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of HUP0402033A2 publication Critical patent/HUP0402033A2/hu

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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    • A—HUMAN NECESSITIES
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
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Abstract

A találmány tárgyát az (I) általános képletű 2-amino-4-piridil-metil-tiazolin-származékok és ezek gyógyászatilag megfelelő sóinakindukálható NO-szintetáz inhibitorként történő alkalmazása képezi,ahol az (I) általános képletben R1 és R2 jelentése azonosan hidroxil-,1-4 szénatomos alkilcsoport, klóratom vagy 1-4 szénatomosalkoxicsoport, vagy R1 és R2 közül legalább az egyik jelentésehidrogénatom, míg a másik jelentése 1-4 szénatomos alkil-, 1-4szénatomos alkoxi-, hidroxilcsoport vagy klóratom. A találmánykiterjed a vegyületek előállítására és ezeket tartalmazógyógyszerkészítményekre. Ó
HU0402033A 2001-11-09 2002-11-07 2-Amino-4-piridil-metil-tiazolin-származékok alkalmazása az indukálható NO-szintetáz inhibitoraként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények HUP0402033A2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0114508A FR2832150B1 (fr) 2001-11-09 2001-11-09 Utilisation de derives de 2-amino-4-pyridylmethyl-thiazoline comme inhibiteurs de no-synthase inductible
US35297802P 2002-01-30 2002-01-30
PCT/FR2002/003808 WO2003039446A2 (fr) 2001-11-09 2002-11-07 Derives de 2-amino-4-pyridylmethyl-thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible

Publications (1)

Publication Number Publication Date
HUP0402033A2 true HUP0402033A2 (hu) 2005-02-28

Family

ID=26213258

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0402033A HUP0402033A2 (hu) 2001-11-09 2002-11-07 2-Amino-4-piridil-metil-tiazolin-származékok alkalmazása az indukálható NO-szintetáz inhibitoraként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

Country Status (22)

Country Link
US (1) US6762196B2 (hu)
EP (1) EP1450750B1 (hu)
JP (1) JP4342309B2 (hu)
CN (1) CN1288153C (hu)
AT (1) ATE446295T1 (hu)
BR (1) BR0206368A (hu)
CA (1) CA2465877C (hu)
CY (1) CY1110284T1 (hu)
DE (1) DE60234117D1 (hu)
DK (1) DK1450750T3 (hu)
ES (1) ES2335090T3 (hu)
HR (1) HRP20040402A2 (hu)
HU (1) HUP0402033A2 (hu)
IL (2) IL161843A0 (hu)
MA (1) MA27143A1 (hu)
MX (1) MXPA04004213A (hu)
NO (1) NO20033131L (hu)
PL (1) PL370267A1 (hu)
PT (1) PT1450750E (hu)
RU (1) RU2004117531A (hu)
SI (1) SI1450750T1 (hu)
WO (1) WO2003039446A2 (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10240735A1 (de) * 2002-08-29 2004-03-18 Eberhard-Karls-Universität Tübingen Universitätsklinikum Verwendung von Modulatoren der NO-Signalkaskade und pharmazeutische Zusammensetzung
CN101346357B (zh) * 2005-10-25 2014-04-02 盐野义制药株式会社 氨基二氢噻嗪衍生物
EP2151435A4 (en) 2007-04-24 2011-09-14 Shionogi & Co PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE
EP2689780A1 (en) 2007-04-24 2014-01-29 Shionogi & Co., Ltd. Intermediates for aminodihydrothiazine derivatives substituted with a cyclic group
AU2009258496B8 (en) 2008-06-13 2014-06-26 Shionogi & Co., Ltd. Sulfur-containing heterocyclic derivative having beta-secretase-inhibiting activity
CN102186841A (zh) 2008-10-22 2011-09-14 盐野义制药株式会社 具有bace1抑制活性的2-氨基嘧啶-4-酮及2-氨基吡啶衍生物
UA110467C2 (uk) 2009-12-11 2016-01-12 Шионогі Енд Ко., Лтд. Похідні оксазину
CN103261199A (zh) 2010-10-29 2013-08-21 盐野义制药株式会社 萘啶衍生物
US9018219B2 (en) 2010-10-29 2015-04-28 Shionogi & Co., Ltd. Fused aminodihydropyrimidine derivative
TW201247635A (en) 2011-04-26 2012-12-01 Shionogi & Co Oxazine derivatives and a pharmaceutical composition for inhibiting BAC1 containing them
WO2014065434A1 (en) 2012-10-24 2014-05-01 Shionogi & Co., Ltd. Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08503940A (ja) * 1992-11-27 1996-04-30 ザ ウエルカム ファウンデーション リミテッド 酵素阻害薬
CN1077886C (zh) * 1993-10-21 2002-01-16 G·D·瑟尔公司 用作一氧化一氮合酶抑制剂的脒基衍生物
WO1996014842A1 (en) * 1994-11-15 1996-05-23 Merck & Co., Inc. Substituted heterocycles as inhibitors of nitric oxide synthase
FR2810037B1 (fr) * 2000-06-09 2004-04-23 Aventis Pharma Sa Utilisation de derives de 2-aminothiazoline comme inhibiteurs de no-synthase inductible

Also Published As

Publication number Publication date
CA2465877A1 (fr) 2003-05-15
NO20033131D0 (no) 2003-07-08
MXPA04004213A (es) 2004-07-08
DE60234117D1 (de) 2009-12-03
RU2004117531A (ru) 2005-04-10
EP1450750A2 (fr) 2004-09-01
EP1450750B1 (fr) 2009-10-21
BR0206368A (pt) 2004-02-10
MA27143A1 (fr) 2005-01-03
ES2335090T3 (es) 2010-03-22
ATE446295T1 (de) 2009-11-15
NO20033131L (no) 2003-08-27
PL370267A1 (en) 2005-05-16
CY1110284T1 (el) 2015-01-14
CA2465877C (fr) 2009-12-29
HRP20040402A2 (en) 2004-10-31
US6762196B2 (en) 2004-07-13
WO2003039446A2 (fr) 2003-05-15
SI1450750T1 (sl) 2010-02-26
DK1450750T3 (da) 2010-03-08
PT1450750E (pt) 2010-01-18
CN1602311A (zh) 2005-03-30
IL161843A0 (en) 2005-11-20
US20030153605A1 (en) 2003-08-14
JP2005517634A (ja) 2005-06-16
IL161843A (en) 2011-08-31
WO2003039446A3 (fr) 2003-11-27
CN1288153C (zh) 2006-12-06
JP4342309B2 (ja) 2009-10-14

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