ME03748B - Derivati 4-amin0-2-(1h-pirazolo[3,4-b]piridin-3-il)-6-okso-6,7-dihidro-5h-pirolo[2,3-d]pirimidina i respektivni(1h-indazol-3-il) derivati kao modulatori cgmp za lečenje kardiovaskularnih bolesti - Google Patents
Derivati 4-amin0-2-(1h-pirazolo[3,4-b]piridin-3-il)-6-okso-6,7-dihidro-5h-pirolo[2,3-d]pirimidina i respektivni(1h-indazol-3-il) derivati kao modulatori cgmp za lečenje kardiovaskularnih bolestiInfo
- Publication number
- ME03748B ME03748B MEP-2020-103A MEP2020103A ME03748B ME 03748 B ME03748 B ME 03748B ME P2020103 A MEP2020103 A ME P2020103A ME 03748 B ME03748 B ME 03748B
- Authority
- ME
- Montenegro
- Prior art keywords
- indazol
- cgmp
- pyrazolo
- pyrrolo
- modulators
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2015/098251 WO2017107052A1 (en) | 2015-12-22 | 2015-12-22 | Soluble guanylate cyclase stimulators |
PCT/US2016/067654 WO2017112617A1 (en) | 2015-12-22 | 2016-12-20 | 4-amino-2-(1h-pyrazolo[3,4-b]pyridin-3-yl)-6-oxo-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidine derivatives and the respective (1h-indazol-3-yl) derivatives as cgmp modulators for treating cardiovascular diseases |
EP16823455.7A EP3394067B1 (en) | 2015-12-22 | 2016-12-20 | 4-amino-2-(1h-pyrazolo[3,4-b]pyridin-3-yl)-6-oxo-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidine derivatives and the respective (1h-indazol-3-yl) derivatives as cgmp modulators for treating cardiovascular diseases |
Publications (1)
Publication Number | Publication Date |
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ME03748B true ME03748B (me) | 2021-04-20 |
Family
ID=57758775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-2020-103A ME03748B (me) | 2015-12-22 | 2016-12-20 | Derivati 4-amin0-2-(1h-pirazolo[3,4-b]piridin-3-il)-6-okso-6,7-dihidro-5h-pirolo[2,3-d]pirimidina i respektivni(1h-indazol-3-il) derivati kao modulatori cgmp za lečenje kardiovaskularnih bolesti |
Country Status (40)
Country | Link |
---|---|
US (2) | US10030027B2 (me) |
EP (1) | EP3394067B1 (me) |
JP (1) | JP6454448B2 (me) |
KR (1) | KR102191312B1 (me) |
CN (1) | CN108738320B (me) |
AR (1) | AR107154A1 (me) |
AU (1) | AU2016377364B2 (me) |
BR (1) | BR112018012579B8 (me) |
CA (1) | CA3009193C (me) |
CL (1) | CL2018001671A1 (me) |
CO (1) | CO2018006300A2 (me) |
CR (1) | CR20180330A (me) |
CY (1) | CY1123173T1 (me) |
DK (1) | DK3394067T3 (me) |
DO (1) | DOP2018000153A (me) |
EA (1) | EA036445B1 (me) |
EC (1) | ECSP18054606A (me) |
ES (1) | ES2794654T3 (me) |
HK (1) | HK1255028A1 (me) |
HR (1) | HRP20200857T1 (me) |
HU (1) | HUE049941T2 (me) |
IL (1) | IL260020B (me) |
LT (1) | LT3394067T (me) |
ME (1) | ME03748B (me) |
MX (2) | MX376256B (me) |
MY (1) | MY194021A (me) |
NI (1) | NI201800069A (me) |
NZ (1) | NZ742891A (me) |
PE (1) | PE20181802A1 (me) |
PH (1) | PH12018501342B1 (me) |
PL (1) | PL3394067T3 (me) |
PT (1) | PT3394067T (me) |
RS (1) | RS60344B1 (me) |
SG (1) | SG11201805272XA (me) |
SI (1) | SI3394067T1 (me) |
SV (1) | SV2018005715A (me) |
TN (1) | TN2018000219A1 (me) |
TW (1) | TWI724079B (me) |
UA (1) | UA122264C2 (me) |
WO (2) | WO2017107052A1 (me) |
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AR108396A1 (es) | 2016-05-06 | 2018-08-15 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
WO2017197555A1 (en) | 2016-05-16 | 2017-11-23 | Merck Sharp & Dohme Corp. | Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators |
WO2017200857A1 (en) | 2016-05-18 | 2017-11-23 | Merck Sharp & Dohme Corp. | Methods for using triazolo-pyrazinyl soluble guanylate cyclase activators in fibrotic disorders |
US20170342060A1 (en) | 2016-05-26 | 2017-11-30 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
EP4137489A1 (en) | 2016-06-20 | 2023-02-22 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
MA45669A (fr) | 2016-07-14 | 2019-05-22 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
MA46045A (fr) | 2016-08-29 | 2021-04-28 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
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IL260701B (en) | 2016-02-01 | 2022-09-01 | Ironwood Pharmaceuticals Inc | Use of certain sgc stimulators and salts thereof in the preparation of medicaments for the treatment of nonalcoholic steatohepatitis (nash) |
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