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ME03748B - Derivati 4-amin0-2-(1h-pirazolo[3,4-b]piridin-3-il)-6-okso-6,7-dihidro-5h­-pirolo[2,3-d]pirimidina i respektivni(1h-indazol-3-il) derivati kao modulatori cgmp za lečenje kardiovaskularnih bolesti - Google Patents

Derivati 4-amin0-2-(1h-pirazolo[3,4-b]piridin-3-il)-6-okso-6,7-dihidro-5h­-pirolo[2,3-d]pirimidina i respektivni(1h-indazol-3-il) derivati kao modulatori cgmp za lečenje kardiovaskularnih bolesti

Info

Publication number
ME03748B
ME03748B MEP-2020-103A MEP2020103A ME03748B ME 03748 B ME03748 B ME 03748B ME P2020103 A MEP2020103 A ME P2020103A ME 03748 B ME03748 B ME 03748B
Authority
ME
Montenegro
Prior art keywords
indazol
cgmp
pyrazolo
pyrrolo
modulators
Prior art date
Application number
MEP-2020-103A
Other languages
German (de)
English (en)
French (fr)
Inventor
Raphelle Berger
Yi-Heng Chen
Guoqing Li
Joie Garfunkle
Hong Li
Shouwu Miao
Subharekha Raghavan
Cameron J Smith
John Stelmach
Alan Whitehead
Rui Zhang
Yong Zhang
Jianmin Fu
Gang Ji
Falong Jiang
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of ME03748B publication Critical patent/ME03748B/me

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MEP-2020-103A 2015-12-22 2016-12-20 Derivati 4-amin0-2-(1h-pirazolo[3,4-b]piridin-3-il)-6-okso-6,7-dihidro-5h­-pirolo[2,3-d]pirimidina i respektivni(1h-indazol-3-il) derivati kao modulatori cgmp za lečenje kardiovaskularnih bolesti ME03748B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2015/098251 WO2017107052A1 (en) 2015-12-22 2015-12-22 Soluble guanylate cyclase stimulators
PCT/US2016/067654 WO2017112617A1 (en) 2015-12-22 2016-12-20 4-amino-2-(1h-pyrazolo[3,4-b]pyridin-3-yl)-6-oxo-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidine derivatives and the respective (1h-indazol-3-yl) derivatives as cgmp modulators for treating cardiovascular diseases
EP16823455.7A EP3394067B1 (en) 2015-12-22 2016-12-20 4-amino-2-(1h-pyrazolo[3,4-b]pyridin-3-yl)-6-oxo-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidine derivatives and the respective (1h-indazol-3-yl) derivatives as cgmp modulators for treating cardiovascular diseases

Publications (1)

Publication Number Publication Date
ME03748B true ME03748B (me) 2021-04-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2020-103A ME03748B (me) 2015-12-22 2016-12-20 Derivati 4-amin0-2-(1h-pirazolo[3,4-b]piridin-3-il)-6-okso-6,7-dihidro-5h­-pirolo[2,3-d]pirimidina i respektivni(1h-indazol-3-il) derivati kao modulatori cgmp za lečenje kardiovaskularnih bolesti

Country Status (40)

Country Link
US (2) US10030027B2 (me)
EP (1) EP3394067B1 (me)
JP (1) JP6454448B2 (me)
KR (1) KR102191312B1 (me)
CN (1) CN108738320B (me)
AR (1) AR107154A1 (me)
AU (1) AU2016377364B2 (me)
BR (1) BR112018012579B8 (me)
CA (1) CA3009193C (me)
CL (1) CL2018001671A1 (me)
CO (1) CO2018006300A2 (me)
CR (1) CR20180330A (me)
CY (1) CY1123173T1 (me)
DK (1) DK3394067T3 (me)
DO (1) DOP2018000153A (me)
EA (1) EA036445B1 (me)
EC (1) ECSP18054606A (me)
ES (1) ES2794654T3 (me)
HK (1) HK1255028A1 (me)
HR (1) HRP20200857T1 (me)
HU (1) HUE049941T2 (me)
IL (1) IL260020B (me)
LT (1) LT3394067T (me)
ME (1) ME03748B (me)
MX (2) MX376256B (me)
MY (1) MY194021A (me)
NI (1) NI201800069A (me)
NZ (1) NZ742891A (me)
PE (1) PE20181802A1 (me)
PH (1) PH12018501342B1 (me)
PL (1) PL3394067T3 (me)
PT (1) PT3394067T (me)
RS (1) RS60344B1 (me)
SG (1) SG11201805272XA (me)
SI (1) SI3394067T1 (me)
SV (1) SV2018005715A (me)
TN (1) TN2018000219A1 (me)
TW (1) TWI724079B (me)
UA (1) UA122264C2 (me)
WO (2) WO2017107052A1 (me)

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TW201734017A (zh) 2017-10-01
PE20181802A1 (es) 2018-11-19
SI3394067T1 (sl) 2020-07-31
JP2018538333A (ja) 2018-12-27
WO2017112617A1 (en) 2017-06-29
CR20180330A (es) 2018-08-21
EP3394067B1 (en) 2020-04-01
SG11201805272XA (en) 2018-07-30
CA3009193A1 (en) 2017-06-29
MX2020011080A (es) 2020-11-06
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