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ME03056B - Jedinjenja 3,4-diamino-6-hloropirazin-2-karboksamida za tretman bolesti posredovanih sa enac - Google Patents

Jedinjenja 3,4-diamino-6-hloropirazin-2-karboksamida za tretman bolesti posredovanih sa enac

Info

Publication number
ME03056B
ME03056B MEP-2018-185A MEP2018185A ME03056B ME 03056 B ME03056 B ME 03056B ME P2018185 A MEP2018185 A ME P2018185A ME 03056 B ME03056 B ME 03056B
Authority
ME
Montenegro
Prior art keywords
enac
chloropyrazine
diamino
treatment
mediated diseases
Prior art date
Application number
MEP-2018-185A
Other languages
German (de)
English (en)
French (fr)
Inventor
Susanne Elisabeth Berglund
Stephen Connolly
Martin Hemmerling
Nafizal Hossain
Anna Kristoffersson
Johan Rune Michael Lundkvist
Grigorios Nikitidis
Lena Elisabeth Ripa
Igor Shamovsky
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ME03056B publication Critical patent/ME03056B/me

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C07D241/28Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MEP-2018-185A 2014-03-18 2015-03-17 Jedinjenja 3,4-diamino-6-hloropirazin-2-karboksamida za tretman bolesti posredovanih sa enac ME03056B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461954674P 2014-03-18 2014-03-18
PCT/GB2015/050765 WO2015140527A1 (en) 2014-03-18 2015-03-17 Chemical compounds
EP15713339.8A EP3119752B1 (en) 2014-03-18 2015-03-17 3,4-diamino-6-chloropyrazine-2-carboxamide compounds for the treatment of enac mediated diseases

Publications (1)

Publication Number Publication Date
ME03056B true ME03056B (me) 2018-10-20

Family

ID=52780553

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2018-185A ME03056B (me) 2014-03-18 2015-03-17 Jedinjenja 3,4-diamino-6-hloropirazin-2-karboksamida za tretman bolesti posredovanih sa enac

Country Status (39)

Country Link
US (3) US9873678B2 (me)
EP (1) EP3119752B1 (me)
JP (1) JP6502469B2 (me)
KR (1) KR102296041B1 (me)
CN (1) CN106103423B (me)
AP (1) AP2016009447A0 (me)
AR (1) AR099790A1 (me)
AU (1) AU2015233195B2 (me)
CA (1) CA2941807C (me)
CL (1) CL2016002303A1 (me)
CR (1) CR20160479A (me)
CY (1) CY1120509T1 (me)
DK (1) DK3119752T3 (me)
DO (1) DOP2016000232A (me)
EA (1) EA029952B1 (me)
ES (1) ES2679618T3 (me)
GT (1) GT201600190A (me)
HR (1) HRP20181123T1 (me)
HU (1) HUE039425T2 (me)
IL (1) IL247610B (me)
LT (1) LT3119752T (me)
ME (1) ME03056B (me)
MX (1) MX368577B (me)
NI (1) NI201600134A (me)
NZ (1) NZ724063A (me)
PE (1) PE20170205A1 (me)
PH (1) PH12016501808A1 (me)
PL (1) PL3119752T3 (me)
PT (1) PT3119752T (me)
RS (1) RS57487B1 (me)
SG (1) SG11201607751SA (me)
SI (1) SI3119752T1 (me)
SM (1) SMT201800378T1 (me)
SV (1) SV2016005278A (me)
TR (1) TR201810207T4 (me)
TW (1) TWI687410B (me)
UY (1) UY36034A (me)
WO (1) WO2015140527A1 (me)
ZA (1) ZA201607136B (me)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7608847B2 (ja) 2021-01-27 2025-01-07 三菱瓦斯化学株式会社 エポキシ樹脂硬化剤、エポキシ樹脂組成物、及び塗料

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US3573306A (en) 1969-03-05 1971-03-30 Merck & Co Inc Process for preparation of n-substituted 3,5-diamino-6-halopyrazinamides
FI820266L (fi) 1981-02-02 1982-08-03 Ici Plc Alkanolaminderivater
US4550111A (en) 1982-01-29 1985-10-29 Imperial Chemical Industries Plc Alkanolamine derivatives
GB8810933D0 (en) 1987-05-26 1988-06-15 Ici America Inc Heterocyclic compounds
GB8810934D0 (en) 1987-05-26 1988-06-15 Ici America Inc Amides
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GB8812343D0 (en) 1988-05-25 1988-06-29 Ici America Inc Amino compounds
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CN1248968A (zh) 1997-02-26 2000-03-29 辉瑞大药厂 杂芳基-己酸酰胺衍生物、其制备方法及其作为MIP-1α与其CCRI受体结合的选择性抑制剂的用途
GB9930557D0 (en) 1999-12-23 2000-02-16 Rolic Ag Optically active materials
WO2001087849A2 (en) 2000-05-12 2001-11-22 Genzyme Corporation Modulators of tnf- alpha signaling
JP2005520791A (ja) 2001-11-08 2005-07-14 イーラン ファーマスーティカルズ、インコーポレイテッド N,n’−置換−1,3−ジアミノ−2−ヒドロキシプロパン誘導体
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US20040087571A1 (en) 2002-10-30 2004-05-06 Pfizer Inc Methods of using CCR1 antagonists as immunomodulatory agents
BR0317426A (pt) 2002-12-20 2005-11-16 Pfizer Prod Inc Inibidores de proteìna de transferência de triglicéridos microssomais
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
AU2005295878A1 (en) 2004-10-13 2006-04-27 University Of Connecticut Cannabinergic lipid ligands
GB0511065D0 (en) 2005-05-31 2005-07-06 Novartis Ag Organic compounds
GB0526240D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
GB0526244D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
WO2008106692A1 (en) 2007-03-01 2008-09-04 Novartis Vaccines And Diagnostics, Inc. Pim kinase inhibitors and methods of their use
KR20100005730A (ko) 2007-05-07 2010-01-15 노파르티스 아게 유기 화합물
PT2444120T (pt) 2007-12-10 2018-01-03 Novartis Ag Análogos da amilorida espirocíclicos como bloqueadores de enac
EP2219646A4 (en) 2007-12-21 2010-12-22 Univ Rochester PROCESS FOR EXTENDING THE LIFE OF EUKARYOTIC ORGANISMS
EA201001772A1 (ru) 2008-05-13 2011-06-30 Новартис Аг Производные 3,5-диамино-6-хлорпиразин-2-карбоновой кислоты и их применение в качестве блокаторов эпителиальных натриевых каналов для лечения заболеваний дыхательных путей
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Also Published As

Publication number Publication date
CA2941807A1 (en) 2015-09-24
EP3119752A1 (en) 2017-01-25
LT3119752T (lt) 2018-08-10
KR20160127135A (ko) 2016-11-02
US9873678B2 (en) 2018-01-23
CL2016002303A1 (es) 2017-01-13
CR20160479A (es) 2017-02-24
JP6502469B2 (ja) 2019-04-17
TWI687410B (zh) 2020-03-11
IL247610A0 (en) 2016-11-30
IL247610B (en) 2019-05-30
NZ724063A (en) 2018-02-23
PH12016501808B1 (en) 2017-01-09
PL3119752T3 (pl) 2018-09-28
MX2016011681A (es) 2016-10-28
US20170107195A1 (en) 2017-04-20
TR201810207T4 (tr) 2018-08-27
CN106103423B (zh) 2019-12-06
AP2016009447A0 (en) 2016-09-30
AU2015233195B2 (en) 2017-04-20
RS57487B1 (sr) 2018-10-31
TW201620880A (zh) 2016-06-16
US10336725B2 (en) 2019-07-02
US20190330187A1 (en) 2019-10-31
PT3119752T (pt) 2018-07-24
HUE039425T2 (hu) 2018-12-28
SMT201800378T1 (it) 2018-09-13
US20180162838A1 (en) 2018-06-14
CN106103423A (zh) 2016-11-09
ZA201607136B (en) 2018-04-25
US10954211B2 (en) 2021-03-23
GT201600190A (es) 2019-07-29
SI3119752T1 (en) 2018-08-31
EA201691641A1 (ru) 2017-02-28
SG11201607751SA (en) 2016-10-28
DK3119752T3 (en) 2018-07-30
PE20170205A1 (es) 2017-04-06
NI201600134A (es) 2017-03-13
EP3119752B1 (en) 2018-05-16
ES2679618T3 (es) 2018-08-29
DOP2016000232A (es) 2016-10-16
AU2015233195A1 (en) 2016-09-22
PH12016501808A1 (en) 2017-01-09
WO2015140527A1 (en) 2015-09-24
SV2016005278A (es) 2016-11-30
EA029952B1 (ru) 2018-06-29
JP2017512830A (ja) 2017-05-25
CA2941807C (en) 2023-03-07
CY1120509T1 (el) 2019-07-10
MX368577B (es) 2019-10-08
AR099790A1 (es) 2016-08-17
HRP20181123T1 (hr) 2018-09-21
UY36034A (es) 2015-09-30
KR102296041B1 (ko) 2021-08-30

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