ME03056B - Jedinjenja 3,4-diamino-6-hloropirazin-2-karboksamida za tretman bolesti posredovanih sa enac - Google Patents
Jedinjenja 3,4-diamino-6-hloropirazin-2-karboksamida za tretman bolesti posredovanih sa enacInfo
- Publication number
- ME03056B ME03056B MEP-2018-185A MEP2018185A ME03056B ME 03056 B ME03056 B ME 03056B ME P2018185 A MEP2018185 A ME P2018185A ME 03056 B ME03056 B ME 03056B
- Authority
- ME
- Montenegro
- Prior art keywords
- enac
- chloropyrazine
- diamino
- treatment
- mediated diseases
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
- C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461954674P | 2014-03-18 | 2014-03-18 | |
PCT/GB2015/050765 WO2015140527A1 (en) | 2014-03-18 | 2015-03-17 | Chemical compounds |
EP15713339.8A EP3119752B1 (en) | 2014-03-18 | 2015-03-17 | 3,4-diamino-6-chloropyrazine-2-carboxamide compounds for the treatment of enac mediated diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
ME03056B true ME03056B (me) | 2018-10-20 |
Family
ID=52780553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-2018-185A ME03056B (me) | 2014-03-18 | 2015-03-17 | Jedinjenja 3,4-diamino-6-hloropirazin-2-karboksamida za tretman bolesti posredovanih sa enac |
Country Status (39)
Country | Link |
---|---|
US (3) | US9873678B2 (me) |
EP (1) | EP3119752B1 (me) |
JP (1) | JP6502469B2 (me) |
KR (1) | KR102296041B1 (me) |
CN (1) | CN106103423B (me) |
AP (1) | AP2016009447A0 (me) |
AR (1) | AR099790A1 (me) |
AU (1) | AU2015233195B2 (me) |
CA (1) | CA2941807C (me) |
CL (1) | CL2016002303A1 (me) |
CR (1) | CR20160479A (me) |
CY (1) | CY1120509T1 (me) |
DK (1) | DK3119752T3 (me) |
DO (1) | DOP2016000232A (me) |
EA (1) | EA029952B1 (me) |
ES (1) | ES2679618T3 (me) |
GT (1) | GT201600190A (me) |
HR (1) | HRP20181123T1 (me) |
HU (1) | HUE039425T2 (me) |
IL (1) | IL247610B (me) |
LT (1) | LT3119752T (me) |
ME (1) | ME03056B (me) |
MX (1) | MX368577B (me) |
NI (1) | NI201600134A (me) |
NZ (1) | NZ724063A (me) |
PE (1) | PE20170205A1 (me) |
PH (1) | PH12016501808A1 (me) |
PL (1) | PL3119752T3 (me) |
PT (1) | PT3119752T (me) |
RS (1) | RS57487B1 (me) |
SG (1) | SG11201607751SA (me) |
SI (1) | SI3119752T1 (me) |
SM (1) | SMT201800378T1 (me) |
SV (1) | SV2016005278A (me) |
TR (1) | TR201810207T4 (me) |
TW (1) | TWI687410B (me) |
UY (1) | UY36034A (me) |
WO (1) | WO2015140527A1 (me) |
ZA (1) | ZA201607136B (me) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7608847B2 (ja) | 2021-01-27 | 2025-01-07 | 三菱瓦斯化学株式会社 | エポキシ樹脂硬化剤、エポキシ樹脂組成物、及び塗料 |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3577418A (en) | 1969-02-12 | 1971-05-04 | Merck & Co Inc | Pyrazinamide derivatives and processes for their preparation |
US3573306A (en) | 1969-03-05 | 1971-03-30 | Merck & Co Inc | Process for preparation of n-substituted 3,5-diamino-6-halopyrazinamides |
FI820266L (fi) | 1981-02-02 | 1982-08-03 | Ici Plc | Alkanolaminderivater |
US4550111A (en) | 1982-01-29 | 1985-10-29 | Imperial Chemical Industries Plc | Alkanolamine derivatives |
GB8810933D0 (en) | 1987-05-26 | 1988-06-15 | Ici America Inc | Heterocyclic compounds |
GB8810934D0 (en) | 1987-05-26 | 1988-06-15 | Ici America Inc | Amides |
US4803206A (en) | 1988-03-07 | 1989-02-07 | Schering Corporation | Antihypertensive acylpyrazines |
GB8812343D0 (en) | 1988-05-25 | 1988-06-29 | Ici America Inc | Amino compounds |
GB8812342D0 (en) | 1988-05-25 | 1988-06-29 | Ici America Inc | Bicyclic compounds |
CN1248968A (zh) | 1997-02-26 | 2000-03-29 | 辉瑞大药厂 | 杂芳基-己酸酰胺衍生物、其制备方法及其作为MIP-1α与其CCRI受体结合的选择性抑制剂的用途 |
GB9930557D0 (en) | 1999-12-23 | 2000-02-16 | Rolic Ag | Optically active materials |
WO2001087849A2 (en) | 2000-05-12 | 2001-11-22 | Genzyme Corporation | Modulators of tnf- alpha signaling |
JP2005520791A (ja) | 2001-11-08 | 2005-07-14 | イーラン ファーマスーティカルズ、インコーポレイテッド | N,n’−置換−1,3−ジアミノ−2−ヒドロキシプロパン誘導体 |
US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
US20040087571A1 (en) | 2002-10-30 | 2004-05-06 | Pfizer Inc | Methods of using CCR1 antagonists as immunomodulatory agents |
BR0317426A (pt) | 2002-12-20 | 2005-11-16 | Pfizer Prod Inc | Inibidores de proteìna de transferência de triglicéridos microssomais |
US6903105B2 (en) | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
AU2005295878A1 (en) | 2004-10-13 | 2006-04-27 | University Of Connecticut | Cannabinergic lipid ligands |
GB0511065D0 (en) | 2005-05-31 | 2005-07-06 | Novartis Ag | Organic compounds |
GB0526240D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
GB0526244D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
WO2008106692A1 (en) | 2007-03-01 | 2008-09-04 | Novartis Vaccines And Diagnostics, Inc. | Pim kinase inhibitors and methods of their use |
KR20100005730A (ko) | 2007-05-07 | 2010-01-15 | 노파르티스 아게 | 유기 화합물 |
PT2444120T (pt) | 2007-12-10 | 2018-01-03 | Novartis Ag | Análogos da amilorida espirocíclicos como bloqueadores de enac |
EP2219646A4 (en) | 2007-12-21 | 2010-12-22 | Univ Rochester | PROCESS FOR EXTENDING THE LIFE OF EUKARYOTIC ORGANISMS |
EA201001772A1 (ru) | 2008-05-13 | 2011-06-30 | Новартис Аг | Производные 3,5-диамино-6-хлорпиразин-2-карбоновой кислоты и их применение в качестве блокаторов эпителиальных натриевых каналов для лечения заболеваний дыхательных путей |
US9315449B2 (en) | 2008-05-15 | 2016-04-19 | Duke University | Substituted pyrazoles as heat shock transcription factor activators |
EP2300010B1 (en) | 2008-06-10 | 2015-03-04 | Novartis AG | Pyrazine derivatives as epithelial sodium channel blockers |
WO2011028740A1 (en) | 2009-09-03 | 2011-03-10 | Glaxo Group Limited | ENaC BLOCKERS |
WO2011079087A1 (en) | 2009-12-23 | 2011-06-30 | Glaxo Group Limited | Enac blockers |
US8372845B2 (en) | 2010-09-17 | 2013-02-12 | Novartis Ag | Pyrazine derivatives as enac blockers |
AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
WO2013192517A2 (en) | 2012-06-21 | 2013-12-27 | Whitehead Institute For Biomedical Research | Compounds for treating infectious diseases |
CA2896686A1 (en) | 2012-12-17 | 2014-06-26 | Parion Sciences, Inc. | 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds |
US9029382B2 (en) | 2012-12-17 | 2015-05-12 | Parion Sciences, Inc. | 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds |
MX379300B (es) | 2012-12-17 | 2025-03-11 | Parion Sciences Inc | Derivados de cloro-pirazin carboxamida con actividad bloqueadora sobre los canales de sodio epiteliales. |
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2015
- 2015-03-16 UY UY0001036034A patent/UY36034A/es not_active Application Discontinuation
- 2015-03-17 JP JP2017500446A patent/JP6502469B2/ja active Active
- 2015-03-17 CR CR20160479A patent/CR20160479A/es unknown
- 2015-03-17 SG SG11201607751SA patent/SG11201607751SA/en unknown
- 2015-03-17 EA EA201691641A patent/EA029952B1/ru not_active IP Right Cessation
- 2015-03-17 PL PL15713339T patent/PL3119752T3/pl unknown
- 2015-03-17 ES ES15713339.8T patent/ES2679618T3/es active Active
- 2015-03-17 KR KR1020167028483A patent/KR102296041B1/ko active Active
- 2015-03-17 SM SM20180378T patent/SMT201800378T1/it unknown
- 2015-03-17 CA CA2941807A patent/CA2941807C/en active Active
- 2015-03-17 HU HUE15713339A patent/HUE039425T2/hu unknown
- 2015-03-17 TW TW104108476A patent/TWI687410B/zh active
- 2015-03-17 DK DK15713339.8T patent/DK3119752T3/en active
- 2015-03-17 PE PE2016001600A patent/PE20170205A1/es unknown
- 2015-03-17 ME MEP-2018-185A patent/ME03056B/me unknown
- 2015-03-17 TR TR2018/10207T patent/TR201810207T4/tr unknown
- 2015-03-17 NZ NZ724063A patent/NZ724063A/en not_active IP Right Cessation
- 2015-03-17 EP EP15713339.8A patent/EP3119752B1/en active Active
- 2015-03-17 AU AU2015233195A patent/AU2015233195B2/en active Active
- 2015-03-17 AP AP2016009447A patent/AP2016009447A0/en unknown
- 2015-03-17 RS RS20180833A patent/RS57487B1/sr unknown
- 2015-03-17 WO PCT/GB2015/050765 patent/WO2015140527A1/en active Application Filing
- 2015-03-17 US US15/124,393 patent/US9873678B2/en active Active
- 2015-03-17 PT PT157133398T patent/PT3119752T/pt unknown
- 2015-03-17 CN CN201580013691.1A patent/CN106103423B/zh active Active
- 2015-03-17 SI SI201530318T patent/SI3119752T1/en unknown
- 2015-03-17 MX MX2016011681A patent/MX368577B/es active IP Right Grant
- 2015-03-17 LT LTEP15713339.8T patent/LT3119752T/lt unknown
- 2015-03-18 AR ARP150100820A patent/AR099790A1/es unknown
-
2016
- 2016-09-04 IL IL247610A patent/IL247610B/en not_active IP Right Cessation
- 2016-09-07 DO DO2016000232A patent/DOP2016000232A/es unknown
- 2016-09-13 NI NI201600134A patent/NI201600134A/es unknown
- 2016-09-13 CL CL2016002303A patent/CL2016002303A1/es unknown
- 2016-09-14 GT GT201600190A patent/GT201600190A/es unknown
- 2016-09-14 SV SV2016005278A patent/SV2016005278A/es unknown
- 2016-09-16 PH PH12016501808A patent/PH12016501808A1/en unknown
- 2016-10-17 ZA ZA2016/07136A patent/ZA201607136B/en unknown
-
2017
- 2017-12-13 US US15/840,339 patent/US10336725B2/en active Active
-
2018
- 2018-07-16 HR HRP20181123TT patent/HRP20181123T1/hr unknown
- 2018-07-18 CY CY20181100750T patent/CY1120509T1/el unknown
-
2019
- 2019-05-10 US US16/408,741 patent/US10954211B2/en active Active
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