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MD20150050A2 - Soluţii midriatice şi antiinflamatorii stabile fără conservanţi pentru injectare - Google Patents

Soluţii midriatice şi antiinflamatorii stabile fără conservanţi pentru injectare Download PDF

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Publication number
MD20150050A2
MD20150050A2 MDA20150050A MD20150050A MD20150050A2 MD 20150050 A2 MD20150050 A2 MD 20150050A2 MD A20150050 A MDA20150050 A MD A20150050A MD 20150050 A MD20150050 A MD 20150050A MD 20150050 A2 MD20150050 A2 MD 20150050A2
Authority
MD
Moldova
Prior art keywords
injection
free
preservative
stable
stable preservative
Prior art date
Application number
MDA20150050A
Other languages
English (en)
Russian (ru)
Inventor
Грегори А. ДЕМОПУЛОС
Хуэй-жун ШЭНЬ
Кларк Е. ТЕДФОРД
Original Assignee
Omeros Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50545210&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD20150050(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Omeros Corporation filed Critical Omeros Corporation
Publication of MD20150050A2 publication Critical patent/MD20150050A2/ro

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/08—Mydriatics or cycloplegics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)
  • Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Prezenta invenţie se referă la compoziţii farmaceutice lichide stabile de ketorolac şi fenilefrină injectabile pentru utilizare în soluţii de irigare în chirurgia oftalmologică.Compoziţia mai conţine un sistem tampon într-un purtător apos şi nu conţine conservanţi şi antioxidanţi.Sistemul tampon preferabil este selectat din sistemul fosfat de sodiu sau citrat de sodiu, iar compoziţia are un pH în intervalul 5,8… 6,8.
MDA20150050A 2012-10-24 2013-10-23 Soluţii midriatice şi antiinflamatorii stabile fără conservanţi pentru injectare MD20150050A2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718026P 2012-10-24 2012-10-24
US201261736179P 2012-12-12 2012-12-12
PCT/US2013/066349 WO2014066485A1 (en) 2012-10-24 2013-10-23 Stable preservative-free mydriatic and anti-inflammatory solutions for injection

Publications (1)

Publication Number Publication Date
MD20150050A2 true MD20150050A2 (ro) 2015-09-30

Family

ID=50545210

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20150050A MD20150050A2 (ro) 2012-10-24 2013-10-23 Soluţii midriatice şi antiinflamatorii stabile fără conservanţi pentru injectare

Country Status (39)

Country Link
US (6) US9066856B2 (ro)
EP (2) EP3909572A1 (ro)
JP (8) JP6017053B2 (ro)
KR (4) KR101808394B1 (ro)
CN (2) CN104822265A (ro)
AP (1) AP2015008459A0 (ro)
AR (1) AR093115A1 (ro)
AU (1) AU2013201465B2 (ro)
BR (1) BR112015009228B1 (ro)
CA (1) CA2887772C (ro)
CL (1) CL2015001078A1 (ro)
CR (1) CR20150233A (ro)
CU (1) CU20150037A7 (ro)
CY (1) CY1124481T1 (ro)
DK (1) DK2911511T3 (ro)
EA (1) EA033811B1 (ro)
ES (1) ES2875432T3 (ro)
GE (1) GEP20186891B (ro)
HR (1) HRP20210980T1 (ro)
HU (1) HUE055537T2 (ro)
IL (1) IL238439B2 (ro)
IN (1) IN2015DN03029A (ro)
LT (1) LT2911511T (ro)
MA (1) MA38096B1 (ro)
MD (1) MD20150050A2 (ro)
MX (2) MX382411B (ro)
MY (1) MY188474A (ro)
NZ (1) NZ628398A (ro)
PE (1) PE20150958A1 (ro)
PH (1) PH12015500850B1 (ro)
PL (1) PL2911511T3 (ro)
PT (1) PT2911511T (ro)
RS (1) RS62188B1 (ro)
SG (1) SG11201502602WA (ro)
SI (1) SI2911511T1 (ro)
SM (1) SMT202100393T1 (ro)
UA (1) UA114650C2 (ro)
WO (1) WO2014066485A1 (ro)
ZA (1) ZA201502684B (ro)

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CN103143022A (zh) 2002-07-30 2013-06-12 奥默罗斯公司 眼科冲洗液及方法
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