[go: up one dir, main page]

MA38096A1 - Solutions mydriatiques et anti-inflammatoires stables sans agents de conservation destinees a etre injectees - Google Patents

Solutions mydriatiques et anti-inflammatoires stables sans agents de conservation destinees a etre injectees

Info

Publication number
MA38096A1
MA38096A1 MA38096A MA38096A MA38096A1 MA 38096 A1 MA38096 A1 MA 38096A1 MA 38096 A MA38096 A MA 38096A MA 38096 A MA38096 A MA 38096A MA 38096 A1 MA38096 A1 MA 38096A1
Authority
MA
Morocco
Prior art keywords
preservatives
stable
mydriatic
injected
inflammatory
Prior art date
Application number
MA38096A
Other languages
English (en)
Other versions
MA38096B1 (fr
Inventor
Gregory A Demopulos
Hui-Rong Shen
Clark E Tedford
Original Assignee
Omeros Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50545210&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA38096(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Omeros Corp filed Critical Omeros Corp
Publication of MA38096A1 publication Critical patent/MA38096A1/fr
Publication of MA38096B1 publication Critical patent/MA38096B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/08—Mydriatics or cycloplegics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)
  • Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La présente invention concerne des formulations liquides stables, sans agents de conservation et sans antioxydants, de phényléphrine et de kétorolac destinées à être injectées.
MA38096A 2012-10-24 2013-10-23 Solutions mydriatiques et anti-inflammatoires stables sans agents de conservation destinees a etre injectees MA38096B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718026P 2012-10-24 2012-10-24
US201261736179P 2012-12-12 2012-12-12
PCT/US2013/066349 WO2014066485A1 (fr) 2012-10-24 2013-10-23 Solutions mydriatiques et anti-inflammatoires stables sans agents de conservation destinées à être injectées

Publications (2)

Publication Number Publication Date
MA38096A1 true MA38096A1 (fr) 2016-10-31
MA38096B1 MA38096B1 (fr) 2019-12-31

Family

ID=50545210

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38096A MA38096B1 (fr) 2012-10-24 2013-10-23 Solutions mydriatiques et anti-inflammatoires stables sans agents de conservation destinees a etre injectees

Country Status (40)

Country Link
US (6) US9066856B2 (fr)
EP (2) EP3909572A1 (fr)
JP (8) JP6017053B2 (fr)
KR (4) KR101808394B1 (fr)
CN (2) CN108721210A (fr)
AP (1) AP2015008459A0 (fr)
AR (1) AR093115A1 (fr)
AU (1) AU2013201465B2 (fr)
BR (1) BR112015009228B1 (fr)
CA (1) CA2887772C (fr)
CL (1) CL2015001078A1 (fr)
CR (1) CR20150233A (fr)
CU (1) CU20150037A7 (fr)
CY (1) CY1124481T1 (fr)
DK (1) DK2911511T3 (fr)
EA (1) EA033811B1 (fr)
ES (1) ES2875432T3 (fr)
GE (1) GEP20186891B (fr)
HK (1) HK1213434A1 (fr)
HR (1) HRP20210980T1 (fr)
HU (1) HUE055537T2 (fr)
IL (1) IL238439B2 (fr)
IN (1) IN2015DN03029A (fr)
LT (1) LT2911511T (fr)
MA (1) MA38096B1 (fr)
MD (1) MD20150050A2 (fr)
MX (2) MX2020012591A (fr)
MY (1) MY188474A (fr)
NZ (1) NZ628398A (fr)
PE (1) PE20150958A1 (fr)
PH (1) PH12015500850B1 (fr)
PL (1) PL2911511T3 (fr)
PT (1) PT2911511T (fr)
RS (1) RS62188B1 (fr)
SG (1) SG11201502602WA (fr)
SI (1) SI2911511T1 (fr)
SM (1) SMT202100393T1 (fr)
UA (1) UA114650C2 (fr)
WO (1) WO2014066485A1 (fr)
ZA (1) ZA201502684B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1684701B (zh) 2002-07-30 2012-10-17 奥默罗斯公司 眼科冲洗液及方法
AU2013201465B2 (en) * 2012-10-24 2016-03-03 Rayner Intraocular Lenses Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
US20210346318A1 (en) * 2013-10-03 2021-11-11 Harrow Ip, Llc Epinephrine-based ophthalmic compositions for intraocular administration and methods for fabricating thereof
AU2014329412B2 (en) 2013-10-03 2020-02-27 Harrow Ip, Llc Epinephrine-based ophthalmic compositions for intraocular administration and methods for fabricating thereof
TWI705812B (zh) * 2014-12-01 2020-10-01 奥默羅斯公司 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液
CN104856990A (zh) * 2015-05-07 2015-08-26 武汉武药科技有限公司 去氧肾上腺素酮咯酸溶液及制备方法
US11213480B1 (en) 2015-08-06 2022-01-04 Hikma Pharmaceuticals International Limited Phenylephrine hydrochloride ready-to-use solution
USD831868S1 (en) 2015-09-17 2018-10-23 Lume Cube, Inc. Compact external light
US10704745B2 (en) 2015-10-13 2020-07-07 Lume Cube, Inc. Mobile light source
KR20190035927A (ko) 2016-08-25 2019-04-03 임프리미스 파마슈티컬스, 인크. 안구 내 투여를 위한 에피네프린-기반 안과용 조성물 및 이의 제조방법
US20180318319A1 (en) * 2017-05-04 2018-11-08 Ocular Science, Inc. Compositions and Methods for Treating Eyes and Methods of Preparation
JP7078843B2 (ja) * 2018-03-26 2022-06-01 サミー株式会社 遊技機
EP3870170A4 (fr) * 2018-10-26 2022-07-20 Ocuphire Pharma, Inc. Méthodes et compositions pour le traitement de la presbytie, de la mydriase et d'autres troubles oculaires
US11071724B2 (en) 2019-05-17 2021-07-27 Ocular Science, Inc. Compositions and methods for treating presbyopia
DE102019125430B3 (de) * 2019-09-20 2020-11-19 Carl Zeiss Meditec Ag Steuerungsvorrichtung für ein ophthalmochirurgisches System, ophthalmochirurgisches System sowie Computerprogrammprodukt
KR102749980B1 (ko) 2020-01-02 2025-01-03 삼성전자주식회사 에어 스페이서를 가지는 반도체 소자
US20210228507A1 (en) * 2020-01-22 2021-07-29 Nevakar Inc. Phenylephrine Hydrochloride Compositions and Containers
US20240058320A1 (en) * 2020-12-17 2024-02-22 Harrow Ip, Llc Mydriatic compositions and methods for fabricating thereof
CN115368310A (zh) 2021-05-18 2022-11-22 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法
US12029729B2 (en) 2021-07-23 2024-07-09 Somerset Therapeutics, Llc Chelated, stable ophthalmological compositions of ketorolac and phenylephrine and applications thereof
US11793789B2 (en) 2021-07-23 2023-10-24 Somerset Therapeutics, Llc Treatment of ophthalmological conditions using buffer-free ophthalmological compositions of ketorolac and phenylephrine
WO2024086268A1 (fr) * 2022-10-19 2024-04-25 Fresenius Kabi Austria Gmbh Formulations liquides de phényléphrine
CN115950992B (zh) * 2023-03-15 2023-06-09 苏州朗易生物医药研究有限公司 一种去氧肾上腺素酮咯酸溶液中有关物质的检测方法及其应用

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4402949A (en) 1979-11-12 1983-09-06 Sandoz Ltd. Stable solutions of hydrogenated ergotalkaloids
US4550022A (en) 1981-10-05 1985-10-29 Alcon Laboratories, Inc. Tissue irrigating solution
JPS58126810A (ja) 1981-12-24 1983-07-28 Kaken Pharmaceut Co Ltd 抗炎症眼科用液剤およびその製法
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
JPS6017053U (ja) 1983-07-11 1985-02-05 住友電気工業株式会社 伝送エラ−検出器
WO1987007141A1 (fr) 1986-05-23 1987-12-03 New England Medical Center Hospitals, Inc. Methode de traitement du glaucome
US5212196A (en) 1986-10-21 1993-05-18 Alcon Laboratories, Inc. Control of post-surgical intraocular pressure using clonidine derivatives
US4938970A (en) 1987-02-06 1990-07-03 Hustead Robert E Painless electrolyte solutions
US5110493A (en) 1987-09-11 1992-05-05 Syntex (U.S.A.) Inc. Ophthalmic NSAID formulations containing a quaternary ammonium preservative and a nonionic surfactant
US4876250A (en) 1988-10-31 1989-10-24 Alcon Laboratories, Inc. Methods for controlling ocular hypertension with angiostatic steroids
DE3833893A1 (de) 1988-10-05 1990-04-12 Bayer Ag Verwendung von basischen nitro-phenyl-dihydropyridin-amiden als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung ueber neue zwischenprodukte
US5051443A (en) 1988-10-12 1991-09-24 Eye Research Institute Of Retina Foundation, Inc. Method for enhancing healing of corneal endothelial wounds
US5036046A (en) 1988-10-12 1991-07-30 Eye Research Institute Of Retina Foundation, Inc. Method for enhancing healing of corneal endothelial wounds
US5371078A (en) 1988-10-31 1994-12-06 Alcon Laboratories, Inc. Angiostatic steroids and methods and compositions for controlling ocular hypertension
US5116868A (en) 1989-05-03 1992-05-26 The Johns Hopkins University Effective ophthalmic irrigation solution
CA2065375A1 (fr) 1989-08-21 1991-02-22 Richard J. Sharpe Methode et composition pour le traitement de l'hypersensibilite, l'inflammation et des troubles hyperproliferatifs de la peau, des yeux et des muqueuses a l'aide de preparations topiques d'inhibiteurs de la serotonine
US5679650A (en) * 1993-11-24 1997-10-21 Fukunaga; Atsuo F. Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine
WO1992004008A1 (fr) 1990-09-07 1992-03-19 Universidad De Alicante Composition pour le traitement des douleurs oculaires
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
IT1252692B (it) 1991-11-27 1995-06-23 Zambon Spa Composizione farmaceutica per uso oftalmico contenente un antiinfiammatorio non steroideo ed un decongestionante come principi attivi
WO1994008602A1 (fr) * 1992-10-21 1994-04-28 Alcon Laboratories, Inc. Composition destinee a irriguer les tissus intraoculaires et a maintenir la mydriase lors d'une chirurgie intraoculaire
US6117907A (en) 1993-04-14 2000-09-12 Sher; Neal A. Topical treatment of ocular pain after corneal surgery
JPH08503968A (ja) 1993-09-29 1996-04-30 アルコン ラボラトリーズ，インコーポレイテッド 増殖因子と代謝拮抗物質を含有する組成物
JPH08503969A (ja) 1993-09-29 1996-04-30 アルコン ラボラトリーズ，インコーポレイテッド 増殖因子と組織形成抑制剤を含有する組成物
US5624893A (en) 1993-10-14 1997-04-29 Alcon Laboratories, Inc. Pharmaceutical compositions and methods of treatment of the cornea following laser irradiation
CA2179147A1 (fr) 1993-12-17 1995-06-22 Gerald D. Cagle Solution d'irrigation intraoculaire amelioree contenat un agent anti-inflammatoire non-steroidien
US6350781B1 (en) 1994-01-14 2002-02-26 Lee Shahinia, Jr. Method and analgesic preparations for sustained and extended corneal analgesia with subanesthetic concentrations of lidocaine
WO1995034298A1 (fr) 1994-06-10 1995-12-21 Telor Ophthalmic Pharmaceuticals, Inc. Inhibition du myosis/de la production de mydriase peroperatoire par des anesthesiques locaux
US5523316A (en) 1994-06-23 1996-06-04 Alcon Laboratories, Inc. Intraocular irrigating solution containing agent for controlling IOP
US6492332B1 (en) 1995-12-12 2002-12-10 Omeros Corporation Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
AU4467396A (en) 1994-12-12 1996-07-10 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain, inflammation and spasm
MX9703988A (es) 1994-12-12 1998-02-28 Omeros Med Sys Inc SOLUCIaN Y MÉTODO DE IRRIGACIaN PARA LA INHIBICIaN DEL DOLOR, LA INFLAMACIaN Y ES ESPASMO.
KR100517210B1 (ko) 1994-12-12 2006-06-07 오메로스 코포레이션 통증,염증및경련억제용관주용액
WO2000023062A2 (fr) 1998-10-20 2000-04-27 Omeros Medical Systems, Inc. Solution et methode d'irrigation destinees a l'inhibition d'une douleur et d'une inflammation
US7091181B2 (en) 1994-12-12 2006-08-15 Omeros Corporation Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
US5612027A (en) 1995-04-18 1997-03-18 Galin; Miles A. Controlled release of miotic and mydriatic drugs in the anterior chamber
US5972326A (en) 1995-04-18 1999-10-26 Galin; Miles A. Controlled release of pharmaceuticals in the anterior chamber of the eye
US5767105A (en) 1995-05-03 1998-06-16 Peyman; Gholam A. Ocular solution
US5798356A (en) 1995-08-07 1998-08-25 Alcon Laboratories, Inc. Angiostatic compounds
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6413961B1 (en) 1995-12-12 2002-07-02 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
US6280745B1 (en) 1997-12-23 2001-08-28 Alliance Pharmaceutical Corp. Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions
WO1998004171A1 (fr) 1996-07-26 1998-02-05 Schein Dental Equipment Co. Mecanisme d'accoudoir pour fauteuils dentaires
GB9704352D0 (en) 1997-03-03 1997-04-23 Chiroscience Ltd Levobupivacaine and its use
WO1998043619A2 (fr) 1997-04-02 1998-10-08 The Regents Of The University Of California Procede d'anesthesie
US5811446A (en) 1997-04-18 1998-09-22 Cytos Pharmaceuticals Llc Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor
US6034256A (en) 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation
US6495598B1 (en) 1997-04-22 2002-12-17 Ophtecs Corporation Perfusate preparation for ophthalmic operation
EP0903151A1 (fr) 1997-09-22 1999-03-24 ASTA Medica Aktiengesellschaft Utilisation de combinations comprenant des antihistamines non sédatives et des agonistes alpha-adrenergiques pour le traitement topical du rhinitis/conjunctivitis et des symptomes du rhume et de la grippe
WO2000001379A1 (fr) 1998-07-01 2000-01-13 Warner-Lambert Company (-)-pseudoephedrine en tant que medicament sympathomimetique
DK1037627T3 (da) 1998-07-14 2001-10-01 Alcon Lab Inc Anvendelse af 11-(3-dimethylamino-propyliden)-6, 11-dihydrodibenz[b,e]oxepin-2-eddikesyre og af farmaceutisk acceptable salte deraf til fremstillingen af et lægemiddel til behandlingen af non-allergiske...
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
FR2782721B1 (fr) 1998-09-01 2000-11-03 Inst Nat Sante Rech Med Nouveaux composes phosphohalohydrines, procede de fabrication et applications
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
ATE291907T1 (de) 1998-10-20 2005-04-15 Omeros Corp Spülende lösung und methoden zur hemmung von schmerzen und entzündungen
US7973068B2 (en) 1998-10-20 2011-07-05 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
US20030087962A1 (en) 1998-10-20 2003-05-08 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
AU1127700A (en) 1998-10-20 2000-05-08 Omeros Medical Systems, Inc. Irrigation solution containing mapk inhibitors and their use for treating pain and inflammation
AU1214800A (en) 1998-10-21 2000-05-08 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
AU1345000A (en) 1998-11-05 2000-05-22 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
AU3119100A (en) 1998-12-17 2000-07-03 Alcon Laboratories, Inc. Methods for the prevention and treatment of post-surgical complications
EP1165095B1 (fr) * 1999-03-02 2008-05-28 Vitreo-Retinal Technologies, Inc. Agents destines a etre administres par voie intravitreenne pour traiter ou prevenir des troubles oculaires
BR0010546A (pt) 1999-05-14 2002-03-05 Univ California Terapia antiinflamatória para infecção mediada inflamatória
CA2388828A1 (fr) 1999-10-22 2001-06-14 Transdermatech, Inc. Formulation d'anesthesique topique
CA2407683C (fr) 2000-04-28 2010-04-13 Memorial Sloan-Kettering Cancer Center Formulations topiques a base d'anesthesique et d'opioide, et utilisations associees
US6218428B1 (en) 2000-04-28 2001-04-17 Emil Chynn Ophthalmic composition
PE20020146A1 (es) 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
AU5754701A (en) 2000-07-13 2002-01-30 Pharmacia Corp Method of using cox-2 inhibitors in the treatment and prevention of ocular cox-2mediated disorders
CN1441679A (zh) 2000-07-14 2003-09-10 阿勒根公司 包含具有提高的溶解度的治疗活性组分的组合物
AR035651A1 (es) 2000-07-28 2004-06-23 Univ Madrid Complutense Uso de derivados de indol para la manufactura de un medicamento para reducir la presion intraocular y una composicion
JP2002161032A (ja) 2000-09-14 2002-06-04 Taisho Pharmaceut Co Ltd 粘膜適用組成物
WO2002024191A1 (fr) 2000-09-20 2002-03-28 Yong Guang Pharmaceutical Co., Ltd. Medicament permettant de traiter et de prevenir la myopie
US20020183279A1 (en) 2001-04-18 2002-12-05 Koichiro Tanaka Pharmaceutical composition containing viscoelastic substance and medication
US20020198209A1 (en) 2001-05-03 2002-12-26 Allergan Sales Inc. Compositions having enhanced pharmacokinetic characteristics
US20030191187A1 (en) 2002-04-01 2003-10-09 Lee Fang Yu Injectable pharmaceutical composition containing a non-steroidal anti-inflammatory drug and method for preparing the same
CN1684701B (zh) * 2002-07-30 2012-10-17 奥默罗斯公司 眼科冲洗液及方法
US7439241B2 (en) 2003-05-27 2008-10-21 Galderma Laboratories, Inc. Compounds, formulations, and methods for treating or preventing rosacea
MX2007007613A (es) * 2004-12-22 2007-08-03 Schering Corp Formulaciones farmaceuticas.
SG161208A1 (en) 2004-12-23 2010-05-27 Roxro Pharma Inc Therapeutic compositions for intranasal administration of ketorolac
FR2882930B1 (fr) 2005-03-09 2009-03-27 Walid Katib Nouvelles compositions ophtalmologiques et leur mode d'utilisation
DOP2007000055A (es) * 2006-04-10 2007-10-31 Senosiain S A De C V Lab Composición farmaceutica que comprende un analgésico y vitaminas
CA2697160A1 (fr) 2007-08-21 2009-02-26 Harbor Biosciences, Inc. Compositions et formulations therapeutiques stabilisees
CN101977595A (zh) 2007-11-08 2011-02-16 阿西克斯医疗公司 用于治疗以及预防眼睑肿胀的组合物
RU2600863C2 (ru) 2007-12-10 2016-10-27 Сентисс Фарма Прайвит Лимитед Офтальмическая композиция, включающая фенилэфрин
US7842714B2 (en) 2008-03-03 2010-11-30 Allergan, Inc. Ketorolac tromethamine compositions for treating ocular pain
US9192571B2 (en) 2008-03-03 2015-11-24 Allergan, Inc. Ketorolac tromethamine compositions for treating or preventing ocular pain
RU2011140486A (ru) * 2009-03-06 2013-04-20 МЕДИММЬЮН, ЭлЭлСи Композиции, содержащие гуманизированные антитела к cd19
US8277781B2 (en) 2009-03-13 2012-10-02 Luitpold Pharmaceuticals, Inc. Device for intranasal administration
WO2010141834A1 (fr) * 2009-06-05 2010-12-09 Aciex Therapeutics, Inc. Formulations ophtalmiques de fluticasone et procédés d'utilisation
JP2012528888A (ja) 2009-06-05 2012-11-15 アーシエックス セラピューティックス， インコーポレイテッド 眼科用配合剤、その製造方法およびその使用方法
US8680510B2 (en) 2010-06-28 2014-03-25 International Business Machines Corporation Method of forming compound semiconductor
US10213431B2 (en) 2010-07-29 2019-02-26 Allergan, Inc. Preservative free brimonidine and timolol solutions
AU2013201465B2 (en) * 2012-10-24 2016-03-03 Rayner Intraocular Lenses Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
TWI705812B (zh) 2014-12-01 2020-10-01 奥默羅斯公司 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液

Also Published As

Publication number Publication date
CR20150233A (es) 2015-08-14
SG11201502602WA (en) 2015-05-28
CN108721210A (zh) 2018-11-02
CN104822265A (zh) 2015-08-05
BR112015009228B1 (pt) 2022-07-19
KR20150068990A (ko) 2015-06-22
IL238439B2 (en) 2023-11-01
BR112015009228A8 (pt) 2022-07-12
MA38096B1 (fr) 2019-12-31
AR093115A1 (es) 2015-05-20
JP2020147606A (ja) 2020-09-17
CA2887772C (fr) 2017-02-21
AU2013201465B2 (en) 2016-03-03
EP2911511A1 (fr) 2015-09-02
PT2911511T (pt) 2021-07-06
ES2875432T3 (es) 2021-11-10
CL2015001078A1 (es) 2015-09-04
KR20200000487A (ko) 2020-01-02
KR101808394B1 (ko) 2017-12-12
MD20150050A2 (ro) 2015-09-30
JP2019081798A (ja) 2019-05-30
LT2911511T (lt) 2021-07-26
RS62188B1 (sr) 2021-08-31
SI2911511T1 (sl) 2021-09-30
JP2016196511A (ja) 2016-11-24
PE20150958A1 (es) 2015-07-09
ZA201502684B (en) 2016-01-27
JP6282699B2 (ja) 2018-02-21
KR102496463B1 (ko) 2023-02-06
MX2020012591A (es) 2022-11-04
AP2015008459A0 (en) 2015-05-31
UA114650C2 (uk) 2017-07-10
HRP20210980T1 (hr) 2021-09-17
IN2015DN03029A (fr) 2015-10-02
SMT202100393T1 (it) 2021-09-14
KR20170128640A (ko) 2017-11-22
PH12015500850B1 (en) 2017-11-17
JP2025019330A (ja) 2025-02-06
US20150342928A1 (en) 2015-12-03
CA2887772A1 (fr) 2014-05-01
JP2015535250A (ja) 2015-12-10
CU20150037A7 (es) 2015-08-27
EP3909572A1 (fr) 2021-11-17
HK1213434A1 (zh) 2016-07-08
JP2017014294A (ja) 2017-01-19
AU2013201465A1 (en) 2014-05-08
US9066856B2 (en) 2015-06-30
WO2014066485A1 (fr) 2014-05-01
KR20210018954A (ko) 2021-02-18
KR102211784B1 (ko) 2021-02-04
US9855246B2 (en) 2018-01-02
EP2911511A4 (fr) 2015-12-16
US20250032452A1 (en) 2025-01-30
IL238439A0 (en) 2015-06-30
EP2911511B1 (fr) 2021-04-14
US20140235691A1 (en) 2014-08-21
US20180085349A1 (en) 2018-03-29
PH12015500850A1 (en) 2015-06-22
JP2018058905A (ja) 2018-04-12
MX2015005089A (es) 2015-07-17
MY188474A (en) 2021-12-13
NZ628398A (en) 2016-03-31
EA033811B1 (ru) 2019-11-27
US12133842B2 (en) 2024-11-05
JP6017053B2 (ja) 2016-10-26
IL238439B1 (en) 2023-07-01
GEP20186891B (en) 2018-09-10
PL2911511T3 (pl) 2021-11-15
CY1124481T1 (el) 2022-07-22
EA201590807A1 (ru) 2015-11-30
DK2911511T3 (en) 2021-06-28
US20220175726A1 (en) 2022-06-09
BR112015009228A2 (pt) 2017-07-04
HUE055537T2 (hu) 2021-12-28
US20170196838A1 (en) 2017-07-13
JP2023041804A (ja) 2023-03-24
US9486406B2 (en) 2016-11-08

Similar Documents

Publication Publication Date Title
MA38096A1 (fr) Solutions mydriatiques et anti-inflammatoires stables sans agents de conservation destinees a etre injectees
EA201591004A1 (ru) Производные бороновой кислоты и их терапевтическое применение
JOP20200175A1 (ar) حقنة
PH12015501082B1 (en) Pyridine -2-amides useful as cb2 agonists
BR112012017488A2 (pt) "dispositivo"
MX2014001368A (es) Soluciones anti-inflamatorias estables para inyección.
BR112014025041B8 (pt) Composição farmacêutica
CO6920289A2 (es) Composición farmacéutica oftalmológica tópica que contiene regorafenib.
CO6592109A2 (es) Nueva forma cristalina de un derivado de ciclopropilbenzamida
BR112014016803A2 (pt) amidas macrocíclicas como inibidoras de protease
EP2890593A4 (fr) Mesures actives de protection contre l'explosion
CR20120521A (es) Combinaciones de principios activos
UA103290C2 (ru) Фармацевтическая композиция ибупрофена для инъекции
IT1401289B1 (it) Composti dotati di attivita' antiossidante nei confronti dei radicali liberi, e composizioni farmaceutiche e cosmetiche che li contengono
BR112013027391A2 (pt) formulação farmacêutica, frasco e kit
FR2993776B1 (fr) Agent actif et compositions cosmetiques anti-rides.
TH1401001184B (th) อุปกรณ์สำหรับการฉีดยาตามขนาดปริมาณโดยอัตโนมัติ
UA109890C2 (xx) Композиція, що включає пестицид і алкоксилат 2-пропілгептиламіну