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MA54546A - Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a - Google Patents

Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a

Info

Publication number
MA54546A
MA54546A MA054546A MA54546A MA54546A MA 54546 A MA54546 A MA 54546A MA 054546 A MA054546 A MA 054546A MA 54546 A MA54546 A MA 54546A MA 54546 A MA54546 A MA 54546A
Authority
MA
Morocco
Prior art keywords
amides useful
heteroaryl amides
kif18a
inhibitors
kif18a inhibitors
Prior art date
Application number
MA054546A
Other languages
English (en)
Inventor
Abhisek Banerjee
Matthew Paul Bourbeau
Jian Jeffrey Chen
Lei Jia
Kexue Li
Liping H Pettus
Nuria A Tamayo
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA54546A publication Critical patent/MA54546A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA054546A 2018-12-20 2019-12-20 Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a MA54546A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862783065P 2018-12-20 2018-12-20

Publications (1)

Publication Number Publication Date
MA54546A true MA54546A (fr) 2022-03-30

Family

ID=69374367

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054546A MA54546A (fr) 2018-12-20 2019-12-20 Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a

Country Status (9)

Country Link
US (1) US20220056015A1 (fr)
EP (1) EP3898616B1 (fr)
JP (2) JP2022513967A (fr)
AU (1) AU2019404576A1 (fr)
CA (1) CA3123227A1 (fr)
ES (1) ES2996960T3 (fr)
MA (1) MA54546A (fr)
MX (1) MX2021007158A (fr)
WO (1) WO2020132649A1 (fr)

Families Citing this family (28)

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Publication number Priority date Publication date Assignee Title
EP3897852A1 (fr) * 2018-12-20 2021-10-27 Amgen Inc. Inhibiteurs de kif18a
WO2021026099A1 (fr) * 2019-08-02 2021-02-11 Amgen Inc. Inhibiteurs de kif18a
CA3146693A1 (fr) * 2019-08-02 2021-02-11 Amgen Inc. Inhibiteurs de kif18a
MX2022001181A (es) * 2019-08-02 2022-02-22 Amgen Inc Inhibidores de kif18a.
US20230406860A1 (en) 2020-10-27 2023-12-21 Amgen Inc. Heterocyclic spiro compounds and methods of use
JP2024517693A (ja) 2021-04-29 2024-04-23 アムジエン・インコーポレーテツド ２－アミノベンゾチアゾール化合物及びその使用方法
CN117980298A (zh) * 2021-06-25 2024-05-03 杭州英创医药科技有限公司 作为kif18a抑制剂的化合物
TW202317092A (zh) 2021-08-26 2023-05-01 美商佛拉斯托醫療公司 Ｋｉｆ１８ａ之吲哚啉抑制劑
CN118076586A (zh) * 2021-09-16 2024-05-24 微境生物医药科技(上海)有限公司 Kif18a抑制剂
JP2024542199A (ja) * 2021-11-19 2024-11-13 ウィゲン・バイオメディシン・テクノロジー・（シャンハイ）・カンパニー・リミテッド Ｋｉｆ１８ａ阻害剤
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CN118715215A (zh) 2022-02-16 2024-09-27 美国安进公司 作为突变kras蛋白抑制剂的喹唑啉化合物及其用途
EP4514790A1 (fr) * 2022-04-28 2025-03-05 Volastra Therapeutics, Inc. Composés pour inhiber kif18a
CN116554151B (zh) * 2022-05-13 2024-09-20 上海湃隆生物科技有限公司 驱动蛋白kif18a抑制剂及其应用
WO2023217232A1 (fr) * 2022-05-13 2023-11-16 上海湃隆生物科技有限公司 Inhibiteur de kinésine kif18a et son utilisation
AU2023299816A1 (en) * 2022-06-30 2025-02-13 Suzhou Genhouse Bio Co., Ltd. Nitrogen-containing compound and use thereof
WO2024035950A1 (fr) * 2022-08-12 2024-02-15 Accent Therapeutics, Inc. Inhibiteurs de kif18a et leurs utilisations
TW202416973A (zh) * 2022-08-18 2024-05-01 美商雅客森醫療公司 Ｋｉｆ１８ａ抑制劑及其用途
CN119072473A (zh) * 2022-09-30 2024-12-03 长春金赛药业有限责任公司 稠环类kif18a抑制剂化合物、药物组合物及其制备方法和应用
WO2024083137A1 (fr) * 2022-10-19 2024-04-25 海南先声再明医药股份有限公司 Composés hydrocarbonés aromatiques hétérocycliques fusionnés, et composition et utilisation de ceux-ci
TW202430166A (zh) * 2022-12-02 2024-08-01 大陸商深圳眾格生物科技有限公司 醯胺或脲類化合物
WO2024146593A1 (fr) * 2023-01-05 2024-07-11 浙江海正药业股份有限公司 Dérivé d'amide aromatique, son procédé de préparation et son utilisation médicale
TW202434237A (zh) * 2023-01-20 2024-09-01 香港商英矽智能科技知識產權有限公司 Kif18a之抑制劑及其用途
WO2024183710A1 (fr) * 2023-03-06 2024-09-12 武汉人福创新药物研发中心有限公司 Composé inhibiteur de kif18a et son utilisation
CN115947717B (zh) * 2023-03-09 2023-05-30 英矽智能科技(上海)有限公司 一类kif18a抑制剂
CN116535400B (zh) * 2023-04-26 2024-08-16 上海湃隆生物科技有限公司 氮杂螺环化合物及其应用
WO2025026392A1 (fr) * 2023-08-02 2025-02-06 上海湃隆生物科技有限公司 Inhibiteur de kinésine kif18a et son utilisation
WO2025036479A1 (fr) * 2023-08-16 2025-02-20 上海湃隆生物科技有限公司 Inhibiteur de kinésine kif18a et son utilisation

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EP3898616C0 (fr) 2024-10-02
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WO2020132649A1 (fr) 2020-06-25
JP2025013928A (ja) 2025-01-28
JP2022513967A (ja) 2022-02-09
ES2996960T3 (en) 2025-02-13
MX2021007158A (es) 2021-08-16
CA3123227A1 (fr) 2020-06-25
EP3898616A1 (fr) 2021-10-27

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