[go: up one dir, main page]

MA50679A - Animaux non humains exprimant un complexe cd3 humanisé - Google Patents

Animaux non humains exprimant un complexe cd3 humanisé

Info

Publication number
MA50679A
MA50679A MA050679A MA50679A MA50679A MA 50679 A MA50679 A MA 50679A MA 050679 A MA050679 A MA 050679A MA 50679 A MA50679 A MA 50679A MA 50679 A MA50679 A MA 50679A
Authority
MA
Morocco
Prior art keywords
humanized
complex
human animals
animals expressing
expressing
Prior art date
Application number
MA050679A
Other languages
English (en)
Inventor
Dayong Guo
Ka-Man Venus Lai
Andrew J Murphy
Kara L Olson
Eric Smith
Gavin Thurston
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54849703&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA50679(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MA50679A publication Critical patent/MA50679A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
MA050679A 2014-11-24 2015-11-23 Animaux non humains exprimant un complexe cd3 humanisé MA50679A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462083653P 2014-11-24 2014-11-24
US201562106999P 2015-01-23 2015-01-23

Publications (1)

Publication Number Publication Date
MA50679A true MA50679A (fr) 2021-03-17

Family

ID=54849703

Family Applications (1)

Application Number Title Priority Date Filing Date
MA050679A MA50679A (fr) 2014-11-24 2015-11-23 Animaux non humains exprimant un complexe cd3 humanisé

Country Status (25)

Country Link
US (4) US20170164588A1 (fr)
EP (3) EP4088572A1 (fr)
JP (5) JP7018314B2 (fr)
KR (2) KR102659123B1 (fr)
CN (2) CN113016720B (fr)
AU (2) AU2015353705C9 (fr)
BR (1) BR112017010793A2 (fr)
CA (1) CA2967823A1 (fr)
CY (1) CY1123714T1 (fr)
DK (2) DK3223605T3 (fr)
ES (2) ES2844000T3 (fr)
HR (2) HRP20220904T1 (fr)
HU (2) HUE059417T2 (fr)
IL (2) IL286414B2 (fr)
LT (2) LT3689140T (fr)
MA (1) MA50679A (fr)
MX (1) MX2017006802A (fr)
PL (2) PL3223605T3 (fr)
PT (2) PT3689140T (fr)
RS (2) RS63410B1 (fr)
RU (2) RU2020122439A (fr)
SG (1) SG11201703800PA (fr)
SI (2) SI3223605T1 (fr)
SM (2) SMT202100181T1 (fr)
WO (1) WO2016085889A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3223605T3 (da) * 2014-11-24 2020-11-16 Regeneron Pharma Ikke-humane dyr, der eksprimerer humaniseret cd3-kompleks
KR102313073B1 (ko) 2014-12-05 2021-10-18 리제너론 파마슈티칼스 인코포레이티드 인간화 분화 클러스터 47 유전자를 가진 비인간 동물
BR112017011982A2 (pt) 2014-12-09 2018-01-16 Regeneron Pharma roedor, polipeptídeo pd-l1, célula ou tecido isolado de roedor, célula-tronco embrionária de roedor, embrião de roedor, e, métodos para produção de um roedor, para reduzir o crescimento do tumor em um roedor, para matar células tumorais em um roedor, para avaliar as propriedades farmacocinéticas de um fármaco e para avaliar a eficácia de um fármaco.
EP3320773B9 (fr) * 2015-07-10 2023-10-11 Chugai Seiyaku Kabushiki Kaisha Souris ayant un gène cd3 humain substitué par un gène cd3 endogène
LT3376857T (lt) 2015-11-20 2021-06-25 Regeneron Pharmaceuticals, Inc. Gyvūnai, ne žmonės, turintys humanizuotą limfocitų aktyvavimo geną
ES2886958T3 (es) 2016-02-29 2021-12-21 Regeneron Pharma Roedores que tienen un gen TMPRSS humanizado
WO2018038046A1 (fr) 2016-08-22 2018-03-01 中外製薬株式会社 Animal non humain à gène modifié exprimant le polypeptide (gpc3) humain
EP3644722B1 (fr) * 2017-06-27 2024-12-11 Regeneron Pharmaceuticals, Inc. Rongeurs comprenant un locus asgr1
CN111386039B (zh) 2017-09-29 2023-02-28 瑞泽恩制药公司 经基因修饰的啮齿动物基因组
AU2018375796B2 (en) 2017-11-30 2024-11-21 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized TRKB locus
WO2019114768A1 (fr) 2017-12-12 2019-06-20 Biocytogen Jiangsu Co., Ltd. Animal non humain génétiquement modifié avec un cd3e d'origine humaine ou chimérique
WO2019190990A1 (fr) 2018-03-26 2019-10-03 Regeneron Pharmaceuticals, Inc. Rongeurs humanisés pour tester des agents thérapeutiques
US10463029B1 (en) * 2018-06-07 2019-11-05 Regeneron Pharmaceuticals, Inc. Rodent model of steel syndrome
ES2983967T3 (es) 2018-07-16 2024-10-28 Regeneron Pharma Modelos de roedores de enfermedad DITRA y usos de estos
CN109355309B (zh) * 2018-10-18 2021-02-05 江苏集萃药康生物科技股份有限公司 一种cd3e基因修饰人源化动物模型的构建方法
CN112300265B (zh) * 2019-07-29 2022-09-27 百奥赛图(北京)医药科技股份有限公司 Il33基因人源化的非人动物的构建方法和应用
WO2021197448A1 (fr) * 2020-04-01 2021-10-07 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Animal non humain génétiquement modifié avec cd38 humaine ou chimérique
EP4139347A4 (fr) * 2020-04-24 2024-06-05 Memorial Sloan Kettering Cancer Center Anticorps anti-cd3 et utilisations associées
WO2022099032A1 (fr) * 2020-11-06 2022-05-12 Bioventures, Llc Lymphocytes t et protéine bifonctionnelle contre le papillomavirus humain
CN112458117B (zh) * 2021-02-02 2021-05-04 百奥赛图(北京)医药科技股份有限公司 Cd155基因人源化的非人动物的构建方法及应用
CN114621971A (zh) * 2021-02-19 2022-06-14 百奥赛图(北京)医药科技股份有限公司 经遗传修饰的非人动物及其构建方法和应用
WO2024173830A2 (fr) 2023-02-17 2024-08-22 Regeneron Pharmaceuticals, Inc. Cellules nk induites sensibles à des anticorps bispécifiques cd3/taa

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0517895B1 (fr) * 1990-12-14 1996-11-20 Cell Genesys, Inc. Chaines chimeriques utilisees comme voies de transduction de signal associe a un recepteur
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
FR2827302B1 (fr) * 2001-07-13 2003-10-10 Genoway Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations
CA2474486C (fr) 2002-01-23 2013-05-14 The University Of Utah Research Foundation Mutagenese chromosomique ciblee au moyen de nucleases en doigt a zinc
EP1344824A1 (fr) * 2002-03-11 2003-09-17 Institut de la Santé et de la Recherche Médicale Gène muté codant pour une protéine LAT et les applications biologiques
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
UA94211C2 (ru) * 2004-06-03 2011-04-26 Новиммюн С.А. Выделенное полностью человеческое моноклональное cd3 антитело
SI1802193T1 (sl) 2004-10-19 2014-08-29 Regeneron Pharmaceuticals, Inc. Postopek za generiranje miši, homozigotne za genetsko modifikacijo
WO2008119565A2 (fr) * 2007-04-03 2008-10-09 Micromet Ag Domaine de liaison spécifique d'espèces croisées
MX2009010611A (es) * 2007-04-03 2010-03-26 Micromet Ag Enlazadores biespecificos, especificos para especies.
FI2155783T4 (fi) 2007-04-03 2022-12-15 Lajien välisesti spesifinen cd3-epsilon-sitoutumisdomeeni
US8632768B2 (en) * 2008-05-30 2014-01-21 University Of Louisville Research Foundation, Inc. Human facilitating cells
RU2547600C2 (ru) * 2008-10-01 2015-04-10 Эмджен Рисерч (Мьюник) Гмбх Pscaxcd3, cd19xcd3, c-metxcd3, эндосиалинxcd3, epcamxcd3, igf-1rxcd3 или fap-альфаxcd3 биспецифическое одноцепочечное антитело с межвидовой специфичностью
EP2389443B1 (fr) * 2009-01-23 2018-11-14 Roger Williams Hospital Vecteurs viraux codant pour de multiples polypeptides non viraux très homologues et leur utilisation
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
US20120117671A1 (en) 2009-07-31 2012-05-10 Hiroyuki Yoneyama Steatohepatitis-liver cancer model animal
US8883496B2 (en) * 2009-12-21 2014-11-11 Regeneron Phamaceuticals, Inc. Humanized FcgR mice
US20110165161A1 (en) * 2009-12-23 2011-07-07 Shih-Yao Lin Anti-epcam antibodies that induce apoptosis of cancer cells and methods using same
EP4052572A1 (fr) 2011-10-28 2022-09-07 Regeneron Pharmaceuticals, Inc. Souris transgéniques exprimant des molécules chimeriques du complexe majeur d'histocompatibilité (mhc) ii
KR102234632B1 (ko) 2011-10-28 2021-04-02 리제너론 파아마슈티컬스, 인크. 사람화된 ｉｌ-6 및 ｉｌ-6 수용체
MY178723A (en) 2011-10-28 2020-10-20 Regeneron Pharma Genetically modified major histocompatibility complex mice
ES2858978T3 (es) * 2011-10-28 2021-09-30 Regeneron Pharma Ratones con receptores de linfocitos T genéticamente modificados
WO2014028776A1 (fr) * 2012-08-15 2014-02-20 Zyngenia, Inc. Complexes multispécifiques monovalents et multivalents et leurs utilisations
CA2882684A1 (fr) * 2012-08-21 2014-02-27 Glaxo Group Limited Compositions comprenant un domaine variable unique et du mesylate de camostat (cm)
EP2896291B1 (fr) 2012-09-13 2019-03-20 Chugai Seiyaku Kabushiki Kaisha Animal non humain comportant un gène knock-in
JOP20200236A1 (ar) 2012-09-21 2017-06-16 Regeneron Pharma الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
RU2015117393A (ru) * 2012-10-08 2016-12-10 Роше Гликарт Аг Лишенные fc антитела, содержащие два Fab-фрагмента, и способы их применения
PT2914102T (pt) 2012-11-05 2018-01-15 Univ Yale Animais não-humanos geneticamente modificados e métodos de utilização dos mesmos
TWI682941B (zh) 2013-02-01 2020-01-21 美商再生元醫藥公司 含嵌合恆定區之抗體
CN105164153B (zh) 2013-02-20 2020-04-24 瑞泽恩制药公司 人源化的t细胞共受体的小鼠
SI2958937T1 (sl) 2013-02-22 2018-12-31 Regeneron Pharmaceuticals, Inc. Miš, ki izraža humanizirani poglavitni histokompatibilnostni kompleks
US20150342163A1 (en) 2013-02-22 2015-12-03 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
CN103509122B (zh) * 2013-09-23 2015-04-15 武汉友芝友生物制药有限公司 一种cd3抗原及其制备方法和用途
CN108441497B (zh) 2013-09-23 2021-10-29 瑞泽恩制药公司 具有人源化信号调节蛋白基因的非人动物
JP6505689B2 (ja) 2013-11-19 2019-04-24 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ヒト化ｂ細胞活性化因子遺伝子を有する非ヒト動物
TWI754319B (zh) 2014-03-19 2022-02-01 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
SG11201604886WA (en) 2014-04-08 2016-07-28 Regeneron Pharma Non-human animals having humanized fc-gamma receptors
NO2785538T3 (fr) 2014-05-07 2018-08-04
EP3145307B1 (fr) 2014-05-19 2019-02-06 Regeneron Pharmaceuticals, Inc. Animaux non humains génétiquement modifiés exprimant l'epo humaine
EP3683238A1 (fr) 2014-06-19 2020-07-22 Regeneron Pharmaceuticals, Inc. Animaux non humains présentant un gène 1 humanisé de la mort cellulaire programmée
DK3223605T3 (da) 2014-11-24 2020-11-16 Regeneron Pharma Ikke-humane dyr, der eksprimerer humaniseret cd3-kompleks

Also Published As

Publication number Publication date
DK3689140T3 (da) 2022-08-01
EP3689140B1 (fr) 2022-05-11
BR112017010793A2 (pt) 2017-12-26
CN113016720A (zh) 2021-06-25
JP7018314B2 (ja) 2022-02-10
JP2021035397A (ja) 2021-03-04
US11937587B2 (en) 2024-03-26
JP2023101757A (ja) 2023-07-21
EP4088572A1 (fr) 2022-11-16
AU2015353705B2 (en) 2022-01-20
US20200275642A1 (en) 2020-09-03
IL286414B1 (en) 2023-12-01
HRP20220904T1 (hr) 2022-10-14
KR20240055876A (ko) 2024-04-29
SI3223605T1 (sl) 2021-03-31
AU2015353705C9 (en) 2022-09-01
SMT202100181T1 (it) 2021-05-07
IL252202B (en) 2021-10-31
RU2017122038A (ru) 2018-12-26
SMT202200438T1 (it) 2023-01-13
HUE059417T2 (hu) 2022-11-28
JP2017536126A (ja) 2017-12-07
US20170164588A1 (en) 2017-06-15
US20210100229A1 (en) 2021-04-08
HUE052603T2 (hu) 2021-05-28
DK3223605T3 (da) 2020-11-16
AU2015353705C1 (en) 2022-08-11
MX2017006802A (es) 2018-01-30
EP3223605B1 (fr) 2020-10-14
JP2022066476A (ja) 2022-04-28
JP7269214B2 (ja) 2023-05-08
ES2844000T3 (es) 2021-07-21
SG11201703800PA (en) 2017-06-29
US10932455B2 (en) 2021-03-02
RU2017122038A3 (fr) 2019-07-17
LT3223605T (lt) 2021-01-11
CY1123714T1 (el) 2022-03-24
EP3223605A1 (fr) 2017-10-04
EP3689140A1 (fr) 2020-08-05
PL3223605T3 (pl) 2021-04-19
KR102659123B1 (ko) 2024-04-22
AU2015353705A1 (en) 2017-06-08
CN113016720B (zh) 2023-02-21
JP7524240B2 (ja) 2024-07-29
CN107105633A (zh) 2017-08-29
ES2923775T3 (es) 2022-09-30
PL3689140T3 (pl) 2022-09-05
PT3689140T (pt) 2022-07-27
KR20170120090A (ko) 2017-10-30
SI3689140T1 (sl) 2022-10-28
IL252202A0 (en) 2017-07-31
LT3689140T (lt) 2022-08-25
RS63410B1 (sr) 2022-08-31
AU2022202578A1 (en) 2022-05-12
HRP20201938T1 (hr) 2021-02-05
RU2726446C2 (ru) 2020-07-14
RS61080B1 (sr) 2020-12-31
CN107105633B (zh) 2021-02-12
RU2020122439A (ru) 2020-09-24
EP3223605B9 (fr) 2021-08-18
IL286414B2 (en) 2024-04-01
CA2967823A1 (fr) 2016-06-02
PT3223605T (pt) 2020-12-24
US20240306616A1 (en) 2024-09-19
WO2016085889A1 (fr) 2016-06-02
JP2024114974A (ja) 2024-08-23
JP7591094B2 (ja) 2024-11-27
IL286414A (en) 2021-10-31

Similar Documents

Publication Publication Date Title
IL286414A (en) Non-human animals expressing a cd3 complex of human origin
IL288264A (en) Genetically modified non-human animals expressing human epo
HK1231369A1 (zh) 人源化或嵌合 抗體
IL251030B (en) Chimeric antigen receptors
DK3434101T3 (da) Ikke-menneskelige dyr, der har et humaniseret signalregulerende proteingen
IL246497B (en) Non-human animals with human fc–gamma receptors
DK3215530T3 (da) Forbedrede il-6 antistoffer
DK3116908T3 (da) Humaniserede kir3dl2-antistoffer
SG11202002002XA (en) Non-human animals expressing humanized c1q complex
TH1601002070A (th) สัตว์ที่ได้รับการฮิวมาไนซ์ด้วย il-15
UA30762S (uk) Поводок для тварин
TH1601001594A (th) สัตว์ที่ไม่ใช่มนุษย์ซึ่งมียีนโปรตีนควบคุมสัญญาณที่ได้รับการฮิวมาไนซ์