[go: up one dir, main page]

MA50400A - Formes cristallines et compositions de modulateurs de cftr - Google Patents

Formes cristallines et compositions de modulateurs de cftr

Info

Publication number
MA50400A
MA50400A MA050400A MA50400A MA50400A MA 50400 A MA50400 A MA 50400A MA 050400 A MA050400 A MA 050400A MA 50400 A MA50400 A MA 50400A MA 50400 A MA50400 A MA 50400A
Authority
MA
Morocco
Prior art keywords
compositions
crystalline forms
cftr modulators
cftr
modulators
Prior art date
Application number
MA050400A
Other languages
English (en)
Inventor
Welchao George Chen
Varsha Dhamankar
Kirk Raymond Dinehart
Eleni Dokou
Lori Ann Ferris
Nishanth Gopinathan
Eric L Haseltine
Katie Mccarty
Catherine Metzler
Samuel Moskowitz
Sarah Robertson
David Waltz
Beili Zhang
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MA50400A publication Critical patent/MA50400A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
MA050400A 2017-10-19 2018-10-19 Formes cristallines et compositions de modulateurs de cftr MA50400A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762574670P 2017-10-19 2017-10-19
US201762574677P 2017-10-19 2017-10-19
US201862650057P 2018-03-29 2018-03-29

Publications (1)

Publication Number Publication Date
MA50400A true MA50400A (fr) 2020-08-26

Family

ID=64110267

Family Applications (1)

Application Number Title Priority Date Filing Date
MA050400A MA50400A (fr) 2017-10-19 2018-10-19 Formes cristallines et compositions de modulateurs de cftr

Country Status (9)

Country Link
US (2) US10654829B2 (fr)
EP (1) EP3697774A1 (fr)
AU (1) AU2018351533B2 (fr)
CA (1) CA3078893A1 (fr)
IL (1) IL273831B2 (fr)
MA (1) MA50400A (fr)
NZ (1) NZ763365A (fr)
TW (1) TWI719349B (fr)
WO (1) WO2019079760A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9782408B2 (en) 2014-10-06 2017-10-10 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
JOP20190042B1 (ar) 2016-09-30 2021-08-17 Vertex Pharma مُعدِّل‏ لمنظم موصلية التليف الكيسي عبر الغشاء، وتركيبات صيدلانية، وطرق للعلاج، وعملية لتصنيع المُعدِّل
PE20241131A1 (es) 2016-12-09 2024-05-24 Vertex Pharma Modulador del regulador de conductancia de transmembrana de fibrosis quistica, composiciones farmaceuticas, metodos de tratamiento y proceso para producir el modulador
AU2018279646B2 (en) 2017-06-08 2023-04-06 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
WO2019018395A1 (fr) 2017-07-17 2019-01-24 Vertex Pharmaceuticals Incorporated Méthodes de traitement de la fibrose kystique
EP3661915B1 (fr) 2017-08-02 2022-03-09 Vertex Pharmaceuticals Incorporated Procédés de préparation de composés de pyrrolidine
MA50400A (fr) 2017-10-19 2020-08-26 Vertex Pharma Formes cristallines et compositions de modulateurs de cftr
NZ765171A (en) 2017-12-08 2024-12-20 Vertex Pharma Processes for making modulators of cystic fibrosis transmembrane conductance regulator
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
IL294042A (en) 2018-02-15 2022-08-01 Vertex Pharma Macrocycles as modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions thereof, their use in the treatment of cycstic fibrosis, and process for making them
WO2019200246A1 (fr) 2018-04-13 2019-10-17 Alexander Russell Abela Modulateurs du régulateur de la conductance transmembranaire de la fibrose kystique, compositions pharmaceutiques, procédés de traitement et procédé de fabrication du modulateur
WO2020214921A1 (fr) * 2019-04-17 2020-10-22 Vertex Pharmaceuticals Incorporated Formes solides de modulateurs de cftr
US11591350B2 (en) 2019-08-14 2023-02-28 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
KR20220064366A (ko) 2019-08-14 2022-05-18 버텍스 파마슈티칼스 인코포레이티드 Cftr 조절제의 결정질 형태
TW202120517A (zh) 2019-08-14 2021-06-01 美商維泰克斯製藥公司 製備cftr調節劑之方法
CR20230120A (es) 2020-08-07 2023-09-01 Vertex Pharma Moduladores del regulador de la conductancia transmembrana de la fibrosis quística
CA3204725A1 (fr) 2020-12-10 2022-06-16 Vertex Pharmaceuticals Incorporated Methodes de traitement de la mucoviscidose
TW202333699A (zh) 2022-02-03 2023-09-01 美商維泰克斯製藥公司 囊腫纖維化之治療方法
CN118974059A (zh) 2022-02-08 2024-11-15 弗特克斯药品有限公司 囊性纤维化跨膜传导调控因子的调节剂
WO2023224931A1 (fr) 2022-05-16 2023-11-23 Vertex Pharmaceuticals Incorporated Méthodes de traitement de la fibrose kystique

Family Cites Families (213)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194599A3 (fr) 1985-03-14 1988-01-20 Nissan Chemical Industries Ltd. Dérivés de benzamide, leur procédé de préparation et fongicides pour le sol les contenant
GB9122590D0 (en) 1991-10-24 1991-12-04 Lilly Industries Ltd Pharmaceutical compounds
DE4410453A1 (de) 1994-03-25 1995-09-28 Hoechst Ag Substituierte heterocyclische Carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel
GB9514160D0 (en) 1994-07-25 1995-09-13 Zeneca Ltd Aromatic compounds
JPH10512272A (ja) 1995-01-19 1998-11-24 ノバルティス アクチエンゲゼルシャフト 除草用組成物
EA001418B1 (ru) 1995-11-23 2001-02-26 Новартис Аг Гербицидная композиция
AU707574B2 (en) 1995-12-15 1999-07-15 Merck Frosst Canada & Co. Tri-aryl ethane derivatives as PDE IV inhibitors
JPH10114654A (ja) 1996-10-09 1998-05-06 Fujisawa Pharmaceut Co Ltd 新規用途
AU6209098A (en) 1997-01-15 1998-08-07 Novartis Ag Herbicidal agent
GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
DE19742951A1 (de) 1997-09-29 1999-04-15 Hoechst Schering Agrevo Gmbh Acylsulfamoylbenzoesäureamide, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung
US20020017295A1 (en) 2000-07-07 2002-02-14 Weers Jeffry G. Phospholipid-based powders for inhalation
DE19802697A1 (de) 1998-01-24 1999-07-29 Bayer Ag Selektive Herbizide auf Basis von N-Aryl-triazolin(thi)onen und N-Arylsulfonylamino(thio)carbonyltriazolin(thi)onen
EP1069112A4 (fr) 1998-02-13 2001-04-18 Kureha Chemical Ind Co Ltd Derives de n-(pnenylsulfonyle) picolinamide, procede de production de ces derniers et herbicide
BR9909440A (pt) 1998-04-06 2000-12-26 Fujisawa Pharmaceutical Co Derivados de indol
AP1398A (en) 1999-06-10 2005-04-21 Warner Lambert Co Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using isoindoline derivatives.
DE19936438A1 (de) 1999-08-03 2001-02-08 Aventis Cropscience Gmbh Kombinationen von Herbiziden und Safenern
DE19940860A1 (de) 1999-08-27 2001-03-01 Bayer Ag Selektive Herbizide auf Basis eines substituierten Phenylsulfonyl aminocarbonyltriazolinons und Safenern II
DE19958381A1 (de) 1999-12-03 2001-06-07 Bayer Ag Herbizide auf Basis von N-Aryl-uracilen
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
AU2001286557A1 (en) 2000-08-23 2002-03-04 Merck Frosst Canada And Co. Method of treating or preventing urinary incontinence using prostanoid ep1 receptor antagonists
AR031130A1 (es) 2000-09-20 2003-09-10 Abbott Lab N-acilsulfonamidas promotoras de la apoptosis
US20020055631A1 (en) 2000-09-20 2002-05-09 Augeri David J. N-acylsulfonamide apoptosis promoters
US6720338B2 (en) 2000-09-20 2004-04-13 Abbott Laboratories N-acylsulfonamide apoptosis promoters
KR20030036917A (ko) 2000-10-10 2003-05-09 스미스클라인 비참 코포레이션 치환된 인돌, 이를 함유하는 약제학적 조성물, 및 이의ＰＰＡＲ-γ결합제로서의 용도
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
DE10119721A1 (de) 2001-04-21 2002-10-31 Bayer Cropscience Gmbh Herbizide Mittel enthaltend Benzoylcyclohexandione und Safener
AU2002257970B2 (en) 2001-05-31 2007-08-02 Vicore Pharma Ab Tricyclic compounds useful as angiotensin II agonists
BR0210616A (pt) 2001-06-28 2004-09-28 Pfizer Prod Inc Indóis, benzofuranos e benzotiofenos substituìdos com triamida, composição farmacêutica, uso dos referidos compostos, bem como processo para preparação dos mesmos
DE10145019A1 (de) 2001-09-13 2003-04-03 Bayer Cropscience Gmbh Kombinationen aus Herbiziden und Safenern
DE10146873A1 (de) 2001-09-24 2003-04-17 Bayer Cropscience Gmbh Heterocyclische Amide und -Iminderivate, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel
KR20050044450A (ko) 2001-11-14 2005-05-12 테바 파마슈티컬 인더스트리즈 리미티드 로사르탄 칼륨의 무정형 및 결정형 형태 및 이의 제조 방법
AU2002354056A1 (en) 2001-11-19 2003-06-10 Ono Pharmaceutical Co., Ltd. Remedies for urinary frequency
DE10157545A1 (de) 2001-11-23 2003-06-12 Bayer Cropscience Gmbh Herbizide Mittel enthaltend Benzoylpyrazole und Safener
WO2004043939A1 (fr) 2002-03-27 2004-05-27 Smithkline Beecham Corporation Composes amide et procedes d'utilisation de ceux-ci
GB0212785D0 (en) 2002-05-31 2002-07-10 Glaxo Group Ltd Compounds
CA2752121A1 (fr) 2002-06-08 2003-12-18 Bayer Cropscience Ag Combinaisons herbicides a base de dicamba, ou d'un de ses sels acceptables du point de vue agricole, et de 4-(2-methoxybenzoylsulfamoyl)-n-cyclopropylbenzamide, ou d'un de ses sels acceptables du point de vueagricol e, comme phytoprotecteurs
DE10237461A1 (de) 2002-08-16 2004-02-26 Bayer Cropscience Gmbh Herbizide Mittel enthaltend Benzoylpyrazole und Safener
US20060019932A1 (en) 2002-09-06 2006-01-26 Mancini Joseph A Treatment of rheumatoid arthritis by inhibition of pde4
EP1562914A1 (fr) 2002-10-22 2005-08-17 Merck Frosst Canada & Co. Inhibiteurs selectifs de la cyclo-oxygenase-2 liberant de l'oxyde nitrique
GB0225548D0 (en) 2002-11-01 2002-12-11 Glaxo Group Ltd Compounds
WO2004046141A1 (fr) 2002-11-21 2004-06-03 Vicore Pharma Ab Nouveaux agonistes tricycliques de l'angiotensine ii
JP2006516028A (ja) 2002-12-20 2006-06-15 ファイザー・プロダクツ・インク ミクロソームトリグリセリド輸送タンパク質阻害剤
CA2505604A1 (fr) 2002-12-20 2004-07-08 Pfizer Products Inc. Inhibiteurs de proteine microsomale de transfert de triglyceride
WO2004078114A2 (fr) 2003-02-28 2004-09-16 Encysive Pharmaceuticals Inc. Pyridine, pyrimidine, quinoline, quinazoline et naphtalene, antagonistes du recepteur de l'urotensine ii
WO2004085420A1 (fr) 2003-03-24 2004-10-07 Vicore Pharma Ab Composes bicycliques utiles en tant qu'agonistes d'angiotensine ii
EP1646615B1 (fr) 2003-06-06 2009-08-26 Vertex Pharmaceuticals Incorporated Derives de pyrimidne utilises en tant que modulateurs de transporteurs de cassette de liaison a l'atp
WO2005049018A1 (fr) 2003-11-14 2005-06-02 Vertex Pharmaceuticals Incorporated Thiazoles et oxazoles utiles en tant que modulateurs de transporteurs de type cassette de liaison a l'atp
GB0328024D0 (en) 2003-12-03 2004-01-07 Glaxo Group Ltd Compounds
WO2005070006A2 (fr) 2004-01-22 2005-08-04 Nitromed, Inc. Composes nitroses et/ou nitrosyles, compositions et procede pour les utiliser
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
CA2554796A1 (fr) 2004-01-30 2005-08-18 Vertex Pharmaceuticals Incorporated Modulateurs de transporteurs de type cassette de liaison a l'atp
WO2005080373A1 (fr) 2004-02-04 2005-09-01 Pfizer Products Inc. Composes de quinoline substitues
TW200533336A (en) 2004-03-02 2005-10-16 Fujisawa Pharmaceutical Co Concomitant drugs
EA011764B1 (ru) 2004-03-05 2009-06-30 Ниссан Кемикал Индастриз, Лтд. Изоксазолинзамещённое производное бензамида и пестицид
WO2005099705A2 (fr) 2004-03-24 2005-10-27 Bayer Pharmaceuticals Corporation Preparation de derives imidazoles et leurs procedes d'utilisation
GB0410121D0 (en) 2004-05-06 2004-06-09 Glaxo Group Ltd Compounds
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
PT2489659T (pt) 2004-06-24 2018-03-07 Vertex Pharma Moduladores de transportadores de cassete de ligação a atp
JP4953297B2 (ja) 2004-09-15 2012-06-13 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有するカルバモイルピリドン誘導体
KR20070064356A (ko) 2004-09-29 2007-06-20 포톨라 파마슈티컬스, 인코포레이티드 치환된 2ｈ-1,3-벤족사진-4(3ｈ)온
JP2008523139A (ja) 2004-12-14 2008-07-03 アストラゼネカ・アクチエボラーグ 置換アミノピリジン類及びその使用
EA200801909A1 (ru) 2004-12-23 2009-06-30 Глэксо Груп Лимитед Соединения пиридина для лечения заболеваний, опосредованных действием простагландина
GB0428173D0 (en) 2004-12-23 2005-01-26 Astrazeneca Ab Compounds
WO2006127588A2 (fr) 2005-05-24 2006-11-30 Vertex Pharmaceuticals Incorporated Modulateurs des transporteurs de cassette de liaison a l'atp
WO2007019397A2 (fr) 2005-08-05 2007-02-15 Genelabs Technologies, Inc. Derives d'aryle et heteroaryle a 6 membres pour le traitement de virus
KR20080053297A (ko) 2005-08-11 2008-06-12 버텍스 파마슈티칼스 인코포레이티드 낭포성 섬유종 트랜스막 전도도 조정자의 조절자
WO2007053641A2 (fr) 2005-11-01 2007-05-10 Mars, Incorporated Procyanidines de type a et inflammation
CA2635214A1 (fr) 2005-12-27 2007-07-05 Vertex Pharmaceuticals Incorporated Composes utiles dans les bio-essais cftr et leurs procedes
US7671221B2 (en) 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
EP2016065B1 (fr) 2005-12-28 2012-09-19 Vertex Pharmaceuticals Incorporated Dérivés de la 1-(benzo[d][1,3]dioxol-5-yl)-n-(phenyl)cyclopropane-carboxamide et composés similaires en tant que modulateurs des transporteurs de cassettes de liaison de l'atp pour le traitement de la fibrose cystique
SI3219705T1 (sl) 2005-12-28 2020-08-31 Vertex Pharmaceuticals Incorporated Farmacevtski sestavki amorfne oblike N-(2,4-bis(1,1-dimetiletil)-5- hidroksifenil)-1,4-dihidro-4-oksokinolin-3-karboksamid
CN101415698A (zh) 2006-04-05 2009-04-22 拜尔农科股份有限公司 杀真菌剂n-环丙基-磺酰胺衍生物
SI3091011T1 (en) 2006-04-07 2018-06-29 Vertex Pharmaceuticals Incorporated Modulators of ATP conveyor belt conveyors
AU2007249269A1 (en) 2006-05-12 2007-11-22 Vertex Pharmaceuticals Incorporated Compositions of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-1,4-dihydro-4-oxoquinoline-3-carboxamide
US8778977B2 (en) 2006-06-30 2014-07-15 Sunesis Pharmaceuticals, Inc. Pyridinonyl PDK1 inhibitors
NZ576642A (en) 2006-11-03 2011-11-25 Vertex Pharma Azaindole derivatives as cftr modulators
JP2010518125A (ja) 2007-02-12 2010-05-27 インターミューン・インコーポレーテッド Ｃ型肝炎ウイルス複製の新規な阻害剤
WO2008141385A1 (fr) 2007-05-21 2008-11-27 Biota Scientific Management Pty Ltd Inhibiteurs de polymérases virales
US8058299B2 (en) 2007-05-22 2011-11-15 Via Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
CA2687608C (fr) 2007-05-25 2013-07-02 Amgen Inc. Composes d'hydroxyethylamine substitues en tant que modulateurs de la beta-secretase et methodes d'utilisation
GB0716532D0 (en) 2007-08-24 2007-10-03 Angeletti P Ist Richerche Bio Therapeutic compounds
BRPI0816116A2 (pt) 2007-08-29 2015-03-03 Schering Corp Derivados de indol 2,3-substituídos para o tratamento de infecções virais.
NZ620027A (en) 2007-09-14 2015-05-29 Vertex Pharma Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
AU2013231151B2 (en) 2007-11-16 2015-06-25 Vertex Pharmaceuticals Incorporated Isoquinoline modulators of ATP-Binding Cassette transporters
CN102099351A (zh) 2007-11-16 2011-06-15 先灵公司 3-杂环取代的吲哚衍生物及其使用方法
GB0723794D0 (en) 2007-12-05 2008-01-16 Lectus Therapeutics Ltd Potassium ion channel modulators and uses thereof
ES2625957T3 (es) 2007-12-07 2017-07-21 Vertex Pharmaceuticals Incorporated Procedimiento para producir ácidos cicloalquilcarboxiamido-piridinabenzoicos
RS60229B1 (sr) 2007-12-07 2020-06-30 Vertex Pharma Čvrsti oblici 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il) ciklopropankarboksamido)-3-metilpiridin-2-il) benzojeve kiseline
AU2013270464B2 (en) 2008-03-31 2016-05-26 Vertex Pharmaceuticals Incorporated Pyridyl derivatives as CFTR modulators
EP2274280A2 (fr) 2008-04-16 2011-01-19 Biolipox AB Composés bis-aryliques destinés à être utilisés en tant que médicaments
US20110112193A1 (en) 2008-05-14 2011-05-12 Peter Nilsson Bis-aryl compounds for use as medicaments
EP2145537A1 (fr) 2008-07-09 2010-01-20 Bayer CropScience AG Régulateur de croissance végétale
UY31982A (es) 2008-07-16 2010-02-26 Boehringer Ingelheim Int Derivados de 1,2-dihidropiridin-3-carboxamidas n-sustituidas
KR20110042356A (ko) 2008-08-13 2011-04-26 버텍스 파마슈티칼스 인코포레이티드 제약 조성물 및 그의 투여
EP2326178A4 (fr) 2008-08-21 2012-10-24 Glaxosmithkline Llc Inhibiteurs de la prolyl-hydroxylase
BRPI0917719A2 (pt) 2008-08-27 2019-11-19 Calcimedica Inc compostos que modulam cálcio intracelular
UA104876C2 (uk) 2008-11-06 2014-03-25 Вертекс Фармасьютікалз Інкорпорейтед Модулятори atф-зв'язувальних касетних транспортерів
CA2742821C (fr) 2008-11-06 2018-10-23 Vertex Pharmaceuticals Incorporated Modulateurs de transporteurs a cassette de liaison a l'atp
US20100160322A1 (en) 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
UA108193C2 (uk) 2008-12-04 2015-04-10 Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань
CA2747835A1 (fr) 2009-01-19 2010-07-22 Abbott Laboratories Agents induisant l'apoptose destines au traitement du cancer et de maladies immunes et auto-immunes
EP2406216B1 (fr) 2009-03-11 2017-04-19 Bayer Intellectual Property GmbH Kétoénoles substitués par halogenalkylméthylenoxy-phényl
SG193156A1 (en) 2009-03-20 2013-09-30 Vertex Pharma Process for making modulators of cystic fibrosis transmembrane conductance regulator
EP2412708A4 (fr) 2009-03-26 2014-07-23 Shionogi & Co Dérivé de 3-hydroxy-4-pyridone substitué
CN102458122A (zh) 2009-04-20 2012-05-16 人类健康研究所 含有哒嗪磺胺衍生物的化合物、组合物和方法
KR20190130676A (ko) 2009-05-26 2019-11-22 애브비 아일랜드 언리미티드 컴퍼니 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
WO2011102514A1 (fr) 2010-02-22 2011-08-25 武田薬品工業株式会社 Composé cyclique aromatique
AU2011227021A1 (en) 2010-03-19 2012-10-18 Vertex Pharmaceuticals Incorporated Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
EP2563778B1 (fr) 2010-03-25 2016-08-24 Vertex Pharmaceuticals Incorporated Forme cristalline de (r)-1(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-méthylpropan-2-yl)-1h-indol-5-yl)cyclopropanecarboxamide
AR081069A1 (es) 2010-04-07 2012-06-06 Vertex Pharma Formas solidas del acido 3-(6-(1-(2,2-difluorbenzo[d][1,3]dioxol-5-il)ciclopropancarboxamido)-3-metilpiridin-2-il)benzoico
DK3150198T3 (da) 2010-04-07 2021-11-01 Vertex Pharma Farmaceutiske sammensætninger af 3-(6-(1-(2,2-difluorbenzo[d][1,3]dioxol-5-yl)-cyclopropancarboxamido)-3-methylpyriodin-2-yl)benzoesyre og indgivelse deraf
US8344137B2 (en) 2010-04-14 2013-01-01 Hoffman-La Roche Inc. 3,3-dimethyl tetrahydroquinoline derivatives
NZ603042A (en) 2010-04-22 2015-02-27 Vertex Pharma Pharmaceutical compositions comprising cftr modulators and administrations thereof
US9035072B2 (en) 2010-04-22 2015-05-19 Vertex Pharmaceuticals Incorporated Process of producing cycloalkylcarboxamido-indole compounds
TWI520960B (zh) 2010-05-26 2016-02-11 艾伯維有限公司 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑
US8563593B2 (en) 2010-06-08 2013-10-22 Vertex Pharmaceuticals Incorporated Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide
RU2013112937A (ru) 2010-08-23 2014-09-27 Вертекс Фармасьютикалз Инкорпорейтед Фармацевтические композиции (r)-1-(2, 2-дифторбензо[d][1, 3]диоксол-5-ил)-n-(2, 3-дигидроксипропил)-6-фтор-2-(1-гидрокси-2-метилпропан-2-ил)-1н-индол-5-ил)циклопропанкарбоксамида и их применение
US20120064157A1 (en) 2010-08-27 2012-03-15 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
WO2012052540A1 (fr) 2010-10-21 2012-04-26 Universitaet Des Saarlandes Inhibiteurs sélectifs de cyp11b1 pour le traitement de maladies dépendantes du cortisol
WO2012087938A1 (fr) 2010-12-20 2012-06-28 Glaxosmithkline Llc Dérivés de quinazolinone en tant qu'agents antiviraux
EP2471363A1 (fr) 2010-12-30 2012-07-04 Bayer CropScience AG Utilisation d'acides aryl-, hétéroaryl- et benzylsulfonaminés, d'esters d'acide aminé, d'amides d'acide aminé et carbonitrile ou leurs sels pour l'augmentation de la tolérance au stress dans des plantes
WO2012102297A1 (fr) 2011-01-26 2012-08-02 杏林製薬株式会社 Dérivé de pyrazolopyridine ou sel de qualité pharmacologique de celui-ci
BR112013021021A2 (pt) 2011-02-17 2016-08-02 Bayer Ip Gmbh 3- (bifenil - 3 - il) - 8, 8 - difluoro - 4 - hidroxi - 1 - azaspiro [4, 5] dec - 3 - eno - 2 - onas substituídas para terapia e cetoenóis espirocíclicos substituídos com halogéneo
WO2012116960A1 (fr) 2011-03-01 2012-09-07 Bayer Cropscience Ag 2-acyloxy-pyrrolin-4-ones
AR085585A1 (es) 2011-04-15 2013-10-09 Bayer Cropscience Ag Vinil- y alquinilciclohexanoles sustituidos como principios activos contra estres abiotico de plantas
EP2714680B1 (fr) 2011-05-27 2015-11-25 Amira Pharmaceuticals, Inc. Inhibiteurs de l'autotaxine hétérocycliques et leurs utilisations
EA201490279A1 (ru) 2011-08-30 2014-08-29 Схди Фаундейшн, Инк. Ингибиторы кинуренин-3-монооксигеназы, фармацевтические композиции и способы их применения
EP2755472B1 (fr) 2011-09-16 2016-08-31 Bayer Intellectual Property GmbH Utilisation de cyprosulfamide pour améliorer le rendement des plantes
WO2013038373A1 (fr) 2011-09-16 2013-03-21 Novartis Ag Dérivés pyrimidinamides
WO2013041602A1 (fr) 2011-09-23 2013-03-28 Bayer Intellectual Property Gmbh Utilisation de dérivés d'acide 1-phényl-pyrazol-3-carboxylique à substitution en position 4 en tant qu'agents actifs contre le stress abiotique chez les végétaux
CA2852991C (fr) 2011-11-08 2019-12-31 Vertex Pharmaceuticals Incorporated Modulateurs de transporteurs de cassette de liaison a l'atp
US8426450B1 (en) 2011-11-29 2013-04-23 Helsinn Healthcare Sa Substituted 4-phenyl pyridines having anti-emetic effect
RU2644723C2 (ru) 2012-01-25 2018-02-13 Вертекс Фармасьютикалз Инкорпорейтед Препараты 3-(6-(1-(2, 2-дифторбензо[d][1, 3]диоксол-5-ил)циклопропанкарбоксамидо)-3-метилпиридин-2-ил)бензойной кислоты
JP2015083542A (ja) 2012-02-08 2015-04-30 大日本住友製薬株式会社 ３位置換プロリン誘導体
CN109966264A (zh) 2012-02-27 2019-07-05 沃泰克斯药物股份有限公司 药物组合物及其施用
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
CA2869847A1 (fr) 2012-04-20 2013-10-24 Vertex Pharmaceuticals Incorporated Formes solides de n-[2,4-bis(1,1-dimethylethyle)-5-hydroxyphenyle]-1,4-dihydro-4-oxoquinoline-3-carboxamide
CN104718188B (zh) 2012-05-22 2018-08-21 基因泰克公司 N-取代的苯甲酰胺类及其在治疗疼痛中的用途
EP2858645A1 (fr) 2012-06-08 2015-04-15 Vertex Pharmaceuticals Incorporated Compositions pharmaceutiques pour le traitement des troubles à médiation par cftr
WO2013185202A1 (fr) 2012-06-14 2013-12-19 Beta Pharma Canada Inc Inducteurs d'apoptose
RU2015103913A (ru) 2012-07-06 2016-08-27 Дженентек, Инк. N-замещенные бензамиды и способы их применение
EP2872122A1 (fr) 2012-07-16 2015-05-20 Vertex Pharmaceuticals Incorporated Compositions pharmaceutiques de (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide et son administration
JP2015178458A (ja) 2012-07-25 2015-10-08 杏林製薬株式会社 ベンゼン環縮合含窒素５員複素環式化合物、またはその薬理学的に許容される塩
CN103571906B (zh) 2012-07-27 2018-12-11 上海泽元海洋生物技术有限公司 一种利用微藻高效生产虾青素的新方法
MX360172B (es) 2012-08-13 2018-10-12 Abbvie Inc Agentes que inducen la apoptosis.
DK2888251T3 (da) 2012-08-21 2019-07-29 Peter Maccallum Cancer Inst Perforinhæmmende benzensulfonamidforbindelser, fremstilling og anvendelser deraf
MX2015002887A (es) 2012-09-06 2015-07-06 Plexxikon Inc Compuestos y metodos para la modulacion de cinasas, e indicaciones para ello.
WO2014047427A2 (fr) 2012-09-21 2014-03-27 Vanderbilt University Inhibiteurs de la mcl-1 à base de benzofurane, de benzothiophène et d'indole substitués
WO2014071247A1 (fr) 2012-11-02 2014-05-08 Dana-Farber Cancer Institute, Inc. Dérivés d'acide pyrrol-1-yl-benzoïque utiles en tant qu'inhibiteurs de myc
TW201422253A (zh) 2012-11-02 2014-06-16 Vertex Pharma 治療ｃｆｔｒ介導疾病之醫藥組合物
BR112015010109A2 (pt) 2012-11-05 2017-07-11 Nant Holdings Ip Llc derivados de indol-5-ol substituídos e suas aplicações terapêuticas
EP2928296A1 (fr) 2012-12-05 2015-10-14 Bayer CropScience AG Utilisation de 1-(aryléthinyl)-cyclohexanols, 1-(hétéroaryléthinyl)-cyclohexanols, 1-(hétérocyclyléthinyl)-cyclohexanols et 1-(cyloalcényléthinyl)-cyclohexanols substitués comme principes actifs contre le stress abiotique des plantes
JP2016504300A (ja) 2012-12-05 2016-02-12 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 置換された１−（アリールエチニル）−、１−（ヘテロアリールエチニル）−、１−（複素環エチニル）−および１−（シクロアルケニルエチニル）ビシクロアルカノールの非生物的植物ストレスに対する活性薬剤としての使用
UA115576C2 (uk) 2012-12-06 2017-11-27 Байєр Фарма Акцієнгезелльшафт Похідні бензимідазолу як антагоністи ер4
GB201223265D0 (en) 2012-12-21 2013-02-06 Selvita Sa Novel benzimidazole derivatives as kinase inhibitors
WO2014109858A1 (fr) 2013-01-14 2014-07-17 Amgen Inc. Méthodes d'utilisation d'inhibiteurs de cycle cellulaire pour moduler une ou plusieurs propriétés d'une culture cellulaire
WO2014152018A1 (fr) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York Octahydrocyclopentapyrroles, leur préparation et leur utilisation
DK2968304T3 (en) 2013-03-14 2019-01-28 Univ Columbia 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE.
EP3998260B1 (fr) 2013-03-15 2023-11-01 Cyclerion Therapeutics, Inc. Stimulateurs sgc
ES2660914T3 (es) 2013-03-29 2018-03-26 Takeda Pharmaceutical Company Limited Derivados de 6-(5-hidroxi-1H-pirazol-1-il)nicotinamida y su uso como inhibidores de PHD
CA2911453C (fr) 2013-05-07 2021-08-03 Galapagos Nv Nouveaux composes et leurs compositions pharmaceutiques pour le traitement de la mucoviscidose.
WO2014181287A1 (fr) 2013-05-09 2014-11-13 Piramal Enterprises Limited Composés hétérocyclyliques et leurs utilisations
AU2014268477A1 (en) 2013-05-24 2015-11-12 The California Institute For Biomedical Research Compounds for treatment of drug resistant and persistent tuberculosis
WO2015010832A1 (fr) 2013-07-22 2015-01-29 Syngenta Participations Ag Dérivés hétérocycliques microbiocides
CA2922341C (fr) 2013-08-28 2022-06-07 Vanderbilt University Inhibiteurs de mcl-1 de type indole substitue
US9663508B2 (en) 2013-10-01 2017-05-30 Amgen Inc. Biaryl acyl-sulfonamide compounds as sodium channel inhibitors
WO2015069287A1 (fr) 2013-11-08 2015-05-14 Allergan, Inc. Composés à utiliser en tant que modulateurs des tyrosine kinases
MX2016006118A (es) 2013-11-12 2016-07-21 Vertex Pharma Proceso para preparar composiciones farmaceuticas para el tratamiento de enfermedades mediadas por regulador de la conductancia transmembrana de la fibrosis quistica (cftr).
PT3925607T (pt) 2014-04-15 2023-09-26 Vertex Pharma Composições farmacêuticas para o tratamento de doenças mediadas pelo regulador de condutância transmembranar da fibrose quística
US9782408B2 (en) 2014-10-06 2017-10-10 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
ES2702288T3 (es) 2014-10-07 2019-02-28 Vertex Pharma Co-cristales de moduladores de regulador de conductancia transmembrana de la fibrosis quística
BR112017010406B1 (pt) 2014-11-18 2021-03-09 Vertex Pharmaceuticals Incorporated processo de realização de teste de alta produtividade de cromatografia líquida de alta eficiência
US10738011B2 (en) 2014-12-23 2020-08-11 Proteostasis Therapeutics, Inc. Derivatives of 5-(hetero)arylpyrazol-3-carboxylic amide or 1-(hetero)aryltriazol-4-carboxylic amide useful for the treatment of inter alia cystic fibrosis
MA41253A (fr) 2014-12-23 2017-10-31 Proteostasis Therapeutics Inc Composés, compositions et procédés pour augmenter l'activité du cftr
EP3256463B1 (fr) 2015-02-15 2019-10-09 F. Hoffmann-La Roche AG Dérivés de 1-(het)arylsulfonyl-(pyrrolidine ou piperidine)-2-carboxamide et leur utilisation en tant qu'antagonistes de trpa1
US10196384B2 (en) 2015-03-31 2019-02-05 Vertex Pharmaceuticals (Europe) Limited Deuterated CFTR modulators
BR112018005454A2 (pt) 2015-09-21 2018-10-09 Vertex Pharmaceuticals Europe Ltd administração de potencializadores de cftr deuterados
JP2019513714A (ja) 2016-03-30 2019-05-30 ジェネンテック， インコーポレイテッド 置換ベンズアミド及びその使用方法
ES2946970T3 (es) 2016-03-31 2023-07-28 Vertex Pharma Regulador de conductancia transmembrana de moduladores de fibrosis quística
AR108203A1 (es) 2016-04-07 2018-07-25 Proteostasis Therapeutics Inc Compuestos, composiciones y métodos para modular cftr (regulador de la conductancia transmembrana de la fibrosis quística)
AU2017256172A1 (en) 2016-04-26 2018-09-06 AbbVie S.à.r.l. Modulators of cystic fibrosis transmembrane conductance regulator protein
US10138227B2 (en) 2016-06-03 2018-11-27 Abbvie S.Á.R.L. Heteroaryl substituted pyridines and methods of use
US10899751B2 (en) 2016-06-21 2021-01-26 Proteostasis Therapeutics, Inc. Compounds, compositions, and methods for increasing CFTR activity
JOP20190042B1 (ar) * 2016-09-30 2021-08-17 Vertex Pharma مُعدِّل‏ لمنظم موصلية التليف الكيسي عبر الغشاء، وتركيبات صيدلانية، وطرق للعلاج، وعملية لتصنيع المُعدِّل
US9981910B2 (en) 2016-10-07 2018-05-29 Abbvie S.Á.R.L. Substituted pyrrolidines and methods of use
US10399940B2 (en) 2016-10-07 2019-09-03 Abbvie S.Á.R.L. Substituted pyrrolidines and methods of use
EP3532461A1 (fr) 2016-10-26 2019-09-04 Proteostasis Therapeutics, Inc. Dérivés n-phényl-2-(3-phényl-6-oxo-1,6-dihydropyridazine-1-yl)acétamide pour traiter la mucoviscidose
CA3041811A1 (fr) 2016-10-26 2018-05-03 Proteostasis Therapeutics, Inc. Composes, compositions et methodes permettant de moduler cftr
EP3532467A1 (fr) 2016-10-26 2019-09-04 Proteostasis Therapeutics, Inc. Composés de pyridazine, compositions et méthodes permettant de moduler cftr
JP6978507B2 (ja) 2016-11-18 2021-12-08 システィック・ファイブロシス・ファンデーション Ｃｆｔｒ増強物質としてのピロロピリミジン
PE20241131A1 (es) 2016-12-09 2024-05-24 Vertex Pharma Modulador del regulador de conductancia de transmembrana de fibrosis quistica, composiciones farmaceuticas, metodos de tratamiento y proceso para producir el modulador
CN110300589B (zh) 2016-12-16 2023-03-10 囊性纤维化基金会 作为cftr增效剂的双环异杂芳基衍生物
US20200123137A1 (en) 2016-12-20 2020-04-23 AbbVie S.à.r.l. Deuterated cftr modulators and methods of use
EP3565815B1 (fr) 2017-01-07 2024-03-13 Fochon Pharmaceuticals, Ltd. Composés en tant qu'agents induisant l'apoptose sélective de bcl-2
TW201831471A (zh) 2017-02-24 2018-09-01 盧森堡商艾伯維公司 囊腫纖化症跨膜傳導調節蛋白的調節劑及其使用方法
WO2018183367A1 (fr) 2017-03-28 2018-10-04 Van Goor Fredrick F Méthodes de traitement de fibrose kystique chez des patients ayant des mutations à fonction résiduelle
WO2018201126A1 (fr) 2017-04-28 2018-11-01 Proteostasis Therapeutics, Inc. Dérivés de 4-sulfonylaminocarbonylquinoléine pour accroître l'activité du cftr
AU2018279646B2 (en) 2017-06-08 2023-04-06 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
CA3068609A1 (fr) 2017-07-01 2019-01-10 Vertex Pharmaceuticals Incorporated Compositions et methodes de traitement de la fibrose kystique
WO2019018353A1 (fr) 2017-07-17 2019-01-24 Vertex Pharmaceuticals Incorporated Méthodes de traitement de la fibrose kystique
WO2019018395A1 (fr) 2017-07-17 2019-01-24 Vertex Pharmaceuticals Incorporated Méthodes de traitement de la fibrose kystique
WO2019026075A1 (fr) 2017-07-31 2019-02-07 Technion Research & Development Foundation Limited Procédés de détection d'adn modifié et non modifié
EP3661915B1 (fr) 2017-08-02 2022-03-09 Vertex Pharmaceuticals Incorporated Procédés de préparation de composés de pyrrolidine
US10988454B2 (en) 2017-09-14 2021-04-27 Abbvie Overseas S.À.R.L. Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
IL273752B2 (en) 2017-10-06 2023-12-01 Proteostasis Therapeutics Inc Ingredients, compounds and methods for increasing CFTR activity
MA50400A (fr) 2017-10-19 2020-08-26 Vertex Pharma Formes cristallines et compositions de modulateurs de cftr
US20210228489A1 (en) 2017-12-04 2021-07-29 Vertex Pharmaceuticals Incorporated Compositions for treating cystic fibrosis
NZ765171A (en) 2017-12-08 2024-12-20 Vertex Pharma Processes for making modulators of cystic fibrosis transmembrane conductance regulator
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
US20210009560A1 (en) 2018-03-30 2021-01-14 Vertex Pharmaceuticals Incorporated Crystalline forms of modulators of cftr
WO2019195739A1 (fr) 2018-04-05 2019-10-10 Alexander Russell Abela Modulateurs du régulateur de la conductance transmembranaire de la fibrose kystique
WO2019200246A1 (fr) 2018-04-13 2019-10-17 Alexander Russell Abela Modulateurs du régulateur de la conductance transmembranaire de la fibrose kystique, compositions pharmaceutiques, procédés de traitement et procédé de fabrication du modulateur

Also Published As

Publication number Publication date
AU2018351533A1 (en) 2020-04-30
IL273831B2 (en) 2024-10-01
NZ763365A (en) 2024-10-25
AU2018351533B2 (en) 2023-02-02
IL273831A (en) 2020-05-31
IL273831B1 (en) 2024-06-01
TWI719349B (zh) 2021-02-21
US11155533B2 (en) 2021-10-26
EP3697774A1 (fr) 2020-08-26
US10654829B2 (en) 2020-05-19
CA3078893A1 (fr) 2019-04-25
TW201922730A (zh) 2019-06-16
AU2018351533A8 (en) 2020-05-07
US20200392109A1 (en) 2020-12-17
US20190119253A1 (en) 2019-04-25
WO2019079760A1 (fr) 2019-04-25

Similar Documents

Publication Publication Date Title
MA50400A (fr) Formes cristallines et compositions de modulateurs de cftr
IL290366A (en) Crystal forms of cftr modulators
EP3645100A4 (fr) Compensation d'insertion d'instrument
MA47596A (fr) Formes cristallines du dérivé 4-pyrimidinesulfamide aprocitentan
PT3368534T (pt) Ditosilato de valbenazina e polimorfos do mesmo
EP3604311A4 (fr) Précurseur dimère de pyrrolobenzodiazépine et composé conjugué ligand-lieur associé
EP3704227A4 (fr) Composition et procédé
DK3473674T3 (da) Polypropylensammensætning
DK3978483T3 (da) Krystallinsk toluensolvat af (s)-afoxolaner
MA50657A (fr) Formulations de niraparib
DK3891145T3 (da) Modulatorer af trex1
MA54143A (fr) Compositions et méthodes
EP3585878A4 (fr) Compositions et procédés de régulation métabolique dynamique robuste
EP3434707A4 (fr) Particules creuses et utilisation de ces particules
EP3545692A4 (fr) Adaptation de résolution de stimulus dynamique
EP3390422A4 (fr) Formes cristallines de lnt
MA53474A (fr) Distribution de lingettes
MA54542A (fr) Compositions de sparsentan amorphe
DK3636640T3 (da) Krystal af heterocyclidenacetamidderivat
DK3678644T3 (da) Formuleringer af copanlisib
EP3836938A4 (fr) Formes solides de benzoxaborole substitué et compositions associées
EP3725829A4 (fr) Composition azéotropique et de type azéotrope
EP3582817C0 (fr) Échafaudage tissulaire et composition d'échafaudage
MA46266A (fr) Formes cristallines
EP3417845A4 (fr) Composition de formation de alpha-gel et composition de alpha-gel