MA46230A - Mutations de protéine d'enveloppe du vih stabilisant la forme trimère - Google Patents
Mutations de protéine d'enveloppe du vih stabilisant la forme trimèreInfo
- Publication number
- MA46230A MA46230A MA046230A MA46230A MA46230A MA 46230 A MA46230 A MA 46230A MA 046230 A MA046230 A MA 046230A MA 46230 A MA46230 A MA 46230A MA 46230 A MA46230 A MA 46230A
- Authority
- MA
- Morocco
- Prior art keywords
- hiv
- envelope protein
- envelope proteins
- hiv envelope
- trimer
- Prior art date
Links
- 101710091045 Envelope protein Proteins 0.000 title abstract 9
- 101710188315 Protein X Proteins 0.000 title abstract 9
- 102100021696 Syncytin-1 Human genes 0.000 title abstract 9
- 239000013638 trimer Substances 0.000 title abstract 3
- 230000035772 mutation Effects 0.000 title abstract 2
- 230000000087 stabilizing effect Effects 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
- C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
- C07K14/16—HIV-1 ; HIV-2
- C07K14/162—HIV-1 ; HIV-2 env, e.g. gp160, gp110/120, gp41, V3, peptid T, CD4-Binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La présente invention concerne des protéines d'enveloppe du virus de l'immunodéficience humaine (vih) présentant des mutations qui stabilisent la forme trimère de la protéine d'enveloppe. Les protéines d'enveloppe du vih présentent certaines substitutions d'acides aminés à des positions particulières dans la séquence de protéine d'enveloppe. Les protéines d'enveloppe du vih décrites dans la description présentent un pourcentage amélioré de formation de trimère et/ou un rendement amélioré en trimère telles que comparées à une protéine d'enveloppe du vih qui ne possède pas l'une ou plusieurs des substitutions d'acides aminés indiquées. La présente invention concerne également des molécules d'acide nucléique et des vecteurs codant pour les protéines d'enveloppe du vih, ainsi que des compositions contenant les protéines d'enveloppe du vih, l'acide nucléique, et les vecteurs.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16188866 | 2016-09-15 | ||
| PCT/EP2017/073141 WO2018050747A1 (fr) | 2016-09-15 | 2017-09-14 | Mutations de protéine d'enveloppe du vih stabilisant la forme trimère |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA46230A true MA46230A (fr) | 2019-07-24 |
| MA46230B1 MA46230B1 (fr) | 2020-10-28 |
Family
ID=57017955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA46230A MA46230B1 (fr) | 2016-09-15 | 2017-09-14 | Mutations de protéine d'enveloppe du vih stabilisant la forme trimère |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US10793607B2 (fr) |
| EP (2) | EP3747463A1 (fr) |
| JP (2) | JP7178344B2 (fr) |
| KR (1) | KR102513146B1 (fr) |
| CN (1) | CN109689091A (fr) |
| AR (1) | AR109528A1 (fr) |
| AU (2) | AU2017327672B2 (fr) |
| BR (1) | BR112019004593A2 (fr) |
| CA (1) | CA3036959A1 (fr) |
| CY (1) | CY1124518T1 (fr) |
| DK (1) | DK3512543T3 (fr) |
| EA (1) | EA201990715A1 (fr) |
| ES (1) | ES2824525T3 (fr) |
| HR (1) | HRP20201458T1 (fr) |
| HU (1) | HUE052008T2 (fr) |
| IL (2) | IL265186B (fr) |
| LT (1) | LT3512543T (fr) |
| MA (1) | MA46230B1 (fr) |
| MD (1) | MD3512543T2 (fr) |
| MX (1) | MX2019002938A (fr) |
| MY (1) | MY190534A (fr) |
| PH (1) | PH12019500280A1 (fr) |
| PL (1) | PL3512543T3 (fr) |
| PT (1) | PT3512543T (fr) |
| RS (1) | RS60919B1 (fr) |
| SG (2) | SG11201901206SA (fr) |
| SI (1) | SI3512543T1 (fr) |
| SM (1) | SMT202000548T1 (fr) |
| TW (1) | TWI742158B (fr) |
| WO (1) | WO2018050747A1 (fr) |
| ZA (1) | ZA201901597B (fr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS59447B1 (sr) | 2015-12-15 | 2019-11-29 | Janssen Vaccines & Prevention Bv | Antigeni, vektori i sastavi virusa humane imunodeficijencije, i postupci njihove primene |
| US11318197B2 (en) | 2016-03-03 | 2022-05-03 | Duke University | Compositions and methods for inducing HIV-1 antibodies |
| WO2017152146A2 (fr) | 2016-03-03 | 2017-09-08 | Duke University | Compositions et procédés pour induire des anticorps du vih-1 |
| CA3022826A1 (fr) * | 2016-05-02 | 2017-11-09 | Leopold KONG | Compositions et procedes associes a des immunogenes du vih-1 |
| EA201892735A1 (ru) | 2016-06-16 | 2019-05-31 | Янссен Вэксинс Энд Превеншн Б.В. | Состав вакцины против hiv |
| EP3506937A1 (fr) | 2016-09-02 | 2019-07-10 | Janssen Vaccines & Prevention B.V. | Procédés pour induire une réponse immunitaire contre une infection par le virus de l'immunodéficience humaine chez des sujets subissant un traitement antirétroviral |
| WO2018050747A1 (fr) | 2016-09-15 | 2018-03-22 | Janssen Vaccines & Prevention B.V. | Mutations de protéine d'enveloppe du vih stabilisant la forme trimère |
| EP3519428A4 (fr) | 2016-10-03 | 2020-07-08 | Duke University | Procédés d'identification d'immunogènes par ciblage de mutations improbables |
| EA202090049A1 (ru) | 2017-06-15 | 2020-04-15 | Янссен Вэксинс Энд Превеншн Б.В. | Поксвирусные векторы, кодирующие антигены вич, и способы их применения |
| SG11202000112XA (en) * | 2017-07-19 | 2020-02-27 | Janssen Vaccines & Prevention Bv | Trimer stabilizing hiv envelope protein mutations |
| EA202092808A1 (ru) | 2018-06-13 | 2021-08-24 | Зе Скриппс Рисёрч Инститьют | Вакцины на основе наночастиц с новыми структурными компонентами |
| EA038287B1 (ru) * | 2018-06-18 | 2021-08-04 | Янссен Вэксинс Энд Превеншн Б.В. | Стабилизирующие тример мутации белка оболочки hiv |
| US12138304B2 (en) | 2018-10-01 | 2024-11-12 | Duke University | HIV-1 envelope stabilizing mutations |
| JP2022523044A (ja) * | 2019-01-22 | 2022-04-21 | ブルーバード バイオ， インコーポレイテッド | ウイルスベクターを製造するための方法及びシステム |
| CN110184298B (zh) * | 2019-05-15 | 2023-05-16 | 武汉璟泓科技股份有限公司 | Hiv突变型表面糖蛋白及其纳米化抗原与制备方法 |
| WO2021097254A1 (fr) * | 2019-11-14 | 2021-05-20 | Emory University | Immunogènes du vih, vaccins et procédés associés |
| US20240000919A1 (en) * | 2020-11-12 | 2024-01-04 | Xiamen University | Modified envelope protein of human immunodeficiency virus and use thereof |
| CA3211197A1 (fr) | 2021-02-23 | 2022-09-01 | Janssen Vaccines & Prevention B.V. | Mutation de proteine d'enveloppe du vih stabilisant un trimere |
| WO2023156505A1 (fr) | 2022-02-17 | 2023-08-24 | Janssen Vaccines & Prevention B.V. | Trimère stabilisant les mutations de protéines d'enveloppe du vih r304v, n302m et t320l |
| WO2023192835A1 (fr) * | 2022-03-27 | 2023-10-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Ectodomaines de l'enveloppe du vih-1 recouverts d'une base et leur utilisation |
| WO2024091921A1 (fr) * | 2022-10-24 | 2024-05-02 | Duke University | Stabilisation d'enveloppes du virus de l'immunodéficience humaine (vih) |
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| EA201892735A1 (ru) | 2016-06-16 | 2019-05-31 | Янссен Вэксинс Энд Превеншн Б.В. | Состав вакцины против hiv |
| EP3506937A1 (fr) | 2016-09-02 | 2019-07-10 | Janssen Vaccines & Prevention B.V. | Procédés pour induire une réponse immunitaire contre une infection par le virus de l'immunodéficience humaine chez des sujets subissant un traitement antirétroviral |
| WO2018050747A1 (fr) | 2016-09-15 | 2018-03-22 | Janssen Vaccines & Prevention B.V. | Mutations de protéine d'enveloppe du vih stabilisant la forme trimère |
| SG11202000112XA (en) * | 2017-07-19 | 2020-02-27 | Janssen Vaccines & Prevention Bv | Trimer stabilizing hiv envelope protein mutations |
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2017
- 2017-09-14 WO PCT/EP2017/073141 patent/WO2018050747A1/fr active Search and Examination
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