MA45069A - Protéines agonistes du récepteur trail monocaténaires - Google Patents

Protéines agonistes du récepteur trail monocaténaires

Info

Publication number: MA45069A
Authority: MA; Morocco
Prior art keywords: catenary; agonist proteins; trail; receiver agonist; trail receiver
Prior art date: 2014-04-23

Application number

MA045069A

Other languages

English (en)

Inventor

Fritz G Buchanan

Christian Gieffers

Oliver Hill

Susan E Lappe

Darren C Phillips

Meinolf Thiemann

Original Assignee

Abbvie Inc

Apogenix Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-04-23

Filing date

2015-04-23

Publication date

2019-04-03

2015-04-23 Application filed by Abbvie Inc, Apogenix Ag filed Critical Abbvie Inc

2019-04-03 Publication of MA45069A publication Critical patent/MA45069A/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Cell Biology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Biophysics (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Communicable Diseases (AREA)
Obesity (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Diabetes (AREA)
Hematology (AREA)
Transplantation (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)

MA045069A 2014-04-23 2015-04-23 Protéines agonistes du récepteur trail monocaténaires MA45069A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201461983152P	2014-04-23	2014-04-23

Publications (1)

Publication Number	Publication Date
MA45069A true MA45069A (fr)	2019-04-03

Family

ID=53055121

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
MA039770A MA39770A (fr)	2014-04-23	2015-04-23	Protéines agonistes du récepteur trail monocaténaires
MA045069A MA45069A (fr)	2014-04-23	2015-04-23	Protéines agonistes du récepteur trail monocaténaires

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
MA039770A MA39770A (fr)	2014-04-23	2015-04-23	Protéines agonistes du récepteur trail monocaténaires

Country Status (38)

Country	Link
US (5)	US9908927B2 (fr)
EP (2)	EP3366699A1 (fr)
JP (2)	JP6523331B2 (fr)
KR (2)	KR102079919B1 (fr)
CN (2)	CN106459221B (fr)
AR (1)	AR100168A1 (fr)
AU (3)	AU2015249649B2 (fr)
BR (1)	BR112016024515B1 (fr)
CA (2)	CA2946402C (fr)
CL (1)	CL2016002683A1 (fr)
CR (1)	CR20160516A (fr)
CY (1)	CY1120281T1 (fr)
DK (1)	DK3134430T3 (fr)
DO (1)	DOP2016000284A (fr)
EC (1)	ECSP16089579A (fr)
ES (1)	ES2672368T3 (fr)
HR (1)	HRP20180950T1 (fr)
HU (1)	HUE038914T2 (fr)
IL (2)	IL248244B (fr)
LT (1)	LT3134430T (fr)
MA (2)	MA39770A (fr)
MX (2)	MX2016013858A (fr)
MY (1)	MY181986A (fr)
NO (1)	NO2776305T3 (fr)
PE (1)	PE20170299A1 (fr)
PH (2)	PH12020500377A1 (fr)
PL (1)	PL3134430T3 (fr)
PT (1)	PT3134430T (fr)
RS (1)	RS57153B1 (fr)
RU (1)	RU2699285C2 (fr)
SG (3)	SG10201806465TA (fr)
SI (1)	SI3134430T1 (fr)
SM (1)	SMT201800286T1 (fr)
TR (1)	TR201806912T4 (fr)
TW (2)	TWI747178B (fr)
UA (1)	UA118286C2 (fr)
UY (1)	UY36095A (fr)
WO (1)	WO2015164588A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2754432T3 (es) *	2015-05-04	2020-04-17	Apogenix Ag	Proteínas agonistas de receptor CD40 de cadena sencilla
EP3364995B1 (fr)	2015-10-23	2021-08-04	Apogenix AG	Protéines agonistes du récepteur cd27 à chaîne unique
AU2016341402B2 (en) *	2015-10-23	2020-08-27	Apogenix Ag	Single-chain GITR-receptor agonist proteins
CN108699129A (zh)	2015-10-23	2018-10-23	阿珀吉科吉尼科斯股份公司	单链light受体激动剂蛋白
WO2017102010A1 (fr) *	2015-12-17	2017-06-22	Biontech Rna Pharmaceuticals Gmbh	Nouvelles protéines de fusion à cytokine
JP7091248B2 (ja)	2016-03-01	2022-06-27	ザボードオブトラスティーズオブザユニヴァーシティオブイリノイ	低減されたｌ－グルタミナーゼ活性および増強された安定性を有するｌ－アスパラギナーゼ変異体および融合タンパク質
CN108884142A (zh) *	2016-03-16	2018-11-23	梅里麦克制药股份有限公司	用于癌症治疗的工程化trail
US10501744B2 (en)	2016-05-04	2019-12-10	Indiana University Research And Technology Corporation	Presentation of bioactive proteins
TWI808055B (zh)	2016-05-11	2023-07-11	美商滬亞生物國際有限公司	Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh)	2016-05-11	2023-03-01	美商滬亞生物國際有限公司	Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
AU2017283487A1 (en) *	2016-06-13	2018-11-22	Merrimack Pharmaceuticals, Inc.	Methods for selecting and treating patients with a trail-based therapeutic or death receptor agonist
EP3360898A1 (fr)	2017-02-14	2018-08-15	Boehringer Ingelheim International GmbH	Molécules bispécifiques présentant une immunoréactivité par rapport à tnf-related apoptosis-inducing ligand receptor 2 et à cadherin 17 pour le traitement du cancer
CA3106549A1 (fr) *	2017-08-11	2019-02-14	The Board Of Trustees Of The University Of Illinois	Variantes tronquees de la l-asparaginase de cochon d'inde et procedes d'utilisation
WO2019178433A1 (fr)	2018-03-15	2019-09-19	Abbvie Inc.	Abbv-621 en association avec des agents anticancéreux pour le traitement du cancer du pancréas
WO2019178438A1 (fr)	2018-03-15	2019-09-19	Abbvie Inc.	Abbv-621 en combinaison avec des agents anticancéreux pour le traitement du cancer
CN115836084A (zh)	2020-05-15	2023-03-21	阿珀吉尼科斯股份公司	多特异性免疫调节剂
EP4346885A1 (fr)	2021-05-28	2024-04-10	Julius-Maximilians-Universität Würzburg	Molécules de liaison protéiques recombinantes
WO2023088876A1 (fr)	2021-11-16	2023-05-25	Apogenix Ag	Modulateurs immunitaires multi-spécifiques

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU7645700A (en)	1999-10-07	2001-05-10	Maxygen Aps	Single-chain antagonist polypeptides
DE19963859A1 (de)	1999-12-30	2001-07-12	Apotech Res & Dev Ltd	Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen
CA2314199A1 (fr)	2000-07-21	2002-01-21	Robert Simoneau	Puce c
ATE437891T1 (de)	2000-12-07	2009-08-15	Lilly Co Eli	Glp-1 fusionsproteine
US7317091B2 (en)	2002-03-01	2008-01-08	Xencor, Inc.	Optimized Fc variants
US7538088B2 (en) *	2002-04-26	2009-05-26	California Institute Of Technology	Method for inhibiting angiogenesis by administration of the extracellular domain of D1-1 polypeptide
DE102004014983A1 (de)	2004-03-26	2005-10-20	Univ Stuttgart	Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung
US20060188498A1 (en) *	2005-02-18	2006-08-24	Genentech, Inc.	Methods of using death receptor agonists and EGFR inhibitors
CA2597789A1 (fr) *	2005-04-15	2006-10-19	Rappaport Family Institute For Research In The Medical Sciences	Molecules et procedes d'utilisation correspondants pour le traitement d'affections associees a mcp-1/ccr2
JP5255435B2 (ja)	2005-04-26	2013-08-07	メディミューン，エルエルシー	ヒンジドメイン操作による抗体エフェクター機能の調節
EP1894940A1 (fr)	2006-08-28	2008-03-05	Apogenix GmbH	Protéines de fusion de la superfamille TNF
EP3321277B1 (fr)	2007-07-10	2019-09-18	Apogenix AG	Protéines de fusion collectines de la superfamille des tnf
EP3002299A1 (fr)	2008-06-03	2016-04-06	AbbVie Inc.	Immunoglobulines à deux domaines variables et leurs utilisations
HUE025236T2 (en)	2008-07-21	2016-03-29	Apogenix Gmbh	TNFSF single chain molecules
US20110287001A1 (en) *	2008-09-22	2011-11-24	Tetralogic Pharmaceuticals	Method of treatment
CA2739663A1 (fr) *	2008-10-10	2010-05-15	Anaphore, Inc.	Polypeptides qui se lient a trail-r1 et trail-r2
EP2382236B1 (fr)	2009-01-09	2016-08-17	Apogenix AG	Protéines de fusion formant des trimères
EP2389192A4 (fr) *	2009-01-23	2013-01-16	Biogen Idec Inc	Polypeptides fc stabilisés avec une fonction effectrice réduite et procédés d'utilisation
CA2785139A1 (fr)	2009-12-22	2011-06-30	Novartis Ag	Proteine hybride tetravalente a region constante d'anticorps anti-cd-47 a utiliser en therapie
JP6041799B2 (ja)	2010-04-13	2016-12-14	メディミューン，エルエルシー	Ｔｒａｉｌｒ２特異的多量体足場
US9764038B2 (en) *	2011-12-23	2017-09-19	Innate Pharma	Enzymatic conjugation of antibodies
SG11201500134QA (en) *	2012-07-18	2015-03-30	Apogenix Gmbh	Composition comprising a mixture of cd95-fc isoforms

2012
- 2012-11-06 NO NO12790406A patent/NO2776305T3/no unknown
2015
- 2015-04-23 RU RU2016145608A patent/RU2699285C2/ru active
- 2015-04-23 ES ES15721089.9T patent/ES2672368T3/es active Active
- 2015-04-23 CR CR20160516A patent/CR20160516A/es unknown
- 2015-04-23 SM SM20180286T patent/SMT201800286T1/it unknown
- 2015-04-23 MX MX2016013858A patent/MX2016013858A/es active IP Right Grant
- 2015-04-23 TR TR2018/06912T patent/TR201806912T4/tr unknown
- 2015-04-23 JP JP2016564068A patent/JP6523331B2/ja not_active Expired - Fee Related
- 2015-04-23 BR BR112016024515-6A patent/BR112016024515B1/pt not_active IP Right Cessation
- 2015-04-23 SG SG10201806465TA patent/SG10201806465TA/en unknown
- 2015-04-23 WO PCT/US2015/027270 patent/WO2015164588A1/fr not_active Ceased
- 2015-04-23 AU AU2015249649A patent/AU2015249649B2/en not_active Ceased
- 2015-04-23 UA UAA201611802A patent/UA118286C2/uk unknown
- 2015-04-23 PH PH1/2020/500377A patent/PH12020500377A1/en unknown
- 2015-04-23 CN CN201580031858.7A patent/CN106459221B/zh not_active Expired - Fee Related
- 2015-04-23 SG SG10202111785VA patent/SG10202111785VA/en unknown
- 2015-04-23 US US14/694,358 patent/US9908927B2/en active Active
- 2015-04-23 EP EP18155146.6A patent/EP3366699A1/fr not_active Withdrawn
- 2015-04-23 SI SI201530223T patent/SI3134430T1/en unknown
- 2015-04-23 TW TW109106778A patent/TWI747178B/zh not_active IP Right Cessation
- 2015-04-23 DK DK15721089.9T patent/DK3134430T3/en active
- 2015-04-23 PT PT157210899T patent/PT3134430T/pt unknown
- 2015-04-23 AR ARP150101224A patent/AR100168A1/es active IP Right Grant
- 2015-04-23 CA CA2946402A patent/CA2946402C/fr active Active
- 2015-04-23 PL PL15721089T patent/PL3134430T3/pl unknown
- 2015-04-23 UY UY0001036095A patent/UY36095A/es active IP Right Grant
- 2015-04-23 RS RS20180450A patent/RS57153B1/sr unknown
- 2015-04-23 MA MA039770A patent/MA39770A/fr unknown
- 2015-04-23 CA CA3184067A patent/CA3184067A1/fr active Pending
- 2015-04-23 KR KR1020167032819A patent/KR102079919B1/ko not_active Expired - Fee Related
- 2015-04-23 SG SG11201608767XA patent/SG11201608767XA/en unknown
- 2015-04-23 TW TW104113087A patent/TWI683825B/zh not_active IP Right Cessation
- 2015-04-23 LT LTEP15721089.9T patent/LT3134430T/lt unknown
- 2015-04-23 MA MA045069A patent/MA45069A/fr unknown
- 2015-04-23 KR KR1020197035100A patent/KR20190135546A/ko not_active Ceased
- 2015-04-23 CN CN202010767219.XA patent/CN111718424A/zh active Pending
- 2015-04-23 HR HRP20180950TT patent/HRP20180950T1/hr unknown
- 2015-04-23 HU HUE15721089A patent/HUE038914T2/hu unknown
- 2015-04-23 PE PE2016002016A patent/PE20170299A1/es unknown
- 2015-04-23 MY MYPI2016703814A patent/MY181986A/en unknown
- 2015-04-23 EP EP15721089.9A patent/EP3134430B1/fr active Active
2016
- 2016-10-07 IL IL248244A patent/IL248244B/en active IP Right Grant
- 2016-10-19 DO DO2016000284A patent/DOP2016000284A/es unknown
- 2016-10-19 PH PH12016502079A patent/PH12016502079A1/en unknown
- 2016-10-21 MX MX2019013587A patent/MX2019013587A/es unknown
- 2016-10-21 CL CL2016002683A patent/CL2016002683A1/es unknown
- 2016-11-23 EC ECIEPI201689579A patent/ECSP16089579A/es unknown
2018
- 2018-02-02 US US15/887,509 patent/US20180222962A1/en not_active Abandoned
- 2018-05-25 CY CY20181100568T patent/CY1120281T1/el unknown
- 2018-11-30 AU AU2018271369A patent/AU2018271369B2/en not_active Ceased
2019
- 2019-04-24 JP JP2019082671A patent/JP6714751B2/ja not_active Expired - Fee Related
2020
- 2020-02-11 IL IL272612A patent/IL272612A/en unknown
- 2020-03-30 AU AU2020202247A patent/AU2020202247A1/en not_active Abandoned
- 2020-08-14 US US16/993,569 patent/US20210040178A1/en not_active Abandoned
2023
- 2023-07-14 US US18/352,769 patent/US20240174731A1/en not_active Abandoned
2024
- 2024-09-23 US US18/892,964 patent/US20250145688A1/en active Pending

Also Published As

Publication number	Publication date
KR20170012257A (ko)	2017-02-02
PT3134430T (pt)	2018-04-20
MX2019013587A (es)	2020-01-13
US20210040178A1 (en)	2021-02-11
UA118286C2 (uk)	2018-12-26
TW202024123A (zh)	2020-07-01
IL248244B (en)	2020-03-31
US9908927B2 (en)	2018-03-06
MA39770A (fr)	2015-10-29
CA3184067A1 (fr)	2015-10-29
CN106459221A (zh)	2017-02-22
TW201620928A (zh)	2016-06-16
CY1120281T1 (el)	2019-07-10
PH12016502079B1 (en)	2016-12-19
CN106459221B (zh)	2020-09-01
TWI747178B (zh)	2021-11-21
WO2015164588A1 (fr)	2015-10-29
RS57153B1 (sr)	2018-07-31
HUE038914T2 (hu)	2018-12-28
AU2015249649A1 (en)	2016-11-10
SG11201608767XA (en)	2016-11-29
SG10202111785VA (en)	2021-12-30
AR100168A1 (es)	2016-09-14
MY181986A (en)	2021-01-18
CA2946402A1 (fr)	2015-10-29
EP3134430B1 (fr)	2018-03-21
JP6523331B2 (ja)	2019-05-29
US20250145688A1 (en)	2025-05-08
AU2015249649B2 (en)	2018-10-04
CR20160516A (es)	2017-05-10
NZ725476A (en)	2023-09-29
TWI683825B (zh)	2020-02-01
TR201806912T4 (tr)	2018-06-21
ECSP16089579A (es)	2018-05-31
CA2946402C (fr)	2023-02-28
RU2016145608A (ru)	2018-05-28
PH12016502079A1 (en)	2016-12-19
KR20190135546A (ko)	2019-12-06
RU2016145608A3 (fr)	2018-12-26
PH12020500377A1 (en)	2022-11-14
RU2699285C2 (ru)	2019-09-04
CL2016002683A1 (es)	2017-07-07
IL248244A0 (en)	2016-11-30
MX2016013858A (es)	2017-08-02
DOP2016000284A (es)	2017-02-15
NO2776305T3 (fr)	2018-01-27
US20180222962A1 (en)	2018-08-09
SI3134430T1 (en)	2018-05-31
IL272612A (en)	2020-03-31
BR112016024515B1 (pt)	2020-03-31
LT3134430T (lt)	2018-05-10
ES2672368T3 (es)	2018-06-14
HRP20180950T1 (hr)	2018-08-10
KR102079919B1 (ko)	2020-02-24
UY36095A (es)	2015-10-30
BR112016024515A2 (pt)	2017-10-10
JP6714751B2 (ja)	2020-06-24
AU2018271369A1 (en)	2018-12-20
DK3134430T3 (en)	2018-05-22
JP2017513503A (ja)	2017-06-01
JP2019162114A (ja)	2019-09-26
US20150337027A1 (en)	2015-11-26
EP3134430A1 (fr)	2017-03-01
AU2018271369B2 (en)	2020-01-02
CN111718424A (zh)	2020-09-29
EP3366699A1 (fr)	2018-08-29
US20240174731A1 (en)	2024-05-30
SG10201806465TA (en)	2018-08-30
AU2020202247A1 (en)	2020-04-23
PE20170299A1 (es)	2017-05-06
SMT201800286T1 (it)	2018-07-17
PL3134430T3 (pl)	2018-08-31

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DK3702450T3 (da)	2024-07-15	Protein
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EP3353793A4 (fr)	2019-05-08	Récepteur rf
HRP20182029T1 (hr)	2019-02-08	Uti-fuzijski proteini
LT3178931T (lt)	2021-04-12	Anti-orai1 antikūnas
LT3126391T (lt)	2020-02-10	Hpa-1a antikūnai
LT3628731T (lt)	2021-08-10	Naujas antipresepsino antikūnas
EP3418079A4 (fr)	2019-10-16	Récepteur
DK3099793T3 (da)	2020-03-16	Protein
MA44599A (fr)	2019-02-13	Récepteur volumétrique
DK3310756T3 (da)	2021-03-08	Thromboxanreceptorantagonister
UA32617S (uk)	2016-07-25	Кальян