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LT3134430T - Viengubos grandinės trail receptoriaus agonisto baltymai - Google Patents

Viengubos grandinės trail receptoriaus agonisto baltymai

Info

Publication number
LT3134430T
LT3134430T LTEP15721089.9T LT15721089T LT3134430T LT 3134430 T LT3134430 T LT 3134430T LT 15721089 T LT15721089 T LT 15721089T LT 3134430 T LT3134430 T LT 3134430T
Authority
LT
Lithuania
Prior art keywords
receptor agonist
agonist proteins
chain trail
trail
chain
Prior art date
Application number
LTEP15721089.9T
Other languages
English (en)
Inventor
Oliver Hill
Christian Gieffers
Meinolf Thiemann
Fritz BUCHANAN
Darren Phillips
Susan LAPPE
Original Assignee
Abbvie Inc.
Apogenix Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc., Apogenix Ag filed Critical Abbvie Inc.
Publication of LT3134430T publication Critical patent/LT3134430T/lt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
LTEP15721089.9T 2014-04-23 2015-04-23 Viengubos grandinės trail receptoriaus agonisto baltymai LT3134430T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461983152P 2014-04-23 2014-04-23
PCT/US2015/027270 WO2015164588A1 (en) 2014-04-23 2015-04-23 Single-chain trail-receptor agonist proteins

Publications (1)

Publication Number Publication Date
LT3134430T true LT3134430T (lt) 2018-05-10

Family

ID=53055121

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP15721089.9T LT3134430T (lt) 2014-04-23 2015-04-23 Viengubos grandinės trail receptoriaus agonisto baltymai

Country Status (38)

Country Link
US (5) US9908927B2 (lt)
EP (2) EP3366699A1 (lt)
JP (2) JP6523331B2 (lt)
KR (2) KR102079919B1 (lt)
CN (2) CN106459221B (lt)
AR (1) AR100168A1 (lt)
AU (3) AU2015249649B2 (lt)
BR (1) BR112016024515B1 (lt)
CA (2) CA2946402C (lt)
CL (1) CL2016002683A1 (lt)
CR (1) CR20160516A (lt)
CY (1) CY1120281T1 (lt)
DK (1) DK3134430T3 (lt)
DO (1) DOP2016000284A (lt)
EC (1) ECSP16089579A (lt)
ES (1) ES2672368T3 (lt)
HR (1) HRP20180950T1 (lt)
HU (1) HUE038914T2 (lt)
IL (2) IL248244B (lt)
LT (1) LT3134430T (lt)
MA (2) MA39770A (lt)
MX (2) MX2016013858A (lt)
MY (1) MY181986A (lt)
NO (1) NO2776305T3 (lt)
PE (1) PE20170299A1 (lt)
PH (2) PH12020500377A1 (lt)
PL (1) PL3134430T3 (lt)
PT (1) PT3134430T (lt)
RS (1) RS57153B1 (lt)
RU (1) RU2699285C2 (lt)
SG (3) SG10201806465TA (lt)
SI (1) SI3134430T1 (lt)
SM (1) SMT201800286T1 (lt)
TR (1) TR201806912T4 (lt)
TW (2) TWI747178B (lt)
UA (1) UA118286C2 (lt)
UY (1) UY36095A (lt)
WO (1) WO2015164588A1 (lt)

Families Citing this family (18)

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ES2754432T3 (es) * 2015-05-04 2020-04-17 Apogenix Ag Proteínas agonistas de receptor CD40 de cadena sencilla
EP3364995B1 (en) 2015-10-23 2021-08-04 Apogenix AG Single-chain cd27-receptor agonist proteins
AU2016341402B2 (en) * 2015-10-23 2020-08-27 Apogenix Ag Single-chain GITR-receptor agonist proteins
CN108699129A (zh) 2015-10-23 2018-10-23 阿珀吉科吉尼科斯股份公司 单链light受体激动剂蛋白
WO2017102010A1 (en) * 2015-12-17 2017-06-22 Biontech Rna Pharmaceuticals Gmbh Novel cytokine fusion proteins
JP7091248B2 (ja) 2016-03-01 2022-06-27 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ 低減されたl-グルタミナーゼ活性および増強された安定性を有するl-アスパラギナーゼ変異体および融合タンパク質
CN108884142A (zh) * 2016-03-16 2018-11-23 梅里麦克制药股份有限公司 用于癌症治疗的工程化trail
US10501744B2 (en) 2016-05-04 2019-12-10 Indiana University Research And Technology Corporation Presentation of bioactive proteins
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
AU2017283487A1 (en) * 2016-06-13 2018-11-22 Merrimack Pharmaceuticals, Inc. Methods for selecting and treating patients with a trail-based therapeutic or death receptor agonist
EP3360898A1 (en) 2017-02-14 2018-08-15 Boehringer Ingelheim International GmbH Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer
CA3106549A1 (en) * 2017-08-11 2019-02-14 The Board Of Trustees Of The University Of Illinois Truncated guinea pig l-asparaginase variants and methods of use
WO2019178433A1 (en) 2018-03-15 2019-09-19 Abbvie Inc. Abbv-621 in combination with anti-cancer agents for the treatment of pancreatic cancer
WO2019178438A1 (en) 2018-03-15 2019-09-19 Abbvie Inc. Abbv-621 in combination with anti-cancer agents for the treatment of cancer
CN115836084A (zh) 2020-05-15 2023-03-21 阿珀吉尼科斯股份公司 多特异性免疫调节剂
EP4346885A1 (en) 2021-05-28 2024-04-10 Julius-Maximilians-Universität Würzburg Recombinant proteinaceous binding molecules
WO2023088876A1 (en) 2021-11-16 2023-05-25 Apogenix Ag Multi-specific immune modulators

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7645700A (en) 1999-10-07 2001-05-10 Maxygen Aps Single-chain antagonist polypeptides
DE19963859A1 (de) 1999-12-30 2001-07-12 Apotech Res & Dev Ltd Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen
CA2314199A1 (en) 2000-07-21 2002-01-21 Robert Simoneau C-chip
ATE437891T1 (de) 2000-12-07 2009-08-15 Lilly Co Eli Glp-1 fusionsproteine
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US7538088B2 (en) * 2002-04-26 2009-05-26 California Institute Of Technology Method for inhibiting angiogenesis by administration of the extracellular domain of D1-1 polypeptide
DE102004014983A1 (de) 2004-03-26 2005-10-20 Univ Stuttgart Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung
US20060188498A1 (en) * 2005-02-18 2006-08-24 Genentech, Inc. Methods of using death receptor agonists and EGFR inhibitors
CA2597789A1 (en) * 2005-04-15 2006-10-19 Rappaport Family Institute For Research In The Medical Sciences Molecules and methods of using same for treating mcp-1/ccr2 associated diseases
JP5255435B2 (ja) 2005-04-26 2013-08-07 メディミューン,エルエルシー ヒンジドメイン操作による抗体エフェクター機能の調節
EP1894940A1 (en) 2006-08-28 2008-03-05 Apogenix GmbH TNF superfamily fusion proteins
EP3321277B1 (en) 2007-07-10 2019-09-18 Apogenix AG Tnf superfamily collectin fusion proteins
EP3002299A1 (en) 2008-06-03 2016-04-06 AbbVie Inc. Dual variable domain immunoglobulins and uses thereof
HUE025236T2 (en) 2008-07-21 2016-03-29 Apogenix Gmbh TNFSF single chain molecules
US20110287001A1 (en) * 2008-09-22 2011-11-24 Tetralogic Pharmaceuticals Method of treatment
CA2739663A1 (en) * 2008-10-10 2010-05-15 Anaphore, Inc. Polypeptides that bind trail-r1 and trail-r2
EP2382236B1 (en) 2009-01-09 2016-08-17 Apogenix AG Fusion proteins forming trimers
EP2389192A4 (en) * 2009-01-23 2013-01-16 Biogen Idec Inc STABILIZED FC POLYPEPTIDES WITH REDUCED EFFECTOR FUNCTION AND METHOD OF USE
CA2785139A1 (en) 2009-12-22 2011-06-30 Novartis Ag Tetravalent cd47-antibody constant region fusion protein for use in therapy
JP6041799B2 (ja) 2010-04-13 2016-12-14 メディミューン,エルエルシー Trailr2特異的多量体足場
US9764038B2 (en) * 2011-12-23 2017-09-19 Innate Pharma Enzymatic conjugation of antibodies
SG11201500134QA (en) * 2012-07-18 2015-03-30 Apogenix Gmbh Composition comprising a mixture of cd95-fc isoforms

Also Published As

Publication number Publication date
KR20170012257A (ko) 2017-02-02
PT3134430T (pt) 2018-04-20
MX2019013587A (es) 2020-01-13
US20210040178A1 (en) 2021-02-11
UA118286C2 (uk) 2018-12-26
TW202024123A (zh) 2020-07-01
IL248244B (en) 2020-03-31
US9908927B2 (en) 2018-03-06
MA39770A (fr) 2015-10-29
CA3184067A1 (en) 2015-10-29
CN106459221A (zh) 2017-02-22
TW201620928A (zh) 2016-06-16
CY1120281T1 (el) 2019-07-10
PH12016502079B1 (en) 2016-12-19
CN106459221B (zh) 2020-09-01
TWI747178B (zh) 2021-11-21
WO2015164588A1 (en) 2015-10-29
RS57153B1 (sr) 2018-07-31
HUE038914T2 (hu) 2018-12-28
AU2015249649A1 (en) 2016-11-10
SG11201608767XA (en) 2016-11-29
SG10202111785VA (en) 2021-12-30
AR100168A1 (es) 2016-09-14
MY181986A (en) 2021-01-18
CA2946402A1 (en) 2015-10-29
EP3134430B1 (en) 2018-03-21
JP6523331B2 (ja) 2019-05-29
US20250145688A1 (en) 2025-05-08
AU2015249649B2 (en) 2018-10-04
CR20160516A (es) 2017-05-10
MA45069A (fr) 2019-04-03
NZ725476A (en) 2023-09-29
TWI683825B (zh) 2020-02-01
TR201806912T4 (tr) 2018-06-21
ECSP16089579A (es) 2018-05-31
CA2946402C (en) 2023-02-28
RU2016145608A (ru) 2018-05-28
PH12016502079A1 (en) 2016-12-19
KR20190135546A (ko) 2019-12-06
RU2016145608A3 (lt) 2018-12-26
PH12020500377A1 (en) 2022-11-14
RU2699285C2 (ru) 2019-09-04
CL2016002683A1 (es) 2017-07-07
IL248244A0 (en) 2016-11-30
MX2016013858A (es) 2017-08-02
DOP2016000284A (es) 2017-02-15
NO2776305T3 (lt) 2018-01-27
US20180222962A1 (en) 2018-08-09
SI3134430T1 (en) 2018-05-31
IL272612A (en) 2020-03-31
BR112016024515B1 (pt) 2020-03-31
ES2672368T3 (es) 2018-06-14
HRP20180950T1 (hr) 2018-08-10
KR102079919B1 (ko) 2020-02-24
UY36095A (es) 2015-10-30
BR112016024515A2 (pt) 2017-10-10
JP6714751B2 (ja) 2020-06-24
AU2018271369A1 (en) 2018-12-20
DK3134430T3 (en) 2018-05-22
JP2017513503A (ja) 2017-06-01
JP2019162114A (ja) 2019-09-26
US20150337027A1 (en) 2015-11-26
EP3134430A1 (en) 2017-03-01
AU2018271369B2 (en) 2020-01-02
CN111718424A (zh) 2020-09-29
EP3366699A1 (en) 2018-08-29
US20240174731A1 (en) 2024-05-30
SG10201806465TA (en) 2018-08-30
AU2020202247A1 (en) 2020-04-23
PE20170299A1 (es) 2017-05-06
SMT201800286T1 (it) 2018-07-17
PL3134430T3 (pl) 2018-08-31

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