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MA44674A - Inhibiteurs de bromodomaine - Google Patents

Inhibiteurs de bromodomaine

Info

Publication number
MA44674A
MA44674A MA044674A MA44674A MA44674A MA 44674 A MA44674 A MA 44674A MA 044674 A MA044674 A MA 044674A MA 44674 A MA44674 A MA 44674A MA 44674 A MA44674 A MA 44674A
Authority
MA
Morocco
Prior art keywords
bromodomain inhibitors
compounds
formula
present
diseases
Prior art date
Application number
MA044674A
Other languages
English (en)
Other versions
MA44674B1 (fr
Inventor
Steven D Fidanze
Lisa A Hasvold
Bing Li
Dachun Liu
Keith F Mcdaniel
John PRATT
Michael Schrimpf
George S Sheppard
Le Wang
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MA44674A publication Critical patent/MA44674A/fr
Publication of MA44674B1 publication Critical patent/MA44674B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)

Abstract

La présente invention concerne des composés de formule (i) dans laquelle r1, r2, r3, r4, r6, x1, et x2 ont l'une quelconque des valeurs définies dans la spécification, et des sels pharmaceutiquement acceptables de ceux-ci, qui sont utiles en tant qu'agents dans le traitement de maladies et d'affections, y compris des maladies inflammatoires, le cancer, et le sida. La présente invention concerne en outre des compositions pharmaceutiques comprenant des composés de formule (i).
MA44674A 2016-04-15 2017-04-14 Inhibiteurs de bromodomaine MA44674B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2016079362 2016-04-15
PCT/CN2017/080511 WO2017177955A1 (fr) 2016-04-15 2017-04-14 Inhibiteurs de bromodomaine

Publications (2)

Publication Number Publication Date
MA44674A true MA44674A (fr) 2019-02-20
MA44674B1 MA44674B1 (fr) 2020-06-30

Family

ID=60042835

Family Applications (2)

Application Number Title Priority Date Filing Date
MA44674A MA44674B1 (fr) 2016-04-15 2017-04-14 Inhibiteurs de bromodomaine
MA052814A MA52814A (fr) 2016-04-15 2017-04-14 Inhibiteurs de bromodomaine

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA052814A MA52814A (fr) 2016-04-15 2017-04-14 Inhibiteurs de bromodomaine

Country Status (39)

Country Link
US (4) US10633379B2 (fr)
EP (2) EP3693369A3 (fr)
JP (2) JP6978424B2 (fr)
KR (1) KR102250415B1 (fr)
CN (1) CN109071534B (fr)
AR (1) AR108207A1 (fr)
AU (2) AU2017251537B2 (fr)
BR (1) BR112018071216A2 (fr)
CA (1) CA3018802A1 (fr)
CL (1) CL2018002924A1 (fr)
CO (1) CO2018011064A2 (fr)
CR (1) CR20180541A (fr)
CY (1) CY1123025T1 (fr)
DK (1) DK3442972T3 (fr)
DO (1) DOP2018000227A (fr)
EC (1) ECSP18083519A (fr)
ES (1) ES2793239T3 (fr)
HR (1) HRP20200728T1 (fr)
HU (1) HUE050217T2 (fr)
IL (1) IL261586B (fr)
LT (1) LT3442972T (fr)
MA (2) MA44674B1 (fr)
MD (1) MD3442972T2 (fr)
ME (1) ME03759B (fr)
MX (1) MX379459B (fr)
MY (1) MY190795A (fr)
PE (1) PE20190472A1 (fr)
PH (1) PH12018501920B1 (fr)
PL (1) PL3442972T3 (fr)
PT (1) PT3442972T (fr)
RS (1) RS60302B1 (fr)
RU (1) RU2741808C2 (fr)
SG (1) SG11201808003RA (fr)
SI (1) SI3442972T1 (fr)
SM (1) SMT202000312T1 (fr)
TW (3) TWI764237B (fr)
UA (1) UA124764C2 (fr)
UY (1) UY37205A (fr)
WO (1) WO2017177955A1 (fr)

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UA124764C2 (uk) * 2016-04-15 2021-11-17 Еббві Інк. Інгібітори бромодомену
CA3038997A1 (fr) * 2016-10-14 2018-04-19 Abbvie Inc. Inhibiteurs de bromodomaine
JP2020517618A (ja) 2017-04-21 2020-06-18 エピザイム，インコーポレイティド Ｅｈｍｔ２阻害剤との併用療法
CN115716827A (zh) * 2018-07-25 2023-02-28 正大天晴药业集团股份有限公司 作为溴区结构域蛋白抑制剂的亚氨基砜类化合物、药物组合物及其医药用途
CN110776508B (zh) * 2018-07-27 2021-07-16 海创药业股份有限公司 一种brd4抑制剂及其制备方法和用途
CN110964012B (zh) * 2018-09-29 2021-08-13 上海凌达生物医药有限公司 一类稠杂环联芳基苄醇类化合物、制备方法和用途
EP3873474A4 (fr) 2018-10-30 2022-07-13 Nuvation Bio Inc. Composés hétérocycliques utilisés comme inhibiteurs de bet
SG11202110099YA (en) 2019-03-17 2021-10-28 Shanghai Ringene Biopharma Co Ltd Pyrrole amidopyridone compound, preparation method therefor and use thereof
GB201905721D0 (en) * 2019-04-24 2019-06-05 Univ Dundee Compounds
WO2020232214A1 (fr) * 2019-05-14 2020-11-19 Abbvie Inc. Traitement de la leucémie myéloïde aiguë (lma) avec du mivébrésib, un inhibiteur de bromodomaines
MX2022000050A (es) 2019-07-02 2022-05-24 Nuvation Bio Inc Compuestos heterocíclicos como inhibidores de bromodominio extraterminal (bet).
WO2021022078A1 (fr) * 2019-07-30 2021-02-04 Xrad Therapeutics, Inc. Inhibiteurs doubles de l'atm et de l'adn-pk destinés à une utilisation en thérapie antitumorale
CN112625036A (zh) * 2019-10-08 2021-04-09 上海海和药物研究开发股份有限公司 一类具有brd4抑制活性的化合物、其制备方法及用途
WO2021233371A1 (fr) * 2020-05-21 2021-11-25 贝达药业股份有限公司 Composé fonctionnant comme inhibiteur de protéine de bromodomaine, et composition
GB202016977D0 (en) 2020-10-26 2020-12-09 In4Derm Ltd Compounds
EP4183785A4 (fr) * 2020-12-01 2024-08-21 Chengdu Easton Biopharmaceuticals Co., Ltd. Nouvel inhibiteur de bromodomaine bet n-hétérocyclique, procédé de préparation s'y rapportant et utilisation médicale associée
JP2024502469A (ja) * 2021-01-08 2024-01-19 デザイン セラピューティクス，インク． フリードライヒ運動失調症を治療するための方法及び化合物
CN115232131A (zh) * 2021-04-23 2022-10-25 江苏恒瑞医药股份有限公司 含氮杂环类化合物、其制备方法及其在医药上的应用
WO2022228421A1 (fr) * 2021-04-30 2022-11-03 成都苑东生物制药股份有限公司 Nouvel agent de dégradation de protéine protac de bromodomaine brd4 de type nouveau, son procédé de préparation et son utilisation médicale
JP2024523491A (ja) 2021-06-29 2024-06-28 タイ セラピューティクス リミテッド がんの治療に有用なピロロピリドン誘導体
CN115611890B (zh) * 2021-07-15 2024-05-31 成都硕德药业有限公司 一种新型噻吩类bet溴结构域抑制剂、其制备方法及医药用途
WO2025006827A1 (fr) 2023-06-30 2025-01-02 Genzyme Corporation Composés cycliques substitués et méthodes pour traiter la phénylcétonurie et d'autres aminoaciduries

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CN108690020A (zh) 2018-07-04 2018-10-23 清华大学 一种靶向降解bet蛋白的化合物及其应用

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