MA43159B1 - Dérivés d'indoline-2-one - Google Patents
Dérivés d'indoline-2-oneInfo
- Publication number
- MA43159B1 MA43159B1 MA43159A MA43159A MA43159B1 MA 43159 B1 MA43159 B1 MA 43159B1 MA 43159 A MA43159 A MA 43159A MA 43159 A MA43159 A MA 43159A MA 43159 B1 MA43159 B1 MA 43159B1
- Authority
- MA
- Morocco
- Prior art keywords
- diseases
- disease
- disorder
- epilepsy
- treatment
- Prior art date
Links
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010015037 epilepsy Diseases 0.000 abstract 2
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 208000011117 substance-related disease Diseases 0.000 abstract 2
- 208000007848 Alcoholism Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 206010003805 Autism Diseases 0.000 abstract 1
- 208000020706 Autistic disease Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 abstract 1
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 208000028698 Cognitive impairment Diseases 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 208000029726 Neurodevelopmental disease Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 208000028552 Treatment-Resistant Depressive disease Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 201000007930 alcohol dependence Diseases 0.000 abstract 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000030963 borderline personality disease Diseases 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000024714 major depressive disease Diseases 0.000 abstract 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 125000004095 oxindolyl group Chemical class N1(C(CC2=CC=CC=C12)=O)* 0.000 abstract 1
- 210000001525 retina Anatomy 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 230000007958 sleep Effects 0.000 abstract 1
- 201000009032 substance abuse Diseases 0.000 abstract 1
- 231100000736 substance abuse Toxicity 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne des dérivés d'indoline-2-one de formule générale (i), les substituants étant définis dans la revendication 1. Les composés peuvent être utilisés dans le traitement de maladies du système nerveux central associées à des symptômes positifs (psychose) et négatifs de la schizophrénie, de l'abus de substances, de la dépendance à l'alcool et aux drogues, de troubles obsessionnels-compulsifs, de troubles cognitifs, de troubles bipolaires, de troubles de l'humeur, de la dépression majeure, de la dépression résistante au traitement, de troubles de l'anxiété, de la maladie d'alzheimer, de l'autisme, de la maladie de parkinson, de douleurs chroniques, de troubles de la personnalité limite, de maladies neurodégénératives, de troubles du sommeil, du syndrome de fatigue chronique, de la crispation, de maladies inflammatoires, de l'asthme, de la chorée de huntington, du tdah, de la sclérose latérale amyotrophique, des effets de l'arthrite, de maladies auto-immunes, d'infections virales et fongiques, de maladies cardio-vasculaires, de maladies ophtalmologiques et de maladies inflammatoires de la rétine, de problèmes d'équilibre, de l'épilepsie et de troubles neurodéveloppementaux avec épilépsie comorbide.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15193342 | 2015-11-06 | ||
| PCT/EP2016/076332 WO2017076852A1 (fr) | 2015-11-06 | 2016-11-02 | Dérivés d'indoline-2-one |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA43159B1 true MA43159B1 (fr) | 2020-08-31 |
Family
ID=54476820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA43159A MA43159B1 (fr) | 2015-11-06 | 2016-11-02 | Dérivés d'indoline-2-one |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US10710985B2 (fr) |
| EP (1) | EP3371168B1 (fr) |
| JP (1) | JP6857662B2 (fr) |
| KR (1) | KR20180080305A (fr) |
| CN (1) | CN108349944B (fr) |
| AR (1) | AR106588A1 (fr) |
| AU (1) | AU2016348493B2 (fr) |
| CA (1) | CA3002489C (fr) |
| CL (1) | CL2018001085A1 (fr) |
| CO (1) | CO2018005718A2 (fr) |
| CR (1) | CR20180255A (fr) |
| DK (1) | DK3371168T3 (fr) |
| ES (1) | ES2808920T3 (fr) |
| HK (1) | HK1257170A1 (fr) |
| HR (1) | HRP20201158T1 (fr) |
| HU (1) | HUE050083T2 (fr) |
| IL (1) | IL258656A (fr) |
| LT (1) | LT3371168T (fr) |
| MA (1) | MA43159B1 (fr) |
| MX (1) | MX380215B (fr) |
| MY (1) | MY197370A (fr) |
| PE (1) | PE20181885A1 (fr) |
| PH (1) | PH12018500978B1 (fr) |
| PL (1) | PL3371168T3 (fr) |
| PT (1) | PT3371168T (fr) |
| RS (1) | RS60504B1 (fr) |
| RU (1) | RU2727179C2 (fr) |
| SG (1) | SG11201803796SA (fr) |
| SI (1) | SI3371168T1 (fr) |
| TW (1) | TWI631117B (fr) |
| UA (1) | UA122589C2 (fr) |
| WO (1) | WO2017076852A1 (fr) |
| ZA (1) | ZA201802411B (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6857653B2 (ja) | 2015-11-06 | 2021-04-14 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｃｎｓ及び関連障害の治療において使用するためのインドリン−２−オン誘導体 |
| WO2017076932A1 (fr) | 2015-11-06 | 2017-05-11 | F. Hoffmann-La Roche Ag | Dérivés d'indoline-2-one utiles dans le traitement de maladies du système nerveux central |
| PL3371168T3 (pl) | 2015-11-06 | 2020-11-02 | F. Hoffmann-La Roche Ag | Pochodne indolin-2-onu |
| JP6839184B2 (ja) | 2015-11-06 | 2021-03-03 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | インドリン−２−オン誘導体 |
| IL291839A (en) | 2019-10-01 | 2022-06-01 | Empyrean Neuroscience Inc | Genetic engineering of fungi to modulate tryptamine expression |
| CN115298163B (zh) * | 2020-04-29 | 2024-11-19 | 巴斯夫欧洲公司 | 通过钯催化的羰基化反应制备芳族羧酰胺 |
| WO2023130075A2 (fr) | 2021-12-31 | 2023-07-06 | Empyrean Neuroscience, Inc. | Organismes génétiquement modifiés pour produire des alcaloïdes psychotropes |
| WO2025022405A1 (fr) * | 2023-07-26 | 2025-01-30 | Bsense Bio Therapeutics Ltd. | Modulateurs d'un canal potassique et d'un canal trpv1 et leurs utilisations |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3932953A1 (de) * | 1989-10-03 | 1991-04-11 | Boehringer Mannheim Gmbh | Neue 2-bicyclo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3935514A1 (de) | 1989-10-25 | 1991-05-02 | Boehringer Mannheim Gmbh | Neue bicyclo-imidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| TW251284B (fr) | 1992-11-02 | 1995-07-11 | Pfizer | |
| DE4427648A1 (de) | 1994-08-04 | 1996-02-08 | Basf Ag | N-Stubstituierte 3-Azabicyclo[3,2,0,]heptan-Derivate, ihre Herstellung und Verwendung |
| FR2757157B1 (fr) | 1996-12-13 | 1999-12-31 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant |
| KR20010013387A (fr) | 1997-06-16 | 2001-02-26 | 디르크 반테 | Utilisation d'analogues de draflazine dans le traitement de la douleur |
| WO2000040581A1 (fr) | 1999-01-07 | 2000-07-13 | American Home Products Corporation | Derives de la 3,4-dihydro-2h benzo[1,4]oxazine |
| IT1318403B1 (it) | 2000-03-17 | 2003-08-25 | Cooperativa Ct Ricerche Poly T | Esteri polisaccaridici di n-derivati di acido glutammico. |
| EP1272483A2 (fr) | 2000-03-24 | 2003-01-08 | Millenium Pharmaceuticals, Inc. | INHIBITEURS D'OXINIDOLE DU FACTEUR Xa |
| FR2807038B1 (fr) | 2000-04-03 | 2002-08-16 | Sanofi Synthelabo | Nouveaux derives d'indolin-2-one, leur preparation et les compositions pharmaceutiques les contenant |
| WO2002000217A1 (fr) | 2000-06-29 | 2002-01-03 | Neurosearch A/S | Utilisation de derives d'oxindole 3-substitue comme modulateurs du canal potassique kcnq |
| US6524302B2 (en) | 2001-04-26 | 2003-02-25 | Scimed Life Systems, Inc. | Multi-lumen catheter |
| AU2003300124A1 (en) | 2002-12-31 | 2004-07-29 | BUOLAMWINI, John, K | Novel nucleoside transport inhibitors |
| RS20060619A (sr) * | 2004-05-11 | 2008-06-05 | Egis Gyogyszergyar Nyrt., | Piridinski derivati alkil oksindola kao aktivna sredstva koja deluju na 5-ht7 receptor |
| EP1612210B1 (fr) | 2004-06-29 | 2007-09-26 | Grünenthal GmbH | Nouveaux analogues de nitrobenzylthioinosine |
| US20060253263A1 (en) | 2005-04-11 | 2006-11-09 | Meshkin Brian J | Method to optimize drug selection, dosing and evaluation and to help predict therapeutic response and toxicity from immunosuppressant therapy |
| AR053713A1 (es) | 2005-04-20 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos heterociclicos y sus usos como agentes terapeuticos |
| AR056317A1 (es) | 2005-04-20 | 2007-10-03 | Xenon Pharmaceuticals Inc | Compuestos de oxindol y composicion farmaceutica |
| EP1904483A1 (fr) | 2005-07-13 | 2008-04-02 | F. Hoffmann-Roche AG | Derives de benzimidazole tels que 5-ht6, 5-ht24 |
| US20070265270A1 (en) * | 2006-02-21 | 2007-11-15 | Hitchcock Stephen A | Cinnoline derivatives as phosphodiesterase 10 inhibitors |
| WO2007103373A2 (fr) | 2006-03-07 | 2007-09-13 | Combinatorx, Incorporated | Compositions et procédés pour le traitement de troubles immunoinflammatoires |
| AU2007265088B2 (en) | 2006-06-26 | 2013-05-23 | Dart Neuroscience (Cayman) Ltd | Method of modulating neurite outgrowth by the use of a galanin-3 receptor antagonist |
| US7952109B2 (en) | 2006-07-10 | 2011-05-31 | Alcatel-Lucent Usa Inc. | Light-emitting crystal structures |
| WO2008046083A2 (fr) | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Utilisation de composés oxindole comme agents thérapeutiques |
| PE20081401A1 (es) * | 2006-12-28 | 2008-10-24 | Hoffmann La Roche | Derivados de indol como antagonistas de receptores vasopresina |
| SI2114921T1 (sl) | 2006-12-30 | 2013-05-31 | Abbott Gmbh & Co. Kg | Substituiran oksindolni derivat in njegova uporaba kot ligand vazopresinskega receptorja |
| UY30846A1 (es) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
| US20100284984A1 (en) | 2007-07-30 | 2010-11-11 | University Of Rochester | Adenosine and its mimetics. modulators, transport inhibitors, and receptor agonists as a therapeutic tool to replace or improve the efficacy of deep brain stimulation |
| JO3126B1 (ar) | 2007-11-14 | 2017-09-20 | Janssen Pharmaceutica Nv | مثبطات ناقل نيوكليوسيد متوازن اي ان تي 1 |
| WO2009064497A1 (fr) | 2007-11-15 | 2009-05-22 | The University Of North Carolina At Chapel Hill | Phosphatase acide prostatique pour le traitement de la douleur |
| EP2108641A1 (fr) * | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | Nouveaux dérivés substitués de spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one et leur utilisation comme ihibiteurs de p38 mitogen-activated kinase |
| EP2113503A1 (fr) | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | Nouveaux dérivés d'indolin-2-one substitués et leur utilisation comme inhibiteurs de p38 mitogen-activated kinase |
| JO3265B1 (ar) | 2008-12-09 | 2018-09-16 | Novartis Ag | مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض |
| CN103619845B (zh) * | 2011-04-21 | 2016-08-17 | 拜耳知识产权有限责任公司 | 氟烷基取代的吡唑并吡啶及其用途 |
| IN2014MN02105A (fr) * | 2012-04-20 | 2015-09-11 | Annji Pharm Co Ltd | |
| WO2014040969A1 (fr) * | 2012-09-13 | 2014-03-20 | F. Hoffmann-La Roche Ag | 2-oxo-2,3-dihydro-indoles destinés au traitement de troubles du snc |
| CA2915536C (fr) | 2013-06-19 | 2021-10-19 | F. Hoffmann-La Roche Ag | Derives indolin-2-one ou pyrrolo-pyridin/pyrimidin-2-one |
| CR20160578A (es) | 2014-06-26 | 2017-02-21 | Hoffmann La Roche | Derivados de indolin-2-ona o pirrolo-piridin-2-ona |
| MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
| JP6839184B2 (ja) | 2015-11-06 | 2021-03-03 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | インドリン−２−オン誘導体 |
| BR112018008630A2 (pt) | 2015-11-06 | 2018-10-30 | Neurocrine Biosciences Inc | derivados de n-[2-(1-benzilpiperidin-4-il)etil]-4-(pirazin-2-il)-piperazina-1-carboxamida, seus usos, composição farmacêutica |
| US10544139B2 (en) | 2015-11-06 | 2020-01-28 | Samumed, Llc | Treatment of osteoarthritis |
| PL3371168T3 (pl) | 2015-11-06 | 2020-11-02 | F. Hoffmann-La Roche Ag | Pochodne indolin-2-onu |
| WO2017076932A1 (fr) | 2015-11-06 | 2017-05-11 | F. Hoffmann-La Roche Ag | Dérivés d'indoline-2-one utiles dans le traitement de maladies du système nerveux central |
| JP6857653B2 (ja) | 2015-11-06 | 2021-04-14 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｃｎｓ及び関連障害の治療において使用するためのインドリン−２−オン誘導体 |
-
2016
- 2016-11-02 PL PL16788705T patent/PL3371168T3/pl unknown
- 2016-11-02 JP JP2018541528A patent/JP6857662B2/ja active Active
- 2016-11-02 LT LTEP16788705.8T patent/LT3371168T/lt unknown
- 2016-11-02 KR KR1020187015975A patent/KR20180080305A/ko active Pending
- 2016-11-02 ES ES16788705T patent/ES2808920T3/es active Active
- 2016-11-02 EP EP16788705.8A patent/EP3371168B1/fr active Active
- 2016-11-02 DK DK16788705.8T patent/DK3371168T3/da active
- 2016-11-02 WO PCT/EP2016/076332 patent/WO2017076852A1/fr active Application Filing
- 2016-11-02 RS RS20200807A patent/RS60504B1/sr unknown
- 2016-11-02 HU HUE16788705A patent/HUE050083T2/hu unknown
- 2016-11-02 SG SG11201803796SA patent/SG11201803796SA/en unknown
- 2016-11-02 SI SI201630857T patent/SI3371168T1/sl unknown
- 2016-11-02 RU RU2018120703A patent/RU2727179C2/ru active
- 2016-11-02 PH PH1/2018/500978A patent/PH12018500978B1/en unknown
- 2016-11-02 CN CN201680064831.2A patent/CN108349944B/zh active Active
- 2016-11-02 MY MYPI2018000647A patent/MY197370A/en unknown
- 2016-11-02 MA MA43159A patent/MA43159B1/fr unknown
- 2016-11-02 CR CR20180255A patent/CR20180255A/es unknown
- 2016-11-02 MX MX2018005121A patent/MX380215B/es unknown
- 2016-11-02 UA UAA201806057A patent/UA122589C2/uk unknown
- 2016-11-02 PE PE2018000537A patent/PE20181885A1/es unknown
- 2016-11-02 PT PT167887058T patent/PT3371168T/pt unknown
- 2016-11-02 CA CA3002489A patent/CA3002489C/fr active Active
- 2016-11-02 AU AU2016348493A patent/AU2016348493B2/en active Active
- 2016-11-04 AR ARP160103363A patent/AR106588A1/es unknown
- 2016-11-04 TW TW105135901A patent/TWI631117B/zh active
-
2018
- 2018-04-12 IL IL258656A patent/IL258656A/en active IP Right Grant
- 2018-04-12 ZA ZA2018/02411A patent/ZA201802411B/en unknown
- 2018-04-24 CL CL2018001085A patent/CL2018001085A1/es unknown
- 2018-05-04 US US15/971,323 patent/US10710985B2/en active Active
- 2018-05-30 CO CONC2018/0005718A patent/CO2018005718A2/es unknown
- 2018-12-13 HK HK18116051.2A patent/HK1257170A1/zh unknown
-
2020
- 2020-06-10 US US16/897,879 patent/US11066393B2/en active Active
- 2020-07-23 HR HRP20201158TT patent/HRP20201158T1/hr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA43159B1 (fr) | Dérivés d'indoline-2-one | |
| EA033420B1 (ru) | Производные индолин-2-она или пирролопиридин-2-она, обладающие антипсихотической активностью | |
| MX2019010577A (es) | Derivados de benzodiazepina, composiciones, y metodos para tratar el deterioro cognitivo. | |
| EA201890090A1 (ru) | Производные бензодиазепина, композиции и способы для лечения когнитивного нарушения | |
| MA38261A1 (fr) | Composes comprenant un noyau polycyclique destines a etre utilises dans le traitement de l'hepatite c (vhc) | |
| MA34828B1 (fr) | Procédés et produits médicamenteux destinés au traitement de la maladie d'alzheimer | |
| MA33659B1 (fr) | Dihydrobenzocycloalkyl-oxyméthyl-oxazolopyrimidinones substituées, préparation et utilisation de celles-ci | |
| AR106590A1 (es) | Derivados de indolin-2-ona | |
| MX2019007338A (es) | Derivados de benzodiazepina, composiciones y métodos para tratar deterioro cognitivo. | |
| MA46611B1 (fr) | Traitements combinés comprenant des imidazopyrazinones pour le traitement de troubles psychiatriques et/ou cognitifs | |
| MA43113B1 (fr) | Anticorps anti-htr a1 et méthodes d'utilisation de ceux-ci | |
| PH12016501863A1 (en) | Heteroaromatic compounds and their use as dopamine d1 ligands | |
| EA201390710A1 (ru) | Производные бензодиазепина, композиции и способы для лечения когнитивного нарушения | |
| PH12016501993A1 (en) | Heteroaromatic compounds and their use as dopamine d1 ligands | |
| AR106591A1 (es) | Derivados de indolin-2-ona | |
| Nilius et al. | Are brain TRPs viable targets for curing neurodegenerative disorders and improving mental health? | |
| TH1801002657A (th) | อนุพันธ์อินโดลิน-2-โอน | |
| MX2016014845A (es) | Derivados indolin-2-ona y 1,3-dihidro-pirrol[3,2-c]piridin-2-ona. | |
| LU100823B1 (en) | Method of performing differential diagnosis of neurodegenerative diseases in a subject | |
| CERQ | INC 2016, Zarqa University, Jordan April 6, 2016 | |
| EA201691290A1 (ru) | Бензодиазепиновые производные, композиции и способы для лечения когнитивного нарушения | |
| WO2014111525A3 (fr) | Nouvelles polythérapies pour le traitement de maladies du système nerveux | |
| Maffei | GABAergic inhibition in visual cortical plasticity | |
| Sekita-Krzak et al. | ETIOPATHOGENETICAL AND CLINICAL RELATION OF STRESS AND DEPRESSION | |
| EA201992055A1 (ru) | Ингибиторы бета-секретазы |