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MA34004B1 - Protéines de liaison à cd127 - Google Patents

Protéines de liaison à cd127

Info

Publication number
MA34004B1
MA34004B1 MA35147A MA35147A MA34004B1 MA 34004 B1 MA34004 B1 MA 34004B1 MA 35147 A MA35147 A MA 35147A MA 35147 A MA35147 A MA 35147A MA 34004 B1 MA34004 B1 MA 34004B1
Authority
MA
Morocco
Prior art keywords
antigen binding
binding proteins
protein link
diseases
protein
Prior art date
Application number
MA35147A
Other languages
Arabic (ar)
English (en)
Inventor
Ian Kirby
Alexander H Taylor
Thomas Matthew Webb
Yu Xue
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MA34004B1 publication Critical patent/MA34004B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des protéines de liaison à un antigène qui se lient au récepteur humain de l'IL-7 (CD127). Les protéines de liaison à un antigène sont typiquement des anticorps, et sont utiles dans le traitement de maladies ou de troubles chez les êtres humains, particulièrement de maladies auto-immunes telles que la sclérose en plaques.
MA35147A 2010-01-28 2011-01-26 Protéines de liaison à cd127 MA34004B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29901010P 2010-01-28 2010-01-28
PCT/US2011/022507 WO2011094259A2 (fr) 2010-01-28 2011-01-26 Protéines de liaison à cd127

Publications (1)

Publication Number Publication Date
MA34004B1 true MA34004B1 (fr) 2013-02-01

Family

ID=44320081

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35147A MA34004B1 (fr) 2010-01-28 2011-01-26 Protéines de liaison à cd127

Country Status (26)

Country Link
US (2) US8940303B2 (fr)
EP (1) EP2528947A4 (fr)
JP (1) JP5850860B2 (fr)
KR (1) KR20130028055A (fr)
CN (1) CN102812046B (fr)
AR (1) AR080027A1 (fr)
AU (1) AU2011209713B2 (fr)
BR (1) BR112012018914A2 (fr)
CA (1) CA2787070A1 (fr)
CL (1) CL2012002081A1 (fr)
CO (1) CO6592067A2 (fr)
CR (1) CR20120404A (fr)
EA (1) EA023700B1 (fr)
IL (1) IL220899A (fr)
MA (1) MA34004B1 (fr)
MX (1) MX339083B (fr)
MY (1) MY160590A (fr)
NZ (1) NZ601271A (fr)
PE (2) PE20121702A1 (fr)
PH (1) PH12012501549A1 (fr)
SG (1) SG182590A1 (fr)
TW (1) TWI489996B (fr)
UA (1) UA104663C2 (fr)
UY (1) UY33202A (fr)
WO (1) WO2011094259A2 (fr)
ZA (1) ZA201205624B (fr)

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CA2981662C (fr) 2011-01-14 2019-02-05 The Regents Of The University Of California Anticorps therapeutiques contre la proteine ror-1 et leurs methodes d'utilisation
EP2583980A1 (fr) 2011-10-19 2013-04-24 Effimune Anticorps dirigés contre la chaîne alpha du récepteur IL7, leur utilisation pour la préparation de candidats médicaments
EP2955196A1 (fr) * 2014-06-10 2015-12-16 Effimune Anticorps dirigés contre CD127
KR20170065662A (ko) 2014-10-18 2017-06-13 화이자 인코포레이티드 항-il-7r 항체 조성물
JP2018511346A (ja) 2015-03-31 2018-04-26 ブイエイチスクエアード リミテッド ポリペプチド
WO2017055966A1 (fr) 2015-10-01 2017-04-06 Pfizer Inc. Compositions d'anticorps à faible viscosité
WO2017120479A1 (fr) * 2016-01-07 2017-07-13 The Schepens Eye Research Institute, Inc. Thérapeutique pour maladies immuno-inflammatoires oculaires
US11230602B2 (en) * 2016-02-29 2022-01-25 Ose Immunotherapeutics Non-antagonistic antibodies directed against the alpha chain of the IL7 receptor extracellular domain and use thereof in cancer treatment
CN110392695B (zh) * 2016-12-09 2021-02-02 Ose免疫疗法 针对cd127的抗体和多肽
WO2019136180A2 (fr) * 2018-01-04 2019-07-11 Avidity Biosciences Llc Molécules d'acide nucléique hétéroduplex et leurs utilisations
KR20230128134A (ko) * 2019-01-22 2023-09-01 브리스톨-마이어스 스큅 컴퍼니 Il-7r 알파 서브유닛에 대한 항체 및 이의 용도
US20230143091A1 (en) 2019-06-21 2023-05-11 Sorriso Pharmaceuticals, Inc. Compositions
WO2020254827A1 (fr) 2019-06-21 2020-12-24 Vhsquared Limited Polypeptides
AU2020296979A1 (en) 2019-06-21 2022-02-24 Sorriso Pharmaceuticals, Inc. Polypeptides
CN110894237B (zh) * 2019-12-05 2021-08-03 山东省分析测试中心 抗cd127的抗体、分泌该抗体的细胞株及其制备方法和应用
GB2595299B (en) 2020-05-21 2022-08-03 Mabsolve Ltd Modified immunoglobulin FC regions
US20220389104A1 (en) * 2021-05-28 2022-12-08 Ose Immunotherapeutics Method for Treating CD127-Positive Cancers by Administering an Anti-CD127 Agent
EP4499875A1 (fr) 2022-05-30 2025-02-05 Ose Immunotherapeutics Biomarqueurs de l'activité de modulateurs il7r
WO2024040195A1 (fr) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditionnement pour l'ingénierie de cellules immunitaires in vivo
WO2024146955A1 (fr) 2023-01-06 2024-07-11 Twain Therapeutics Pte. Ltd. Molécules de liaison à l'antigène
WO2024146959A1 (fr) 2023-01-06 2024-07-11 Twain Therapeutics Pte. Ltd. Molécules de liaison à l'antigène
EP4455308A1 (fr) 2023-04-24 2024-10-30 Les Laboratoires Servier Signatures géniques il-7r
WO2024249954A1 (fr) 2023-05-31 2024-12-05 Capstan Therapeutics, Inc. Formulations et compositions de nanoparticules lipidiques

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Also Published As

Publication number Publication date
IL220899A0 (en) 2012-09-24
PH12012501549A1 (en) 2016-09-09
CN102812046B (zh) 2015-02-25
MY160590A (en) 2017-03-15
KR20130028055A (ko) 2013-03-18
AU2011209713B2 (en) 2014-04-03
CR20120404A (es) 2012-10-04
UY33202A (es) 2011-08-31
CN102812046A (zh) 2012-12-05
US20120282254A1 (en) 2012-11-08
EP2528947A4 (fr) 2013-09-18
AU2011209713A1 (en) 2012-09-13
JP2013517799A (ja) 2013-05-20
CA2787070A1 (fr) 2011-08-04
MX339083B (es) 2016-04-01
UA104663C2 (xx) 2014-02-25
PE20121702A1 (es) 2012-12-14
PE20170687A1 (es) 2017-06-13
US8940303B2 (en) 2015-01-27
NZ601271A (en) 2014-09-26
JP5850860B2 (ja) 2016-02-03
EP2528947A2 (fr) 2012-12-05
SG182590A1 (en) 2012-08-30
CL2012002081A1 (es) 2012-12-14
MX2012008765A (es) 2012-09-07
IL220899A (en) 2017-08-31
BR112012018914A2 (pt) 2017-07-25
CO6592067A2 (es) 2013-01-02
EA201290589A1 (ru) 2013-05-30
AR080027A1 (es) 2012-03-07
TW201136607A (en) 2011-11-01
WO2011094259A3 (fr) 2011-09-29
ZA201205624B (en) 2014-01-29
EA023700B1 (ru) 2016-07-29
WO2011094259A2 (fr) 2011-08-04
US9150653B2 (en) 2015-10-06
TWI489996B (zh) 2015-07-01
US20110200585A1 (en) 2011-08-18

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