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MA33811B1 - Composés et méthodes utilisés pour la modulation kinases et indications à cet effet - Google Patents

Composés et méthodes utilisés pour la modulation kinases et indications à cet effet

Info

Publication number
MA33811B1
MA33811B1 MA34954A MA34954A MA33811B1 MA 33811 B1 MA33811 B1 MA 33811B1 MA 34954 A MA34954 A MA 34954A MA 34954 A MA34954 A MA 34954A MA 33811 B1 MA33811 B1 MA 33811B1
Authority
MA
Morocco
Prior art keywords
compounds
cancer
diseases
protein kinase
conditions
Prior art date
Application number
MA34954A
Other languages
Arabic (ar)
English (en)
Inventor
Prabha N Ibrahim
Wayne Spevak
Hanna Cho
Songyuan Shi
Chao Zhang
Ying Zhang
Original Assignee
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of MA33811B1 publication Critical patent/MA33811B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

La présente invention concerne des composés et leurs sels, des compositions en contenant, des conjugués, des dérivés et des formes de ceux-ci, ainsi que leurs utilisations. Selon certains aspects et modes de réalisation, les composés ou leurs sels, les compositions en contenant, les conjugués, les dérivés et les formes de ceux-ci décrits ici sont actifs sur au moins une protéine kinase raf. Selon certains aspects et modes de réalisation, les composés décrits ici sont actifs en ce qu'ils inhibent la prolifération d'une lignée cellulaire mutante ras. L'invention concerne également des méthodes d'utilisation desdits composés à des fins de traitement de maladies et d'affections, dont des maladies et affections associées à l'activité de la protéine kinase mutante b-ras v600e, dont le mélanome, le gliome, le glioblastome multiforme, l'astrocytome pilocytique, le cancer colorectal, le cancer de la thyroïde, le cancer du poumon, le cancer de l'ovaire, le cancer de la prostate, le cancer du foie, le cancer de la vésicule biliaire, les tumeurs stromales gastro-intestinales, le cancer du canal cholédoque et le cholangiome. L'invention concerne également des méthodes d'utilisation desdits composés dans le cadre du traitement de maladies et d'affections, dont des maladies et affections associées à l'activité de la protéine kinase c-raf-1, ce qui comprend la douleur aiguë, la douleur chronique ou la polykystose rénale.
MA34954A 2009-11-18 2012-06-11 Composés et méthodes utilisés pour la modulation kinases et indications à cet effet MA33811B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26251009P 2009-11-18 2009-11-18
US38331010P 2010-09-15 2010-09-15
PCT/US2010/057293 WO2011063159A1 (fr) 2009-11-18 2010-11-18 Composés et méthodes utilisés pour la modulation des kinases et indications à cet effet

Publications (1)

Publication Number Publication Date
MA33811B1 true MA33811B1 (fr) 2012-12-03

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Family Applications (1)

Application Number Title Priority Date Filing Date
MA34954A MA33811B1 (fr) 2009-11-18 2012-06-11 Composés et méthodes utilisés pour la modulation kinases et indications à cet effet

Country Status (21)

Country Link
US (2) US8673928B2 (fr)
EP (1) EP2501236B1 (fr)
JP (2) JP2013511541A (fr)
KR (1) KR20120097512A (fr)
CN (2) CN102740698A (fr)
AU (2) AU2010321883A1 (fr)
BR (1) BR112012011792A2 (fr)
CA (1) CA2781287C (fr)
CL (1) CL2012001303A1 (fr)
CO (1) CO6551689A2 (fr)
ES (1) ES2627911T3 (fr)
IL (1) IL219567A0 (fr)
MA (1) MA33811B1 (fr)
MX (1) MX2012005827A (fr)
MY (1) MY156210A (fr)
NZ (1) NZ599872A (fr)
PE (1) PE20121335A1 (fr)
PH (1) PH12012500981A1 (fr)
RU (1) RU2012125070A (fr)
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LT2935248T (lt) 2012-12-21 2018-04-10 Plexxikon Inc. Kinazės moduliavimo junginiai ir būdai bei indikacijos
US20140303121A1 (en) 2013-03-15 2014-10-09 Plexxikon Inc. Heterocyclic compounds and uses thereof
SG11201506687RA (en) 2013-03-15 2015-09-29 Plexxikon Inc Heterocyclic compounds and uses thereof
WO2014194127A1 (fr) 2013-05-30 2014-12-04 Plexxikon Inc. Composés pour modulation de kinases, et indications correspondantes

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US20140288070A1 (en) 2014-09-25
CA2781287A1 (fr) 2011-05-26
AU2010321883A1 (en) 2012-05-31
US20110152258A1 (en) 2011-06-23
CN102740698A (zh) 2012-10-17
JP2013511541A (ja) 2013-04-04
CO6551689A2 (es) 2012-10-31
US9617267B2 (en) 2017-04-11
CN105906631A (zh) 2016-08-31
JP2016185958A (ja) 2016-10-27
KR20120097512A (ko) 2012-09-04
CL2012001303A1 (es) 2012-10-05
RU2012125070A (ru) 2013-12-27
EP2501236A4 (fr) 2013-05-15
PE20121335A1 (es) 2012-10-12
AU2016200485A1 (en) 2016-02-18
CA2781287C (fr) 2018-07-31
US8673928B2 (en) 2014-03-18
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EP2501236B1 (fr) 2017-03-29
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JP6194389B2 (ja) 2017-09-06
AU2016200485B2 (en) 2017-09-28
BR112012011792A2 (pt) 2015-10-13
PH12012500981A1 (en) 2017-08-23
MY156210A (en) 2016-01-29
WO2011063159A1 (fr) 2011-05-26
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EP2501236A1 (fr) 2012-09-26
ES2627911T3 (es) 2017-08-01

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