[go: up one dir, main page]

MA30757B1 - Inhibiteurs de l'akt (proteine kinase b) - Google Patents

Inhibiteurs de l'akt (proteine kinase b)

Info

Publication number
MA30757B1
MA30757B1 MA31573A MA31573A MA30757B1 MA 30757 B1 MA30757 B1 MA 30757B1 MA 31573 A MA31573 A MA 31573A MA 31573 A MA31573 A MA 31573A MA 30757 B1 MA30757 B1 MA 30757B1
Authority
MA
Morocco
Prior art keywords
akt
inhibitors
protein kinase
compound
salt
Prior art date
Application number
MA31573A
Other languages
English (en)
Inventor
Sajan Joseph
Renhua Li
Michael Ray Myers
Aktham Aburub
Jenny Pingqi Dai
Christopher Randall Schmid
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA30757B1 publication Critical patent/MA30757B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE UN 4-[5-(2-AMINO-ÉTHANESULFONYL)-ISOQUINOLÉIN-7-YL]-PHÉNOL OU UN SEL DE QUALITÉ PHARMACEUTIQUE DUDIT COMPOSÉ OU UN HYDRATE DU COMPOSÉ OU DE SON SEL EN TANT QU'INHIBITEURS DE AKT ET AGENTS ANTINÉOPLASIQUES ET/OU ANTIVIRAUX, DE MÊME QUE DES COMPOSITIONS COMPRENANT CES COMPOSÉS ET DES MÉTHODES D'EMPLOI DE CES COMPOSÉS.
MA31573A 2006-06-20 2009-01-19 Inhibiteurs de l'akt (proteine kinase b) MA30757B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80526006P 2006-06-20 2006-06-20
US88576507P 2007-01-19 2007-01-19

Publications (1)

Publication Number Publication Date
MA30757B1 true MA30757B1 (fr) 2009-10-01

Family

ID=38834248

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31573A MA30757B1 (fr) 2006-06-20 2009-01-19 Inhibiteurs de l'akt (proteine kinase b)

Country Status (28)

Country Link
US (1) US7998977B2 (fr)
EP (1) EP2035385B1 (fr)
JP (1) JP2009541335A (fr)
KR (1) KR101067551B1 (fr)
AR (1) AR061240A1 (fr)
AT (1) ATE455102T1 (fr)
AU (1) AU2007261120A1 (fr)
BR (1) BRPI0713136A2 (fr)
CA (1) CA2652612A1 (fr)
CL (1) CL2007001752A1 (fr)
DE (1) DE602007004333D1 (fr)
DK (1) DK2035385T3 (fr)
DO (1) DOP2008000053A (fr)
EA (1) EA015712B1 (fr)
EC (1) ECSP088992A (fr)
ES (1) ES2336630T3 (fr)
HR (1) HRP20100147T1 (fr)
IL (1) IL195005A0 (fr)
MA (1) MA30757B1 (fr)
MX (1) MX2008015904A (fr)
NO (1) NO20090289L (fr)
PE (1) PE20080338A1 (fr)
PL (1) PL2035385T3 (fr)
PT (1) PT2035385E (fr)
SI (1) SI2035385T1 (fr)
TN (1) TNSN08529A1 (fr)
TW (1) TW200812970A (fr)
WO (1) WO2007149730A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009146320A1 (fr) 2008-05-27 2009-12-03 Dmi Life Sciences, Inc. Procédés et composés thérapeutiques
CA2810844C (fr) 2010-09-07 2017-03-21 Dmi Acquisition Corp. Compositions de diketopiperazine destinees au traitement de syndrome metabolique et de troubles associes
PH12014500686A1 (en) 2011-10-10 2020-12-18 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
JP6203734B2 (ja) 2011-10-10 2017-09-27 アンピオ ファーマシューティカルズ，インコーポレイテッド 変形性関節疾患の治療
HK1198812A1 (en) 2011-10-28 2015-06-12 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
MX2015010937A (es) 2013-03-15 2015-10-29 Ampio Pharmaceuticals Inc Composiciones para la movilizacion, autodireccion, expansion y diferenciacion de celulas madre y metodos para usar las mismas.
AU2014293011A1 (en) 2013-07-26 2016-03-17 Race Oncology Ltd. Compositions to improve the therapeutic benefit of bisantrene
EP3183240A4 (fr) 2014-08-18 2018-06-27 Ampio Pharmaceuticals, Inc. Traitement de pathologies articulaires
US10123997B2 (en) * 2015-06-15 2018-11-13 Yong Liao Target for treating hepatitis B virus
HK1246669A1 (zh) 2015-06-22 2018-09-14 Ampio Pharmaceuticals, Inc. 人血清白蛋白低分子量组分在疾病治疗中的应用
WO2017156350A1 (fr) 2016-03-09 2017-09-14 K-Gen, Inc. Méthodes de traitement du cancer
CN115916350B (zh) * 2020-07-22 2024-11-05 南京正大天晴制药有限公司 Akt抑制剂的单位剂量组合物
WO2022017448A1 (fr) * 2020-07-22 2022-01-27 南京正大天晴制药有限公司 Sel et forme cristalline de dérivé de dihydropyrido[2,3-d]pyrimidine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL152807A0 (en) 2000-05-30 2003-06-24 Peptor Ltd Protein kinase inhibitors
EP1611105A1 (fr) 2003-03-28 2006-01-04 Eli Lilly And Company Utilisation d'amides d'acide isoquinoline-5-sulfonique comme inhibiteurs de l'akt (proteine kinase b)
GB0317315D0 (en) 2003-07-24 2003-08-27 Astex Technology Ltd Pharmaceutical compounds
EP1689719A1 (fr) 2003-11-25 2006-08-16 Eli Lilly And Company Derives de 7-phenyl-isoquinoline-5-sulfonylamino en tant qu'inhibiteurs de akt (proteine kinase b)

Also Published As

Publication number Publication date
PE20080338A1 (es) 2008-04-25
EA200970041A1 (ru) 2009-06-30
MX2008015904A (es) 2009-01-12
PL2035385T3 (pl) 2010-06-30
KR20090015978A (ko) 2009-02-12
KR101067551B1 (ko) 2011-09-27
US20090221633A1 (en) 2009-09-03
AU2007261120A1 (en) 2007-12-27
TW200812970A (en) 2008-03-16
EA015712B1 (ru) 2011-10-31
NO20090289L (no) 2009-01-19
EP2035385B1 (fr) 2010-01-13
ECSP088992A (es) 2009-01-30
DOP2008000053A (es) 2009-01-15
ATE455102T1 (de) 2010-01-15
PT2035385E (pt) 2010-03-01
AR061240A1 (es) 2008-08-13
JP2009541335A (ja) 2009-11-26
DK2035385T3 (da) 2010-03-22
ES2336630T3 (es) 2010-04-14
HRP20100147T1 (hr) 2010-04-30
TNSN08529A1 (en) 2010-04-14
SI2035385T1 (sl) 2010-05-31
DE602007004333D1 (de) 2010-03-04
BRPI0713136A2 (pt) 2012-04-17
CA2652612A1 (fr) 2007-12-27
CL2007001752A1 (es) 2008-01-18
WO2007149730A3 (fr) 2008-04-24
US7998977B2 (en) 2011-08-16
WO2007149730A2 (fr) 2007-12-27
EP2035385A2 (fr) 2009-03-18
IL195005A0 (en) 2009-08-03

Similar Documents

Publication Publication Date Title
MA30757B1 (fr) Inhibiteurs de l'akt (proteine kinase b)
MA29549B1 (fr) Arylpyrazoles substitues destines a etre utilises contre des parasites
MA29688B1 (fr) Formulation d'un inhibiteur de l'agregation plaquettaire thienopyridine
MA29550B1 (fr) Derives de n- (pyridine-2-yl) - sulfonamide
HRP20090281T1 (hr) 1,2,3,4-tetrasubstituirani indol za liječenje respiratornih bolesti
PT1984357E (pt) Compostos de 2,4-pirimidinadiamina para tratamento ou prevenção de doenças autoimunes
MA31763B1 (fr) Inhibiteurs de kinase de type polo
NO20090738L (no) Tilveiebringelse av EP2 agonister, fremgangsmate for fremstilling derav, farmasoytiske sammensetninger inneholdende disse forbindelser og fremgangsmater for anvendelse av forbindelsene og sammensetningene for a senke intraokkulaert trykk og behandle glaukom
PL1899329T3 (pl) Pirymidyno-podstawione pochodne benzimidazolu jako inhibitory kinaz białkowych
MXPA03010961A (es) Compuestos de tiazol utiles como inhibidores de proteinas cinasas.
MA30781B1 (fr) Inhibiteur de kinase
MA30784B1 (fr) Derives phenyliques et utilisation de ceux-ci en tant qu'immunomodulateurs.
MX2009002229A (es) Benzotriazoles como moduladores de cinasas.
DE60214703D1 (de) Thiazolverbindungen, die sich als inhibitoren von proteinkinasen eignen
MA31655B1 (fr) Pyrimidines cyclopenta [d] hydroxylés et méthoxylés utilisés en tant qu'inhibiteurs de la protéine kinase akt.
BRPI0606806A2 (pt) compostos indólicos, suas composições e seus usos
UA93351C2 (uk) Похідні фталазіну як інгібітори parp
AU2003297160A1 (en) Benzisoxazole derivatives useful as inhibitors of protein kinases
ATE479687T1 (de) Kinaseinhibitoren
TNSN06053A1 (en) 6-substituted anilino purines as rtk inhibitors
BRPI0417708A (pt) derivados organofosfóricos dos indazóis e sua utilização como inibidores das proteìnas quinases
MY143599A (en) Pyrazole derivatives, compositions containing such compounds and methods of use
TNSN08174A1 (en) Novel 1-aza bicycloalkyl derivatives for the treatment of psychotic and neurodegenerative disorders
IN2014DN08578A (fr)
ATE532781T1 (de) 5-(acylamino)indazol-derivate als kinase- inhibitoren